| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Doaa A Ghareeb, Hend M Husse. Vanadium improves brain acetylcholinesterase activity on early stage alloxan-diabetic rats. Neuroscience letters. vol 436. issue 1. 2008-07-22. PMID:18378083. |
therefore, vanadate administration could protect against direct action of lipid peroxidation on brain ache and in this way, it might be useful in the prevention of cholinergic neural dysfunction, which is one of the major complications in diabetes. |
2008-07-22 |
2023-08-12 |
rat |
| Bozica Radić, Ana Lucić Vrdoljak, Davor Zeljezić, Nino Fuchs, Suzana Berend, Nevenka Kopja. Evaluation of HI-6 oxime: potential use in protection of human acetylcholinesterase inhibited by antineoplastic drug irinotecan and its cyto/genotoxicity in vitro. Acta biochimica Polonica. vol 54. issue 3. 2008-07-11. PMID:17713603. |
the function of acetylcholinesterase (ache) is the rapid hydrolysis of the neurotransmitter acetylcholine (ach), which is involved in the numerous cholinergic pathways in both the central and the peripheral nervous system. |
2008-07-11 |
2023-08-12 |
human |
| Monica Rosa Loizzo, Rosa Tundis, Federica Menichini, Francesco Menichin. Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: an update. Current medicinal chemistry. vol 15. issue 12. 2008-06-30. PMID:18473814. |
moreover, the inhibition of ache holds a key role not only to enhance cholinergic transmission in the brain but also to reduce the aggregation of beta-amyloid and the formation of the neurotoxic fibrils in ad. |
2008-06-30 |
2023-08-12 |
Not clear |
| Scott D Bembenek, John M Keith, Michael A Letavic, Richard Apodaca, Ann J Barbier, Lisa Dvorak, Leah Aluisio, Kirsten L Miller, Timothy W Lovenberg, Nicholas I Carruther. Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling. Bioorganic & medicinal chemistry. vol 16. issue 6. 2008-06-13. PMID:18249544. |
both histamine h(3) receptor antagonists and ache inhibitors improve and augment cholinergic neurotransmission in the cortex. |
2008-06-13 |
2023-08-12 |
Not clear |
| L R Vieira, A Sousa, M F Frasco, I Lima, F Morgado, L Guilhermin. Acute effects of Benzo[a]pyrene, anthracene and a fuel oil on biomarkers of the common goby Pomatoschistus microps (Teleostei, Gobiidae). The Science of the total environment. vol 395. issue 2-3. 2008-06-09. PMID:18346779. |
all the substances inhibited p. microps acetylcholinesterase (ache) indicating that they have at least one mechanism of neurotoxicity in common: the disruption of cholinergic transmission by inhibition of ache. |
2008-06-09 |
2023-08-12 |
Not clear |
| Luis M Carcoba, Miguel Santiago, Donald E Moss, Rafael Cabez. In utero methanesulfonyl fluoride differentially affects learning and maze performance in the absence of long-lasting cholinergic changes in the adult rat. Pharmacology, biochemistry, and behavior. vol 88. issue 4. 2008-05-08. PMID:17920111. |
therefore, methanesulfonyl fluoride (msf), an irreversible ache inhibitor that shows high selectivity for the cns was used to produce ache inhibition in utero to study subsequent adult behaviors, sleep, and cholinergic markers. |
2008-05-08 |
2023-08-12 |
rat |
| Anna Rostedt Punga, Mikio Sawada, Erik V Stålber. Electrophysiological signs and the prevalence of adverse effects of acetylcholinesterase inhibitors in patients with myasthenia gravis. Muscle & nerve. vol 37. issue 3. 2008-05-02. PMID:18069667. |
fourteen patients (64%) experienced daily cholinergic adverse effects, and muscarinic side effects correlated with ache activity. |
2008-05-02 |
2023-08-12 |
Not clear |
| Dongren Yang, Angela Howard, Donald Bruun, Mispa Ajua-Alemanj, Cecile Pickart, Pamela J Lei. Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase. Toxicology and applied pharmacology. vol 228. issue 1. 2008-04-28. PMID:18076960. |
a primary role of acetylcholinesterase (ache) is regulation of cholinergic neurotransmission by hydrolysis of synaptic acetylcholine. |
2008-04-28 |
2023-08-12 |
mouse |
| J E Cohen, G Zimmerman, N Melamed-Book, A Friedman, A Dori, H Sore. Transgenic inactivation of acetylcholinesterase impairs homeostasis in mouse hippocampal granule cells. Hippocampus. vol 18. issue 2. 2008-03-03. PMID:17960645. |
because cholinergic neurotransmission influences both of these functions, we hypothesized that cholinergic signaling, affected by acetylcholinesterase (ache) activity, expression level, and alternative splicing, may provide a link between these processes. |
2008-03-03 |
2023-08-12 |
mouse |
| Alexandra A Anderson, Dmitry S Ushakov, Michael A Ferenczi, Ryoichi Mori, Paul Martin, Jane L Saffel. Morphoregulation by acetylcholinesterase in fibroblasts and astrocytes. Journal of cellular physiology. vol 215. issue 1. 2008-02-19. PMID:17948252. |
acetylcholinesterase (ache) terminates neurotransmission at cholinergic synapses by hydrolysing acetylcholine, but also has non-enzymatic morphoregulatory effects on neurons such as stimulation of neurite outgrowth. |
