| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carey Pope, Subramanya Karanth, Jing Li. Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action. Environmental toxicology and pharmacology. vol 19. issue 3. 2012-10-02. PMID:21783509. |
under normal conditions, however, extensive inhibition of ache leads to excess synaptic acetylcholine levels, over-stimulation of cholinergic receptors, alteration of postsynaptic cell function and consequent signs of cholinergic toxicity. |
2012-10-02 |
2023-08-12 |
human |
| Oksana Lockridge, Ellen G Duysen, Troy Voelker, Charles M Thompson, Lawrence M Schopfe. Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice. Environmental toxicology and pharmacology. vol 19. issue 3. 2012-10-02. PMID:21783513. |
a lethal dose of op caused the same cholinergic signs of toxicity in mice with zero ache as in mice with normal amounts of ache. |
2012-10-02 |
2023-08-12 |
mouse |
| S B Mushigeri, M Davi. Fenvalerate induced changes in the Ach and associated AchE activity in different tissues of fish Cirrhinus mrigala (Hamilton) under lethal and sub-lethal exposure period. Environmental toxicology and pharmacology. vol 20. issue 1. 2012-10-02. PMID:21783569. |
fish, c. mrigala on exposure to lethal and sub-lethal concentration of synthetic pyrethroid insecticide, fenvalerate showed inhibition in the activity of the ache suggesting decrease in the cholinergic transmission and consequent accumulation of ach in the tissues, namely, gill, muscle, liver and brain. |
2012-10-02 |
2023-08-12 |
Not clear |
| Lucas M Bronicki, Bernard J Jasmi. Trans-acting factors governing acetylcholinesterase mRNA metabolism in neurons. Frontiers in molecular neuroscience. vol 5. 2012-10-02. PMID:22461767. |
the most characterized function of acetylcholinesterase (ache) is to terminate cholinergic signaling at neuron-neuron and neuro-muscular synapses. |
2012-10-02 |
2023-08-12 |
Not clear |
| Joanne Knowle. Donepezil in Alzheimer's disease: an evidence-based review of its impact on clinical and economic outcomes. Core evidence. vol 1. issue 3. 2012-10-02. PMID:22500154. |
it is a specific and reversible inhibitor of acetylcholinesterase (ache); by increasing levels of available acetylcholine, donepezil may compensate for the loss of functioning cholinergic brain cells. |
2012-10-02 |
2023-08-12 |
Not clear |
| María-Ximena Silveyra, María-Salud García-Ayllón, Elena Gómez de Barreda, David H Small, Salvador Martínez, Jesús Avila, Javier Sáez-Valer. Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:21530001. |
here, we examined potential alterations in the level of the cholinergic enzyme acetylcholinesterase (ache) in the brain of transgenic mice (tg-vlw) expressing human tau mutations. |
2012-09-28 |
2023-08-12 |
mouse |
| Guillaume Mercey, Tristan Verdelet, Julien Renou, Maria Kliachyna, Rachid Baati, Florian Nachon, Ludovic Jean, Pierre-Yves Renar. Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. Accounts of chemical research. vol 45. issue 5. 2012-09-20. PMID:22360473. |
the irreversible inhibition of ache causes the neurotransmitter to accumulate in the synaptic cleft, leading to overstimulation of cholinergic receptors, seizures, respiratory arrest, and death. |
2012-09-20 |
2023-08-12 |
Not clear |
| Yun Che. Organophosphate-induced brain damage: mechanisms, neuropsychiatric and neurological consequences, and potential therapeutic strategies. Neurotoxicology. vol 33. issue 3. 2012-09-18. PMID:22498093. |
organophosphate (op)-induced brain damage is defined as progressive damage to the brain, resulting from the cholinergic neuronal excitotoxicity and dysfunction induced by op-induced irreversible ache inhibition. |
2012-09-18 |
2023-08-12 |
Not clear |
| Vikas Kotagal, Martijn L T M Müller, Daniel I Kaufer, Robert A Koeppe, Nicolaas I Bohne. Thalamic cholinergic innervation is spared in Alzheimer disease compared to parkinsonian disorders. Neuroscience letters. vol 514. issue 2. 2012-09-14. PMID:22414859. |
we investigated thalamic cholinergic afferent integrity by measuring ppn-thalamic (ppn-thal) acetylcholinesterase (ache) activity via pet imaging in alzheimer (ad), parkinson disease without dementia (pd), parkinson disease with dementia (pdd) and dementia with lewy bodies (dlb). |
2012-09-14 |
2023-08-12 |
human |
| D Chand Basha, M Usha Rani, C Bhuvaneswari Devi, M Ram Kumar, G Rajarami Redd. Perinatal lead exposure alters postnatal cholinergic and aminergic system in rat brain: reversal effect of calcium co-administration. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 4. 2012-09-13. PMID:22326442. |
these alterations were greater at pnd 35 and more pronounced in the cholinergic system (ach and ache) of hippocampus and the aminergic system (epinephrine, dopamine and mao) of cerebellum. |
2012-09-13 |
2023-08-12 |
rat |
| Alexios Bimpis, Apostolos Papalois, Stylianos Tsakiris, Apostolos Zarros, Konstantinos Kalafatakis, John Botis, Vasileios Stolakis, Konstantinos M Zissis, Charis Liap. Activation of acetylcholinesterase after U-74389G administration in a porcine model of intracerebral hemorrhage. Metabolic brain disease. vol 27. issue 2. 2012-09-07. PMID:22476954. |
