| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philip J Welsby, Michael J Rowan, Roger Anwy. Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus. The European journal of neuroscience. vol 29. issue 1. 2009-02-19. PMID:19077124. |
in particular, the involvement of activation of intracellular kinases was examined using selective kinase antagonists, and the effects of enhancing cholinergic function with positive allosteric modulators of the alpha7 nachr and with acetylcholinesterase (ache) inhibitors were also investigated. |
2009-02-19 |
2023-08-12 |
rat |
| S K Tayebati, M A Di Tullio, F Ament. Vesicular acetylcholine transporter (VAChT) in the brain of spontaneously hypertensive rats (SHR): effect of treatment with an acetylcholinesterase inhibitor. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 30. issue 8. 2009-02-06. PMID:19021024. |
the sensitivity of manipulation of cholinergic system on vacht was assessed in rats treated for four weeks with the acetylcholinesterase (ache) inhibitor galantamine (3 mg/kg/day). |
2009-02-06 |
2023-08-12 |
rat |
| Juan Li, Biyun Shao, Liang Zhu, Yongyao Cui, Changzhi Dong, Jean-Marc Miezan Ezoulin, Xiaoling Gao, Qiushi Ren, Françoise Heymans, Hongzhuan Che. PMS777, a bis-interacting ligand for PAF receptor antagonism and AChE inhibition, attenuates PAF-induced neurocytotoxicity in SH-SY5Y cells. Cellular and molecular neurobiology. vol 28. issue 1. 2009-01-28. PMID:17712622. |
we have previously reported that a novel tetrahydrofuran-derived bis-interacting ligand pms777 had satisfying potencies for paf receptor blockade and ache inhibition, and markedly improved cholinergic dysfunction-induced cognitive impairment in mice. |
2009-01-28 |
2023-08-12 |
mouse |
| Guojun Chen, Paul Chen, Huibing Tan, Da Ma, Fei Dou, Jian Feng, Zhen Ya. Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's disease. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17555845. |
inhibitors of acetylcholinesterase (ache), which act to enhance cholinergic function by prolonging the action of endogenously released ach, have been used as the major therapy of ad. |
2009-01-23 |
2023-08-12 |
mouse |
| Guojun Chen, Paul Chen, Huibing Tan, Da Ma, Fei Dou, Jian Feng, Zhen Ya. Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's disease. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17555845. |
to understand the functional roles of cholinergic enhancement in prefrontal cortex (pfc), a key brain region for cognition, we examined the impact of ache inhibitors in pfc neurons on synaptic responses mediated by the nmda receptor (nmdar), an important player in learning and memory. |
2009-01-23 |
2023-08-12 |
mouse |
| O V Zaĭtseva, T V Kuznetsov. [Distribution of acetylcholinesterase activity in the digestive system of the gastropod molluscs Littorina littorea and Achatina fulica]. Morfologiia (Saint Petersburg, Russia). vol 133. issue 1. 2009-01-13. PMID:19069417. |
with the use of the histochemical procedure for the demonstration of acetylcholinesterase (ache) activity, the distribution cholinergic regulatory elements was studied in the esophagus, the pharynx, the stomach, the liver (the digestive gland) and the intestine in sea and terrestrial gastropod molluscs that differed in their general organization level, lifestyle, habitat and feeding type. |
2009-01-13 |
2023-08-12 |
Not clear |
| Finla Chathu, Amee Krishnakumar, Cheramadathikudyil S Paulos. Acetylcholine esterase activity and behavioral response in hypoxia induced neonatal rats: effect of glucose, oxygen and epinephrine supplementation. Brain and cognition. vol 68. issue 1. 2008-12-22. PMID:18406032. |
in the present study, we assessed the changes in the cholinergic system by measuring the acetylcholinesterase (ache) activity and the behavioral responses shown by hypoxia induced neonatal rats and hypoxic rats supplemented with glucose, oxygen and epinephrine using elevated plus-maze and open-field test. |
2008-12-22 |
2023-08-12 |
rat |
| R R Kaizer, M C Corrêa, L R S Gris, C S da Rosa, D Bohrer, V M Morsch, Maria Rosa Chitolina Schetinge. Effect of long-term exposure to aluminum on the acetylcholinesterase activity in the central nervous system and erythrocytes. Neurochemical research. vol 33. issue 11. 2008-12-12. PMID:18470612. |
ache activity in erythrocytes may be considered a marker of easy access of the central cholinergic status. |
2008-12-12 |
2023-08-12 |
rat |
| María-Salud García-Ayllón, Omar Cauli, María-Ximena Silveyra, Regina Rodrigo, Asunción Candela, Antonio Compañ, Rodrigo Jover, Miguel Pérez-Mateo, Salvador Martínez, Vicente Felipo, Javier Sáez-Valer. Brain cholinergic impairment in liver failure. Brain : a journal of neurology. vol 131. issue Pt 11. 2008-12-12. PMID:18772221. |
portacaval shunted rats which display increased levels of cerebral ammonia did not show any brain cholinergic abnormalities, confirming that high ammonia levels do not play a role in brain ache changes. |
2008-12-12 |
2023-08-12 |
human |
| Roy C Y Choi, Mokka K W Mok, Anna W H Cheung, Nina L Siow, Heidi Q Xie, Karl W K Tsi. Regulation of PRiMA-linked G(4) AChE by a cAMP-dependent signaling pathway in cultured rat pheochromocyoma PC12 cells. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18514641. |
