| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siyoung Lee, Jisung Kim, Sang Gwon Seo, Bo-Ryoung Choi, Jung-Soo Han, Ki Won Lee, Jiyoung Ki. Sulforaphane alleviates scopolamine-induced memory impairment in mice. Pharmacological research. vol 85. 2015-01-27. PMID:24836869. |
mice that received scopolamine alone showed impaired learning and memory retention and considerably decreased cholinergic system reactivity in the hippocampus and frontal cortex, as indicated by a decreased acetylcholine (ach) level and an increased acetylcholinesterase (ache) activity. |
2015-01-27 |
2023-08-13 |
mouse |
| Siyoung Lee, Jisung Kim, Sang Gwon Seo, Bo-Ryoung Choi, Jung-Soo Han, Ki Won Lee, Jiyoung Ki. Sulforaphane alleviates scopolamine-induced memory impairment in mice. Pharmacological research. vol 85. 2015-01-27. PMID:24836869. |
sulforaphane significantly attenuated the scopolamine-induced memory impairment and improved cholinergic system reactivity, as indicated by an increased ach level, decreased ache activity, and increased choline acetyltransferase (chat) expression in the hippocampus and frontal cortex. |
2015-01-27 |
2023-08-13 |
mouse |
| Heba S Aboul Ezz, Yasser A Khadrawy, Iman M Moura. The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats. Cytotechnology. vol 67. issue 1. 2015-01-15. PMID:24337652. |
these results suggest that bpa has cardiotoxic effects which are mediated by the oxidative stress resulting from the overproduction of free radicals, the deficiency of no and the inhibition of ache leading to cholinergic activation. |
2015-01-15 |
2023-08-12 |
rat |
| M Merad, W Soufi, S Ghalem, F Boukli, M H Baig, K Ahmad, Mohammad A Kama. Molecular interaction of acetylcholinesterase with carnosic acid derivatives: a neuroinformatics study. CNS & neurological disorders drug targets. vol 13. issue 3. 2015-01-07. PMID:24059305. |
acetylcholinesterase (ache) plays a biological role in the termination of nerve impulse transmissions at cholinergic synapses by rapid hydrolysis of its substrate, "acetylcholine". |
2015-01-07 |
2023-08-12 |
Not clear |
| Xiaoli Xu, Qin Li, Lv Zhou, Liqiang R. Neurochemical mechanism of the gastrointestinal interdigestive migrating motor complex in rats with acute inflammatory stomach ache. Neural regeneration research. vol 7. issue 27. 2015-01-05. PMID:25558227. |
these results indicated that nitrergic neurons, cholinergic neurons, vasoactive intestinal peptide neurons and calcitonin gene-related peptide neurons in the enteric nervous system may be involved in changes to the gastrointestinal interdigestive migrating motor complex following stomach ache, and that electroacupuncture can regulate this process. |
2015-01-05 |
2023-08-13 |
rat |
| Javier Del Pino, Garbriela Zeballos, María José Anadon, Miguel Andrés Capo, María Jesús Díaz, Jimena García, María Teresa Frej. Higher sensitivity to cadmium induced cell death of basal forebrain cholinergic neurons: a cholinesterase dependent mechanism. Toxicology. vol 325. 2014-12-18. PMID:25201352. |
this study proves that cadmium induces a more pronounced, but not selective, cell death on acetylcholinesterase (ache) on cholinergic neurons. |
2014-12-18 |
2023-08-13 |
Not clear |
| b' Branka Markovi\\xc4\\x87, Nevena V Radonji\\xc4\\x87, Milan Aksi\\xc4\\x87, Branislav Filipovi\\xc4\\x87, Nata\\xc5\\xa1a Petronijevi\\xc4\\x8. Long-term effects of maternal deprivation on cholinergic system in rat brain. BioMed research international. vol 2014. 2014-12-09. PMID:24711997.' |
the aim of this study was to examine long-term effects of maternal separation on acetylcholinesterase (ache) activity in different brain structures and the density of cholinergic fibers in hippocampus and retrosplenial (rs) cortex. |
