| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David A Hicks, Natalia Z Makova, Mallory Gough, Edward T Parkin, Natalia N Nalivaeva, Anthony J Turne. The amyloid precursor protein represses expression of acetylcholinesterase in neuronal cell lines. The Journal of biological chemistry. vol 288. issue 36. 2014-02-04. PMID:23897820. |
in this study, we examined whether app is involved in the regulation of acetylcholinesterase (ache), which is a key protein of the cholinergic system and has been shown to accelerate amyloid fibril formation and increase their toxicity. |
2014-02-04 |
2023-08-12 |
Not clear |
| Vladimir Farar, Anna Hrabovska, Eric Krejci, Jaromir Myslivece. Developmental adaptation of central nervous system to extremely high acetylcholine levels. PloS one. vol 8. issue 7. 2014-02-03. PMID:23861875. |
acetylcholinesterase (ache) is a key enzyme in termination of fast cholinergic transmission. |
2014-02-03 |
2023-08-12 |
mouse |
| Vladimir Farar, Anna Hrabovska, Eric Krejci, Jaromir Myslivece. Developmental adaptation of central nervous system to extremely high acetylcholine levels. PloS one. vol 8. issue 7. 2014-02-03. PMID:23861875. |
in brain, acetylcholine (ach) is produced by cholinergic neurons and released in extracellular space where it is cleaved by ache anchored by protein prima. |
2014-02-03 |
2023-08-12 |
mouse |
| Nitsan Maharshak, Shani Shenhar-Tsarfaty, Nimrod Aroyo, Naama Orpaz, Irene Guberman, Jonathan Canaani, Zamir Halpern, Iris Dotan, Shlomo Berliner, Hermona Sore. MicroRNA-132 modulates cholinergic signaling and inflammation in human inflammatory bowel disease. Inflammatory bowel diseases. vol 19. issue 7. 2014-01-22. PMID:23598815. |
microrna-132 (mir-132) targets acetylcholinesterase (ache) and potentiates the cholinergic blockade of inflammatory reactions in cultured cells and experimental mice, but the implications of this interaction to human inflammatory disease remained unexplored. |
2014-01-22 |
2023-08-12 |
mouse |
| Alexandre A Tonin, Aleksandro S Da Silva, Gustavo R Thomé, Lizielle S Oliveira, Maria R C Schetinger, Vera M Morsch, Mariana M Flores, Rafael A Fighera, Gustavo Toscan, Fernanda F Vogel, Sonia T A Lope. Neospora caninum: Activity of cholinesterases during the acute and chronic phases of an experimental infection in gerbils. Experimental parasitology. vol 135. issue 4. 2014-01-17. PMID:24140613. |
since the participation of the cholinergic system in the immune response is well documented, the aim of this study was to evaluate the relationship between n. caninum infection and activities of acetylcholinesterase (ache) and butyrylcholinesterase (bche) during the acute and chronic phase of infection. |
2014-01-17 |
2023-08-12 |
cattle |
| Alexandre A Tonin, Aleksandro S Da Silva, Gustavo R Thomé, Lizielle S Oliveira, Maria R C Schetinger, Vera M Morsch, Mariana M Flores, Rafael A Fighera, Gustavo Toscan, Fernanda F Vogel, Sonia T A Lope. Neospora caninum: Activity of cholinesterases during the acute and chronic phases of an experimental infection in gerbils. Experimental parasitology. vol 135. issue 4. 2014-01-17. PMID:24140613. |
based on the results obtained, it was possible to observe a response of the cholinergic system, providing different grades of ache and bche activities, in response to the acute and chronic infection of gerbils experimentally infected with n. caninum. |
2014-01-17 |
2023-08-12 |
cattle |
| Nichole M Neugebauer, Emily B Einstein, Maria B Lopez, Tristan D McClure-Begley, Yann S Mineur, Marina R Picciott. Morphine dependence and withdrawal induced changes in cholinergic signaling. Pharmacology, biochemistry, and behavior. vol 109. 2014-01-07. PMID:23651795. |
acetylcholinesterase (ache) activity and [³h]-epibatidine binding were evaluated in order to determine if morphine dependence and withdrawal induces alterations in cholinergic signaling or expression of high affinity nicotinic acetylcholine receptors (nachrs) in the midbrain (mb), medial habenula (mhb) and interpeduncular nucleus (ipn). |
2014-01-07 |
2023-08-12 |
mouse |
| Ana Paula Murray, María Belén Faraoni, María Julia Castro, Natalia Paola Alza, Valeria Cavallar. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer's Disease Therapy. Current neuropharmacology. vol 11. issue 4. 2014-01-01. PMID:24381530. |
the fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery of an important number of secondary metabolites and plant extracts with the ability of inhibiting the enzyme ache, which, according to the cholinergic hypothesis, increases the levels of the neurotransmitter acetylcholine in the brain, thus improving cholinergic functions in patients with alzheimer's disease and alleviating the symptoms of this neurological disorder. |
2014-01-01 |
2023-08-12 |
Not clear |
| Paul M Nagy, Isabelle Auber. B6eGFPChAT mice overexpressing the vesicular acetylcholine transporter exhibit spontaneous hypoactivity and enhanced exploration in novel environments. Brain and behavior. vol 3. issue 4. 2014-01-01. PMID:24381809. |
focus has been on blocking acetylcholinesterase (ache) and enhancing ach synthesis to improve cholinergic neurotransmission. |
2014-01-01 |
2023-08-12 |
mouse |
