| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chanjuan Zhang, Likun Hu, Dong Liu, Jian Huang, Wenhan Li. Circumdatin D Exerts Neuroprotective Effects by Attenuating LPS-Induced Pro-Inflammatory Responses and Downregulating Acetylcholinesterase Activity Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32523534. |
inhibitors toward inflammation and targeting ache are regarded to promote cholinergic signaling of the central nervous system in ad therapy. |
2020-09-28 |
2023-08-13 |
Not clear |
| Joana Ferreira, Sara Santos, Helena Pereir. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-09-28. PMID:32765630. |
acetylcholinesterase (ache) inhibitors are used to treat alzheimer's patients because they enhance cholinergic neurotransmission. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hatice Esra Aslan, Yeliz Demir, Muhammet Serhat Özaslan, Fikret Türkan, Şükrü Beydemir, Ömer Irfan Küfrevioğl. The behavior of some chalcones on acetylcholinesterase and carbonic anhydrase activity. Drug and chemical toxicology. vol 42. issue 6. 2020-07-21. PMID:29860891. |
acetylcholinesterase (ache) is a serine hydrolase and mostly abundant at neuromuscular junctions and cholinergic brain synapses. |
2020-07-21 |
2023-08-13 |
human |
| Md Tanvir Kabir, Md Sahab Uddin, Mst Marium Begum, Shanmugam Thangapandiyan, Md Sohanur Rahman, Lotfi Aleya, Bijo Mathew, Muniruddin Ahmed, George E Barreto, Ghulam Md Ashra. Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning. Current pharmaceutical design. vol 25. issue 33. 2020-06-12. PMID:31593530. |
acetylcholinesterase (ache) remains a highly viable target for the symptomatic improvement in ad because cholinergic deficit is a consistent and early finding in ad. |
2020-06-12 |
2023-08-13 |
Not clear |
| Prayasee Baruah, Grace Basumatary, Semen O Yesylevskyy, Kripamoy Aguan, Ghanashyam Bez, Sivaprasad Mitr. Novel coumarin derivatives as potent acetylcholinesterase inhibitors: insight into efficacy, mode and site of inhibition. Journal of biomolecular structure & dynamics. vol 37. issue 7. 2020-06-02. PMID:29663860. |
the inhibitory efficacy of two substituted coumarin derivatives on the activity of neurodegenerative enzyme acetylcholinesterase (ache) was assessed in aqueous buffer as well as in the presence of human serum albumin (hsa) and compared against standard cholinergic ad drug, donepezil (don). |
2020-06-02 |
2023-08-13 |
human |
| Xin Wang, Ping Li, Qi Ding, Chuanchen Wu, Wen Zhang, Bo Tan. Observation of Acetylcholinesterase in Stress-Induced Depression Phenotypes by Two-Photon Fluorescence Imaging in the Mouse Brain. Journal of the American Chemical Society. vol 141. issue 5. 2020-05-27. PMID:30638380. |
acetylcholinesterase (ache), a key hydrolase in the cholinergic system, directly determines the degradation of neurotransmitters. |
2020-05-27 |
2023-08-13 |
mouse |
| Aurélie Nervo, André-Guilhem Calas, Florian Nachon, Eric Krejc. Respiratory failure triggered by cholinesterase inhibitors may involve activation of a reflex sensory pathway by acetylcholine spillover. Toxicology. vol 424. 2020-05-14. PMID:31175885. |
indeed, the role of ache at the cholinergic synapses is not only to accurately control the synaptic transmission but also to prevent the spillover of ach. |
2020-05-14 |
2023-08-13 |
mouse |
| Zrinka Kovarik, Nikolina Maček Hrvat, Jarosław Kalisiak, Maja Katalinić, Rakesh K Sit, Tamara Zorbaz, Zoran Radić, Valery V Fokin, K Barry Sharpless, Palmer Taylo. Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase. Toxicology and applied pharmacology. vol 372. 2020-04-06. PMID:30978400. |
currently used therapy in counteracting excessive cholinergic stimulation consists of a muscarinic antagonist (atropine) and an oxime reactivator of inhibited ache, but the classical oximes are particularly ineffective in counteracting tabun exposure. |
2020-04-06 |
2023-08-13 |
human |
| Fernanda D'Avila da Silva, Pablo Andrei Nogara, Estael Ochoa-Rodríguez, Yanier Nuñez-Figueredo, Maylin Wong-Guerra, Denis Broock Rosemberg, João Batista Teixeira da Roch. Molecular docking and in vitro evaluation of a new hybrid molecule (JM-20) on cholinesterase activity from different sources. Biochimie. vol 168. 2020-04-06. PMID:31770565. |
the main function of ache is the hydrolysis of the neurotransmitter acetylcholine (ach) at the neuromuscular and in cholinergic brain synapses. |
2020-04-06 |
2023-08-13 |
human |
| Leticia B Wessler, Hemelin R Farias, Julia F Ronsani, Gabriela Candiotto, Paulo C L Dos Santos, Jade de Oliveira, Eduardo P Rico, Emilio L Strec. Acute exposure to leucine modifies behavioral parameters and cholinergic activity in zebrafish. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 78. 2020-04-03. PMID:31589917. |
in addition, we evaluated the effects of high levels of leucine in the acetylcholinesterase (ache) and choline acetyltransferase (chat) activities, components of cholinergic neurotransmission system. |
2020-04-03 |
2023-08-13 |
zebrafish |
| Lilly Toker, Israel Silman, Tzviya Zeev-Ben-Mordehai, Joel L Sussman, Lawrence M Schopfer, Oksana Lockridg. Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers. Chemico-biological interactions. vol 319. 2020-03-16. PMID:32087110. |
