| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adriana Bolekova, Darina Kluchova, Tatiana Spakovska, Frantisek Dorko, Kvetuse Lovasov. Postnatal development of nitrergic and cholinergic structures in rat spinal cord. Archives italiennes de biologie. vol 149. issue 3. 2012-06-21. PMID:22028090. |
our results confirmed the presence of nitrergic and cholinergic neurons in investigated areas of the sc and indicated their fully functioning of nadph-d and ache positive structures in sc from the third postnatal week. |
2012-06-21 |
2023-08-12 |
rat |
| Daniele Tomassoni, Assia Catalani, Carlo Cinque, Maria Antonietta Di Tullio, Seyed Khosrow Tayebati, Angela Cadoni, Innocent Ejike Nwankwo, Enea Traini, Francesco Ament. Effects of cholinergic enhancing drugs on cholinergic transporters in the brain and peripheral blood lymphocytes of spontaneously hypertensive rats. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:22191561. |
this study has assessed the influence of 4 week treatment with two different cholinergic enhancing drugs, the cholinergic precursor choline alphoscerate (alpha-glyceryl-phosphorylcholine) or the acetylcholinesterase (ache) inhibitor galantamine on high affinity choline uptake transporter (cht) and vesicular ach transporter (vacht) expression in the brain of spontaneously hypertensive rats (shr). |
2012-06-14 |
2023-08-12 |
rat |
| Daniele Tomassoni, Assia Catalani, Carlo Cinque, Maria Antonietta Di Tullio, Seyed Khosrow Tayebati, Angela Cadoni, Innocent Ejike Nwankwo, Enea Traini, Francesco Ament. Effects of cholinergic enhancing drugs on cholinergic transporters in the brain and peripheral blood lymphocytes of spontaneously hypertensive rats. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:22191561. |
the different activity of the cholinergic precursor and of the ache inhibitor on parameters investigated is likely related to their mechanism of action. |
2012-06-14 |
2023-08-12 |
rat |
| Daniele Tomassoni, Assia Catalani, Carlo Cinque, Maria Antonietta Di Tullio, Seyed Khosrow Tayebati, Angela Cadoni, Innocent Ejike Nwankwo, Enea Traini, Francesco Ament. Effects of cholinergic enhancing drugs on cholinergic transporters in the brain and peripheral blood lymphocytes of spontaneously hypertensive rats. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:22191561. |
differences in the activity of the cholinergic precursor and ache inhibitor investigated on cht and vacht suggests that association between choline alphoscerate and ache/cholinesterase inhibitors may represent a strategy for potentiating deficient cholinergic neurotransmission worthwhile of being investigated in clinical trials. |
2012-06-14 |
2023-08-12 |
rat |
| Astrid Vogel-Hopker, Laura E Sperling, Paul G Laye. Co-opting functions of cholinesterases in neural, limb and stem cell development. Protein and peptide letters. vol 19. issue 2. 2012-06-08. PMID:21933123. |
also, possible roles of ache in neuritic growth and of cholinergic regulations in stem cells are briefly outlined. |
2012-06-08 |
2023-08-12 |
Not clear |
| Xiaowei Shi, Zhi Zhou, Lingling Wang, Feng Yue, Mengqiang Wang, Chuanyan Yang, Linsheng Son. The immunomodulation of acetylcholinesterase in zhikong scallop Chlamys farreri. PloS one. vol 7. issue 1. 2012-06-04. PMID:22292052. |
acetycholinesterase (ache; ec 3.1.1.7) is an essential hydrolytic enzyme in the cholinergic nervous system, which plays an important role during immunomodulation in vertebrates. |
2012-06-04 |
2023-08-12 |
Not clear |
| Miroslav Pohank. Cholinesterases, a target of pharmacology and toxicology. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. vol 155. issue 3. 2012-05-23. PMID:22286807. |