| Eran Nizri, Talma Brenne. Modulation of inflammatory pathways by the immune cholinergic system. Amino acids. vol 45. issue 1. 2013-12-18. PMID:22194043. |
theses effects are mediated by cholinergic muscarinic and nicotinic receptors and other cholinergic components present in immune cells, such as acetylcholinesterase (ache) and cholineacetyltransferase. |
2013-12-18 |
2023-08-12 |
Not clear |
| Veena Beri, Scott A Wildman, Kazuro Shiomi, Ziyad F Al-Rashid, Jonah Cheung, Terrone L Rosenberr. The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity. Biochemistry. vol 52. issue 42. 2013-12-12. PMID:24040835. |
cholinergic synaptic transmission often requires extremely rapid hydrolysis of acetylcholine by acetylcholinesterase (ache). |
2013-12-12 |
2023-08-12 |
Not clear |
| T Antonelli, M C Tomasini, M Castellazzi, P Sola, C Tamborino, D Ferraro, L Ferraro, E Granier. Biological markers in cerebrospinal fluid for axonal impairment in multiple sclerosis: acetylcholinesterase activity cannot be considered a useful biomarker. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 5. 2013-12-09. PMID:23247598. |
the acetylcholinesterase (ache), essential enzyme for the regulation of turnover of acetylcholine, can be considered the most important biochemical indicator of cholinergic signaling in the nervous system. |
2013-12-09 |
2023-08-12 |
human |
| T Antonelli, M C Tomasini, M Castellazzi, P Sola, C Tamborino, D Ferraro, L Ferraro, E Granier. Biological markers in cerebrospinal fluid for axonal impairment in multiple sclerosis: acetylcholinesterase activity cannot be considered a useful biomarker. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 5. 2013-12-09. PMID:23247598. |
based on the role of the ache in the regulation of cholinergic signaling in the nervous system, the aim of the present study is to evaluate the activity of ache in different pathological conditions: ms, other inflammatory neurological disorders (oind) and non-inflammatory neurological disorders (nind). |
2013-12-09 |
2023-08-12 |
human |
| T Antonelli, M C Tomasini, M Castellazzi, P Sola, C Tamborino, D Ferraro, L Ferraro, E Granier. Biological markers in cerebrospinal fluid for axonal impairment in multiple sclerosis: acetylcholinesterase activity cannot be considered a useful biomarker. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 5. 2013-12-09. PMID:23247598. |
however, ache measured in csf can probably not be considered a useful biomarker for the assessment of the functional alterations of cholinergic system in pathological conditions. |
2013-12-09 |
2023-08-12 |
human |
| Lijuan Xin, Ritupriya Yamujala, Yuehu Wang, Huan Wang, Wen-Hsuan Wu, Michael A Lawton, Chunlin Long, Rong D. Acetylcholineestarase-inhibiting alkaloids from Lycoris radiata delay paralysis of amyloid beta-expressing transgenic C. elegans CL4176. PloS one. vol 8. issue 5. 2013-12-09. PMID:23675513. |
the "cholinergic hypothesis" of ad prompts us to search for plant-derived acetylcholineesterase (ache) inhibitors such as galanthamine that has been licensed in europe for ad treatment. |
2013-12-09 |
2023-08-12 |
human |
| E G Kakani, M Trakala, E Drosopoulou, P Mavragani-Tsipidou, K D Mathiopoulo. Genomic structure, organization and localization of the acetylcholinesterase locus of the olive fruit fly, Bactrocera oleae. Bulletin of entomological research. vol 103. issue 1. 2013-12-02. PMID:22967668. |
acetylcholinesterase (ache), encoded by the ace gene, is a key enzyme of cholinergic neurotransmission. |
2013-12-02 |
2023-08-12 |
drosophila_melanogaster |
| L Stan Leung, Jingyi Ma, Bixia Shen, Ilan Nachim, Tao Lu. Medial septal lesion enhances general anesthesia response. Experimental neurology. vol 247. 2013-11-26. PMID:23376225. |
lesion of the medial septum was confirmed by thionin-stained histological sections as well as loss of acetylcholinesterase (ache) staining in the hippocampus, indicating a depletion of septohippocampal cholinergic afferents. |
2013-11-26 |
2023-08-12 |
rat |
| Jose R Suarez-Lopez, David R Jacobs, John H Himes, Bruce H Alexande. Acetylcholinesterase activity, cohabitation with floricultural workers, and blood pressure in Ecuadorian children. Environmental health perspectives. vol 121. issue 5. 2013-11-19. PMID:23359481. |
acetylcholinesterase (ache) inhibitors are commonly used pesticides that can effect hemodynamic changes through increased cholinergic stimulation. |
2013-11-19 |
2023-08-12 |
Not clear |
| Franziska Mohr, Martina Zimmermann, Jochen Klei. Mice heterozygous for AChE are more sensitive to AChE inhibitors but do not respond to BuChE inhibition. Neuropharmacology. vol 67. 2013-11-04. PMID:23147415. |
an impaired central cholinergic system is at least partly involved in alzheimer's disease (ad) pathogenesis, with cholinergic markers such as acetylcholinesterase (ache) activity and protein levels decreasing as cognitive decline progresses. |
2013-11-04 |
2023-08-12 |
mouse |
| Franziska Mohr, Martina Zimmermann, Jochen Klei. Mice heterozygous for AChE are more sensitive to AChE inhibitors but do not respond to BuChE inhibition. Neuropharmacology. vol 67. 2013-11-04. PMID:23147415. |
ad patients receive ache inhibitor drugs to enhance cholinergic responses in the brain. |
2013-11-04 |
2023-08-12 |
mouse |