| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rosilene R Kaizer, Jessié M Gutierres, Roberta Schmatz, Rosélia M Spanevello, Vera M Morsch, Maria R C Schetinger, João B T Roch. In vitro and in vivo interactions of aluminum on NTPDase and AChE activities in lymphocytes of rats. Cellular immunology. vol 265. issue 2. 2010-11-16. PMID:20832780. |
these results may demonstrate the ability of al to elicit the immune system, where ntpdase and ache activities can act as purinergic and cholinergic markers in lymphocytes. |
2010-11-16 |
2023-08-12 |
rat |
| Tatsuya Kikuchi, Toshimitsu Okamura, Kiyoshi Fukushi, Toshiaki Iri. Piperidine-4-methanthiol ester derivatives for a selective acetylcholinesterase assay. Biological & pharmaceutical bulletin. vol 33. issue 4. 2010-11-12. PMID:20410609. |
the activity of acetylcholinesterase (ache) is measured to obtain pathological information about the cholinergic system in various disease states and to assess the effect of ache inhibitors. |
2010-11-12 |
2023-08-12 |
human |
| Einor Ben Assayag, Shani Shenhar-Tsarfaty, Keren Ofek, Lilach Soreq, Irena Bova, Ludmila Shopin, Ronan M G Berg, Shlomo Berliner, Itzhak Shapira, Natan M Bornstein, Hermona Sore. Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality. Molecular medicine (Cambridge, Mass.). vol 16. issue 7-8. 2010-11-08. PMID:20464061. |
our study sought diagnostic values of ache and cholinergic status (cs, the total capacity for acetylcholine hydrolysis) in suspected stroke patients. |
2010-11-08 |
2023-08-12 |
Not clear |
| Bombi Lee, Bong-Jun Sur, Jeong-Jun Han, Insop Shim, Song Her, Hye-Jung Lee, Dae-Hyun Hah. Krill phosphatidylserine improves learning and memory in Morris water maze in aged rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 6. 2010-11-02. PMID:20677367. |
changes in the cholinergic system were examined by measuring choline acetyltransferase (chat) and acetylcholinesterase (ache) immunoreactivity in the hippocampus. |
2010-11-02 |
2023-08-12 |
rat |
| Kazim Husain, Rais A Ansari, Leon Ferde. Pharmacological agents in the prophylaxis/treatment of organophosphorous pesticide intoxication. Indian journal of experimental biology. vol 48. issue 7. 2010-10-21. PMID:20929049. |
poisoning includes acute cholinergic crisis as a result of ache inhibition, intermediate syndrome (ims) due to neuromuscular necrosis and organophosphate-induced delayed neuropathy (opidn) due to inhibition of neuropathy target esterase (nte). |
2010-10-21 |
2023-08-12 |
human |
| Yoshihiko Ito, Taketsugu Harada, Kasumi Fushimi, Yoshiyuki Kagawa, Hidenobu Oka, Hiroshi Nakazawa, Reiko Homma, Yoshihisa Kato, Shizuo Yamad. Pharmacokinetic and pharmacodynamic analysis of acetylcholinesterase inhibition by distigmine bromide in rats. Drug metabolism and pharmacokinetics. vol 25. issue 3. 2010-10-12. PMID:20610884. |
distigmine bromide (distigmine) is associated with a serious adverse reaction, cholinergic crisis, due to a marked decrease in serum acetylcholinesterase (ache) levels. |
2010-10-12 |
2023-08-12 |
rat |
| Chunyuan Luo, Carolyn Chambers, Nagarajan Pattabiraman, Min Tong, Prasanthi Tipparaju, Ashima Saxen. Y124 at the peripheral anionic site is important for the reactivation of nerve agent-inhibited acetylcholinesterase by H oximes. Biochemical pharmacology. vol 80. issue 9. 2010-10-06. PMID:20655881. |
the toxicity of organophosphorus (op) nerve agents is manifested through irreversible inhibition of acetylcholinesterase (ache) at the cholinergic synapses, which stops nerve signal transmission, resulting in a cholinergic crisis and eventually death of the poisoned person. |
2010-10-06 |
2023-08-12 |
human |
| Chunyuan Luo, Carolyn Chambers, Nagarajan Pattabiraman, Min Tong, Prasanthi Tipparaju, Ashima Saxen. Y124 at the peripheral anionic site is important for the reactivation of nerve agent-inhibited acetylcholinesterase by H oximes. Biochemical pharmacology. vol 80. issue 9. 2010-10-06. PMID:20655881. |
oxime compounds used in nerve agent antidote regimen reactivate nerve agent-inhibited ache and halt the development of this cholinergic crisis. |
2010-10-06 |
2023-08-12 |
human |
| Ethika Tyagi, Rahul Agrawal, Chandishwar Nath, Rakesh Shukl. Effect of melatonin on neuroinflammation and acetylcholinesterase activity induced by LPS in rat brain. European journal of pharmacology. vol 640. issue 1-3. 2010-10-04. PMID:20450904. |
to study the cholinergic intervention during neuroinflammatory conditions acetylcholinesterase (ache) enzyme activity was taken as marker of cholinergic activity. |
2010-10-04 |
2023-08-12 |
rat |
| Steeve Hervé Thany, Hélène Tricoire-Leignel, Bruno Lapie. Identification of cholinergic synaptic transmission in the insect nervous system. Advances in experimental medicine and biology. vol 683. 2010-09-30. PMID:20737784. |