we, herein, report the findings of our study concerning the role of acetylcholinesterase (ache; a crucial membrane-bound enzyme involved in cholinergic neurotransmission) in a porcine model of spontaneous ich, with a focus on the first 4 and 24 h following the lesion's induction, in combination with a study of the effectiveness of the lazaroid antioxidant u-74389g administration. |
2012-09-07 |
2023-08-12 |
Not clear |
| David H Smal. Dysregulation of Ca2+ homeostasis in Alzheimer's disease: role in acetylcholinesterase production and AMPA receptor internalization. Neuro-degenerative diseases. vol 10. issue 1-4. 2012-08-29. PMID:22301681. |
as aβ-induced ca(2+) entry may increase neuronal excitability, the increase in ache and the downregulation of cell surface ampa receptors may be part of a homeostatic mechanism which maintains normal levels of cholinergic and glutamatergic signaling. |
2012-08-29 |
2023-08-12 |
Not clear |
| Mona Mehta, Abdu Adem, Marwan Sabbag. New acetylcholinesterase inhibitors for Alzheimer's disease. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22216416. |
acetylcholinesterase (ache) remains a highly viable target for the symptomatic improvement in alzheimer's disease (ad) because cholinergic deficit is a consistent and early finding in ad. |
2012-08-23 |
2023-08-12 |
Not clear |
| Katja S Kroker, Georg Rast, Riccardo Giovannini, Anelise Marti, Cornelia Dorner-Ciossek, Holger Rosenbroc. Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP. Neuropharmacology. vol 62. issue 5-6. 2012-07-23. PMID:22245562. |
it aims to compensate for the deficit in cholinergic neurotransmission by blocking acetylcholinesterase (ache) and thus increases the concentration of extracellular acetylcholine. |
2012-07-23 |
2023-08-12 |
rat |
| Guo-Jun Lang, Kun Yan Zhu, Chuan-Xi Zhan. Can acetylcholinesterase serve as a target for developing more selective insecticides? Current drug targets. vol 13. issue 4. 2012-07-23. PMID:22280346. |
because ache is expressed in all invertebrate and vertebrate animals as a key enzyme of the cholinergic system, the toxicity of anticholinesterase insecticides to mammals and non-target species such as beneficial insects has been a great concern. |
2012-07-23 |
2023-08-12 |
Not clear |
| Adriana Bolekova, Darina Kluchova, Tatiana Spakovska, Frantisek Dorko, Kvetuse Lovasov. Postnatal development of nitrergic and cholinergic structures in rat spinal cord. Archives italiennes de biologie. vol 149. issue 3. 2012-06-21. PMID:22028090. |
this work is presenting results of histochemical study of the nadph-d and ache expression (nitrergic and cholinergic neurons) in the spinal cord (sc) during various periods in its development. |
2012-06-21 |
2023-08-12 |
rat |
| Adriana Bolekova, Darina Kluchova, Tatiana Spakovska, Frantisek Dorko, Kvetuse Lovasov. Postnatal development of nitrergic and cholinergic structures in rat spinal cord. Archives italiennes de biologie. vol 149. issue 3. 2012-06-21. PMID:22028090. |
our results confirmed the presence of nitrergic and cholinergic neurons in investigated areas of the sc and indicated their fully functioning of nadph-d and ache positive structures in sc from the third postnatal week. |
2012-06-21 |
2023-08-12 |
rat |
| Daniele Tomassoni, Assia Catalani, Carlo Cinque, Maria Antonietta Di Tullio, Seyed Khosrow Tayebati, Angela Cadoni, Innocent Ejike Nwankwo, Enea Traini, Francesco Ament. Effects of cholinergic enhancing drugs on cholinergic transporters in the brain and peripheral blood lymphocytes of spontaneously hypertensive rats. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:22191561. |
this study has assessed the influence of 4 week treatment with two different cholinergic enhancing drugs, the cholinergic precursor choline alphoscerate (alpha-glyceryl-phosphorylcholine) or the acetylcholinesterase (ache) inhibitor galantamine on high affinity choline uptake transporter (cht) and vesicular ach transporter (vacht) expression in the brain of spontaneously hypertensive rats (shr). |
2012-06-14 |
2023-08-12 |
rat |
| Daniele Tomassoni, Assia Catalani, Carlo Cinque, Maria Antonietta Di Tullio, Seyed Khosrow Tayebati, Angela Cadoni, Innocent Ejike Nwankwo, Enea Traini, Francesco Ament. Effects of cholinergic enhancing drugs on cholinergic transporters in the brain and peripheral blood lymphocytes of spontaneously hypertensive rats. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:22191561. |
the different activity of the cholinergic precursor and of the ache inhibitor on parameters investigated is likely related to their mechanism of action. |
2012-06-14 |
2023-08-12 |
rat |
| Daniele Tomassoni, Assia Catalani, Carlo Cinque, Maria Antonietta Di Tullio, Seyed Khosrow Tayebati, Angela Cadoni, Innocent Ejike Nwankwo, Enea Traini, Francesco Ament. Effects of cholinergic enhancing drugs on cholinergic transporters in the brain and peripheral blood lymphocytes of spontaneously hypertensive rats. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:22191561. |
differences in the activity of the cholinergic precursor and ache inhibitor investigated on cht and vacht suggests that association between choline alphoscerate and ache/cholinesterase inhibitors may represent a strategy for potentiating deficient cholinergic neurotransmission worthwhile of being investigated in clinical trials. |
2012-06-14 |
2023-08-12 |
rat |