| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji-Woon Kim, Hana Seung, Kyung Ja Kwon, Mee Jung Ko, Eun Joo Lee, Hyun Ah Oh, Chang Soon Choi, Ki Chan Kim, Edson Luck Gonzales, Jueng Soo You, Dong-Hee Choi, Jongmin Lee, Seol-Heui Han, Sung Min Yang, Jae Hoon Cheong, Chan Young Shin, Geon Ho Bah. Subchronic treatment of donepezil rescues impaired social, hyperactive, and stereotypic behavior in valproic acid-induced animal model of autism. PloS one. vol 9. issue 8. 2015-04-23. PMID:25133713. |
we found that prenatal exposure of valproic acid (vpa) induced dysregulation of cholinergic neuronal development, most notably the up-regulation of acetylcholinesterase (ache) in the prefrontal cortex of affected rat and mouse offspring. |
2015-04-23 |
2023-08-13 |
mouse |
| Cédric Lecoutey, Damien Hedou, Thomas Freret, Patrizia Giannoni, Florence Gaven, Marc Since, Valentine Bouet, Céline Ballandonne, Sophie Corvaisier, Aurélie Malzert Fréon, Serge Mignani, Thierry Cresteil, Michel Boulouard, Sylvie Claeysen, Christophe Rochais, Patrick Dallemagn. Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 36. 2015-04-20. PMID:25157130. |
we show herein that rs67333 is also a submicromolar acetylcholinesterase (ache) inhibitor and therefore, could contribute, through this effect, to the restoration of the cholinergic neurotransmission that becomes altered in ad. |
2015-04-20 |
2023-08-13 |
Not clear |
| Shun Shimoham. [Development of therapies for Alzheimer's disease based on cholinergic hypothesis-status quo and future directions]. Rinsho shinkeigaku = Clinical neurology. vol 53. issue 11. 2015-04-13. PMID:24291871. |
rivastigmine increase acetylcholine in the cholinergic synapse by inhibition of both ache and butyrylcholinesterase. |
2015-04-13 |
2023-08-12 |
Not clear |
| Linn Malmsten, Swetha Vijayaraghavan, Outi Hovatta, Amelia Marutle, Taher Darreh-Shor. Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation. Journal of cellular and molecular medicine. vol 18. issue 9. 2015-04-13. PMID:25109373. |
secretion of cytokines and the enzymes acetylcholinesterase (ache), butyrylcholinesterase (buche) and choline acetyltransferase (chat) involved in cholinergic signalling was measured in medium throughout the differentiation. |
2015-04-13 |
2023-08-13 |
human |
| Hai-Ming Xu, Heidi Qunhui Xie, Wu-Qun Tao, Zhi-Guang Zhou, Shuai-Zhang Li, Bin Zha. Dioxin and dioxin-like compounds suppress acetylcholinesterase activity via transcriptional downregulations in vitro. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24243026. |
these findings on dlcs are similar with those on 2,3,7,8-tcdd, pointing to the possibility that exposure to dioxin and dlcs, which frequently coexist in the contaminated environments, may concurrently interfere with the cholinergic functions via ache. |
2015-04-06 |
2023-08-12 |
Not clear |
| María-Letizia Campanari, María-Salud García-Ayllón, Lidia Blazquez-Llorca, Wilson K W Luk, Karl Tsim, Javier Sáez-Valer. Acetylcholinesterase protein level is preserved in the Alzheimer's brain. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24318838. |
acetylcholinesterase (ache) is a key enzyme in the cholinergic nervous system and is one of the most studied proteins in the field of alzheimer's disease (ad). |
2015-04-06 |
2023-08-12 |
Not clear |
| Karina Silvia Matos, Elaine F F da Cunha, Ruben Abagyan, Teodorico C Ramalh. Computational evidence for the reactivation process of human acetylcholinesterase inhibited by carbamates. Combinatorial chemistry & high throughput screening. vol 17. issue 6. 2015-04-06. PMID:24344993. |
