| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miroslav Pohank. Copper, aluminum, iron and calcium inhibit human acetylcholinesterase in vitro. Environmental toxicology and pharmacology. vol 37. issue 1. 2014-10-28. PMID:24473150. |
acetylcholinesterase (ache) is an important part of cholinergic nerves where it participates in termination of neurotransmission. |
2014-10-28 |
2023-08-12 |
human |
| Eric M Prager, Vassiliki Aroniadou-Anderjaska, Camila P Almeida-Suhett, Taiza H Figueiredo, James P Apland, Maria F M Brag. Acetylcholinesterase inhibition in the basolateral amygdala plays a key role in the induction of status epilepticus after soman exposure. Neurotoxicology. vol 38. 2014-10-24. PMID:23817175. |
it is well-established that seizure initiation is due to excessive cholinergic activity triggered by the nerve agent-induced irreversible inhibition of acetylcholinesterase (ache). |
2014-10-24 |
2023-08-12 |
rat |
| Surbhi Gupta, Bhupesh Sharm. Pharmacological modulation of I(1)-imidazoline and α2-adrenoceptors in sub acute brain ischemia induced vascular dementia. European journal of pharmacology. vol 723. 2014-10-07. PMID:24333661. |
cholinergic status was assessed by brain acetylcholinesterase (ache) activity. |
2014-10-07 |
2023-08-12 |
mouse |
| Matilde Yáñez, Dolores Viñ. Dual inhibitors of monoamine oxidase and cholinesterase for the treatment of Alzheimer disease. Current topics in medicinal chemistry. vol 13. issue 14. 2014-10-04. PMID:23889051. |
inhibition of ache increases neurotransmission at cholinergic synapses and reduce temporally the cognitive deficit. |
2014-10-04 |
2023-08-12 |
Not clear |
| Antoine-Scott Badin, John Eraifej, Susan Greenfiel. High-resolution spatio-temporal bioactivity of a novel peptide revealed by optical imaging in rat orbitofrontal cortex in vitro: possible implications for neurodegenerative diseases. Neuropharmacology. vol 73. 2014-08-13. PMID:23711548. |
acetylcholinesterase (ache) is now well known to have a secondary, non-enzymatic function independent of cholinergic transmission. |
2014-08-13 |
2023-08-12 |
rat |
| M Zimmerman. Neuronal AChE splice variants and their non-hydrolytic functions: redefining a target of AChE inhibitors? British journal of pharmacology. vol 170. issue 5. 2014-08-08. PMID:23991627. |
this review aims to provide clarification as to the role of these ache splice variants and their interplay with other cholinergic parameters and their being targets of ache inhibition: ache-r is particularly involved in the mediation of (anti-)apoptotic events in cholinergic cells, involving adaptation of various cholinergic parameters and a time-dependent link to the expression of neuroprotective factors. |
2014-08-08 |
2023-08-12 |
Not clear |
| M Zimmerman. Neuronal AChE splice variants and their non-hydrolytic functions: redefining a target of AChE inhibitors? British journal of pharmacology. vol 170. issue 5. 2014-08-08. PMID:23991627. |
there is direct evidence for roles of ache-t and ache-r in neurodegeneration and neuroprotection, with these roles involving ache as a key modulator of the cholinergic system: in vivo data further encourages the use of ache inhibitors in the treatment of neurodegenerative conditions such as ad since effects on both enzymatic activity and the enzyme's non-hydrolytic functions can be postulated. |
2014-08-08 |
2023-08-12 |
Not clear |
| Per Johansson, Erik G Almqvist, Jan-Ove Johansson, Niklas Mattsson, Ulf Andreasson, Oskar Hansson, Anders Wallin, Kaj Blennow, Henrik Zetterberg, Johan Svensso. Cerebrospinal fluid (CSF) 25-hydroxyvitamin D concentration and CSF acetylcholinesterase activity are reduced in patients with Alzheimer's disease. PloS one. vol 8. issue 11. 2014-08-05. PMID:24312390. |
