| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J R Atack, C May, J A Kaye, S I Rapopor. Cerebrospinal fluid gradients of acetylcholinesterase and butyrylcholinesterase activity in healthy aging. Neurochemistry international. vol 16. issue 4. 2012-10-02. PMID:20504592. |
brain and spinal cord) origin of ache in lumbar csf would explain the relatively modest changes in lumbar csf ache activity in diseases involving certain central cholinergic systems, most notably alzheimer's disease. |
2012-10-02 |
2023-08-12 |
human |
| S Ribarič, P Cvirn, A Stefanovsk. Continuous low amplitude direct current stimulation of the crushed peripheral nerve accelerates the early recovery of choline acetyltransferase but not of acetylcholinesterase activity in fast and slow muscles. Restorative neurology and neuroscience. vol 7. issue 2. 2012-10-02. PMID:21551776. |
chat is a specific marker of cholinergic nerve terminals and may reflect axon ingrowth, and ache reflects the re-establishment of neuromuscular junctions and recovery of muscle activity. |
2012-10-02 |
2023-08-12 |
rat |
| M K Schulz, J A McNulty, T P Hogan, J Zimmer, A J Castr. Biochemical and anatomical analysis of cholinergic, noradrenergic and serotonergic innervation of fetal neocortical transplants placed in excitotoxin-induced neocortical lesions of adult rats. Restorative neurology and neuroscience. vol 7. issue 3. 2012-10-02. PMID:21551780. |
cholinergic fiber innervation was examined at 3 months post grafting by measuring acetylcholinesterase (ache) and choline acetyl-transferase (chat) enzyme activities within the grafts and within the corresponding host cortex by radiochemical enzyme assays as well as by ache histochemistry for the visualization of ache positive fibers. |
2012-10-02 |
2023-08-12 |
rat |
| C N Pope, J Li. Age-related differences in sensitivity to organophosphorus pesticides. Environmental toxicology and pharmacology. vol 4. issue 3-4. 2012-10-02. PMID:21781839. |
the primary mechanism of action for op insecticides is inhibition of acetylcholinesterase (ache), an enzyme dynamically involved in cholinergic neurotransmission. |
2012-10-02 |
2023-08-12 |
rat |
| Carey Pope, Subramanya Karanth, Jing Li. Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action. Environmental toxicology and pharmacology. vol 19. issue 3. 2012-10-02. PMID:21783509. |
under normal conditions, however, extensive inhibition of ache leads to excess synaptic acetylcholine levels, over-stimulation of cholinergic receptors, alteration of postsynaptic cell function and consequent signs of cholinergic toxicity. |
2012-10-02 |
2023-08-12 |
human |
| Oksana Lockridge, Ellen G Duysen, Troy Voelker, Charles M Thompson, Lawrence M Schopfe. Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice. Environmental toxicology and pharmacology. vol 19. issue 3. 2012-10-02. PMID:21783513. |
a lethal dose of op caused the same cholinergic signs of toxicity in mice with zero ache as in mice with normal amounts of ache. |
2012-10-02 |
2023-08-12 |
mouse |
| S B Mushigeri, M Davi. Fenvalerate induced changes in the Ach and associated AchE activity in different tissues of fish Cirrhinus mrigala (Hamilton) under lethal and sub-lethal exposure period. Environmental toxicology and pharmacology. vol 20. issue 1. 2012-10-02. PMID:21783569. |
fish, c. mrigala on exposure to lethal and sub-lethal concentration of synthetic pyrethroid insecticide, fenvalerate showed inhibition in the activity of the ache suggesting decrease in the cholinergic transmission and consequent accumulation of ach in the tissues, namely, gill, muscle, liver and brain. |
2012-10-02 |
2023-08-12 |
Not clear |
| Lucas M Bronicki, Bernard J Jasmi. Trans-acting factors governing acetylcholinesterase mRNA metabolism in neurons. Frontiers in molecular neuroscience. vol 5. 2012-10-02. PMID:22461767. |
the most characterized function of acetylcholinesterase (ache) is to terminate cholinergic signaling at neuron-neuron and neuro-muscular synapses. |
2012-10-02 |
2023-08-12 |
Not clear |
| Joanne Knowle. Donepezil in Alzheimer's disease: an evidence-based review of its impact on clinical and economic outcomes. Core evidence. vol 1. issue 3. 2012-10-02. PMID:22500154. |
it is a specific and reversible inhibitor of acetylcholinesterase (ache); by increasing levels of available acetylcholine, donepezil may compensate for the loss of functioning cholinergic brain cells. |
2012-10-02 |
2023-08-12 |
Not clear |
| María-Ximena Silveyra, María-Salud García-Ayllón, Elena Gómez de Barreda, David H Small, Salvador Martínez, Jesús Avila, Javier Sáez-Valer. Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:21530001. |
here, we examined potential alterations in the level of the cholinergic enzyme acetylcholinesterase (ache) in the brain of transgenic mice (tg-vlw) expressing human tau mutations. |
2012-09-28 |
2023-08-12 |
mouse |
