| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roberta Schmatz, Cinthia Melazzo Mazzanti, Roselia Spanevello, Naiara Stefanello, Jessié Gutierres, Paula Acosta Maldonado, Maisa Corrêa, Cíntia Saydelles da Rosa, Lara Becker, Margarete Bagatini, Jamile Fabbrin Gonçalves, Jeandre Dos Santos Jaques, Maria Rosa Schetinger, Vera Maria Morsc. Ectonucleotidase and acetylcholinesterase activities in synaptosomes from the cerebral cortex of streptozotocin-induced diabetic rats and treated with resveratrol. Brain research bulletin. vol 80. issue 6. 2010-01-20. PMID:19723569. |
in conclusion, this study demonstrated that the resveratrol interfere with the purinergic and cholinergic neurotransmission by altering ntpdase, 5'-nucleotidase and ache activities in cerebral cortex synaptosomes of diabetic rats. |
2010-01-20 |
2023-08-12 |
rat |
| Bárbara Aisa, Francisco Javier Gil-Bea, Beatriz Marcos, Rosa Tordera, Berta Lasheras, Joaquín Del Río, Maria J Ramíre. Neonatal stress affects vulnerability of cholinergic neurons and cognition in the rat: involvement of the HPA axis. Psychoneuroendocrinology. vol 34. issue 10. 2010-01-12. PMID:19505767. |
ms rats subjected to a cholinergic lesion by administration of the immunotoxin 192 igg-saporin, showed significant decreases in both choline acetyltransferase (chat) and acetylcholinesterase (ache) activity compared to control lesioned rats. |
2010-01-12 |
2023-08-12 |
rat |
| Julie Espallergues, Laurie Galvan, Florence Sabatier, Vanessa Rana-Poussine, Tangui Maurice, Arnaud Chatonne. Behavioral phenotyping of heterozygous acetylcholinesterase knockout (AChE+/-) mice showed no memory enhancement but hyposensitivity to amnesic drugs. Behavioural brain research. vol 206. issue 2. 2010-01-06. PMID:19766675. |
decrease in the expression or activity of acetylcholinesterase (ache) enzymatic activity results in increased cholinergic tonus in the brain and periphery, with concomitant regulations of nicotinic and muscarinic receptors expression. |
2010-01-06 |
2023-08-12 |
mouse |
| M Banni, Z Bouraoui, C Clerandeau, J F Narbonne, H Boussett. Mixture toxicity assessment of cadmium and benzo[a]pyrene in the sea worm Hediste diversicolor. Chemosphere. vol 77. issue 7. 2009-12-21. PMID:19758679. |
the cholinergic system was evaluated using the acetylcholinesterase activity (ache). |
2009-12-21 |
2023-08-12 |
Not clear |
| Mireille Basselin, Henry N Nguyen, Lisa Chang, Jane M Bell, Stanley I Rapopor. Acute but not chronic donepezil increases muscarinic receptor-mediated signaling via arachidonic acid in unanesthetized rats. Journal of Alzheimer's disease : JAD. vol 17. issue 2. 2009-12-16. PMID:19363262. |
donepezil, an acetylcholinesterase (ache) inhibitor used for treating alzheimer's disease patients, is thought to act by increasing brain extracellular acetylcholine (ach), and ach binding to cholinergic receptors. |
2009-12-16 |
2023-08-12 |
rat |
| Mostofa Jamal, Kiyoshi Ameno, Takanori Miki, Weihuan Wang, Mitsuru Kumihashi, Toyohi Isse, Toshihiro Kawamoto, Kyoko Kitagawa, Keiichi Nakayama, Iwao Ijiri, Hiroshi Kinoshit. Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficient mice models. Brain research. vol 1295. 2009-12-16. PMID:19664611. |
wild-type (wt) mice exhibited a remarkable decrease in chat and ache mrna expression at both time points only after 4-g/kg etoh treatment compared with the naive control, whereas ko mice showed a considerable reduction in cholinergic markers after 2- and 4-g/kg etoh treatment. |
2009-12-16 |
2023-08-12 |
mouse |
| Anne Dick, Rodney For. Cholinergic and oxidative stress mechanisms in sudden infant death syndrome. Acta paediatrica (Oslo, Norway : 1992). vol 98. issue 11. 2009-12-11. PMID:19706020. |
to determine whether biochemical parameters of cholinergic and oxidative stress function including red cell acetylcholinesterase (ache), serum/plasma thyroglobulin, selenium, iron, ferritin, vitamins c, e, and a affect risk in apparent life-threatening event (alte), sudden infant death syndrome (sids), and sudden unexpected death in infancy (sudi). |
2009-12-11 |
2023-08-12 |
Not clear |
| Muniswamy David, Vineetkumar K Patil, Sameer G Chebbi, Shambangouda R Marigoudar, Jagadeesh B Chittaragi, Ramesh Halapp. Gas-liquid chromatography for fenvalerate residue analysis: in vivo alterations in the acetylcholinesterase activity and acetylcholine in different tissues of the fish, Labeo rohita (Hamilton). Toxicology mechanisms and methods. vol 19. issue 6-7. 2009-12-04. PMID:19778241. |
l. rohita on exposure to lethal (6 microg/l) and sub-lethal (0.75 microg/l) concentrations of fenvalerate showed time- and dose-dependent inhibition in the activity of ache, suggesting a decrease in the cholinergic transmission and consequent accumulation of acetylcholine (ach) in the tissues (brain, gill, liver, and muscle) leading to continuous nerve impulses, causing prolonged muscle contraction which, as a consequence, causes paralysis and results in death. |
2009-12-04 |
2023-08-12 |
Not clear |
| Rashmi Jha, Syed Ibrahim Rizv. Age-dependent decline in erythrocyte acetylcholinesterase activity: correlation with oxidative stress. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. vol 153. issue 3. 2009-11-24. PMID:19851431. |