acetylcholinesterase (ache) terminates cholinergic neurotransmission by hydrolyzing acetylcholine. |
2020-03-16 |
2023-08-13 |
Not clear |
| Oksana Gerlits, Xiaotian Kong, Xiaolin Cheng, Troy Wymore, Donald K Blumenthal, Palmer Taylor, Zoran Radić, Andrey Kovalevsk. Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase. The Journal of biological chemistry. vol 294. issue 27. 2020-03-10. PMID:31138650. |
inhibited ache cannot hydrolyze the neurotransmitter acetylcholine leading to its build-up at the cholinergic synapses and creating an acute cholinergic crisis. |
2020-03-10 |
2023-08-13 |
human |
| Sabrina G Müller, Ana Paula Pesarico, Suzan G Rosa, Franciele Martini, Cristina W Nogueir. Contribution of cholinergic system and Nrf2/HO-1 signaling to the anti-amnesic action of 7-fluoro-1,3-diphenylisoquinoline-1-amine in mice. Chemico-biological interactions. vol 317. 2020-03-04. PMID:32001261. |
scopolamine induced amnesia and cholinergic dysfunction by increasing the acetylcholinesterase (ache) activity and content, decreasing the muscarinic m1 receptor levels in the prefrontal cortex and hippocampus of mice. |
2020-03-04 |
2023-08-13 |
mouse |
| Sabrina G Müller, Ana Paula Pesarico, Suzan G Rosa, Franciele Martini, Cristina W Nogueir. Contribution of cholinergic system and Nrf2/HO-1 signaling to the anti-amnesic action of 7-fluoro-1,3-diphenylisoquinoline-1-amine in mice. Chemico-biological interactions. vol 317. 2020-03-04. PMID:32001261. |
considering fdpi effects on the hippocampus, it was effective against the cholinergic dysfunction, ache activity and content, and m1 receptor levels, which collectively could contribute to its anti-amnesic effect. |
2020-03-04 |
2023-08-13 |
mouse |
| Yu-Ting Hu, Xin-Lu Chen, Shu-Han Huang, Qiong-Bin Zhu, Si-Yang Yu, Yi Shen, Arja Sluiter, Joost Verhaagen, Juan Zhao, Dick Swaab, Ai-Min Ba. Early growth response-1 regulates acetylcholinesterase and its relation with the course of Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 29. issue 4. 2020-02-12. PMID:30511454. |
we conclude that the egr1 can upregulate ache expression by a direct effect on its gene promoter, which may contribute significantly to the changes in cholinergic function in the course of ad. |
2020-02-12 |
2023-08-13 |
mouse |
| Charlotte Whitmore, Christopher D Lindsay, Mike Bird, Samuel J Gore, Helen Rice, Rebecca L Williams, Christopher M Timperley, A Christopher Gree. Assessment of false transmitters as treatments for nerve agent poisoning. Toxicology letters. vol 321. 2020-01-27. PMID:31830555. |
nerve agents inhibit acetylcholinesterase (ache), leading to a build-up of acetylcholine (ach) and overstimulation at cholinergic synapses. |
2020-01-27 |
2023-08-13 |
human |
| Devashree N Patil, Sushama A Patil, Srinivas Sistla, Jyoti P Jadha. Comparative biophysical characterization: A screening tool for acetylcholinesterase inhibitors. PloS one. vol 14. issue 5. 2020-01-14. PMID:31150404. |
the oldest cholinergic hypothesis is used to elevate the level of cognitive impairment and acetylcholinesterase (ache) comprises the major targeted enzyme in ad. |
2020-01-14 |
2023-08-13 |
Not clear |
| Irina A Vladimirova, Igor B Philyppov, Ganna V Sotkis, Eugenia M Kulieva, Yelyzaveta Y Shuba, Kseniya L Gulak, Roman Skryma, Natalia Prevarskaya, Yaroslav M Shub. Impairment of cholinergic bladder contractility in rat model of type I diabetes complicated by cystitis: Contribution of neurotransmitter-degrading ectoenzymes. European journal of pharmacology. vol 860. 2020-01-08. PMID:31299187. |
we conclude that decreased ache activities associated with diabetes and likely cystitis provide complementary factor to the described in literature altered expression of mach receptor subtypes linked to diabetes as well as to cystitis to produce dramatic modification of cholinergic nmt. |
2020-01-08 |
2023-08-13 |
rat |
| Shani Shenhar-Tsarfaty, Shiri Sherf-Dagan, Galia Berman, Muriel Webb, Asnat Raziel, Andrei Keidar, David Goitein, Nasser Sakran, Eti Zwang, Itzhak Shapira, David Zeltser, Shlomo Berliner, Ori Rogowski, Oren Shibolet, Shira Zelber-Sag. Obesity-related acetylcholinesterase elevation is reversed following laparoscopic sleeve gastrectomy. International journal of obesity (2005). vol 43. issue 2. 2020-01-03. PMID:29491490. |
however, the association between morbid obesity and ache and the changes in cholinergic tone following bariatric laparoscopic sleeve gastrectomy (lsg) surgery-induced weight reduction were never analyzed. |
2020-01-03 |
2023-08-13 |
Not clear |
| Yaghoub Pourshojaei, Khalil Eskandari, Ali Asadipou. Highly Significant Scaffolds to Design and Synthesis Cholinesterase Inhibitors as Anti-Alzheimer Agents. Mini reviews in medicinal chemistry. vol 19. issue 19. 2019-12-26. PMID:31538893. |
based on the cholinergic hypothesis, and xray crystallographic determination of the structure of acetylcholinesterase (ache) enzyme, the level of acetylcholine (ach, an important neurotransmitter associated with memory) in the hippocampus and cortex area of the brain has a direct effect on alzheimer. |
2019-12-26 |
2023-08-13 |
Not clear |