| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Antonelli, M C Tomasini, M Castellazzi, P Sola, C Tamborino, D Ferraro, L Ferraro, E Granier. Biological markers in cerebrospinal fluid for axonal impairment in multiple sclerosis: acetylcholinesterase activity cannot be considered a useful biomarker. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 5. 2013-12-09. PMID:23247598. |
however, ache measured in csf can probably not be considered a useful biomarker for the assessment of the functional alterations of cholinergic system in pathological conditions. |
2013-12-09 |
2023-08-12 |
human |
| Lijuan Xin, Ritupriya Yamujala, Yuehu Wang, Huan Wang, Wen-Hsuan Wu, Michael A Lawton, Chunlin Long, Rong D. Acetylcholineestarase-inhibiting alkaloids from Lycoris radiata delay paralysis of amyloid beta-expressing transgenic C. elegans CL4176. PloS one. vol 8. issue 5. 2013-12-09. PMID:23675513. |
the "cholinergic hypothesis" of ad prompts us to search for plant-derived acetylcholineesterase (ache) inhibitors such as galanthamine that has been licensed in europe for ad treatment. |
2013-12-09 |
2023-08-12 |
human |
| E G Kakani, M Trakala, E Drosopoulou, P Mavragani-Tsipidou, K D Mathiopoulo. Genomic structure, organization and localization of the acetylcholinesterase locus of the olive fruit fly, Bactrocera oleae. Bulletin of entomological research. vol 103. issue 1. 2013-12-02. PMID:22967668. |
acetylcholinesterase (ache), encoded by the ace gene, is a key enzyme of cholinergic neurotransmission. |
2013-12-02 |
2023-08-12 |
drosophila_melanogaster |
| L Stan Leung, Jingyi Ma, Bixia Shen, Ilan Nachim, Tao Lu. Medial septal lesion enhances general anesthesia response. Experimental neurology. vol 247. 2013-11-26. PMID:23376225. |
lesion of the medial septum was confirmed by thionin-stained histological sections as well as loss of acetylcholinesterase (ache) staining in the hippocampus, indicating a depletion of septohippocampal cholinergic afferents. |
2013-11-26 |
2023-08-12 |
rat |
| Jose R Suarez-Lopez, David R Jacobs, John H Himes, Bruce H Alexande. Acetylcholinesterase activity, cohabitation with floricultural workers, and blood pressure in Ecuadorian children. Environmental health perspectives. vol 121. issue 5. 2013-11-19. PMID:23359481. |
acetylcholinesterase (ache) inhibitors are commonly used pesticides that can effect hemodynamic changes through increased cholinergic stimulation. |
2013-11-19 |
2023-08-12 |
Not clear |
| Franziska Mohr, Martina Zimmermann, Jochen Klei. Mice heterozygous for AChE are more sensitive to AChE inhibitors but do not respond to BuChE inhibition. Neuropharmacology. vol 67. 2013-11-04. PMID:23147415. |
an impaired central cholinergic system is at least partly involved in alzheimer's disease (ad) pathogenesis, with cholinergic markers such as acetylcholinesterase (ache) activity and protein levels decreasing as cognitive decline progresses. |
2013-11-04 |
2023-08-12 |
mouse |
| Franziska Mohr, Martina Zimmermann, Jochen Klei. Mice heterozygous for AChE are more sensitive to AChE inhibitors but do not respond to BuChE inhibition. Neuropharmacology. vol 67. 2013-11-04. PMID:23147415. |
ad patients receive ache inhibitor drugs to enhance cholinergic responses in the brain. |
2013-11-04 |
2023-08-12 |
mouse |
| Franziska Mohr, Martina Zimmermann, Jochen Klei. Mice heterozygous for AChE are more sensitive to AChE inhibitors but do not respond to BuChE inhibition. Neuropharmacology. vol 67. 2013-11-04. PMID:23147415. |
the present study characterises the cholinergic system of mice heterozygous for ache (hz) as a suitable in vivo model for permanently reduced ache activity. |
2013-11-04 |
2023-08-12 |
mouse |
| G A Reid, N Chilukuri, S Darves. Butyrylcholinesterase and the cholinergic system. Neuroscience. vol 234. 2013-10-25. PMID:23305761. |
the cholinergic neurotransmitter acetylcholine is synthesized by choline acetyltransferase (chat) and its action terminated by acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2013-10-25 |
2023-08-12 |
mouse |
| G A Reid, N Chilukuri, S Darves. Butyrylcholinesterase and the cholinergic system. Neuroscience. vol 234. 2013-10-25. PMID:23305761. |
the predominance of ache has focused much attention on understanding the relationship of this enzyme to chat-positive cholinergic neurons. |
2013-10-25 |
2023-08-12 |
mouse |
| Preet Anand, Baldev Sing. A review on cholinesterase inhibitors for Alzheimer's disease. Archives of pharmacal research. vol 36. issue 4. 2013-10-25. PMID:23435942. |
cholinesterase inhibitors enhance cholinergic transmission directly by inhibiting the enzyme acetylcholinesterase (ache) which hydrolyses acetylcholine. |
2013-10-25 |
2023-08-12 |
Not clear |
| C F Höhmann, P T Carroll, F F Ebne. Acetylcholine levels and choline acetyltransferase activity in turtle cortex. Brain research. vol 258. issue 1. 2013-10-22. PMID:24010173. |