little is known of vitamin d concentration in cerebrospinal fluid (csf) in alzheimer's disease (ad) and its relation with csf acetylcholinesterase (ache) activity, a marker of cholinergic function. |
2014-08-05 |
2023-08-12 |
Not clear |
| Athina A Strilakou, Stylianos T Tsakiris, Konstantinos G Kalafatakis, Aikaterini T Stylianaki, Petros L Karkalousos, Andreas V Koulouris, Iordanis S Mourouzis, Charis A Liap. Carnitine modulates crucial myocardial adenosine triphosphatases and acetylcholinesterase enzyme activities in choline-deprived rats. Canadian journal of physiology and pharmacology. vol 92. issue 1. 2014-07-25. PMID:24383876. |
choline is also the precursor of acetylcholine (cholinergic component of the heart's autonomic nervous system), whose levels are regulated by acetylcholinesterase (ache). |
2014-07-25 |
2023-08-12 |
rat |
| Athina A Strilakou, Stylianos T Tsakiris, Konstantinos G Kalafatakis, Aikaterini T Stylianaki, Petros L Karkalousos, Andreas V Koulouris, Iordanis S Mourouzis, Charis A Liap. Carnitine modulates crucial myocardial adenosine triphosphatases and acetylcholinesterase enzyme activities in choline-deprived rats. Canadian journal of physiology and pharmacology. vol 92. issue 1. 2014-07-25. PMID:24383876. |
this study aimed to investigate the impact of dietary choline deprivation on the activity of rat myocardial ache (cholinergic marker), na(+)/k(+)-atpase, and mg(2+)-atpase, and the possible effects of carnitine supplementation (carnitine, structurally relevant to choline, is used as an adjunct in treating cardiac diseases). |
2014-07-25 |
2023-08-12 |
rat |
| Hajer Attig, Naouel Kamel, Susanna Sforzini, Alessandro Dagnino, Jebali Jamel, Hamadi Boussetta, Aldo Viarengo, Mohamed Bann. Effects of thermal stress and nickel exposure on biomarkers responses in Mytilus galloprovincialis (Lam). Marine environmental research. vol 94. 2014-07-11. PMID:24424117. |
the cholinergic system was monitored using the acetylcholinesterase activity (ache). |
2014-07-11 |
2023-08-12 |
cat |
| Orit Chai, Adi Sommer, Gabriel Zimmerman, Hermona Soreq, Alon Friedman, Tali Bdolah-Abram, Itamar Aroch, Merav H Shami. Acetylcholinesterase activity in the cerebrospinal fluid of dogs with seizures. Veterinary journal (London, England : 1997). vol 198. issue 1. 2014-06-19. PMID:23988333. |
recent studies in animal models have focused on the role of cholinergic elements, mainly acetylcholinesterase (ache) and the 'readthrough' acetylcholinesterase isoform (ache-r), in seizures. |
2014-06-19 |
2023-08-12 |
dog |
| Anastasia A Borodinova, Denis V Abramochkin, Galina S Sukhov. Non-quantal release of acetylcholine in rat atrial myocardium is inhibited by noradrenaline. Experimental physiology. vol 98. issue 12. 2014-06-02. PMID:23975902. |
during the incubation of myocardium in the presence of acetylcholinesterase (ache) inhibitors, non-quantal ach release leads to accumulation of ach in the myocardium and cholinergic effects, which are proportional to the intensity of non-quantal secretion. |
2014-06-02 |
2023-08-12 |
rat |
| Anastasia A Borodinova, Denis V Abramochkin, Galina S Sukhov. Non-quantal release of acetylcholine in rat atrial myocardium is inhibited by noradrenaline. Experimental physiology. vol 98. issue 12. 2014-06-02. PMID:23975902. |
cholinergic changes of electrical activity induced by the ache inhibitor paraoxon (5 × 10(-6) m) in isolated rat right atrial preparations were determined by means of a standard microlectrode technique and used as a measure of the intensity of non-quantal release. |
