| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Russo, A Frustaci, A Del Bufalo, M Fini, A Cesari. From traditional European medicine to discovery of new drug candidates for the treatment of dementia and Alzheimer's disease: acetylcholinesterase inhibitors. Current medicinal chemistry. vol 20. issue 8. 2013-09-13. PMID:23210783. |
the leading alzheimer's disease (ad) therapeutics to date involves inhibitors of acetylcholinesterase (ache), which should, in principle, elevate cholinergic signaling and limit inflammation. |
2013-09-13 |
2023-08-12 |
Not clear |
| Roy C Y Choi, Glanice K Y Chu, Nina L Siow, Amanda W Y Yung, Lisa Y Yung, Pinky S C Lee, Christopher C W Lo, Joseph Simon, Tina T X Dong, Eric A Barnard, Karl W K Tsi. Activation of UTP-sensitive P2Y2 receptor induces the expression of cholinergic genes in cultured cortical neurons: a signaling cascade triggered by Ca2+ mobilization and extracellular regulated kinase phosphorylation. Molecular pharmacology. vol 84. issue 1. 2013-09-11. PMID:23592515. |
notably, agonist-dependent stimulation of p2y2r elevated the neuronal expression of cholinergic genes encoding ache, prima (an anchor for the globular form ache), and choline acetyltransferase, and this induction was mediated by a signaling cascade that involved ca(2+) mobilization and extracellular regulated kinases 1/2 activation. |
2013-09-11 |
2023-08-12 |
rat |
| O Soukup, D Jun, G Tobin, K Kuc. The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors. Archives of toxicology. vol 87. issue 4. 2013-09-10. PMID:23179755. |
this review addresses issues correlated with non-reactivating effects of oxime reactivators with a special focus on the muscarinic and nicotinic receptors, but involvement of other cholinergic structures such as ache and choline uptake carriers are discussed too. |
2013-09-10 |
2023-08-12 |
Not clear |
| Xiao-Lei Zhu, Ning-Xi Yu, Ge-Fei Hao, Wen-Chao Yang, Guang-Fu Yan. Structural basis of femtomolar inhibitors for acetylcholinesterase subtype selectivity: insights from computational simulations. Journal of molecular graphics & modelling. vol 41. 2013-09-10. PMID:23500627. |
acetylcholinesterase (ache) is a key enzyme of the cholinergic nervous system. |
2013-09-10 |
2023-08-12 |
mouse |
| Hitoshi Shinotoh, Shigeki Hiran. [Neuroimaging in corticobasal syndrome]. Brain and nerve = Shinkei kenkyu no shinpo. vol 65. issue 1. 2013-09-03. PMID:23300102. |
a pet study showed decreased acetylcholinesterase (ache) activity in the fronto-parietal cortex, as well as a correlation between cortical ache activity and mini-mental state examination score in cbs patients, suggesting that cholinergic stimulant therapy may be effective for dementia in cbs. |
2013-09-03 |
2023-08-12 |
Not clear |
| Alicia M Ruggiero, Jane Wright, Shawn M Ferguson, Michelle Lewis, Katie S Emerson, Hideki Iwamoto, Michael T Ivy, Ericka C Holmstrand, Elizabeth A Ennis, C David Weaver, Randy D Blakel. Nonoisotopic assay for the presynaptic choline transporter reveals capacity for allosteric modulation of choline uptake. ACS chemical neuroscience. vol 3. issue 10. 2013-08-20. PMID:23077721. |
current therapies to enhance cns cholinergic function rely primarily on extracellular acetylcholinesterase (ache) inhibition, a pharmacotherapeutic strategy that produces dose-limiting side effects. |
2013-08-20 |
2023-08-12 |
human |
| Soo-Jeong Kim, Jun-Ho Lee, Hwan-Suck Chung, Joo-Hyun Song, Joohun Ha, Hyunsu Ba. Neuroprotective Effects of AMP-Activated Protein Kinase on Scopolamine Induced Memory Impairment. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 17. issue 4. 2013-08-15. PMID:23946693. |
in addition, they showed enhanced acetylcholinesterase (ache)-reactive neurons in the hippocampus, implying increased cholinergic activity in response to ampk. |
2013-08-15 |
2023-08-12 |
rat |
