| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Runa S Naik, Joachim Hartmann, Cornelia Kiewert, Ellen G Duysen, Oksana Lockridge, Jochen Klei. Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. vol 12. issue 1. 2009-09-25. PMID:19470293. |
alzheimer s disease is characterized by a dysfunction of central cholinergic systems and is treated by inhibitors of acetylcholinesterase (ache). |
2009-09-25 |
2023-08-12 |
mouse |
| Theodore A Slotkin, Ian T Ryde, Nicola Wrench, Jennifer A Card, Frederic J Seidle. Nonenzymatic role of acetylcholinesterase in neuritic sprouting: regional changes in acetylcholinesterase and choline acetyltransferase after neonatal 6-hydroxydopamine lesions. Neurotoxicology and teratology. vol 31. issue 3. 2009-09-16. PMID:19452616. |
these results support the view that ache is involved in neurite formation, unrelated to its enzymatic role in cholinergic neurotransmission. |
2009-09-16 |
2023-08-12 |
rat |
| Sangu Muthuraju, Panchanan Maiti, Preeti Solanki, Alpesh Kumar Sharma, Amitabh, Shashi Bala Singh, Dipti Prasad, Govindasamy Ilavazhaga. Acetylcholinesterase inhibitors enhance cognitive functions in rats following hypobaric hypoxia. Behavioural brain research. vol 203. issue 1. 2009-08-31. PMID:19446892. |
cholinergic markers like acetylcholine (ach) and acetylcholinesterase (ache) were evaluated in hippocampus and cortex of rats. |
2009-08-31 |
2023-08-12 |
rat |
| Sangu Muthuraju, Panchanan Maiti, Preeti Solanki, Alpesh Kumar Sharma, Amitabh, Shashi Bala Singh, Dipti Prasad, Govindasamy Ilavazhaga. Acetylcholinesterase inhibitors enhance cognitive functions in rats following hypobaric hypoxia. Behavioural brain research. vol 203. issue 1. 2009-08-31. PMID:19446892. |
the acheis were able to improve the cholinergic activity by restoring the level of ach by blocking the ache activity. |
2009-08-31 |
2023-08-12 |
rat |
| Milan Jokanović, Milica Prostra. Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds. Current medicinal chemistry. vol 16. issue 17. 2009-08-03. PMID:19519385. |
ache inhibition results in the accumulation of acetylcholine at cholinergic receptor sites, producing continuous stimulation of cholinergic fibers throughout the central and peripheral nervous systems. |
2009-08-03 |
2023-08-12 |
human |
| Roberta Schmatz, Cinthia Melazzo Mazzanti, Roselia Spanevello, Naiara Stefanello, Jessié Gutierres, Maisa Corrêa, Michelle Melgarejo da Rosa, Maribel A Rubin, Maria Rosa Chitolina Schetinger, Vera Maria Morsc. Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. European journal of pharmacology. vol 610. issue 1-3. 2009-07-29. PMID:19303406. |
in conclusion, the present findings showed that treatment with resveratrol prevents the increase in ache activity and consequently memory impairment in diabetic rats, demonstrating that this compound can modulate cholinergic neurotransmission and consequently improve cognition. |
2009-07-29 |
2023-08-12 |
rat |
| Monika Sadanand. Acetylcholinesterase in central vocal control nuclei of the zebra finch (Taeniopygia guttata). Journal of biosciences. vol 29. issue 2. 2009-06-24. PMID:15286416. |
ache presence in the vocal control system suggests innervation by either afferent projecting cholinergic systems and/or local circuit cholinergic neurons. |
2009-06-24 |
2023-08-12 |
Not clear |
| Anne-Marie O'Donnell, Prem Pur. Cholinergic innervation in the developing chick cloaca and colorectum. Journal of pediatric surgery. vol 44. issue 2. 2009-06-09. PMID:19231541. |
the ache histochemistry can therefore be used to label acetylcholine-positive nerve cells and fibres, giving an overview of cholinergic innervation in the gut. |
2009-06-09 |
2023-08-12 |
human |
| M L Bolognesi, M Rosini, V Andrisano, M Bartolini, A Minarini, V Tumiatti, C Melchiorr. MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond. Current pharmaceutical design. vol 15. issue 6. 2009-05-12. PMID:19199985. |
our first rationally designed mtdl was the polyamine caproctamine (1), which provided a synergistic cholinergic action against ad by antagonizing muscarinic m(2) autoreceptors and inhibiting acetylcholinesterase (ache). |
2009-05-12 |
2023-08-12 |
Not clear |
| Kazufumi Hirano, Thomas M Piers, Kirsten L Searle, Neil D Miller, A Richard Rutter, Paul F Chapma. Procognitive 5-HT6 antagonists in the rat forced swimming test: potential therapeutic utility in mood disorders associated with Alzheimer's disease. Life sciences. vol 84. issue 15-16. 2009-05-01. PMID:19302808. |
brain microdialysis studies demonstrated that 5-ht(6) antagonists enhance not only cholinergic but also monoaminergic neurotransmission, a property that may differentiate from acetylcholine esterase (ache) inhibitors such as donepezil. |
2009-05-01 |
2023-08-12 |
rat |
| B P Paudya. Organophosphorus poisoning. JNMA; journal of the Nepal Medical Association. vol 47. issue 172. 2009-04-14. PMID:19079407. |
the toxicity of these op pesticides is due to the irreversible inhibition of acetylcholinesterase (ache) enzyme leading to accumulation of acetylcholine and subsequent over-activation of cholinergic receptors in various parts of the body. |
