| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anél Petzer, Brian H Harvey, Jacobus P Petze. The interactions of azure B, a metabolite of methylene blue, with acetylcholinesterase and butyrylcholinesterase. Toxicology and applied pharmacology. vol 274. issue 3. 2014-03-21. PMID:24161345. |
although the ache and buche inhibitory activities of azure b are twofold and fivefold, respectively, less potent than those recorded for mb [ic50(ache)=0.214μm; ic50(buche)=0.389μm] under identical conditions, azure b may be a contributor to mb's in vivo activation of the cholinergic system and beneficial effects in alzheimer's disease. |
2014-03-21 |
2023-08-12 |
human |
| Elisabet Viayna, Raimon Sabate, Diego Muñoz-Torrer. Dual inhibitors of β-amyloid aggregation and acetylcholinesterase as multi-target anti-Alzheimer drug candidates. Current topics in medicinal chemistry. vol 13. issue 15. 2014-03-10. PMID:23931440. |
another protein that seems to occupy a prominent position within the complex pathological network of ad is the enzyme acetylcholinesterase (ache), with classical and non-classical activities involved at the late (cholinergic deficit) and early (aβ aggregation) phases of the disease. |
2014-03-10 |
2023-08-12 |
human |
| Valentina Garibotto, Marco Tettamanti, Alessandra Marcone, Ioana Florea, Andrea Panzacchi, Rosamaria Moresco, Jere R Virta, Juha Rinne, Stefano F Cappa, Daniela Peran. Cholinergic activity correlates with reserve proxies in Alzheimer's disease. Neurobiology of aging. vol 34. issue 11. 2014-03-05. PMID:23820589. |
the significant correlation between ache activity in structures belonging to the memory network and reserve proxies suggests that the brain reserve in ad is associated with a preserved/stimulated cholinergic neurotransmission. |
2014-03-05 |
2023-08-12 |
human |
| Miroslav Pohanka, Vojtech Adam, Rene Kize. An acetylcholinesterase-based chronoamperometric biosensor for fast and reliable assay of nerve agents. Sensors (Basel, Switzerland). vol 13. issue 9. 2014-02-27. PMID:23999806. |
the enzyme acetylcholinesterase (ache) is an important part of cholinergic nervous system, where it stops neurotransmission by hydrolysis of the neurotransmitter acetylcholine. |
2014-02-27 |
2023-08-12 |
Not clear |
| Seok-Joo Park, Eun-Joo Shin, Sun Seek Min, Jihua An, Zhengyi Li, Yoon Hee Chung, Ji Hoon Jeong, Jae-Hyung Bach, Seung-Yeol Nah, Won-Ki Kim, Choon-Gon Jang, Yong-Sun Kim, Yo-Ichi Nabeshima, Toshitaka Nabeshima, Hyoung-Chun Ki. Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 8. 2014-02-13. PMID:23389690. |
cholinergic parameters (ie, acetylcholine (ach), choline acetyltransferase (chat), and acetylcholinesterase (ache)) and nmdar-dependent long-term potentiation (ltp) were significantly impaired in klotho mutant mice. |
2014-02-13 |
2023-08-12 |
mouse |
| Michaela Prinz, Sülünay Parlar, Gülşah Bayraktar, Vildan Alptüzün, Ercin Erciyas, Adyary Fallarero, Daniela Karlsson, Pia Vuorela, Malgorzata Burek, Carola Förster, Ezgi Turunc, Guliz Armagan, Ayfer Yalcin, Carola Schiller, Kristina Leuner, Manuel Krug, Christoph A Sotriffer, Ulrike Holzgrab. 1,4-Substituted 4-(1H)-pyridylene-hydrazone-type inhibitors of AChE, BuChE, and amyloid-β aggregation crossing the blood-brain barrier. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 49. issue 4. 2014-02-11. PMID:23643737. |
here, following the cholinergic hypothesis, we aimed to inhibit both acetyl- and butyrylcholinesterase (ache and buche) in order to increase the concentration of acetylcholine in the synaptic cleft. |
2014-02-11 |
2023-08-12 |
Not clear |
| Joana Osswald, António Paulo Carvalho, Laura Guimarães, Lúcia Guilhermin. Toxic effects of pure anatoxin-a on biomarkers of rainbow trout, Oncorhynchus mykiss. Toxicon : official journal of the International Society on Toxinology. vol 70. 2014-02-05. PMID:23648421. |