| Gersilene Valente de Oliveira, Patrícia Xavier Lima Gomes, Fernanda Yvelize Ramos de Araújo, Silvânia Maria Mendes Vasconcelos, Hélio Vitoriano Nobre Júnior, Francisca Cléa Florenço de Sousa, David F de Lucena, Thomas N Hyphantis, André Férrer Carvalho, Danielle Silveira Macêd. Prevention of haloperidol-induced alterations in brain acetylcholinesterase activity by vitamins B co-administration in a rodent model of tardive dyskinesia. Metabolic brain disease. vol 28. issue 1. 2013-08-02. PMID:23095989. |
here, based on the fact that alterations in cholinergic neurotransmission are related to td pathophysiology and that vitamins b seems to influence brain cholinergic neurotransmission, we decided to investigate the effects of vitamins b1, b6, b12 and their association, vitamin b cocktail in haloperidol-induced cholinergic alterations, evaluated by alterations in acetylcholinesterase (ache) activity, in striatum, prefrontal cortex and hippocampus, as a way to determine the participation of cholinergic neurotransmission, in these vitamins antidyskinetic mechanism. |
2013-08-02 |
2023-08-12 |
rat |
| Eugénie Carletti, Jacques-Philippe Colletier, Lawrence M Schopfer, Gianluca Santoni, Patrick Masson, Oksana Lockridge, Florian Nachon, Martin Wei. Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry. Chemical research in toxicology. vol 26. issue 2. 2013-07-29. PMID:23339663. |
tocp is metabolized to cresyl saligenin phosphate (cbdp), a potent irreversible inhibitor of butyrylcholinesterase (bche), a natural bioscavenger present in the bloodstream, and acetylcholinesterase (ache), the off-switch at cholinergic synapses. |
2013-07-29 |
2023-08-12 |
mouse |
| Lei An, Zhuo Yang, Tao Zhan. Melamine induced spatial cognitive deficits associated with impairments of hippocampal long-term depression and cholinergic system in Wistar rats. Neurobiology of learning and memory. vol 100. 2013-07-23. PMID:23231966. |
furthermore, the function of cholinergic system was damaged associated with decreased ach level and enhanced ache activity in melamine-treated rats. |
2013-07-23 |
2023-08-12 |
rat |
| Sa Rang Oh, Su-Jin Kim, Dong Hyun Kim, Jong Hoon Ryu, Eun-Mi Ahn, Ji Wook Jun. Angelica keiskei ameliorates scopolamine-induced memory impairments in mice. Biological & pharmaceutical bulletin. vol 36. issue 1. 2013-06-26. PMID:23132631. |
acetylcholinesterase (ache) activity assay was performed to investigate the cholinergic antagonistic effect of ak in the hippocampus. |
2013-06-26 |
2023-08-12 |
mouse |
| Guangfeng Li, Anne Gleinich, Helene Lau, Martina Zimmerman. Staurosporine-induced apoptosis presents with unexpected cholinergic effects in a differentiated neuroblastoma cell line. Neurochemistry international. vol 61. issue 7. 2013-06-05. PMID:22841891. |
the effects of various additional phosphorylation inhibitors on ache activity suggest that these unexpected cholinergic effects, firstly, are linked to the impact of staurosporine on phosphorylation and, secondly, reveal themselves in a first phase of cellular adaption that precedes neurotoxicity and subsequent cell death. |
2013-06-05 |
2023-08-12 |
Not clear |
| Alessandra Marcone, Valentina Garibotto, Rosa Maria Moresco, Ioana Florea, Andrea Panzacchi, Assunta Carpinelli, Jere R Virta, Marco Tettamanti, Barbara Borroni, Alessandro Padovani, Alessandra Bertoldo, Karl Herholz, Juha O Rinne, Stefano Francesco Cappa, Daniela Peran. [11C]-MP4A PET cholinergic measurements in amnestic mild cognitive impairment, probable Alzheimer's disease, and dementia with Lewy bodies: a Bayesian method and voxel-based analysis. Journal of Alzheimer's disease : JAD. vol 31. issue 2. 2013-06-04. PMID:22596267. |
the comparable ache reductions in pad and amci converters indicate the presence of a widespread impairment of the cholinergic system already in the mci phase. |
2013-06-04 |
2023-08-12 |
human |
