| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Orit Chai, Adi Sommer, Gabriel Zimmerman, Hermona Soreq, Alon Friedman, Tali Bdolah-Abram, Itamar Aroch, Merav H Shami. Acetylcholinesterase activity in the cerebrospinal fluid of dogs with seizures. Veterinary journal (London, England : 1997). vol 198. issue 1. 2014-06-19. PMID:23988333. |
recent studies in animal models have focused on the role of cholinergic elements, mainly acetylcholinesterase (ache) and the 'readthrough' acetylcholinesterase isoform (ache-r), in seizures. |
2014-06-19 |
2023-08-12 |
dog |
| Anastasia A Borodinova, Denis V Abramochkin, Galina S Sukhov. Non-quantal release of acetylcholine in rat atrial myocardium is inhibited by noradrenaline. Experimental physiology. vol 98. issue 12. 2014-06-02. PMID:23975902. |
during the incubation of myocardium in the presence of acetylcholinesterase (ache) inhibitors, non-quantal ach release leads to accumulation of ach in the myocardium and cholinergic effects, which are proportional to the intensity of non-quantal secretion. |
2014-06-02 |
2023-08-12 |
rat |
| Anastasia A Borodinova, Denis V Abramochkin, Galina S Sukhov. Non-quantal release of acetylcholine in rat atrial myocardium is inhibited by noradrenaline. Experimental physiology. vol 98. issue 12. 2014-06-02. PMID:23975902. |
cholinergic changes of electrical activity induced by the ache inhibitor paraoxon (5 × 10(-6) m) in isolated rat right atrial preparations were determined by means of a standard microlectrode technique and used as a measure of the intensity of non-quantal release. |
2014-06-02 |
2023-08-12 |
rat |
| Jae-Sung Rhee, Bo-Mi Kim, Chang-Bum Jeong, Heum Gi Park, Kenneth Mei Yee Leung, Young-Mi Lee, Jae-Seong Le. Effect of pharmaceuticals exposure on acetylcholinesterase (AchE) activity and on the expression of AchE gene in the monogonont rotifer, Brachionus koreanus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 158. issue 4. 2014-06-02. PMID:24028855. |
particularly, atp, cbz, and tmp may have a toxic cholinergic effect on rotifer b. koreanus by inhibiting ache activity. |
2014-06-02 |
2023-08-12 |
human |
| Alexandre A Tonin, Aleksandro S Da Silva, Andressa S Schafer, Adelina R Aires, Camila B Oliveira, Daniela Zanini, Maria R C Schetinger, Vera M Morsch, Sonia T A Lopes, Silvia G Monteiro, Marta L R Lea. Influence of experimental infection by Haemonchus contortus on acetylcholinesterase activity in lymphocytes of lambs. Experimental parasitology. vol 139. 2014-05-13. PMID:24560768. |
the lymphocytes are cells with direct participation in the cholinergic system; therefore, based on these results, it can be concluded that the experimental infection with h. contortus influences the number of lymphocytes, and consequently the ache activity in these cells. |
2014-05-13 |
2023-08-12 |
Not clear |
| Miroslav Pohanka, Oto Pavlis, Jiri Pikul. Tacrine alters antibodies level in Francisella tularensis-infected mice. Neuro endocrinology letters. vol 34 Suppl 2. 2014-05-05. PMID:24362106. |
it is hypothesized that the cholinergic anti-inflammatory pathway is a common mechanism how inhibitors of ache can influence immunity. |
2014-05-05 |
2023-08-12 |
mouse |
| Maria Gonzalez-Rey, Maria João Bebiann. Effects of non-steroidal anti-inflammatory drug (NSAID) diclofenac exposure in mussel Mytilus galloprovincialis. Aquatic toxicology (Amsterdam, Netherlands). vol 148. 2014-04-25. PMID:24525329. |
phase ii gst remained unaltered in both tissues, while the up-regulation of the ache activity was directly related to the vitellogenin-like protein levels in exposed females, indicating an alteration in the estrogenic activity, rather than a breakdown in cholinergic neurotransmission function. |
2014-04-25 |
2023-08-12 |
cat |
| Rosa M Giraldez-Perez, Susana P Gaytan, Rosario Pasar. Cholinergic and nitrergic neuronal networks in the goldfish telencephalon. Acta neurobiologiae experimentalis. vol 73. issue 3. 2014-04-21. PMID:24129483. |