acetylcholinesterase (ache) is responsible for hydrolysis of acetylcholine (ach), a function, which if disrupted, leads to cholinergic syndrome. |
2015-04-06 |
2023-08-12 |
human |
| Mihaela-Liliana Ţînţaş, Lénaïg Foucout, Sylvain Petit, Sylvain Oudeyer, Fabienne Gourand, Louisa Barré, Cyril Papamicaël, Vincent Levache. New developments in redox chemical delivery systems by means of 1,4-dihydroquinoline-based targetor: application to galantamine delivery to the brain. European journal of medicinal chemistry. vol 81. 2015-03-30. PMID:24852273. |
these strategies have been applied in the present case to the ache inhibitor galantamine with the aim of alleviating adverse effects observed with cholinergic ad treatment. |
2015-03-30 |
2023-08-13 |
Not clear |
| Ademir J Schmidel, Karla L Assmann, Chariane C Werlang, Kanandra T Bertoncello, Francini Francescon, Cassiano L Rambo, Gabriela M Beltrame, Daiane Calegari, Cibele B Batista, Rachel E Blaser, Walter A Roman Júnior, Greicy M M Conterato, Angelo L Piato, Leila Zanatta, Jacir Dal Magro, Denis B Rosember. Subchronic atrazine exposure changes defensive behaviour profile and disrupts brain acetylcholinesterase activity of zebrafish. Neurotoxicology and teratology. vol 44. 2015-03-06. PMID:24893294. |
furthermore, to investigate a putative role of cholinergic signalling on atz-mediated effects, we tested whether this herbicide alters acetylcholinesterase (ache) activity in brain and muscle preparations. |
2015-03-06 |
2023-08-13 |
zebrafish |
| Marcella Reale, Marta Di Nicola, Lucia Velluto, Chiara D'Angelo, Erica Costantini, Debomoy K Lahiri, Mohammad A Kamal, Qian-sheng Yu, Nigel H Grei. Selective acetyl- and butyrylcholinesterase inhibitors reduce amyloid-β ex vivo activation of peripheral chemo-cytokines from Alzheimer's disease subjects: exploring the cholinergic anti-inflammatory pathway. Current Alzheimer research. vol 11. issue 6. 2015-02-26. PMID:24359497. |
co-incubation with selective ache/buche inhibitors, (-)-phenserine (ache) and (-)-cymserine analogues (buche), mitigated the rise in cytokine levels and suggest that augmentation of the cholinergic anti-inflammatory pathway may prove valuable in ad. |
2015-02-26 |
2023-08-12 |
human |
| Manal F El-Khadragy, Ebtesam M Al-Olayan, Ahmed E Abdel Monei. Neuroprotective effects of Citrus reticulata in scopolamine-induced dementia oxidative stress in rats. CNS & neurological disorders drug targets. vol 13. issue 4. 2015-02-23. PMID:24938777. |
brain acetylcholinesterase enzyme (ache) activity was measured to assess the central cholinergic activity. |
2015-02-23 |
2023-08-13 |
rat |
| Manal F El-Khadragy, Ebtesam M Al-Olayan, Ahmed E Abdel Monei. Neuroprotective effects of Citrus reticulata in scopolamine-induced dementia oxidative stress in rats. CNS & neurological disorders drug targets. vol 13. issue 4. 2015-02-23. PMID:24938777. |
scopolamine administration induced a significant impairment of central cholinergic activity in rats, as indicated by a marked increase in ache activity. |
2015-02-23 |
2023-08-13 |
rat |
| Michael Allgaier, Clemens Allgaie. An update on drug treatment options of Alzheimer's disease. Frontiers in bioscience (Landmark edition). vol 19. 2015-02-07. PMID:24896354. |
hence, rebalancing the cholinergic input to improve the cognitive symptoms of ad by inhibition of acetylcholine esterase (ache) is still the only mechanistic target in addition to n-methyl-d-aspartate (nmda) receptor blockade by memantine that can be addressed by currently approved medications. |
2015-02-07 |
2023-08-13 |
Not clear |
