| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yeheng Zhou, Wei Sun, Jiale Peng, Hui Yan, Li Zhang, Xingyong Liu, Zhili Zu. Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments. Bioorganic chemistry. vol 93. 2020-10-20. PMID:31585263. |
ache is a classical and key target of cholinergic disorders. |
2020-10-20 |
2023-08-13 |
Not clear |
| Maria-Letizia Campanari, María-Salud García-Ayllón, Sorana Ciura, Javier Sáez-Valero, Edor Kabash. Neuromuscular Junction Impairment in Amyotrophic Lateral Sclerosis: Reassessing the Role of Acetylcholinesterase. Frontiers in molecular neuroscience. vol 9. 2020-10-01. PMID:28082868. |
interestingly, in addition to their cholinergic role ache is thought to play several "non-classical" roles that do not require catalytic function, most prominent among these is the facilitation of neurite growth, nmj formation and survival. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jaymie R Voorhees, Diane S Rohlman, Pamela J Lein, Andrew A Piepe. Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds. Frontiers in neuroscience. vol 10. 2020-10-01. PMID:28149268. |
these compounds potently inhibit acetylcholinesterase (ache), the enzyme that inactivates acetylcholine at neuronal synapses, and acute exposure to high op levels can cause cholinergic crisis in humans and animals. |
2020-10-01 |
2023-08-13 |
Not clear |
| Etta Y L Liu, Miranda L Xu, Yan Jin, Qiyun Wu, Tina T X Dong, Karl W K Tsi. Genistein, a Phytoestrogen in Soybean, Induces the Expression of Acetylcholinesterase via G Protein-Coupled Receptor 30 in PC12 Cells. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:29535608. |
in parallel, the expression of tetrameric form of proline-rich membrane anchor (prima)-linked acetyl-cholinesterase (g4 ache), a key enzyme to hydrolyze acetylcholine in cholinergic synapses, was induced in a dose-dependent manner: this induction included the associated protein prima. |
2020-10-01 |
2023-08-13 |
Not clear |
| Stephen Brimijoin, Yang Gao, Liyi Geng, Vicky P Che. Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29535625. |
ache is universally understood as essential to cholinergic neurotransmission, voluntary muscle performance, and cognition, among other roles, and its catalytic impact is essential for life. |
2020-10-01 |
2023-08-13 |
mouse |
| Cong Lu, Yan Wang, Teng Xu, Qi Li, Donghui Wang, Lijing Zhang, Bei Fan, Fengzhong Wang, Xinmin Li. Genistein Ameliorates Scopolamine-Induced Amnesia in Mice Through the Regulation of the Cholinergic Neurotransmission, Antioxidant System and the ERK/CREB/BDNF Signaling. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30369882. |
additionally, ge remarkably promoted the cholinergic neurotransmission and protected against the oxidative stress damage in the hippocampus of scop-treated mice, as indicated by decreasing ache activity, elevating chat activity and ach level, increasing sod activity, lowering the level of mda and increasing gsh content. |
2020-10-01 |
2023-08-13 |
mouse |
| Edna Blotnick-Rubin, Lili Angliste. Fine Localization of Acetylcholinesterase in the Synaptic Cleft of the Vertebrate Neuromuscular Junction. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:29725289. |
acetylcholinesterase (ache) is concentrated at cholinergic synapses, where it is a major factor in controlling the duration of transmitter action. |
2020-09-30 |
2023-08-13 |
mouse |
| Angela K Tiethof, Jason R Richardson, Ronald P Har. Knockdown of Butyrylcholinesterase but Not Inhibition by Chlorpyrifos Alters Early Differentiation Mechanisms in Human Neural Stem Cells. Toxics. vol 6. issue 3. 2020-09-30. PMID:30200437. |
the organophosphate pesticide chlorpyrifos (cpf) primarily exerts toxicity through the inhibition of ache, which results in excess cholinergic stimulation at the synapse. |
2020-09-30 |
2023-08-13 |
human |
| Huixin Chen, Xiang Wu, Xinmei Gu, Yiying Zhou, Luying Ye, Ke Zhang, Hanbo Pan, Jialing Wang, Hua Wei, Binbin Zhu, C Benjamin Naman, Shinghung Mak, Paul R Carlier, Wei Cui, Yifan Ha. Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30483056. |
furthermore, a10e substantially enhanced choline acetyltransferase (chat)-positive area and decreased ache activity, in the hippocampus regions of surgery-treated mice, indicating that a10e could prevent surgery-induced dysfunction of cholinergic system, possibly via increasing the synthesis of acetylcholine and the inhibition of ache. |
2020-09-30 |
2023-08-13 |
mouse |
| Woo Bin Yoon, Hyeon Jun Choi, Ji Eun Kim, Ji Won Park, Mi Ju Kang, Su Ji Bae, Young Ju Lee, You Sang Choi, Kil Soo Kim, Young-Suk Jung, Joon-Yong Cho, Dae Youn Hwang, Hyun Keun Son. Comparison of scopolamine-induced cognitive impairment responses in three different ICR stocks. Laboratory animal research. vol 34. issue 4. 2020-09-30. PMID:30671121. |
to determine cholinergic dysfunction induction by spl exposure, activity of acetylcholinesterase (ache) assessed in the three icr stocks revealed no difference of acetylcholinesterase activity. |
2020-09-30 |
2023-08-13 |
mouse |