enzymes assessed in muscle tissues were related to cholinergic transmission (acetylcholinesterase [ache]), energy metabolism (lactate dehydrogenase [ldh] and nadp⁺-dependent isocitrate dehydrogenase [idh]). |
2014-02-05 |
2023-08-12 |
Not clear |
| David A Hicks, Natalia Z Makova, Mallory Gough, Edward T Parkin, Natalia N Nalivaeva, Anthony J Turne. The amyloid precursor protein represses expression of acetylcholinesterase in neuronal cell lines. The Journal of biological chemistry. vol 288. issue 36. 2014-02-04. PMID:23897820. |
in this study, we examined whether app is involved in the regulation of acetylcholinesterase (ache), which is a key protein of the cholinergic system and has been shown to accelerate amyloid fibril formation and increase their toxicity. |
2014-02-04 |
2023-08-12 |
Not clear |
| Vladimir Farar, Anna Hrabovska, Eric Krejci, Jaromir Myslivece. Developmental adaptation of central nervous system to extremely high acetylcholine levels. PloS one. vol 8. issue 7. 2014-02-03. PMID:23861875. |
acetylcholinesterase (ache) is a key enzyme in termination of fast cholinergic transmission. |
2014-02-03 |
2023-08-12 |
mouse |
| Vladimir Farar, Anna Hrabovska, Eric Krejci, Jaromir Myslivece. Developmental adaptation of central nervous system to extremely high acetylcholine levels. PloS one. vol 8. issue 7. 2014-02-03. PMID:23861875. |
in brain, acetylcholine (ach) is produced by cholinergic neurons and released in extracellular space where it is cleaved by ache anchored by protein prima. |
2014-02-03 |
2023-08-12 |
mouse |
| Nitsan Maharshak, Shani Shenhar-Tsarfaty, Nimrod Aroyo, Naama Orpaz, Irene Guberman, Jonathan Canaani, Zamir Halpern, Iris Dotan, Shlomo Berliner, Hermona Sore. MicroRNA-132 modulates cholinergic signaling and inflammation in human inflammatory bowel disease. Inflammatory bowel diseases. vol 19. issue 7. 2014-01-22. PMID:23598815. |
microrna-132 (mir-132) targets acetylcholinesterase (ache) and potentiates the cholinergic blockade of inflammatory reactions in cultured cells and experimental mice, but the implications of this interaction to human inflammatory disease remained unexplored. |
2014-01-22 |
2023-08-12 |
mouse |
| Alexandre A Tonin, Aleksandro S Da Silva, Gustavo R Thomé, Lizielle S Oliveira, Maria R C Schetinger, Vera M Morsch, Mariana M Flores, Rafael A Fighera, Gustavo Toscan, Fernanda F Vogel, Sonia T A Lope. Neospora caninum: Activity of cholinesterases during the acute and chronic phases of an experimental infection in gerbils. Experimental parasitology. vol 135. issue 4. 2014-01-17. PMID:24140613. |
since the participation of the cholinergic system in the immune response is well documented, the aim of this study was to evaluate the relationship between n. caninum infection and activities of acetylcholinesterase (ache) and butyrylcholinesterase (bche) during the acute and chronic phase of infection. |
2014-01-17 |
2023-08-12 |
cattle |
| Alexandre A Tonin, Aleksandro S Da Silva, Gustavo R Thomé, Lizielle S Oliveira, Maria R C Schetinger, Vera M Morsch, Mariana M Flores, Rafael A Fighera, Gustavo Toscan, Fernanda F Vogel, Sonia T A Lope. Neospora caninum: Activity of cholinesterases during the acute and chronic phases of an experimental infection in gerbils. Experimental parasitology. vol 135. issue 4. 2014-01-17. PMID:24140613. |
based on the results obtained, it was possible to observe a response of the cholinergic system, providing different grades of ache and bche activities, in response to the acute and chronic infection of gerbils experimentally infected with n. caninum. |
2014-01-17 |
2023-08-12 |
cattle |