2014-12-09 |
2023-08-13 |
rat |
| Fouad H Darras, Steffen Pockes, Guozheng Huang, Sarah Wehle, Andrea Strasser, Hans-Joachim Wittmann, Martin Nimczick, Christoph A Sotriffer, Michael Decke. Synthesis, biological evaluation, and computational studies of Tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists. ACS chemical neuroscience. vol 5. issue 3. 2014-12-03. PMID:24422467. |
combination of ache inhibiting and histamine h3 receptor antagonizing properties in a single molecule might show synergistic effects to improve cognitive deficits in alzheimer's disease, since both pharmacological actions are able to enhance cholinergic neurotransmission in the cortex. |
2014-12-03 |
2023-08-12 |
Not clear |
| Nadia Mushtaq, Roberta Schmatz, Luciane B Pereira, Mushtaq Ahmad, Naiara Stefanello, Juliano M Vieira, Fátima Abdalla, Marília V Rodrigues, Jucimara Baldissarelli, Luana Paula Pelinson, Diéssica P Dalenogare, Karine Paula Reichert, Eduardo M Dutra, Nádia Mulinacci, Marzia Innocenti, Maria Bellumori, Vera Maria Morsch, Maria Rosa Schetinge. Rosmarinic acid prevents lipid peroxidation and increase in acetylcholinesterase activity in brain of streptozotocin-induced diabetic rats. Cell biochemistry and function. vol 32. issue 3. 2014-12-01. PMID:24301255. |
in conclusion, the present findings showed that treatment with ra prevents the lipid peroxidation and consequently the increase in ache activity in diabetic rats, demonstrating that this compound can modulate cholinergic neurotransmission and prevent damage oxidative in brain in the diabetic state. |
2014-12-01 |
2023-08-12 |
rat |
| Helen M Campanha, Félix Carvalho, Paul M Schlosse. Active and peripheral anionic sites of acetylcholinesterase have differential modulation effects on cell proliferation, adhesion and neuritogenesis in the NG108-15 cell line. Toxicology letters. vol 230. issue 2. 2014-11-25. PMID:24680925. |
the classical enzymatic role of acetylcholinesterase (ache) is to terminate impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine (ach). |
2014-11-25 |
2023-08-12 |
mouse |
| Ali Afrasiabi, Gholam Hossein Riazi, Shayan Abbasi, Ali Dadras, Behafarid Ghalandari, Hossein Seidkhani, Seyed Mohamad Sadegh Modaresi, Neda Masoudian, Amir Amani, Shahin Ahmadia. Synaptosomal acetylcholinesterase activity variation pattern in the presence of electromagnetic fields. International journal of biological macromolecules. vol 65. 2014-11-24. PMID:24418344. |
acetylcholinesterase (ache) is the enzyme that controls the acetylcholine (ach) concentrations in cholinergic synaptic clefts by hydrolyzing ach to choline and acetate. |
2014-11-24 |
2023-08-12 |
Not clear |
| María-Salud García-Ayllón, María-Letizia Campanari, María-Fernanda Montenegro, Inmaculada Cuchillo-Ibáñez, Olivia Belbin, Alberto Lleó, Karl Tsim, Cecilio J Vidal, Javier Sáez-Valer. Presenilin-1 influences processing of the acetylcholinesterase membrane anchor PRiMA. Neurobiology of aging. vol 35. issue 7. 2014-11-17. PMID:24612677. |
in this study, we explore if ps1 participates in the processing of the cholinergic acetylcholinesterase (ache). |
2014-11-17 |
2023-08-12 |
mouse |
| Yaron Arbel, Shani Shenhar-Tsarfaty, Nir Waiskopf, Ariel Finkelstein, Amir Halkin, Miri Revivo, Shlomo Berliner, Itzhak Herz, Itzhak Shapira, Gad Keren, Hermona Soreq, Shmuel Bana. Decline in serum cholinesterase activities predicts 2-year major adverse cardiac events. Molecular medicine (Cambridge, Mass.). vol 20. 2014-10-28. PMID:24395570. |
cholinergic status was determined by measuring the cumulative capacity of serum acetylcholinesterase (ache) and butyrylcholinesterase (bche) to hydrolyze the ache substrate acetylthiocholine. |
