| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria-Letizia Campanari, María-Salud García-Ayllón, Olivia Belbin, Joan Galcerán, Alberto Lleó, Javier Sáez-Valer. Acetylcholinesterase modulates presenilin-1 levels and γ-secretase activity. Journal of Alzheimer's disease : JAD. vol 41. issue 3. 2015-09-18. PMID:24699279. |
the cholinergic enzyme acetylcholinesterase (ache) and the catalytic component of the γ-secretase complex, presenilin-1 (ps1), are known to interact. |
2015-09-18 |
2023-08-13 |
human |
| Franciele Martini, César Augusto Bruning, Suelen Mendonca Soares, Cristina Wayne Nogueira, Gilson Zen. Inhibitory effect of ebselen on cerebral acetylcholinesterase activity in vitro: kinetics and reversibility of inhibition. Current pharmaceutical design. vol 21. issue 7. 2015-09-11. PMID:25312723. |
there is evidence that ebselen inhibits acetylcholinesterase (ache) activity, an enzyme that plays a key role in the cholinergic system by hydrolyzing acetylcholine (ach), in vitro and ex vivo. |
2015-09-11 |
2023-08-13 |
Not clear |
| Robert Zdanowski, Małgorzata Krzyżowska, Sławomir Lewicki, Piotr Rutkowski, Monika Leśniak, Marek Saracyn, Marcin Niemcewicz, Aleksander Michalski, Marek Kowalczy. Effect of isopropyl methylphosphonofluoridate (IMPF) poisoning on selected immunological parameters of angiogenesis. Annals of agricultural and environmental medicine : AAEM. vol 21. issue 4. 2015-08-28. PMID:25528912. |
acetylcholinesterase (ache) and cholinergic receptors play an important role in the immune system, including lymphocyte-induced angiogenesis. |
2015-08-28 |
2023-08-13 |
mouse |
| Mohamed A Elnasharty, Ahmed Sayed-Ahme. Expression and localization of pChAT as a novel method to study cholinergic innervation of rat adrenal gland. Acta histochemica. vol 116. issue 8. 2015-08-20. PMID:25239149. |
cholinergic innervation of the rat adrenal gland has been analyzed previously using cholinergic markers including acetylcholinesterase (ache), choline acetyltransferase (chat) and vesicular acetylcholine transporter (vacht). |
2015-08-20 |
2023-08-13 |
rat |
| Panit Yamchuen, Sathid Aimjongjun, Nanteetip Limpeancho. Oxidized low density lipoprotein increases acetylcholinesterase activity correlating with reactive oxygen species production. Neurochemistry international. vol 78. 2015-08-17. PMID:25111460. |
these findings support the notion that oxidized ldls are cytotoxic and that their action on ache may reduce central cholinergic transmission in ad and affirm ache as a continued rational for anticholinesterase therapy but in conjunction with antioxidant/antihyperlipidemic cotreatments. |
2015-08-17 |
2023-08-13 |
human |
| Hui-Jun Xi, Ren-Pei Wu, Jing-Jing Liu, Ling-Juan Zhang, Zhao-Shen L. Role of acetylcholinesterase in lung cancer. Thoracic cancer. vol 6. issue 4. 2015-08-14. PMID:26273392. |
acetylcholinesterase (ache) plays a key role in catalytic hydrolysis of cholinergic neurotransmitters. |
2015-08-14 |
2023-08-13 |
Not clear |
| Koneni V Sashidhara, Ram K Modukuri, Pooja Jadiya, Ranga Prasad Dodda, Manoj Kumar, Balasubramaniam Sridhar, Vikash Kumar, Rizwanul Haque, Mohammad Imran Siddiqi, Aamir Nazi. Benzofuran-chalcone hybrids as potential multifunctional agents against Alzheimer's disease: synthesis and in vivo studies with transgenic Caenorhabditis elegans. ChemMedChem. vol 9. issue 12. 2015-07-24. PMID:25251917. |
these compounds were also found to decrease acetylcholinesterase (ache) levels, reduce oxidative stress in the worms, lower lipid content, and to provide protection against chemically induced cholinergic neurodegeneration. |