| Guillaume Mercey, Tristan Verdelet, Julien Renou, Maria Kliachyna, Rachid Baati, Florian Nachon, Ludovic Jean, Pierre-Yves Renar. Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. Accounts of chemical research. vol 45. issue 5. 2012-09-20. PMID:22360473. |
the irreversible inhibition of ache causes the neurotransmitter to accumulate in the synaptic cleft, leading to overstimulation of cholinergic receptors, seizures, respiratory arrest, and death. |
2012-09-20 |
2023-08-12 |
Not clear |
| Yun Che. Organophosphate-induced brain damage: mechanisms, neuropsychiatric and neurological consequences, and potential therapeutic strategies. Neurotoxicology. vol 33. issue 3. 2012-09-18. PMID:22498093. |
organophosphate (op)-induced brain damage is defined as progressive damage to the brain, resulting from the cholinergic neuronal excitotoxicity and dysfunction induced by op-induced irreversible ache inhibition. |
2012-09-18 |
2023-08-12 |
Not clear |
| Vikas Kotagal, Martijn L T M Müller, Daniel I Kaufer, Robert A Koeppe, Nicolaas I Bohne. Thalamic cholinergic innervation is spared in Alzheimer disease compared to parkinsonian disorders. Neuroscience letters. vol 514. issue 2. 2012-09-14. PMID:22414859. |
we investigated thalamic cholinergic afferent integrity by measuring ppn-thalamic (ppn-thal) acetylcholinesterase (ache) activity via pet imaging in alzheimer (ad), parkinson disease without dementia (pd), parkinson disease with dementia (pdd) and dementia with lewy bodies (dlb). |
2012-09-14 |
2023-08-12 |
human |
| D Chand Basha, M Usha Rani, C Bhuvaneswari Devi, M Ram Kumar, G Rajarami Redd. Perinatal lead exposure alters postnatal cholinergic and aminergic system in rat brain: reversal effect of calcium co-administration. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 4. 2012-09-13. PMID:22326442. |
these alterations were greater at pnd 35 and more pronounced in the cholinergic system (ach and ache) of hippocampus and the aminergic system (epinephrine, dopamine and mao) of cerebellum. |
2012-09-13 |
2023-08-12 |
rat |
| Alexios Bimpis, Apostolos Papalois, Stylianos Tsakiris, Apostolos Zarros, Konstantinos Kalafatakis, John Botis, Vasileios Stolakis, Konstantinos M Zissis, Charis Liap. Activation of acetylcholinesterase after U-74389G administration in a porcine model of intracerebral hemorrhage. Metabolic brain disease. vol 27. issue 2. 2012-09-07. PMID:22476954. |
we, herein, report the findings of our study concerning the role of acetylcholinesterase (ache; a crucial membrane-bound enzyme involved in cholinergic neurotransmission) in a porcine model of spontaneous ich, with a focus on the first 4 and 24 h following the lesion's induction, in combination with a study of the effectiveness of the lazaroid antioxidant u-74389g administration. |
2012-09-07 |
2023-08-12 |
Not clear |
| David H Smal. Dysregulation of Ca2+ homeostasis in Alzheimer's disease: role in acetylcholinesterase production and AMPA receptor internalization. Neuro-degenerative diseases. vol 10. issue 1-4. 2012-08-29. PMID:22301681. |
as aβ-induced ca(2+) entry may increase neuronal excitability, the increase in ache and the downregulation of cell surface ampa receptors may be part of a homeostatic mechanism which maintains normal levels of cholinergic and glutamatergic signaling. |
2012-08-29 |
2023-08-12 |
Not clear |
| Mona Mehta, Abdu Adem, Marwan Sabbag. New acetylcholinesterase inhibitors for Alzheimer's disease. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22216416. |
acetylcholinesterase (ache) remains a highly viable target for the symptomatic improvement in alzheimer's disease (ad) because cholinergic deficit is a consistent and early finding in ad. |
2012-08-23 |
2023-08-12 |
Not clear |
| Katja S Kroker, Georg Rast, Riccardo Giovannini, Anelise Marti, Cornelia Dorner-Ciossek, Holger Rosenbroc. Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP. Neuropharmacology. vol 62. issue 5-6. 2012-07-23. PMID:22245562. |
it aims to compensate for the deficit in cholinergic neurotransmission by blocking acetylcholinesterase (ache) and thus increases the concentration of extracellular acetylcholine. |
2012-07-23 |
2023-08-12 |
rat |
| Guo-Jun Lang, Kun Yan Zhu, Chuan-Xi Zhan. Can acetylcholinesterase serve as a target for developing more selective insecticides? Current drug targets. vol 13. issue 4. 2012-07-23. PMID:22280346. |
because ache is expressed in all invertebrate and vertebrate animals as a key enzyme of the cholinergic system, the toxicity of anticholinesterase insecticides to mammals and non-target species such as beneficial insects has been a great concern. |
2012-07-23 |
2023-08-12 |
Not clear |
| Adriana Bolekova, Darina Kluchova, Tatiana Spakovska, Frantisek Dorko, Kvetuse Lovasov. Postnatal development of nitrergic and cholinergic structures in rat spinal cord. Archives italiennes de biologie. vol 149. issue 3. 2012-06-21. PMID:22028090. |
this work is presenting results of histochemical study of the nadph-d and ache expression (nitrergic and cholinergic neurons) in the spinal cord (sc) during various periods in its development. |
2012-06-21 |
2023-08-12 |
rat |