2014-10-28 |
2023-08-12 |
Not clear |
| Yaron Arbel, Shani Shenhar-Tsarfaty, Nir Waiskopf, Ariel Finkelstein, Amir Halkin, Miri Revivo, Shlomo Berliner, Itzhak Herz, Itzhak Shapira, Gad Keren, Hermona Soreq, Shmuel Bana. Decline in serum cholinesterase activities predicts 2-year major adverse cardiac events. Molecular medicine (Cambridge, Mass.). vol 20. 2014-10-28. PMID:24395570. |
we found that patients with mace presented lower cholinergic status and ache values at catheterization (1,127 ± 422 and 359 ± 153 nmol substrate hydrolyzed per minute per milliliter, respectively) than no-mace patients (1,760 ± 546 and 508 ± 183 nmol substrate hydrolyzed per minute per milliliter, p < 0.001 and p < 0.001, respectively), whose levels were comparable to those of matched healthy controls (1,622 ± 303 and 504 ± 126 nmol substrate hydrolyzed per minute per milliliter, respectively). |
2014-10-28 |
2023-08-12 |
Not clear |
| Yaron Arbel, Shani Shenhar-Tsarfaty, Nir Waiskopf, Ariel Finkelstein, Amir Halkin, Miri Revivo, Shlomo Berliner, Itzhak Herz, Itzhak Shapira, Gad Keren, Hermona Soreq, Shmuel Bana. Decline in serum cholinesterase activities predicts 2-year major adverse cardiac events. Molecular medicine (Cambridge, Mass.). vol 20. 2014-10-28. PMID:24395570. |
in a multivariate analysis, patients with ache or total cholinergic status values below median showed conspicuously elevated risk for mace (hazard ratio 1.85 [95% confidence interval [ci] 1.09-3.15, p = 0.02] and 2.21 [95% ci 1.22-4.00, p = 0.009]) compared with those above median, even after adjusting for potential confounders. |
2014-10-28 |
2023-08-12 |
Not clear |
| Miroslav Pohank. Copper, aluminum, iron and calcium inhibit human acetylcholinesterase in vitro. Environmental toxicology and pharmacology. vol 37. issue 1. 2014-10-28. PMID:24473150. |
acetylcholinesterase (ache) is an important part of cholinergic nerves where it participates in termination of neurotransmission. |
2014-10-28 |
2023-08-12 |
human |
| Eric M Prager, Vassiliki Aroniadou-Anderjaska, Camila P Almeida-Suhett, Taiza H Figueiredo, James P Apland, Maria F M Brag. Acetylcholinesterase inhibition in the basolateral amygdala plays a key role in the induction of status epilepticus after soman exposure. Neurotoxicology. vol 38. 2014-10-24. PMID:23817175. |
it is well-established that seizure initiation is due to excessive cholinergic activity triggered by the nerve agent-induced irreversible inhibition of acetylcholinesterase (ache). |
2014-10-24 |
2023-08-12 |
rat |
| Surbhi Gupta, Bhupesh Sharm. Pharmacological modulation of I(1)-imidazoline and α2-adrenoceptors in sub acute brain ischemia induced vascular dementia. European journal of pharmacology. vol 723. 2014-10-07. PMID:24333661. |
cholinergic status was assessed by brain acetylcholinesterase (ache) activity. |
2014-10-07 |
2023-08-12 |
mouse |
| Matilde Yáñez, Dolores Viñ. Dual inhibitors of monoamine oxidase and cholinesterase for the treatment of Alzheimer disease. Current topics in medicinal chemistry. vol 13. issue 14. 2014-10-04. PMID:23889051. |
inhibition of ache increases neurotransmission at cholinergic synapses and reduce temporally the cognitive deficit. |
2014-10-04 |
2023-08-12 |
Not clear |
| Antoine-Scott Badin, John Eraifej, Susan Greenfiel. High-resolution spatio-temporal bioactivity of a novel peptide revealed by optical imaging in rat orbitofrontal cortex in vitro: possible implications for neurodegenerative diseases. Neuropharmacology. vol 73. 2014-08-13. PMID:23711548. |
acetylcholinesterase (ache) is now well known to have a secondary, non-enzymatic function independent of cholinergic transmission. |
2014-08-13 |
2023-08-12 |
rat |