the purpose of this study was to examine pallial and subpallial cholinoceptive, cholinergic and nitrergic populations in the goldfish telencephalon by means of histochemical and immunohistochemical techniques in order to identify neurons containing acetylcholinesterase (ache), choline acetyltransferase (chat), nadph-diaphorase (nadphd), and neuronal nitric oxide synthase (nnos), and to relate their distribution to their putative functional significance. |
2014-04-21 |
2023-08-12 |
Not clear |
| N Rajasekar, Subhash Dwivedi, Santosh Kumar Tota, Pradeep Kumar Kamat, Kashif Hanif, Chandishwar Nath, Rakesh Shukl. Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice. European journal of pharmacology. vol 715. issue 1-3. 2014-04-14. PMID:23685326. |
oka administration resulted in memory impairment with a decreased cerebral blood flow (cbf) (measured by laser doppler flowmetry), atp level and increased mitochondrial (ca(2+))i, neuroinflammation (increased tnf-α, il-1β, cox-2 and gfap), oxidative-nitrosative stress, increased caspase-9 and cholinergic dysfunction (decreased ache activity/expression and α7 nicotinic acetylcholine receptor expression) in cerebral cortex and hippocampus of mice brain. |
2014-04-14 |
2023-08-12 |
mouse |
| Yoojin Seo, Yooyoung Shin, Hyung-Sik Kim, Insung Kang, In-Sun Hong, Soon Won Choi, Kyung-Rok Yu, Kyung-Sun Kan. Donepezil enhances Purkinje cell survival and alleviates motor dysfunction by inhibiting cholesterol synthesis in a murine model of Niemann Pick disease type C. Journal of neuropathology and experimental neurology. vol 73. issue 3. 2014-04-10. PMID:24487798. |
donepezil enhances purkinje cell survival and alleviates motor dysfunction by inhibiting cholesterol synthesis in a murine model of niemann pick disease type c. neurodegenerative processes are often accompanied by disruption of cholinergic systems; therefore, acetylcholinesterase (ache) inhibitors (acheis) may have therapeutic potential in some neurological conditions. |
2014-04-10 |
2023-08-12 |
mouse |
| Pandy Vijayapandi, VamsiKrishna Annabathina, B SivaNagaSrikanth, Vankadari Manjunath, Praveena Boggavarapu, Ameen Kunhu Mohammed P, Konasani RajendraPrasad, C T Kumarappa. In vitro anticholinergic and antihistaminic activities of Acorus calamus Linn. leaves extracts. African journal of traditional, complementary, and alternative medicines : AJTCAM. vol 10. issue 1. 2014-04-08. PMID:24082330. |
the present investigation was aimed at determining the effects of hexane, acetone, methanol and aqueous extracts of acorus calamus leaves (ache, acae, acme and acaqe) on cholinergic and histaminic system using isolated frog rectus abdominis muscle and guinea pig ileum. |
2014-04-08 |
2023-08-12 |
Not clear |
| V D'Andrea, E Bianchi, S Taurone, F Mignini, C Cavallotti, M Artic. Cholinergic innervation of human mesenteric lymphatic vessels. Folia morphologica. vol 72. issue 4. 2014-03-28. PMID:24402754. |
therefore, our aim is to analyse the cholinergic nerve fibres of lymphatic vessels using the traditional enzymatic techniques of staining, plus the biochemical modifications of acetylcholinesterase (ache) activity. |
2014-03-28 |
2023-08-12 |
human |
| Dhrubajyoti Mukherjee, Sugato Banerje. Learning and memory promoting effects of crude garlic extract. Indian journal of experimental biology. vol 51. issue 12. 2014-03-26. PMID:24579375. |
influence of lasuna on central cholinergic activity and its antioxidant properties were also studied by estimating the cortical acetylcholinesterase (ache) activity and reduced glutathione (gsh) levels respectively. |
2014-03-26 |
2023-08-12 |
mouse |
| Anél Petzer, Brian H Harvey, Jacobus P Petze. The interactions of azure B, a metabolite of methylene blue, with acetylcholinesterase and butyrylcholinesterase. Toxicology and applied pharmacology. vol 274. issue 3. 2014-03-21. PMID:24161345. |