the catalytic subunit of acetylcholinesterase (ache(t)) interacts with proline-rich membrane anchor (prima) to form prima-linked g(4) ache on membrane surface for its cholinergic function. |
2008-12-10 |
2023-08-12 |
rat |
| Julie Espallergues, Laurie Galvan, Laurence Lepourry, Béatrice Bonafos, Tangui Maurice, Arnaud Chatonne. Hyposensitivity to the amnesic effects of scopolamine or amyloid beta(25-35) peptide in heterozygous acetylcholinesterase knockout (AChE(+/-)) mice. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18533140. |
therefore, the hyper-activity of cholinergic systems in ache(+/-) mice did not result in increased memory abilities, but prevented the deleterious effects of muscarinic blockade or amyloid toxicity. |
2008-12-10 |
2023-08-12 |
mouse |
| Wei Su, Jun Wu, Wei-Yuan Ye, Xue-Jun Zhan. A monoclonal antibody against synaptic AChE: a useful tool for detecting apoptotic cells. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18538755. |
the classical function of acetylcholinesterase (ache) is to terminate synaptic transmission at cholinergic synapses by rapidly hydrolyzing the neurotransmitter acetylcholine (ach). |
2008-12-10 |
2023-08-12 |
Not clear |
| Julian R Haigh, Lee J Lefkowitz, Benedict R Capacio, Bhupendra P Doctor, Richard K Gordo. Advantages of the WRAIR whole blood cholinesterase assay: comparative analysis to the micro-Ellman, Test-mate ChE, and Michel (DeltapH) assays. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18555983. |
red blood cell ache (rbc-ache) and plasma bche can be used as sensitive biomarkers to detect exposure to op nerve agents, pesticides, and cholinergic drugs. |
2008-12-10 |
2023-08-12 |
human |
| Jiri Bajgar, Josef Fusek, Jiri Kassa, Daniel Jun, Kamil Kuca, Petr Haje. An attempt to assess functionally minimal acetylcholinesterase activity necessary for survival of rats intoxicated with nerve agents. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18579126. |
acetylcholinesterase (ache, ec 3.1.1.7) is an important enzyme for cholinergic nerve transmission. |
2008-12-10 |
2023-08-12 |
rat |
| Shigeki Hirano, Hitoshi Shinotoh, Kimihito Arai, Akiyo Aotsuka, Fumihiko Yasuno, Noriko Tanaka, Tsuneyoshi Ota, Koichi Sato, Kiyoshi Fukushi, Shuji Tanada, Takamichi Hattori, Toshiaki Iri. PET study of brain acetylcholinesterase in cerebellar degenerative disorders. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 8. 2008-10-20. PMID:18412283. |
reduction of ache activities in the thalamus and cerebellum in msa and in the thalamus in sca-3 suggest that cholinergic modulating drugs may have a role in the treatment of ataxia and other symptoms in these disorders. |
2008-10-20 |
2023-08-12 |
human |
| Hung-Bun Lam, Ching-Hua Yeh, Kai-Chun Cheng, Chao-Tien Hsu, Juei-Tang Chen. Effect of cholinergic denervation on hepatic fibrosis induced by carbon tetrachloride in rats. Neuroscience letters. vol 438. issue 1. 2008-09-08. PMID:18472332. |
acetylcholinesterase (ache) staining showed the distribution of cholinergic nerve around fibrosis scaring septa. |
2008-09-08 |
2023-08-12 |
rat |
| Ilkay Orhan, Fatma Tosun, Bilge Sene. Coumarin, anthroquinone and stilbene derivatives with anticholinesterase activity. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 63. issue 5-6. 2008-08-26. PMID:18669022. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are the key enzymes in pathogenesis of alzheimer's disease (ad), which is characterized by a deficit in central cholinergic transmission. |
2008-08-26 |
2023-08-12 |
Not clear |
| Chiara Giuliano, Vinay Parikh, Josh R Ward, Christian Chiamulera, Martin Sarte. Increases in cholinergic neurotransmission measured by using choline-sensitive microelectrodes: enhanced detection by hydrolysis of acetylcholine on recording sites? Neurochemistry international. vol 52. issue 7. 2008-08-08. PMID:18346819. |
collectively, these results indicate that co-coating of microelectrodes with ache does not enhance the detection of cholinergic activity in the cortex compared with measurements via recording sites coated only with chox. |
2008-08-08 |
2023-08-12 |
Not clear |
| S Cellek, R Thangiah, E M Jarvie, S Vivekanandan, O Lalude, G J Sange. Synergy between 5-HT4 receptor activation and acetylcholinesterase inhibition in human colon and rat forestomach. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 5. 2008-08-06. PMID:18194150. |
our aim was to investigate the hypothesis that the effect of ache inhibition will synergise with the ability of 5-ht4 receptor agonism to increase cholinergic activity, leading to an effect greater than that evoked by each action alone. |
2008-08-06 |
2023-08-12 |
human |
| Ariane Hornick, Stefan Schwaiger, Judith M Rollinger, Nguyen Phung Vo, Helmut Prast, Hermann Stuppne. Extracts and constituents of Leontopodium alpinum enhance cholinergic transmission: brain ACh increasing and memory improving properties. Biochemical pharmacology. vol 76. issue 2. 2008-07-31. PMID:18541221. |
only silphiperfolene acetate showed in vitro ache inhibitory activity, thus suggesting the other sesquiterpenes to stimulate cholinergic transmission by an alternative mechanism of action. |
2008-07-31 |
2023-08-12 |
mouse |