of the two types, butyrylcholinesterase and acetylcholinesterase (ache), ache plays the key role in ending cholinergic neurotransmission. |
2012-05-23 |
2023-08-12 |
Not clear |
| A Sherin, J Anu, K T Peeyush, S Smijin, M Anitha, B T Roshni, C S Paulos. Cholinergic and GABAergic receptor functional deficit in the hippocampus of insulin-induced hypoglycemic and streptozotocin-induced diabetic rats. Neuroscience. vol 202. 2012-05-18. PMID:22155651. |
expression of cholinergic enzymes; acetylcholine esterase (ache) and choline acetyltransferase (chat) upregulated and downregulated, respectively, in diabetic group, which was further exacerbated by hypoglycemia. |
2012-05-18 |
2023-08-12 |
rat |
| A Sherin, K T Peeyush, S Jayanarayanan, K K Amee, C S Paulos. Decreased cholinergic receptor expression in the striatum: motor function deficit in hypoglycemic and diabetic rats. Cellular and molecular neurobiology. vol 32. issue 1. 2012-05-17. PMID:21796364. |
cholinergic enzymes: ache and chat gene expression, radioreceptor binding assay and immunohistochemistry of muscarinic m1, m3 receptors and α7nachr were carried out. |
2012-05-17 |
2023-08-12 |
rat |
| Nejat Gacar, Oguz Mutlu, Tijen Utkan, Ipek Komsuoglu Celikyurt, Semil Selcen Gocmez, Güner Ula. Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats. Pharmacology, biochemistry, and behavior. vol 99. issue 3. 2012-05-16. PMID:21624386. |
in conclusion, we suggested that resveratrol had improving effects on learning and memory by acting on muscarinic cholinergic receptors and at least in part, may reverse ache activity. |
2012-05-16 |
2023-08-12 |
rat |
| Alessandra Antunes dos Santos, Danúbia Bonfanti dos Santos, Renata Pietsch Ribeiro, Dirleise Colle, Kaite Cristiane Peres, Júlia Hermes, Anderson Machado Barbosa, Alcir Luiz Dafré, Andreza Fabro de Bem, Kamil Kuca, Marcelo Farin. Effects of K074 and pralidoxime on antioxidant and acetylcholinesterase response in malathion-poisoned mice. Neurotoxicology. vol 32. issue 6. 2012-05-02. PMID:21723318. |
the organophosphorus (op) pesticide malathion is a highly neurotoxic compound and its toxicity is primarily caused by the inhibition of acetylcholinesterase (ache), leading to cholinergic syndrome. |
2012-05-02 |
2023-08-12 |
mouse |
| Vesna A Eterović, Dinely Pérez, Antonio H Martins, Brenda L Cuadrado, Marimée Carrasco, P A Ferchmi. A cembranoid protects acute hippocampal slices against paraoxon neurotoxicity. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 7. 2012-04-26. PMID:21569834. |
many neurotoxic organophosphates (ops) inhibit acetylcholinesterase (ache) and as a result can cause a life threatening cholinergic crisis. |
2012-04-26 |
2023-08-12 |
Not clear |
| Lotta Berg, C David Andersson, Elisabet Artursson, Andreas Hörnberg, Anna-Karin Tunemalm, Anna Linusson, Fredrik Ekströ. Targeting acetylcholinesterase: identification of chemical leads by high throughput screening, structure determination and molecular modeling. PloS one. vol 6. issue 11. 2012-04-09. PMID:22140425. |
acetylcholinesterase (ache) is an essential enzyme that terminates cholinergic transmission by rapid hydrolysis of the neurotransmitter acetylcholine. |
2012-04-09 |
2023-08-12 |
mouse |
| Paul S Price, Karl D Schnelle, Cheryl B Cleveland, Michael J Bartels, Paul M Hinderliter, Charles Timchalk, Torka S Poe. Application of a source-to-outcome model for the assessment of health impacts from dietary exposures to insecticide residues. Regulatory toxicology and pharmacology : RTP. vol 61. issue 1. 2012-04-06. PMID:21651950. |
predictions of rbc ache are compared to levels of inhibition associated with reported exposure-related effects in humans to determine the potential for the occurrence of adverse cholinergic effects. |