| Sedigheh Bakhtiari, Nahid Beladi Moghadam, Marjan Ehsani, Hamed Mortazavi, Siamak Sabour, Mahin Bakhsh. Can Salivary Acetylcholinesterase be a Diagnostic Biomarker for Alzheimer? Journal of clinical and diagnostic research : JCDR. vol 11. issue 1. 2020-09-29. PMID:28274046. |
due to the specific biosynthesis of acetylcholinesterase (ache) of cholinergic neurons, the enzyme has been proposed as a potential biochemical marker of cholinergic activity. |
2020-09-29 |
2023-08-13 |
Not clear |
| Erik Andrade-Jorge, José Bribiesca-Carlos, Francisco J Martínez-Martínez, Marvin A Soriano-Ursúa, Itzia I Padilla-Martínez, José G Trujillo-Ferrar. Crystal structure, DFT calculations and evaluation of 2-(2-(3,4-dimethoxyphenyl)ethyl)isoindoline-1,3-dione as AChE inhibitor. Chemistry Central journal. vol 12. issue 1. 2020-09-29. PMID:29938351. |
various reports have shown that phthalimide derivatives are potent inhibitors of ache, a key enzyme involved in the deterioration of the cholinergic system during the development of alzheimer's disease. |
2020-09-29 |
2023-08-13 |
Not clear |
| Mark E Gurne. Genetic Association of Phosphodiesterases With Human Cognitive Performance. Frontiers in molecular neuroscience. vol 12. 2020-09-29. PMID:30800055. |
notably absent was genetic association in healthy subjects to targets of cns drug discovery designed to improve cognition in disease states by the modulation of cholinergic [acetylcholinesterase (ache), choline acetyltransferase (chat), nicotinic alpha 7 acetylcholine receptor (chrna7)], serotonergic (htr6), histaminergic (hrh3), or glutamatergic (grm5) pathways. |
2020-09-29 |
2023-08-13 |
human |
| Chanjuan Zhang, Likun Hu, Dong Liu, Jian Huang, Wenhan Li. Circumdatin D Exerts Neuroprotective Effects by Attenuating LPS-Induced Pro-Inflammatory Responses and Downregulating Acetylcholinesterase Activity Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32523534. |
circumdatin d exerts neuroprotective effects by attenuating lps-induced pro-inflammatory responses and downregulating acetylcholinesterase activity alzheimer's disease (ad) is a prevalent neurodegenerative disorder with multifactorial causes, of which systemic inflammation may play a key role to promote neurodegeneration, and acetylcholinesterase (ache) is a target protein to induce cholinergic transmission. |
2020-09-28 |
2023-08-13 |
Not clear |
| Chanjuan Zhang, Likun Hu, Dong Liu, Jian Huang, Wenhan Li. Circumdatin D Exerts Neuroprotective Effects by Attenuating LPS-Induced Pro-Inflammatory Responses and Downregulating Acetylcholinesterase Activity Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32523534. |
inhibitors toward inflammation and targeting ache are regarded to promote cholinergic signaling of the central nervous system in ad therapy. |
2020-09-28 |
2023-08-13 |
Not clear |
| Joana Ferreira, Sara Santos, Helena Pereir. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-09-28. PMID:32765630. |
acetylcholinesterase (ache) inhibitors are used to treat alzheimer's patients because they enhance cholinergic neurotransmission. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hatice Esra Aslan, Yeliz Demir, Muhammet Serhat Özaslan, Fikret Türkan, Şükrü Beydemir, Ömer Irfan Küfrevioğl. The behavior of some chalcones on acetylcholinesterase and carbonic anhydrase activity. Drug and chemical toxicology. vol 42. issue 6. 2020-07-21. PMID:29860891. |
acetylcholinesterase (ache) is a serine hydrolase and mostly abundant at neuromuscular junctions and cholinergic brain synapses. |
2020-07-21 |
2023-08-13 |
human |
| Md Tanvir Kabir, Md Sahab Uddin, Mst Marium Begum, Shanmugam Thangapandiyan, Md Sohanur Rahman, Lotfi Aleya, Bijo Mathew, Muniruddin Ahmed, George E Barreto, Ghulam Md Ashra. Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning. Current pharmaceutical design. vol 25. issue 33. 2020-06-12. PMID:31593530. |
acetylcholinesterase (ache) remains a highly viable target for the symptomatic improvement in ad because cholinergic deficit is a consistent and early finding in ad. |
2020-06-12 |
2023-08-13 |
Not clear |
| Prayasee Baruah, Grace Basumatary, Semen O Yesylevskyy, Kripamoy Aguan, Ghanashyam Bez, Sivaprasad Mitr. Novel coumarin derivatives as potent acetylcholinesterase inhibitors: insight into efficacy, mode and site of inhibition. Journal of biomolecular structure & dynamics. vol 37. issue 7. 2020-06-02. PMID:29663860. |
the inhibitory efficacy of two substituted coumarin derivatives on the activity of neurodegenerative enzyme acetylcholinesterase (ache) was assessed in aqueous buffer as well as in the presence of human serum albumin (hsa) and compared against standard cholinergic ad drug, donepezil (don). |
2020-06-02 |
2023-08-13 |
human |
| Xin Wang, Ping Li, Qi Ding, Chuanchen Wu, Wen Zhang, Bo Tan. Observation of Acetylcholinesterase in Stress-Induced Depression Phenotypes by Two-Photon Fluorescence Imaging in the Mouse Brain. Journal of the American Chemical Society. vol 141. issue 5. 2020-05-27. PMID:30638380. |
acetylcholinesterase (ache), a key hydrolase in the cholinergic system, directly determines the degradation of neurotransmitters. |
2020-05-27 |
2023-08-13 |
mouse |