2014-06-02 |
2023-08-12 |
rat |
| Jae-Sung Rhee, Bo-Mi Kim, Chang-Bum Jeong, Heum Gi Park, Kenneth Mei Yee Leung, Young-Mi Lee, Jae-Seong Le. Effect of pharmaceuticals exposure on acetylcholinesterase (AchE) activity and on the expression of AchE gene in the monogonont rotifer, Brachionus koreanus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 158. issue 4. 2014-06-02. PMID:24028855. |
particularly, atp, cbz, and tmp may have a toxic cholinergic effect on rotifer b. koreanus by inhibiting ache activity. |
2014-06-02 |
2023-08-12 |
human |
| Alexandre A Tonin, Aleksandro S Da Silva, Andressa S Schafer, Adelina R Aires, Camila B Oliveira, Daniela Zanini, Maria R C Schetinger, Vera M Morsch, Sonia T A Lopes, Silvia G Monteiro, Marta L R Lea. Influence of experimental infection by Haemonchus contortus on acetylcholinesterase activity in lymphocytes of lambs. Experimental parasitology. vol 139. 2014-05-13. PMID:24560768. |
the lymphocytes are cells with direct participation in the cholinergic system; therefore, based on these results, it can be concluded that the experimental infection with h. contortus influences the number of lymphocytes, and consequently the ache activity in these cells. |
2014-05-13 |
2023-08-12 |
Not clear |
| Miroslav Pohanka, Oto Pavlis, Jiri Pikul. Tacrine alters antibodies level in Francisella tularensis-infected mice. Neuro endocrinology letters. vol 34 Suppl 2. 2014-05-05. PMID:24362106. |
it is hypothesized that the cholinergic anti-inflammatory pathway is a common mechanism how inhibitors of ache can influence immunity. |
2014-05-05 |
2023-08-12 |
mouse |
| Maria Gonzalez-Rey, Maria João Bebiann. Effects of non-steroidal anti-inflammatory drug (NSAID) diclofenac exposure in mussel Mytilus galloprovincialis. Aquatic toxicology (Amsterdam, Netherlands). vol 148. 2014-04-25. PMID:24525329. |
phase ii gst remained unaltered in both tissues, while the up-regulation of the ache activity was directly related to the vitellogenin-like protein levels in exposed females, indicating an alteration in the estrogenic activity, rather than a breakdown in cholinergic neurotransmission function. |
2014-04-25 |
2023-08-12 |
cat |
| Rosa M Giraldez-Perez, Susana P Gaytan, Rosario Pasar. Cholinergic and nitrergic neuronal networks in the goldfish telencephalon. Acta neurobiologiae experimentalis. vol 73. issue 3. 2014-04-21. PMID:24129483. |
the purpose of this study was to examine pallial and subpallial cholinoceptive, cholinergic and nitrergic populations in the goldfish telencephalon by means of histochemical and immunohistochemical techniques in order to identify neurons containing acetylcholinesterase (ache), choline acetyltransferase (chat), nadph-diaphorase (nadphd), and neuronal nitric oxide synthase (nnos), and to relate their distribution to their putative functional significance. |
2014-04-21 |
2023-08-12 |
Not clear |
| N Rajasekar, Subhash Dwivedi, Santosh Kumar Tota, Pradeep Kumar Kamat, Kashif Hanif, Chandishwar Nath, Rakesh Shukl. Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice. European journal of pharmacology. vol 715. issue 1-3. 2014-04-14. PMID:23685326. |
oka administration resulted in memory impairment with a decreased cerebral blood flow (cbf) (measured by laser doppler flowmetry), atp level and increased mitochondrial (ca(2+))i, neuroinflammation (increased tnf-α, il-1β, cox-2 and gfap), oxidative-nitrosative stress, increased caspase-9 and cholinergic dysfunction (decreased ache activity/expression and α7 nicotinic acetylcholine receptor expression) in cerebral cortex and hippocampus of mice brain. |
2014-04-14 |
2023-08-12 |
mouse |