2012-04-06 |
2023-08-12 |
Not clear |
| A Barelli, P M Soave, M Del Vicario, R Barell. New experimental Oximes in the management of organophosphorus pesticides poisoning. Minerva anestesiologica. vol 77. issue 12. 2012-04-04. PMID:21799476. |
the main toxic mechanism of opcs is the inhibition of the enzymes acetylcholinesterase (ache) and butyrylcholinesterase (buche), resulting in accumulation of acetylcholine (ach) at the synapse with cholinergic crisis and possible death. |
2012-04-04 |
2023-08-12 |
Not clear |
| Shuuichi Mori, Sachiho Kubo, Takuyu Akiyoshi, Shigeru Yamada, Tsuyoshi Miyazaki, Harumi Hotta, Junzo Desaki, Masahiko Kishi, Tetsuro Konishi, Yuri Nishino, Atsuo Miyazawa, Naoki Maruyama, Kazuhiro Shigemot. Antibodies against muscle-specific kinase impair both presynaptic and postsynaptic functions in a murine model of myasthenia gravis. The American journal of pathology. vol 180. issue 2. 2012-03-25. PMID:22142810. |
furthermore, musk-injected mice exhibited acetylcholinesterase (ache) inhibitor-evoked cholinergic hypersensitivity, as is observed in musk-mg patients, and a decrease in both ache and the ache-anchoring protein collagen q at postsynaptic membranes. |
2012-03-25 |
2023-08-12 |
mouse |
| Mabruka H Tarhoni, Vasanthy Vigneswara, Marie Smith, Susan Anderson, Peter Wigmore, John E Lees, David E Ray, Wayne G Carte. Detection, quantification, and microlocalisation of targets of pesticides using microchannel plate autoradiographic imagers. Molecules (Basel, Switzerland). vol 16. issue 10. 2012-03-15. PMID:21989313. |
they share a common chemical signature that facilitates their binding and adduction of acetylcholinesterase (ache) within nerve synapses to induce cholinergic toxicity. |
2012-03-15 |
2023-08-12 |
rat |
| Rui Liu, Tiantai Zhang, Haiguang Yang, Xi Lan, Jian Ying, Guanhua D. The flavonoid apigenin protects brain neurovascular coupling against amyloid-β₂₅₋₃₅-induced toxicity in mice. Journal of Alzheimer's disease : JAD. vol 24. issue 1. 2012-03-06. PMID:21297270. |
our results demonstrate that oral administration of apigenin for aβ₂₅₋₃₅-induced amnesic mice conferred robust neurovascular coupling protection, involving improvement of the learning and memory capabilities, maintenance of neurovascular unit integrity, modulation of microvascular function, reduction of neurovascular oxidative damage, increase of regional cerebral blood flow, improvement of cholinergic system involving the inhibition of ache activity and elevation of ach level, and modification of bndf, trkb, and phospho-creb levels. |
2012-03-06 |
2023-08-12 |
mouse |
| L Palanikumar, A K Kumaraguru, C M Ramakritinan, M Anan. Biochemical response of anthracene and benzo [a] pyrene in milkfish Chanos chanos. Ecotoxicology and environmental safety. vol 75. issue 1. 2012-03-06. PMID:21944957. |
both the pahs inhibited ache indicating that they have at least one mechanism of neurotoxicity in common: the disruption of cholinergic transmission by inhibition of ache. |
2012-03-06 |
2023-08-12 |
cat |
| Leo Pezzementi, Eric Krejci, Arnaud Chatonnet, Murray E Selkirk, Jacqueline B Matthew. A tetrameric acetylcholinesterase from the parasitic nematode Dictyocaulus viviparus associates with the vertebrate tail proteins PRiMA and ColQ. Molecular and biochemical parasitology. vol 181. issue 1. 2012-02-22. PMID:22027027. |
this is the first demonstration of an ache(t) from a parasitic nematode that can assemble into heterologous forms with vertebrate proteins that anchor the enzyme in cholinergic synapses. |
2012-02-22 |
2023-08-12 |
cattle |