these biochemical results support the idea that the ache staining pattern in the outer half of the molecular layer may reflect the laminar distribution of cholinergic fiber activity in this simple cortex. |
2013-10-22 |
2023-08-12 |
Not clear |
| Csaba Szigeti, Norbert Bencsik, Aurel Janos Simonka, Adam Legradi, Peter Kasa, Karoly Guly. Long-term effects of selective immunolesions of cholinergic neurons of the nucleus basalis magnocellularis on the ascending cholinergic pathways in the rat: a model for Alzheimer's disease. Brain research bulletin. vol 94. 2013-10-17. PMID:23357177. |
choline acetyltransferase (chat) immunohistochemistry was applied to identify the loss of cholinergic neurons in the nbm, while acetylcholinesterase (ache) enzyme histochemistry was used to analyze the decreases in the number of cholinoceptive neurons in the nbm and the cholinergic fiber density in the fr1 and hl cortical areas in response to the nbm lesion. |
2013-10-17 |
2023-08-12 |
rat |
| Qingwei Ruan, Fang Liu, Zhanjuan Gao, Deqiu Kong, Xiaona Hu, Dongmei Shi, Zhijun Bao, Zhuowei Y. The anti-inflamm-aging and hepatoprotective effects of huperzine A in D-galactose-treated rats. Mechanisms of ageing and development. vol 134. issue 3-4. 2013-09-30. PMID:23313706. |
huperzine a exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting ache activity and via the activation of the cholinergic anti-inflammatory pathway. |
2013-09-30 |
2023-08-12 |
rat |
| Fakhra Amin, Bilqees Ban. Studies on interaction of buffalo brain cystatin with donepezil: an Alzheimer's drug. International journal of Alzheimer's disease. vol 2013. 2013-09-24. PMID:24062965. |
donepezil, an acetyl cholinesterase inhibitor (ache), is commonly prescribed to patients with alzheimer's disease (ad) to enhance cholinergic neurotransmission. |
2013-09-24 |
2023-08-12 |
Not clear |
| Lan Zhang, Ru-Yi Zhang, Ya-Li Li, Li Zhang, Cui-Fei Ye, Lin L. [Effects of Shenwu capsule on learning-memory ability and cholinergic function of brain in AD-like rat model induced by chronic infusion of sodium azide by minipump]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 38. issue 9. 2013-09-17. PMID:23944056. |
shenwu capsule significantly improved learning and memory ability and the mechanism may be related with the improved cholinergic function in model brain: chat activity and m-binding significantly increased in shenwu treated groups compared with model group; and the increased activity of ache in hippocampus returned to normal. |
2013-09-17 |
2023-08-12 |
rat |
| P Russo, A Frustaci, A Del Bufalo, M Fini, A Cesari. From traditional European medicine to discovery of new drug candidates for the treatment of dementia and Alzheimer's disease: acetylcholinesterase inhibitors. Current medicinal chemistry. vol 20. issue 8. 2013-09-13. PMID:23210783. |
the leading alzheimer's disease (ad) therapeutics to date involves inhibitors of acetylcholinesterase (ache), which should, in principle, elevate cholinergic signaling and limit inflammation. |
2013-09-13 |
2023-08-12 |
Not clear |
| Roy C Y Choi, Glanice K Y Chu, Nina L Siow, Amanda W Y Yung, Lisa Y Yung, Pinky S C Lee, Christopher C W Lo, Joseph Simon, Tina T X Dong, Eric A Barnard, Karl W K Tsi. Activation of UTP-sensitive P2Y2 receptor induces the expression of cholinergic genes in cultured cortical neurons: a signaling cascade triggered by Ca2+ mobilization and extracellular regulated kinase phosphorylation. Molecular pharmacology. vol 84. issue 1. 2013-09-11. PMID:23592515. |
notably, agonist-dependent stimulation of p2y2r elevated the neuronal expression of cholinergic genes encoding ache, prima (an anchor for the globular form ache), and choline acetyltransferase, and this induction was mediated by a signaling cascade that involved ca(2+) mobilization and extracellular regulated kinases 1/2 activation. |
2013-09-11 |
2023-08-12 |
rat |
| O Soukup, D Jun, G Tobin, K Kuc. The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors. Archives of toxicology. vol 87. issue 4. 2013-09-10. PMID:23179755. |
this review addresses issues correlated with non-reactivating effects of oxime reactivators with a special focus on the muscarinic and nicotinic receptors, but involvement of other cholinergic structures such as ache and choline uptake carriers are discussed too. |
2013-09-10 |
2023-08-12 |
Not clear |
| Xiao-Lei Zhu, Ning-Xi Yu, Ge-Fei Hao, Wen-Chao Yang, Guang-Fu Yan. Structural basis of femtomolar inhibitors for acetylcholinesterase subtype selectivity: insights from computational simulations. Journal of molecular graphics & modelling. vol 41. 2013-09-10. PMID:23500627. |
acetylcholinesterase (ache) is a key enzyme of the cholinergic nervous system. |
2013-09-10 |
2023-08-12 |
mouse |