2015-07-24 |
2023-08-13 |
human |
| Ian R Macdonald, Kenneth Rockwood, Earl Martin, Sultan Darves. Cholinesterase inhibition in Alzheimer's disease: is specificity the answer? Journal of Alzheimer's disease : JAD. vol 42. issue 2. 2015-07-20. PMID:24898642. |
acetylcholinesterase (ache) catalyzes the hydrolysis of the cholinergic neurotransmitter acetylcholine. |
2015-07-20 |
2023-08-13 |
Not clear |
| Ian R Macdonald, Kenneth Rockwood, Earl Martin, Sultan Darves. Cholinesterase inhibition in Alzheimer's disease: is specificity the answer? Journal of Alzheimer's disease : JAD. vol 42. issue 2. 2015-07-20. PMID:24898642. |
the lack of clinical efficacy for the highly specific and potent ache inhibitor, (-) huperzine a, is intriguing, given the known cholinergic deficit in ad. |
2015-07-20 |
2023-08-13 |
Not clear |
| Miroslav Pohanka, Vitezslav Vlce. Preparation and performance of a colorimetric biosensor using acetylcholinesterase and indoxylacetate for assay of nerve agents and drugs. Interdisciplinary toxicology. vol 7. issue 4. 2015-06-25. PMID:26109903. |
acetylcholinesterase (ache; ec 3.1.1.7) is one of the most crucial components of the cholinergic nervous system and thus many of the toxins interact with this enzyme. |
2015-06-25 |
2023-08-13 |
Not clear |
| Miroslav Pohanka, Vitezslav Vlce. Preparation and performance of a colorimetric biosensor using acetylcholinesterase and indoxylacetate for assay of nerve agents and drugs. Interdisciplinary toxicology. vol 7. issue 4. 2015-06-25. PMID:26109903. |
as to inhibitors, nerve agents used as chemical warfare, some insecticides, and drugs influencing the cholinergic system are common examples of ache inhibitors. |
2015-06-25 |
2023-08-13 |
Not clear |
| Galina F Makhaeva, Elena V Rudakova, Nichole D Hein, Olga G Serebryakova, Nadezhda V Kovaleva, Natalia P Boltneva, John K Fink, Rudy J Richardso. Further studies toward a mouse model for biochemical assessment of neuropathic potential of organophosphorus compounds. Journal of applied toxicology : JAT. vol 34. issue 12. 2015-06-22. PMID:24395470. |
inhibition and aging of neuropathy target esterase (nte) by neuropathic organophosphorus (op) compounds triggers op compound-induced delayed neuropathy (opidn), whereas inhibition of acetylcholinesterase (ache) produces cholinergic toxicity. |
2015-06-22 |
2023-08-12 |
mouse |
| Gulseher Sarah Sirin, Yingkai Zhan. How is acetylcholinesterase phosphonylated by soman? An ab initio QM/MM molecular dynamics study. The journal of physical chemistry. A. vol 118. issue 39. 2015-06-16. PMID:24786171. |
acetylcholinesterase (ache) is a crucial enzyme in the cholinergic nerve system that hydrolyzes acetylcholine (ach) and terminates synaptic signals by reducing the effective concentration of ach in the synaptic clefts. |
2015-06-16 |
2023-08-13 |
Not clear |
| Kathrine Eggers Pedersen, Niladri Basu, Robert Letcher, Alana K Greaves, Christian Sonne, Rune Dietz, Bjarne Styrishav. Brain region-specific perfluoroalkylated sulfonate (PFSA) and carboxylic acid (PFCA) accumulation and neurochemical biomarker responses in east Greenland polar bears (Ursus maritimus). Environmental research. vol 138. 2015-06-15. PMID:25682255. |
nine brain regions from nine polar bears were analyzed for enzyme activity (monoamine oxidase (mao), acetylcholinesterase (ache) and glutamine synthetase (gs)) and receptor density (dopamine-2 (d2), muscarinic cholinergic (machr) and gamma-butyric acid type a (gaba-a)) along with pfsa and pfca concentrations. |
