| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guojun Chen, Paul Chen, Huibing Tan, Da Ma, Fei Dou, Jian Feng, Zhen Ya. Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's disease. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17555845. |
to understand the functional roles of cholinergic enhancement in prefrontal cortex (pfc), a key brain region for cognition, we examined the impact of ache inhibitors in pfc neurons on synaptic responses mediated by the nmda receptor (nmdar), an important player in learning and memory. |
2009-01-23 |
2023-08-12 |
mouse |
| O V Zaĭtseva, T V Kuznetsov. [Distribution of acetylcholinesterase activity in the digestive system of the gastropod molluscs Littorina littorea and Achatina fulica]. Morfologiia (Saint Petersburg, Russia). vol 133. issue 1. 2009-01-13. PMID:19069417. |
with the use of the histochemical procedure for the demonstration of acetylcholinesterase (ache) activity, the distribution cholinergic regulatory elements was studied in the esophagus, the pharynx, the stomach, the liver (the digestive gland) and the intestine in sea and terrestrial gastropod molluscs that differed in their general organization level, lifestyle, habitat and feeding type. |
2009-01-13 |
2023-08-12 |
Not clear |
| Finla Chathu, Amee Krishnakumar, Cheramadathikudyil S Paulos. Acetylcholine esterase activity and behavioral response in hypoxia induced neonatal rats: effect of glucose, oxygen and epinephrine supplementation. Brain and cognition. vol 68. issue 1. 2008-12-22. PMID:18406032. |
in the present study, we assessed the changes in the cholinergic system by measuring the acetylcholinesterase (ache) activity and the behavioral responses shown by hypoxia induced neonatal rats and hypoxic rats supplemented with glucose, oxygen and epinephrine using elevated plus-maze and open-field test. |
2008-12-22 |
2023-08-12 |
rat |
| R R Kaizer, M C Corrêa, L R S Gris, C S da Rosa, D Bohrer, V M Morsch, Maria Rosa Chitolina Schetinge. Effect of long-term exposure to aluminum on the acetylcholinesterase activity in the central nervous system and erythrocytes. Neurochemical research. vol 33. issue 11. 2008-12-12. PMID:18470612. |
ache activity in erythrocytes may be considered a marker of easy access of the central cholinergic status. |
2008-12-12 |
2023-08-12 |
rat |
| María-Salud García-Ayllón, Omar Cauli, María-Ximena Silveyra, Regina Rodrigo, Asunción Candela, Antonio Compañ, Rodrigo Jover, Miguel Pérez-Mateo, Salvador Martínez, Vicente Felipo, Javier Sáez-Valer. Brain cholinergic impairment in liver failure. Brain : a journal of neurology. vol 131. issue Pt 11. 2008-12-12. PMID:18772221. |
portacaval shunted rats which display increased levels of cerebral ammonia did not show any brain cholinergic abnormalities, confirming that high ammonia levels do not play a role in brain ache changes. |
2008-12-12 |
2023-08-12 |
human |
| Roy C Y Choi, Mokka K W Mok, Anna W H Cheung, Nina L Siow, Heidi Q Xie, Karl W K Tsi. Regulation of PRiMA-linked G(4) AChE by a cAMP-dependent signaling pathway in cultured rat pheochromocyoma PC12 cells. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18514641. |
the catalytic subunit of acetylcholinesterase (ache(t)) interacts with proline-rich membrane anchor (prima) to form prima-linked g(4) ache on membrane surface for its cholinergic function. |
2008-12-10 |
2023-08-12 |
rat |
| Julie Espallergues, Laurie Galvan, Laurence Lepourry, Béatrice Bonafos, Tangui Maurice, Arnaud Chatonne. Hyposensitivity to the amnesic effects of scopolamine or amyloid beta(25-35) peptide in heterozygous acetylcholinesterase knockout (AChE(+/-)) mice. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18533140. |
therefore, the hyper-activity of cholinergic systems in ache(+/-) mice did not result in increased memory abilities, but prevented the deleterious effects of muscarinic blockade or amyloid toxicity. |
2008-12-10 |
2023-08-12 |
mouse |
| Wei Su, Jun Wu, Wei-Yuan Ye, Xue-Jun Zhan. A monoclonal antibody against synaptic AChE: a useful tool for detecting apoptotic cells. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18538755. |
the classical function of acetylcholinesterase (ache) is to terminate synaptic transmission at cholinergic synapses by rapidly hydrolyzing the neurotransmitter acetylcholine (ach). |
2008-12-10 |
2023-08-12 |
Not clear |
| Julian R Haigh, Lee J Lefkowitz, Benedict R Capacio, Bhupendra P Doctor, Richard K Gordo. Advantages of the WRAIR whole blood cholinesterase assay: comparative analysis to the micro-Ellman, Test-mate ChE, and Michel (DeltapH) assays. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18555983. |
red blood cell ache (rbc-ache) and plasma bche can be used as sensitive biomarkers to detect exposure to op nerve agents, pesticides, and cholinergic drugs. |
2008-12-10 |
2023-08-12 |
human |
| Jiri Bajgar, Josef Fusek, Jiri Kassa, Daniel Jun, Kamil Kuca, Petr Haje. An attempt to assess functionally minimal acetylcholinesterase activity necessary for survival of rats intoxicated with nerve agents. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18579126. |
acetylcholinesterase (ache, ec 3.1.1.7) is an important enzyme for cholinergic nerve transmission. |