a major criteria initially used to localize cholinergic neuronal elements in nervous systems tissues that involve acetylcholine (ach) as neurotransmitter is mainly based on immunochemical studies using choline acetyltransferase (chat), an enzyme which catalyzes ach biosynthesis and the ach degradative enzyme named acetylcholinesterase (ache). |
2010-09-30 |
2023-08-12 |
Not clear |
| Yanzi Zhou, Shenglong Wang, Yingkai Zhan. Catalytic reaction mechanism of acetylcholinesterase determined by Born-Oppenheimer ab initio QM/MM molecular dynamics simulations. The journal of physical chemistry. B. vol 114. issue 26. 2010-09-27. PMID:20550161. |
acetylcholinesterase (ache) is a remarkably efficient serine hydrolase responsible for the termination of impulse signaling at cholinergic synapses. |
2010-09-27 |
2023-08-12 |
Not clear |
| Natalia Wszelaki, Agnieszka Kuciun, Anna Karolina Kis. Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity. Acta pharmaceutica (Zagreb, Croatia). vol 60. issue 1. 2010-09-23. PMID:20228046. |
acetylcholinesterase (ache) inhibitors are widely used for the symptomatic treatment of alzheimer's disease (ad) to enhance central cholinergic transmission. |
2010-09-23 |
2023-08-12 |
Not clear |
| Sangu Muthuraju, Panchanan Maiti, Preeti Solanki, Alpesh Kumar Sharma, Shashi Bala Singh, Dipti Prasad, Govindasamy Ilavazhaga. Cholinesterase inhibitors ameliorate spatial learning deficits in rats following hypobaric hypoxia. Experimental brain research. vol 203. issue 3. 2010-09-03. PMID:20458473. |
cholinergic markers like acetylcholine (ach) and acetyl cholinesterase (ache) were evaluated from cortex and hippocampus. |
2010-09-03 |
2023-08-12 |
rat |
| Peter Eyer, Franz Worek, Horst Thiermann, Michael Eddlesto. Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:19883634. |
it is generally accepted that inhibition of acetylcholinesterase (ache) is the most important acute toxic action of organophosphorus compounds, leading to accumulation of acetylcholine followed by a dysfunction of cholinergic signaling. |
2010-09-01 |
2023-08-12 |
mouse |
| Peter Eyer, Franz Worek, Horst Thiermann, Michael Eddlesto. Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:19883634. |
however, the degree of ache inhibition is not uniformly correlated with cholinergic dysfunction, probably because the excess of essential ache varies among tissues. |
2010-09-01 |
2023-08-12 |
mouse |
| Horst Thiermann, Thomas Seeger, Sascha Gonder, Nadja Herkert, Bernd Antkowiak, Thomas Zilker, Florian Eyer, Franz Wore. Assessment of neuromuscular dysfunction during poisoning by organophosphorus compounds. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20036651. |
it is both of central and peripheral origin due to impaired cholinergic signalling upon inhibition of acetylcholinesterase (ache). |
2010-09-01 |
2023-08-12 |
human |
| Suzana Berend, Bozica Radić, Kamil Kuca, Ana Lucić Vrdolja. The antidotal efficacy of the bispyridinium oximes K027 and TMB-4 against tabun poisoning in mice. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20138854. |
inhibition of ache results in accumulation of acetylcholine (ach) at the synaptic cleft of the cholinergic neurons, leading to overstimulation of cholinergic receptors. |
2010-09-01 |
2023-08-12 |
mouse |
| Julian R Haigh, Michael Adler, James P Apland, Sharad S Deshpande, Charles B Barham, Patrick Desmond, Irwin Koplovitz, David E Lenz, Richard K Gordo. Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20144889. |
organophosphate (op) chemical warfare agents such as gd exert their toxic effects by inhibiting acetylcholinesterase (ache) from terminating the action of acetylcholine at postsynaptic sites in cholinergic nerve terminals (including crucial peripheral muscle such as diaphragm). |
2010-09-01 |
2023-08-12 |
marmoset |
| Heidi Q Xie, K Wing Leung, Vicky P Chen, Gallant K L Chan, Sherry L Xu, Ava J Y Guo, Kevin Y Zhu, Ken Y Z Zheng, Cathy W Bi, Janis Y X Zhan, Wallace K P Chan, Roy C Y Choi, Karl W K Tsi. PRiMA directs a restricted localization of tetrameric AChE at synapses. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20178777. |
acetylcholinesterase (ache), a highly polymorphic enzyme with various splicing variants and molecular isoforms, plays an essential role in the cholinergic neurotransmission by hydrolyzing acetylcholine into choline and acetate. |
2010-09-01 |
2023-08-12 |
Not clear |
| Soma Chanda, Jian Song, Peter Rezk, Praveena Sabnekar, Bhupendra P Doctor, Alfred M Sciuto, Madhusoodana P Nambia. Gastrointestinal acetylcholinesterase activity following endotracheal microinstillation inhalation exposure to sarin in guinea pigs. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20227400. |
these results suggest that the ache activity is different in different regions of the gi tract and highest levels of ache inhibition following sarin exposure were seen in regions exhibiting higher overall ache activity and cholinergic function. |
2010-09-01 |
2023-08-12 |
Not clear |