although the ache and buche inhibitory activities of azure b are twofold and fivefold, respectively, less potent than those recorded for mb [ic50(ache)=0.214μm; ic50(buche)=0.389μm] under identical conditions, azure b may be a contributor to mb's in vivo activation of the cholinergic system and beneficial effects in alzheimer's disease. |
2014-03-21 |
2023-08-12 |
human |
| Elisabet Viayna, Raimon Sabate, Diego Muñoz-Torrer. Dual inhibitors of β-amyloid aggregation and acetylcholinesterase as multi-target anti-Alzheimer drug candidates. Current topics in medicinal chemistry. vol 13. issue 15. 2014-03-10. PMID:23931440. |
another protein that seems to occupy a prominent position within the complex pathological network of ad is the enzyme acetylcholinesterase (ache), with classical and non-classical activities involved at the late (cholinergic deficit) and early (aβ aggregation) phases of the disease. |
2014-03-10 |
2023-08-12 |
human |
| Valentina Garibotto, Marco Tettamanti, Alessandra Marcone, Ioana Florea, Andrea Panzacchi, Rosamaria Moresco, Jere R Virta, Juha Rinne, Stefano F Cappa, Daniela Peran. Cholinergic activity correlates with reserve proxies in Alzheimer's disease. Neurobiology of aging. vol 34. issue 11. 2014-03-05. PMID:23820589. |
the significant correlation between ache activity in structures belonging to the memory network and reserve proxies suggests that the brain reserve in ad is associated with a preserved/stimulated cholinergic neurotransmission. |
2014-03-05 |
2023-08-12 |
human |
| Miroslav Pohanka, Vojtech Adam, Rene Kize. An acetylcholinesterase-based chronoamperometric biosensor for fast and reliable assay of nerve agents. Sensors (Basel, Switzerland). vol 13. issue 9. 2014-02-27. PMID:23999806. |
the enzyme acetylcholinesterase (ache) is an important part of cholinergic nervous system, where it stops neurotransmission by hydrolysis of the neurotransmitter acetylcholine. |
2014-02-27 |
2023-08-12 |
Not clear |
| Seok-Joo Park, Eun-Joo Shin, Sun Seek Min, Jihua An, Zhengyi Li, Yoon Hee Chung, Ji Hoon Jeong, Jae-Hyung Bach, Seung-Yeol Nah, Won-Ki Kim, Choon-Gon Jang, Yong-Sun Kim, Yo-Ichi Nabeshima, Toshitaka Nabeshima, Hyoung-Chun Ki. Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 8. 2014-02-13. PMID:23389690. |
cholinergic parameters (ie, acetylcholine (ach), choline acetyltransferase (chat), and acetylcholinesterase (ache)) and nmdar-dependent long-term potentiation (ltp) were significantly impaired in klotho mutant mice. |
2014-02-13 |
2023-08-12 |
mouse |
| Michaela Prinz, Sülünay Parlar, Gülşah Bayraktar, Vildan Alptüzün, Ercin Erciyas, Adyary Fallarero, Daniela Karlsson, Pia Vuorela, Malgorzata Burek, Carola Förster, Ezgi Turunc, Guliz Armagan, Ayfer Yalcin, Carola Schiller, Kristina Leuner, Manuel Krug, Christoph A Sotriffer, Ulrike Holzgrab. 1,4-Substituted 4-(1H)-pyridylene-hydrazone-type inhibitors of AChE, BuChE, and amyloid-β aggregation crossing the blood-brain barrier. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 49. issue 4. 2014-02-11. PMID:23643737. |
here, following the cholinergic hypothesis, we aimed to inhibit both acetyl- and butyrylcholinesterase (ache and buche) in order to increase the concentration of acetylcholine in the synaptic cleft. |
2014-02-11 |
2023-08-12 |
Not clear |
| Joana Osswald, António Paulo Carvalho, Laura Guimarães, Lúcia Guilhermin. Toxic effects of pure anatoxin-a on biomarkers of rainbow trout, Oncorhynchus mykiss. Toxicon : official journal of the International Society on Toxinology. vol 70. 2014-02-05. PMID:23648421. |
enzymes assessed in muscle tissues were related to cholinergic transmission (acetylcholinesterase [ache]), energy metabolism (lactate dehydrogenase [ldh] and nadp⁺-dependent isocitrate dehydrogenase [idh]). |
2014-02-05 |
2023-08-12 |
Not clear |