| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katarina Pegan, Urska Matkovic, Tomaz Mars, Katarina Mis, Sergej Pirkmajer, Janez Brecelj, Zoran Grubi. Acetylcholinesterase is involved in apoptosis in the precursors of human muscle regeneration. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20338155. |
the best established role of acetylcholinesterase (ec 3.1.1.7, ache) is termination of neurotransmission at cholinergic synapses. |
2010-09-01 |
2023-08-12 |
human |
| Katarina Pegan, Urska Matkovic, Tomaz Mars, Katarina Mis, Sergej Pirkmajer, Janez Brecelj, Zoran Grubi. Acetylcholinesterase is involved in apoptosis in the precursors of human muscle regeneration. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20338155. |
however, ache is also located at sites, where no other cholinergic components are present and there is accumulating evidence for non-cholinergic functions of this protein. |
2010-09-01 |
2023-08-12 |
human |
| Katarina Pegan, Urska Matkovic, Tomaz Mars, Katarina Mis, Sergej Pirkmajer, Janez Brecelj, Zoran Grubi. Acetylcholinesterase is involved in apoptosis in the precursors of human muscle regeneration. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20338155. |
in the process of skeletal muscle formation, ache is expressed already at the stage of mononuclear myoblast, which is long before other cholinergic components can be demonstrated in this tissue. |
2010-09-01 |
2023-08-12 |
human |
| M G Aluigi, C Guida, C Falug. Apoptosis as a specific biomarker of diazinon toxicity in NTera2-D1 cells. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20338157. |
its property to express a whole set of molecules related to the cholinergic neurotransmission system, including active acetylcholinesterase (ache, ec 3.1.1.7) makes it a good alternative model for testing the effects of neurotoxic compounds, such as organophosphorus (op) insecticides, whose primary target is the inhibition of ache activity. |
2010-09-01 |
2023-08-12 |
human |
| Zaheer-ul-Haq, Sobia Ahsan Halim, Reaz Uddin, Jeffry D Madur. Benchmarking docking and scoring protocol for the identification of potential acetylcholinesterase inhibitors. Journal of molecular graphics & modelling. vol 28. issue 8. 2010-08-12. PMID:20447848. |
acetylcholinesterase (ache) plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ach). |
2010-08-12 |
2023-08-12 |
Not clear |
| Elena Soriano, Abdelouahid Samadi, Mourad Chioua, Cristóbal de los Ríos, José Marco-Contelle. Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate. Bioorganic & medicinal chemistry letters. vol 20. issue 9. 2010-07-27. PMID:20350807. |
the synthesis and the ache/buche inhibition studies are reported, confirming that compound 2 is a potent and selective ache inhibitor, and consequently, a new lead compound for further development into new dual cas/pas cholinergic agents for the treatment of alzheimer's disease. |
2010-07-27 |
2023-08-12 |
Not clear |
| K Lovasova, D Kluchova, A Bolekova, F Dorko, T Spakovsk. Distribution of NADPH-diaphorase and AChE activity in the anterior leaflet of rat mitral valve. European journal of histochemistry : EJH. vol 54. issue 1. 2010-07-15. PMID:20353912. |
ache positive (cholinergic) nerve fibres were identified forming dense network and fibres organized in stripes. |
2010-07-15 |
2023-08-12 |
rat |
| Ramesh Halappa, Muniswamy Davi. In vivo inhibition of acetylcholinesterase activity in functionally different tissues of the freshwater fish, Cyprinus carpio, under chlorpyrifos exposure. Drug metabolism and drug interactions. vol 24. issue 2-4. 2010-07-08. PMID:20408496. |
depression of ache activity suggested decreased cholinergic transmission and consequent accumulation of acetylcholine (ach). |
2010-07-08 |
2023-08-12 |
Not clear |
| Sang-Hoon Lee, Jin-Sook Park, Se-Kwon Kim, Chang-Bum Ahn, Jae-Young J. Chitooligosaccharides suppress the level of protein expression and acetylcholinesterase activity induced by Abeta25-35 in PC12 cells. Bioorganic & medicinal chemistry letters. vol 19. issue 3. 2010-07-06. PMID:19097785. |
clinical applications of acetylcholinesterase (ache) inhibitors are widespread in alzheimer's sufferers in order to activate central cholinergic system and alleviate cognitive deficits by inhibiting the hydrolysis of acetylcholine. |
2010-07-06 |
2023-08-12 |
Not clear |
| Gracielle Alves-Amaral, Marcelo Pires-Oliveira, Ana Luiza Andrade-Lopes, Tiago Chiavegatti, Rosely Oliveira Godinh. Gender-related differences in circadian rhythm of rat plasma acetyl- and butyrylcholinesterase: effects of sex hormone withdrawal. Chemico-biological interactions. vol 186. issue 1. 2010-07-01. PMID:20399201. |
the role of acetylcholinesterase (ache) in the termination of the cholinergic response through acetylcholine (ach) hydrolysis and the involvement of plasma butyrylcholinesterase (buche), mainly of hepatic origin, in the metabolism of xenobiotics with ester bonds is well known. |
2010-07-01 |
2023-08-12 |
rat |
| Jamile F Gonçalves, Amanda M Fiorenza, Roselia M Spanevello, Cinthia M Mazzanti, Guilherme V Bochi, Fabiane G Antes, Naiara Stefanello, Maribel A Rubin, Valderi L Dressler, Vera M Morsch, Maria Rosa C Schetinge. N-acetylcysteine prevents memory deficits, the decrease in acetylcholinesterase activity and oxidative stress in rats exposed to cadmium. Chemico-biological interactions. vol 186. issue 1. 2010-07-01. PMID:20399762. |