2008-02-19 |
2023-08-12 |
mouse |
| Luis Marco, Maria do Carmo Carreira. Galanthamine, a natural product for the treatment of Alzheimer's disease. Recent patents on CNS drug discovery. vol 1. issue 1. 2008-02-15. PMID:18221196. |
galanthamine is a long-acting, selective, reversible and competitive ache inhibitor that has recently been tested in ad patients and found to be readily absorbed, to be a performance enhancer on memory tests in some patients, and to be well tolerated, although some cholinergic side effects were observed. |
2008-02-15 |
2023-08-12 |
Not clear |
| J Bajgar, K Kuca, D Jun, L Bartosova, J Fuse. Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents. Current drug metabolism. vol 8. issue 8. 2008-02-04. PMID:18220560. |
understanding the mechanism of action of organophosphates (op)/nerve agents -- irreversible acetylcholinesterase (ache, ec 3.1.1.7) inhibition at the cholinergic synapses followed by metabolic dysbalance of the organism -- two therapeutic principles for antidotal treatment are derived. |
2008-02-04 |
2023-08-12 |
Not clear |
| J Bajgar, K Kuca, D Jun, L Bartosova, J Fuse. Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents. Current drug metabolism. vol 8. issue 8. 2008-02-04. PMID:18220560. |
the main drugs are anticholinergics that antagonize the effects of accumulated acetylcholine at the cholinergic synapses and cholinesterase reactivators (oximes) reactivating inhibited ache. |
2008-02-04 |
2023-08-12 |
Not clear |
| I Swapna, K V SathyaSaikumar, Ch R K Murthy, A Dutta Gupta, B Senthilkumara. Alterations in kinetic and thermotropic properties of cerebral membrane-bound acetylcholineesterase during thioacetamide-induced hepatic encephalopathy: correlation with membrane lipid changes. Brain research. vol 1153. 2008-01-09. PMID:17482580. |
acetylcholinesterase (ache) is an important peripheral membrane-bound enzyme, crucial for cholinergic neurotransmission. |
2008-01-09 |
2023-08-12 |
rat |
| Ethika Tyagi, Rahul Agrawal, Chandishwar Nath, Rakesh Shukl. Effect of anti-dementia drugs on LPS induced neuroinflammation in mice. Life sciences. vol 80. issue 21. 2008-01-02. PMID:17395211. |
interleukin-2 (il-2) and isoforms of acetylcholinesterase (ache) were estimated in different brain areas as marker for neuroinflammation and cholinergic activity respectively. |
2008-01-02 |
2023-08-12 |
mouse |
| Eduardo Pacheco Rico, Denis Broock Rosemberg, Renato Dutra Dias, Mauricio Reis Bogo, Carla Denise Bona. Ethanol alters acetylcholinesterase activity and gene expression in zebrafish brain. Toxicology letters. vol 174. issue 1-3. 2007-12-18. PMID:17888594. |
these findings suggest that the alterations on zebrafish ache could reveal molecular mechanisms related to cholinergic signaling in alcoholism. |
2007-12-18 |
2023-08-12 |
zebrafish |
| Mariapaola Piccardi, Donatella Congiu, Alessio Squassina, Francesca Manconi, Paolo Francesco Putzu, Rosa Maria Mereu, Caterina Chillotti, Maria Del Zomp. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503475. |
the resulting reduction in cholinergic activity is associated with decreased levels of the neurotransmitter acetylcholine (ach), decreased activity of acetylcholinesterase (ache), choline acetyltransferase (chat), and increased butyrylcholinesterase (bche) activity. |
2007-12-06 |
2023-08-12 |
human |
| Seung-O Ko, Tak-Heun Kim, Hye Kyung Lee, Jeong-Chae Lee, Eui-Sic Ch. Temporospatial localization of acetylcholinesterase activity in the dental epithelium during mouse tooth development. Life sciences. vol 81. issue 15. 2007-12-06. PMID:17905311. |
acetylcholinesterase (ache), a principal modulator of cholinergic neurotransmission, also has been demonstrated to be involved in the morphogenetic processes of neuronal and non-neuronal tissues. |
2007-12-06 |
2023-08-12 |
mouse |
| Irene Simintzi, Kleopatra H Schulpis, Panagoula Angelogianni, Charis Liapi, Stylianos Tsakiri. The effect of aspartame on acetylcholinesterase activity in hippocampal homogenates of suckling rats. Pharmacological research. vol 56. issue 2. 2007-11-01. PMID:17580119. |
neurological disturbances have been implicated with aspartame (asp) consumption and the cholinergic system with acetylcholinesterase (ache) seems actively involved. |
2007-11-01 |
2023-08-12 |
rat |
| Marcia D Howard, Nikita Mirajkar, Subramanya Karanth, Carey N Pop. Comparative effects of oral chlorpyrifos exposure on cholinesterase activity and muscarinic receptor binding in neonatal and adult rat heart. Toxicology. vol 238. issue 2-3. 2007-10-31. PMID:17644233. |
organophosphorus (op) pesticides elicit acute toxicity by inhibiting acetylcholinesterase (ache), the enzyme responsible for inactivating acetylcholine (ach) at cholinergic synapses. |
2007-10-31 |
2023-08-12 |
rat |