2015-06-15 |
2023-08-13 |
Not clear |
| Nils Richter, Inka Allendorf, Oezguer A Onur, Lutz Kracht, Markus Dietlein, Marc Tittgemeyer, Bernd Neumaier, Gereon R Fink, Juraj Kukolj. The integrity of the cholinergic system determines memory performance in healthy elderly. NeuroImage. vol 100. 2015-05-12. PMID:24952230. |
cerebral acetylcholinesterase (ache) activity, a measure of the integrity of the cholinergic system, can be assessed in vivo using positron emission tomography (pet) and [(11)c]n-methyl-4-piperidyl acetate (mp4a). |
2015-05-12 |
2023-08-13 |
Not clear |
| Deok Jea Cha, Si Hyeock Le. Evolutionary origin and status of two insect acetylcholinesterases and their structural conservation and differentiation. Evolution & development. vol 17. issue 1. 2015-05-12. PMID:25627717. |
acetylcholinesterase (ache) plays a pivotal role in synaptic transmission in the cholinergic nervous system of most animals, including insects. |
2015-05-12 |
2023-08-13 |
Not clear |
| Alexandra I Zugno, Maria Paula Matos, Leila Canever, Daiane B Fraga, Renata D De Luca, Fernando V Ghedim, Pedro F Deroza, Mariana B de Oliveira, Felipe D Pacheco, Samira S Valvassori, Ana Maria Volpato, Josiane Budni, João Queved. Evaluation of acetylcholinesterase activity and behavioural alterations induced by ketamine in an animal model of schizophrenia. Acta neuropsychiatrica. vol 26. issue 1. 2015-05-11. PMID:25142099. |
cognitive deficits in schizophrenia play a crucial role in its clinical manifestation and seem to be related to changes in the cholinergic system, specifically the action of acetylcholinesterase (ache). |
2015-05-11 |
2023-08-13 |
Not clear |
| Ji-Woon Kim, Hana Seung, Kyung Ja Kwon, Mee Jung Ko, Eun Joo Lee, Hyun Ah Oh, Chang Soon Choi, Ki Chan Kim, Edson Luck Gonzales, Jueng Soo You, Dong-Hee Choi, Jongmin Lee, Seol-Heui Han, Sung Min Yang, Jae Hoon Cheong, Chan Young Shin, Geon Ho Bah. Subchronic treatment of donepezil rescues impaired social, hyperactive, and stereotypic behavior in valproic acid-induced animal model of autism. PloS one. vol 9. issue 8. 2015-04-23. PMID:25133713. |
we found that prenatal exposure of valproic acid (vpa) induced dysregulation of cholinergic neuronal development, most notably the up-regulation of acetylcholinesterase (ache) in the prefrontal cortex of affected rat and mouse offspring. |
2015-04-23 |
2023-08-13 |
mouse |
| Cédric Lecoutey, Damien Hedou, Thomas Freret, Patrizia Giannoni, Florence Gaven, Marc Since, Valentine Bouet, Céline Ballandonne, Sophie Corvaisier, Aurélie Malzert Fréon, Serge Mignani, Thierry Cresteil, Michel Boulouard, Sylvie Claeysen, Christophe Rochais, Patrick Dallemagn. Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 36. 2015-04-20. PMID:25157130. |
we show herein that rs67333 is also a submicromolar acetylcholinesterase (ache) inhibitor and therefore, could contribute, through this effect, to the restoration of the cholinergic neurotransmission that becomes altered in ad. |
2015-04-20 |
2023-08-13 |
Not clear |
| Shun Shimoham. [Development of therapies for Alzheimer's disease based on cholinergic hypothesis-status quo and future directions]. Rinsho shinkeigaku = Clinical neurology. vol 53. issue 11. 2015-04-13. PMID:24291871. |
rivastigmine increase acetylcholine in the cholinergic synapse by inhibition of both ache and butyrylcholinesterase. |
2015-04-13 |
2023-08-12 |
Not clear |