2009-04-14 |
2023-08-12 |
Not clear |
| Cinthia M Mazzanti, Roselia Spanevello, Musthaq Ahmed, Luciane B Pereira, Jamile F Gonçalves, Maisa Corrêa, Roberta Schmatz, Naiara Stefanello, Daniela B R Leal, Alexandre Mazzanti, Adriano T Ramos, Tessie B Martins, Cristiane Cademartori Danesi, Dominguita L Graça, Vera M Morsch, Maria Rosa C Schetinge. Pre-treatment with ebselen and vitamin E modulate acetylcholinesterase activity: interaction with demyelinating agents. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 27. issue 1. 2009-04-09. PMID:18930802. |
in conclusion, this study demonstrated that ebs and vit e interfere with the cholinergic neurotransmission by altering ache activity in the different brain regions and in the erythrocytes. |
2009-04-09 |
2023-08-12 |
rat |
| Ethika Tyagi, Rahul Agrawal, Chandishwar Nath, Rakesh Shukl. Influence of LPS-induced neuroinflammation on acetylcholinesterase activity in rat brain. Journal of neuroimmunology. vol 205. issue 1-2. 2009-03-19. PMID:18838174. |
proinflammatory cytokines (tnf-alpha and il-1beta), acetylcholinesterase (ache) activity, malondialdehyde (mda) and reduced glutathione (gsh) were studied as markers for neuroinflammation, cholinergic activity and oxidative stress respectively in different brain regions at different time points after lps injection. |
2009-03-19 |
2023-08-12 |
rat |
| Ethika Tyagi, Rahul Agrawal, Chandishwar Nath, Rakesh Shukl. Influence of LPS-induced neuroinflammation on acetylcholinesterase activity in rat brain. Journal of neuroimmunology. vol 205. issue 1-2. 2009-03-19. PMID:18838174. |
enhanced ache activity with these inflammatory markers after lps administration indicates a possible relationship between neuroinflammation and cholinergic system during the development of neurodegenerative diseases. |
2009-03-19 |
2023-08-12 |
rat |
| R Jazi, R Lalonde, S Qian, C Straziell. Regional brain evaluation of acetylcholinesterase activity in PS1/A246E transgenic mice. Neuroscience research. vol 63. issue 2. 2009-03-17. PMID:19056437. |
forebrain cholinergic innervation was estimated in transgenic mice with the a246e mutation by measuring the activity of the non-specific catabolic enzyme, acetylcholinesterase (ache). |
2009-03-17 |
2023-08-12 |
mouse |
| R Jazi, R Lalonde, S Qian, C Straziell. Regional brain evaluation of acetylcholinesterase activity in PS1/A246E transgenic mice. Neuroscience research. vol 63. issue 2. 2009-03-17. PMID:19056437. |
in particular, ache activity was upregulated in major cholinergic cell nuclei (medial septum, vertical diagonal band, substantia inominata) and in cortical and thalamic regions (eye field, posterior parietal and visual cortices, posterior thalamic and lateral geniculate nuclei) responsible for selective attention and visuomotor coordination, as well as limbic structures (hippocampal formation and amygdala) with related regions (midline, periventricular, reticular thalamic nuclei, and lateral prefrontal, agranular insular cortices) involved in cognition, arousal, emotion, and plasticity. |
2009-03-17 |
2023-08-12 |
mouse |
| Charis Liapi, Argyro Kyriakaki, Apostolos Zarros, Hussam Al-Humadi, Vasileios Stolakis, Elena Gkrouzman, Foteini Anifantaki, Nikolina Skandali, Marios Margaritis, Stylianos Tsakiri. Effects of adult-onset choline deprivation on the activities of acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase in crucial rat brain regions. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 47. issue 1. 2009-03-16. PMID:18992298. |
the observed differentially affected activities of ache, (na+,k+)-atpase and mg2+-atpase (induced by cd) could result in modulations of cholinergic neurotransmission, neural excitability, metabolic energy production, mg2+ homeostasis and protein synthesis (that might have a variety of neurophysiological consequences depending on the brain region in which they seem to occur). |
2009-03-16 |
2023-08-12 |
rat |
| Kangsik Jung, Bomi Lee, Sang Jun Han, Jong Hoon Ryu, Dong-Hyun Ki. Mangiferin ameliorates scopolamine-induced learning deficits in mice. Biological & pharmaceutical bulletin. vol 32. issue 2. 2009-03-12. PMID:19182383. |
these results suggest that mangiferin can improve long-term cholinergic memory deficits by ache inhibition or cholinergic receptor stimulation and inhibition of nf-kappab activation. |
2009-03-12 |
2023-08-12 |
mouse |
| F Nardi, B Barazzuoli, S Ciolfi, A Carapelli, R Dallai, F Frat. Acetylcholinesterase genes in the basal Hexapod Orchesella villosa. Insect molecular biology. vol 18. issue 1. 2009-03-04. PMID:19016914. |
acetylcholinesterase (ache) is a key enzyme of the cholinergic nerve system. |
2009-03-04 |
2023-08-12 |
Not clear |
| Emma M Jarvie, Selim Cellek, Gareth J Sange. Potentiation by cholinesterase inhibitors of cholinergic activity in rat isolated stomach and colon. Pharmacological research. vol 58. issue 5-6. 2009-02-20. PMID:18824231. |
these data indicate that the abilities of different ache inhibitors to increase gi cholinergic activity differ markedly. |
2009-02-20 |
2023-08-12 |
rat |