| b' Milan Jokanovi\\xc4\\x8. Structure-activity relationship and efficacy of pyridinium oximes in the treatment of poisoning with organophosphorus compounds: a review of recent data. Current topics in medicinal chemistry. vol 12. issue 16. 2013-06-04. PMID:23030612.' |
ache inhibition results in the accumulation of acetylcholine at cholinergic receptor sites, producing continuous stimulation of cholinergic fibers throughout the central and peripheral nervous systems. |
2013-06-04 |
2023-08-12 |
human |
| Mi Ra Lee, Beom Sik Yun, Oh Hyun In, Chang Keun Sun. Comparative study of korean white, red, and black ginseng extract on cholinesterase inhibitory activity and cholinergic function. Journal of ginseng research. vol 35. issue 4. 2013-05-30. PMID:23717087. |
to better understand the mechanisms of the possible effect of ginseng extract on the cholinergic function, this study assessed the expression of the cholinergic markers of choline acetyltransferase (chat) and ache using western blot and rt-pcr analysis in the brains of amnesic mice. |
2013-05-30 |
2023-08-12 |
mouse |
| Helen Mumford, Cerys J Docx, Matthew E Price, A Christopher Green, John E H Tattersall, Stuart J Armstron. Human plasma-derived BuChE as a stoichiometric bioscavenger for treatment of nerve agent poisoning. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:22981459. |
survival was presumed to be due to immediate alleviation of the cholinergic crisis by the conventional pharmacological treatment drugs, in conjunction with bioscavenger that prevented further absorbed agent reaching the ache targets. |
2013-05-28 |
2023-08-12 |
human |
| David A Hicks, Natalia Z Makova, Natalia N Nalivaeva, Anthony J Turne. Characterisation of acetylcholinesterase release from neuronal cells. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23047022. |
although acetylcholinesterase (ache) is primarily a hydrolytic enzyme, metabolising the neurotransmitter acetylcholine in cholinergic synapses, it also has some non-catalytic functions in the brain which are far less well characterised. |
2013-05-28 |
2023-08-12 |
mouse |
| Paul G Layer, Janine Klaczinski, Anika Salfelder, Laura E Sperling, Gopenath Thangaraj, Corina Tuschl, Astrid Vogel-Höpke. Cholinesterases in development: AChE as a firewall to inhibit cell proliferation and support differentiation. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23047026. |
in search for alternative, "non-classical" functions of cholinesterases (ches), ache could either work within the frame of classic cholinergic systems, but in non-neural tissues ("non-synaptic function"), or act non-enzymatically. |
2013-05-28 |
2023-08-12 |
mouse |
| Katarina Mis, Urska Matkovic, Sergej Pirkmajer, Marina Sciancalepore, Paola Lorenzon, Tomaz Mars, Zoran Grubi. Acetylcholinesterase and agrin: different functions, similar expression patterns, multiple roles. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23117006. |
ache is a cholinergic and agrin a synaptogenetic component. |
2013-05-28 |
2023-08-12 |
rat |
| Yvonne J Rosenberg, Beth Laube, Lingjun Mao, Xiaoming Jiang, Segundo Hernandez-Abanto, Keunmyoung D Lee, Robert Adam. Pulmonary delivery of an aerosolized recombinant human butyrylcholinesterase pretreatment protects against aerosolized paraoxon in macaques. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23178380. |
to address this, studies have been performed in mice and macaques using chinese hamster ovary cells (cho)-derived recombinant (r) bche delivered by the pulmonary route, to examine whether the deposition of both macaque (ma) and human (hu) rbche administered as aerosols (aer) favored the creation and retention of an efficient protective "pulmonary bioshield" that could scavenge incoming (inhaled) ops in situ thereby preventing entry into the circulation and inhibition of plasma bche and ache on red blood cells (rbc-ache) and in cholinergic synapses. |
2013-05-28 |
2023-08-12 |
mouse |