2008-12-10 |
2023-08-12 |
rat |
| Shigeki Hirano, Hitoshi Shinotoh, Kimihito Arai, Akiyo Aotsuka, Fumihiko Yasuno, Noriko Tanaka, Tsuneyoshi Ota, Koichi Sato, Kiyoshi Fukushi, Shuji Tanada, Takamichi Hattori, Toshiaki Iri. PET study of brain acetylcholinesterase in cerebellar degenerative disorders. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 8. 2008-10-20. PMID:18412283. |
reduction of ache activities in the thalamus and cerebellum in msa and in the thalamus in sca-3 suggest that cholinergic modulating drugs may have a role in the treatment of ataxia and other symptoms in these disorders. |
2008-10-20 |
2023-08-12 |
human |
| Hung-Bun Lam, Ching-Hua Yeh, Kai-Chun Cheng, Chao-Tien Hsu, Juei-Tang Chen. Effect of cholinergic denervation on hepatic fibrosis induced by carbon tetrachloride in rats. Neuroscience letters. vol 438. issue 1. 2008-09-08. PMID:18472332. |
acetylcholinesterase (ache) staining showed the distribution of cholinergic nerve around fibrosis scaring septa. |
2008-09-08 |
2023-08-12 |
rat |
| Ilkay Orhan, Fatma Tosun, Bilge Sene. Coumarin, anthroquinone and stilbene derivatives with anticholinesterase activity. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 63. issue 5-6. 2008-08-26. PMID:18669022. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are the key enzymes in pathogenesis of alzheimer's disease (ad), which is characterized by a deficit in central cholinergic transmission. |
2008-08-26 |
2023-08-12 |
Not clear |
| Chiara Giuliano, Vinay Parikh, Josh R Ward, Christian Chiamulera, Martin Sarte. Increases in cholinergic neurotransmission measured by using choline-sensitive microelectrodes: enhanced detection by hydrolysis of acetylcholine on recording sites? Neurochemistry international. vol 52. issue 7. 2008-08-08. PMID:18346819. |
collectively, these results indicate that co-coating of microelectrodes with ache does not enhance the detection of cholinergic activity in the cortex compared with measurements via recording sites coated only with chox. |
2008-08-08 |
2023-08-12 |
Not clear |
| S Cellek, R Thangiah, E M Jarvie, S Vivekanandan, O Lalude, G J Sange. Synergy between 5-HT4 receptor activation and acetylcholinesterase inhibition in human colon and rat forestomach. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 5. 2008-08-06. PMID:18194150. |
our aim was to investigate the hypothesis that the effect of ache inhibition will synergise with the ability of 5-ht4 receptor agonism to increase cholinergic activity, leading to an effect greater than that evoked by each action alone. |
2008-08-06 |
2023-08-12 |
human |
| Ariane Hornick, Stefan Schwaiger, Judith M Rollinger, Nguyen Phung Vo, Helmut Prast, Hermann Stuppne. Extracts and constituents of Leontopodium alpinum enhance cholinergic transmission: brain ACh increasing and memory improving properties. Biochemical pharmacology. vol 76. issue 2. 2008-07-31. PMID:18541221. |
only silphiperfolene acetate showed in vitro ache inhibitory activity, thus suggesting the other sesquiterpenes to stimulate cholinergic transmission by an alternative mechanism of action. |
2008-07-31 |
2023-08-12 |
mouse |
| Doaa A Ghareeb, Hend M Husse. Vanadium improves brain acetylcholinesterase activity on early stage alloxan-diabetic rats. Neuroscience letters. vol 436. issue 1. 2008-07-22. PMID:18378083. |
therefore, vanadate administration could protect against direct action of lipid peroxidation on brain ache and in this way, it might be useful in the prevention of cholinergic neural dysfunction, which is one of the major complications in diabetes. |
2008-07-22 |
2023-08-12 |
rat |
| Bozica Radić, Ana Lucić Vrdoljak, Davor Zeljezić, Nino Fuchs, Suzana Berend, Nevenka Kopja. Evaluation of HI-6 oxime: potential use in protection of human acetylcholinesterase inhibited by antineoplastic drug irinotecan and its cyto/genotoxicity in vitro. Acta biochimica Polonica. vol 54. issue 3. 2008-07-11. PMID:17713603. |
the function of acetylcholinesterase (ache) is the rapid hydrolysis of the neurotransmitter acetylcholine (ach), which is involved in the numerous cholinergic pathways in both the central and the peripheral nervous system. |
2008-07-11 |
2023-08-12 |
human |
| Monica Rosa Loizzo, Rosa Tundis, Federica Menichini, Francesco Menichin. Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: an update. Current medicinal chemistry. vol 15. issue 12. 2008-06-30. PMID:18473814. |
moreover, the inhibition of ache holds a key role not only to enhance cholinergic transmission in the brain but also to reduce the aggregation of beta-amyloid and the formation of the neurotoxic fibrils in ad. |
2008-06-30 |
2023-08-12 |
Not clear |
| Scott D Bembenek, John M Keith, Michael A Letavic, Richard Apodaca, Ann J Barbier, Lisa Dvorak, Leah Aluisio, Kirsten L Miller, Timothy W Lovenberg, Nicholas I Carruther. Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling. Bioorganic & medicinal chemistry. vol 16. issue 6. 2008-06-13. PMID:18249544. |
both histamine h(3) receptor antagonists and ache inhibitors improve and augment cholinergic neurotransmission in the cortex. |
2008-06-13 |
2023-08-12 |
Not clear |