| Ericka C Holmstrand, David Lund, Ajeesh Koshy Cherian, Jane Wright, Rolicia F Martin, Elizabeth A Ennis, Gregg D Stanwood, Martin Sarter, Randy D Blakel. Transgenic overexpression of the presynaptic choline transporter elevates acetylcholine levels and augments motor endurance. Neurochemistry international. vol 73. 2015-02-02. PMID:24274995. |
the hemicholinium-3 (hc-3) sensitive, high-affinity choline transporter (cht) sustains cholinergic signaling via the presynaptic uptake of choline derived from dietary sources or from acetylcholinesterase (ache)-mediated hydrolysis of acetylcholine (ach). |
2015-02-02 |
2023-08-12 |
mouse |
| Siyoung Lee, Jisung Kim, Sang Gwon Seo, Bo-Ryoung Choi, Jung-Soo Han, Ki Won Lee, Jiyoung Ki. Sulforaphane alleviates scopolamine-induced memory impairment in mice. Pharmacological research. vol 85. 2015-01-27. PMID:24836869. |
mice that received scopolamine alone showed impaired learning and memory retention and considerably decreased cholinergic system reactivity in the hippocampus and frontal cortex, as indicated by a decreased acetylcholine (ach) level and an increased acetylcholinesterase (ache) activity. |
2015-01-27 |
2023-08-13 |
mouse |
| Siyoung Lee, Jisung Kim, Sang Gwon Seo, Bo-Ryoung Choi, Jung-Soo Han, Ki Won Lee, Jiyoung Ki. Sulforaphane alleviates scopolamine-induced memory impairment in mice. Pharmacological research. vol 85. 2015-01-27. PMID:24836869. |
sulforaphane significantly attenuated the scopolamine-induced memory impairment and improved cholinergic system reactivity, as indicated by an increased ach level, decreased ache activity, and increased choline acetyltransferase (chat) expression in the hippocampus and frontal cortex. |
2015-01-27 |
2023-08-13 |
mouse |
| Heba S Aboul Ezz, Yasser A Khadrawy, Iman M Moura. The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats. Cytotechnology. vol 67. issue 1. 2015-01-15. PMID:24337652. |
these results suggest that bpa has cardiotoxic effects which are mediated by the oxidative stress resulting from the overproduction of free radicals, the deficiency of no and the inhibition of ache leading to cholinergic activation. |
2015-01-15 |
2023-08-12 |
rat |
| M Merad, W Soufi, S Ghalem, F Boukli, M H Baig, K Ahmad, Mohammad A Kama. Molecular interaction of acetylcholinesterase with carnosic acid derivatives: a neuroinformatics study. CNS & neurological disorders drug targets. vol 13. issue 3. 2015-01-07. PMID:24059305. |
acetylcholinesterase (ache) plays a biological role in the termination of nerve impulse transmissions at cholinergic synapses by rapid hydrolysis of its substrate, "acetylcholine". |
2015-01-07 |
2023-08-12 |
Not clear |
| Xiaoli Xu, Qin Li, Lv Zhou, Liqiang R. Neurochemical mechanism of the gastrointestinal interdigestive migrating motor complex in rats with acute inflammatory stomach ache. Neural regeneration research. vol 7. issue 27. 2015-01-05. PMID:25558227. |
these results indicated that nitrergic neurons, cholinergic neurons, vasoactive intestinal peptide neurons and calcitonin gene-related peptide neurons in the enteric nervous system may be involved in changes to the gastrointestinal interdigestive migrating motor complex following stomach ache, and that electroacupuncture can regulate this process. |
2015-01-05 |
2023-08-13 |
rat |
| Javier Del Pino, Garbriela Zeballos, María José Anadon, Miguel Andrés Capo, María Jesús Díaz, Jimena García, María Teresa Frej. Higher sensitivity to cadmium induced cell death of basal forebrain cholinergic neurons: a cholinesterase dependent mechanism. Toxicology. vol 325. 2014-12-18. PMID:25201352. |
this study proves that cadmium induces a more pronounced, but not selective, cell death on acetylcholinesterase (ache) on cholinergic neurons. |
2014-12-18 |
2023-08-13 |
Not clear |