the present findings show that treatment with nac prevented the cd-mediated decrease in ache activity, as well as oxidative stress and consequent memory impairment in cd-exposed rats, demonstrating that this compound may modulate cholinergic neurotransmission and consequently improve cognition. |
2010-07-01 |
2023-08-12 |
rat |
| Jean Marc Miezan Ezoulin, Bi-Yun Shao, Zheng Xia, Qiong Xie, Juan Li, Yong-Yao Cui, Hao Wang, Chang-Zhi Dong, Yan-Xing Zhao, France Massicot, Zhui-Bai Qiu, Françoise Heymans, Hong-Zhuan Che. Novel piperazine derivative PMS1339 exhibits tri-functional properties and cognitive improvement in mice. The international journal of neuropsychopharmacology. vol 12. issue 10. 2010-06-29. PMID:19460190. |
the acetylcholinesterase (ache) inhibitors are the first class of drugs used to enhance surviving cholinergic activities. |
2010-06-29 |
2023-08-12 |
mouse |
| Yvonne Rook, Kai-Uwe Schmidtke, Friedemann Gaube, Dirk Schepmann, Bernhard Wünsch, Jörg Heilmann, Jochen Lehmann, Thomas Winckle. Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. Journal of medicinal chemistry. vol 53. issue 9. 2010-06-11. PMID:20361801. |
inhibitors of acetylcholinesterase (ache) and butyrylcholinesterase (bche) improve cholinergic signaling in the central nervous system and thus ache inhibitors are well established in the therapy of ad to improve memory disturbances and other cognitive symptoms. |
2010-06-11 |
2023-08-12 |
Not clear |
| H Sore. Cholinergic mechanisms--tenth international symposium. 1-5 September 1998, Arcachon, France. IDrugs : the investigational drugs journal. vol 1. issue 7. 2010-06-09. PMID:18465647. |
cholinergic drugs are currently in use, or in advanced stages of development, for the chronic treatment of alzheimer's disease (ad) and myasthenia gravis, as well as for the treatment of acute intoxication with organophosphate or carbamate inhibitors of the ach hydrolyzing enzyme acetyl-cholinesterase (ache). |
2010-06-09 |
2023-08-12 |
Not clear |
| Vineetkumar K Patil, Muniswamy Davi. Behavioral and morphological endpoints: as an early response to sublethal malathion intoxication in the freshwater fish, Labeo rohita. Drug and chemical toxicology. vol 33. issue 2. 2010-06-08. PMID:20307142. |
inhibition of ache activity results in excess accumulation of acetylcholine in cholinergic synapses, leading to hyperstimulation and cessation of neuronal transmission (i.e., paralysis). |
2010-06-08 |
2023-08-12 |
Not clear |
| Denis V Abramochkin, Leniz F Nurullin, Anastasia A Borodinova, Nadezhda V Tarasova, Galina S Sukhova, Eugen E Nikolsky, Leonid V Rosenshtrauk. Non-quantal release of acetylcholine from parasympathetic nerve terminals in the right atrium of rats. Experimental physiology. vol 95. issue 2. 2010-05-06. PMID:19767403. |
acetylcholinesterase (ache) inhibitors provoke typical cholinergic effects in the isolated right atrium of the rat due to the accumulation of acetylcholine (ach). |
2010-05-06 |
2023-08-12 |
rat |
| Ramanna V Rajesh, Paul G Layer, Rathanam Boopath. High aryl acylamidase activity associated with cobra venom acetylcholinesterase: biological significance. Biochimie. vol 91. issue 11-12. 2010-04-23. PMID:19695303. |
both serotonergenic and cholinergic inhibitors inhibited the cobra venom aaa activity in a concentration dependent manner, which also underlines the association of aaa with ache of cobra venom. |
2010-04-23 |
2023-08-12 |
human |
| Wolfgang Härtig, Johannes Kacza, Bernd-Reiner Paulke, Jens Grosche, Ute Bauer, Anke Hoffmann, Paul W Elsinghorst, Michael Gütscho. In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles. The European journal of neuroscience. vol 31. issue 1. 2010-04-16. PMID:20092557. |
the drastic loss of cholinergic projection neurons in the basal forebrain is a hallmark of alzheimer's disease (ad), and drugs most frequently applied for the treatment of dementia include inhibitors of the acetylcholine-degrading enzyme acetylcholinesterase (ache). |
2010-04-16 |
2023-08-12 |
mouse |
| N Suganthy, S Karutha Pandian, K Pandima Dev. Neuroprotective effect of seaweeds inhabiting South Indian coastal area (Hare Island, Gulf of Mannar Marine Biosphere Reserve): Cholinesterase inhibitory effect of Hypnea valentiae and Ulva reticulata. Neuroscience letters. vol 468. issue 3. 2010-04-06. PMID:19897016. |
until date the only symptomatic treatment for this disease is based on the "cholinergic hypothesis" where the drugs enhance acetylcholine levels in the brain by inhibiting acetylcholinesterase (ache). |
2010-04-06 |
2023-08-12 |
Not clear |
| Jessica J Roland, Michelle Levinson, Ryan P Vetreno, Lisa M Savag. Differential effects of systemic and intraseptal administration of the acetylcholinesterase inhibitor tacrine on the recovery of spatial behavior in an animal model of diencephalic amnesia. European journal of pharmacology. vol 629. issue 1-3. 2010-03-30. PMID:20006600. |
several lines of evidence suggest that acetylcholinesterase inhibitors (ache) have their cognitive enhancing effects by stimulating cholinergic receptors within the medial septum. |
2010-03-30 |
2023-08-12 |
rat |