| Nichole M Neugebauer, Emily B Einstein, Maria B Lopez, Tristan D McClure-Begley, Yann S Mineur, Marina R Picciott. Morphine dependence and withdrawal induced changes in cholinergic signaling. Pharmacology, biochemistry, and behavior. vol 109. 2014-01-07. PMID:23651795. |
acetylcholinesterase (ache) activity and [³h]-epibatidine binding were evaluated in order to determine if morphine dependence and withdrawal induces alterations in cholinergic signaling or expression of high affinity nicotinic acetylcholine receptors (nachrs) in the midbrain (mb), medial habenula (mhb) and interpeduncular nucleus (ipn). |
2014-01-07 |
2023-08-12 |
mouse |
| Ana Paula Murray, María Belén Faraoni, María Julia Castro, Natalia Paola Alza, Valeria Cavallar. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer's Disease Therapy. Current neuropharmacology. vol 11. issue 4. 2014-01-01. PMID:24381530. |
the fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery of an important number of secondary metabolites and plant extracts with the ability of inhibiting the enzyme ache, which, according to the cholinergic hypothesis, increases the levels of the neurotransmitter acetylcholine in the brain, thus improving cholinergic functions in patients with alzheimer's disease and alleviating the symptoms of this neurological disorder. |
2014-01-01 |
2023-08-12 |
Not clear |
| Paul M Nagy, Isabelle Auber. B6eGFPChAT mice overexpressing the vesicular acetylcholine transporter exhibit spontaneous hypoactivity and enhanced exploration in novel environments. Brain and behavior. vol 3. issue 4. 2014-01-01. PMID:24381809. |
focus has been on blocking acetylcholinesterase (ache) and enhancing ach synthesis to improve cholinergic neurotransmission. |
2014-01-01 |
2023-08-12 |
mouse |
| Eran Nizri, Talma Brenne. Modulation of inflammatory pathways by the immune cholinergic system. Amino acids. vol 45. issue 1. 2013-12-18. PMID:22194043. |
theses effects are mediated by cholinergic muscarinic and nicotinic receptors and other cholinergic components present in immune cells, such as acetylcholinesterase (ache) and cholineacetyltransferase. |
2013-12-18 |
2023-08-12 |
Not clear |
| Veena Beri, Scott A Wildman, Kazuro Shiomi, Ziyad F Al-Rashid, Jonah Cheung, Terrone L Rosenberr. The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity. Biochemistry. vol 52. issue 42. 2013-12-12. PMID:24040835. |
cholinergic synaptic transmission often requires extremely rapid hydrolysis of acetylcholine by acetylcholinesterase (ache). |
2013-12-12 |
2023-08-12 |
Not clear |
| T Antonelli, M C Tomasini, M Castellazzi, P Sola, C Tamborino, D Ferraro, L Ferraro, E Granier. Biological markers in cerebrospinal fluid for axonal impairment in multiple sclerosis: acetylcholinesterase activity cannot be considered a useful biomarker. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 5. 2013-12-09. PMID:23247598. |
the acetylcholinesterase (ache), essential enzyme for the regulation of turnover of acetylcholine, can be considered the most important biochemical indicator of cholinergic signaling in the nervous system. |
2013-12-09 |
2023-08-12 |
human |
| T Antonelli, M C Tomasini, M Castellazzi, P Sola, C Tamborino, D Ferraro, L Ferraro, E Granier. Biological markers in cerebrospinal fluid for axonal impairment in multiple sclerosis: acetylcholinesterase activity cannot be considered a useful biomarker. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 5. 2013-12-09. PMID:23247598. |
based on the role of the ache in the regulation of cholinergic signaling in the nervous system, the aim of the present study is to evaluate the activity of ache in different pathological conditions: ms, other inflammatory neurological disorders (oind) and non-inflammatory neurological disorders (nind). |
2013-12-09 |
2023-08-12 |
human |