ache activity in erythrocytes may be considered as a marker of central cholinergic status. |
2009-11-24 |
2023-08-12 |
human |
| Yong Wang, Xin Ge, Xiao Fang Xu, Xiao Jing Wan. Acetylcholinesterase inhibitor is a potentially useful therapeutic agent for nicotine-induced periodontal disease. Medical hypotheses. vol 73. issue 4. 2009-11-16. PMID:19625132. |
we hypothesize that there is a non-neuronal cholinergic system in periodontal tissue that is activated by excess nicotine, which increases expression of ache, thus increasing apoptosis of periodontal cells. |
2009-11-16 |
2023-08-12 |
Not clear |
| L R Vieira, C Gravato, A M V M Soares, F Morgado, L Guilhermin. Acute effects of copper and mercury on the estuarine fish Pomatoschistus microps: linking biomarkers to behaviour. Chemosphere. vol 76. issue 10. 2009-11-03. PMID:19628251. |
furthermore, significant and positive correlations were found between some biomarkers (ache and erod) and behavioural parameters, while negative correlations were found for others (lpo, anti-oxidant enzymes and ldh) suggesting that disruption of cholinergic function through ache inhibition, decreased detoxification capability due to erod inhibition, additional energetic demands to face chemical stress, and oxidative stress and damage may contribute to decrease the swimming performance of fish. |
2009-11-03 |
2023-08-12 |
cat |
| H R Girisha, J N Narendra Sharath Chandra, Sriramamurthy Boppana, Manish Malviya, C T Sadashiva, Kanchugarakoppal S Rangapp. Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase. European journal of medicinal chemistry. vol 44. issue 10. 2009-10-14. PMID:19493592. |
hypocholinergic function associated with alzheimer's disease (ad) is well-accepted hypothesis, in this regard, many research attempts have been made to elevate the reduced cholinergic neurotransmission, among them two main treatment strategies were widely explored, namely stimulation of muscarinic receptor 1 and/or reversible inhibition of acetylcholinesterase (ache) enzyme. |
2009-10-14 |
2023-08-12 |
rat |
| Ramanna V Rajesh, Loganathan Chitra, Paul G Layer, Rathanam Boopath. The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain. Biochimie. vol 91. issue 9. 2009-10-14. PMID:19607873. |
the appearance of cholinergic trait often precedes synaptogenesis, indicating the involvement of cholinesterase proteins in nervous system development, particularly so acetylcholinesterase (ache). |
2009-10-14 |
2023-08-12 |
chicken |
| Ramanna V Rajesh, Loganathan Chitra, Paul G Layer, Rathanam Boopath. The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain. Biochimie. vol 91. issue 9. 2009-10-14. PMID:19607873. |
in addition to ache's acclaimed esterase activity, its lesser known non-cholinergic functions have gained much attention, because of ache protein expression in areas other than cholinergic innervations; one such function could be exerted by its associated aryl acylamidase (aaa) activity. |
2009-10-14 |
2023-08-12 |
chicken |
| Yuanxin Chen, Victor V Dyakin, Craig A Branch, Babak Ardekani, Dunsheng Yang, David N Guilfoyle, Jesse Peterson, Corrinne Peterhoff, Stephen D Ginsberg, Anne M Cataldo, Ralph A Nixo. In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model. Neurobiology of aging. vol 30. issue 9. 2009-10-09. PMID:18180075. |
basal forebrain cholinergic neurons (bfcns) in the msn, identified by choline acetyltransferase (chat) and nerve growth factor receptors p75(ntr) and trka immunolabeling were reduced in ts65dn brains and in situ acetylcholinesterase (ache) activity was depleted distally along projecting cholinergic fibers, and selectively on pre- and postsynaptic profiles in these target areas. |
2009-10-09 |
2023-08-12 |
mouse |
| b' Milan Jokanovi\\xc4\\x8. Medical treatment of acute poisoning with organophosphorus and carbamate pesticides. Toxicology letters. vol 190. issue 2. 2009-09-28. PMID:19651196.' |
ache inhibition results in the accumulation of acetylcholine at cholinergic receptor sites, producing continuous stimulation of cholinergic fibers throughout the nervous systems. |
2009-09-28 |
2023-08-12 |
human |
| Runa S Naik, Joachim Hartmann, Cornelia Kiewert, Ellen G Duysen, Oksana Lockridge, Jochen Klei. Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. vol 12. issue 1. 2009-09-25. PMID:19470293. |
alzheimer s disease is characterized by a dysfunction of central cholinergic systems and is treated by inhibitors of acetylcholinesterase (ache). |
2009-09-25 |
2023-08-12 |
mouse |
| Theodore A Slotkin, Ian T Ryde, Nicola Wrench, Jennifer A Card, Frederic J Seidle. Nonenzymatic role of acetylcholinesterase in neuritic sprouting: regional changes in acetylcholinesterase and choline acetyltransferase after neonatal 6-hydroxydopamine lesions. Neurotoxicology and teratology. vol 31. issue 3. 2009-09-16. PMID:19452616. |
these results support the view that ache is involved in neurite formation, unrelated to its enzymatic role in cholinergic neurotransmission. |
2009-09-16 |
2023-08-12 |
rat |
| Sangu Muthuraju, Panchanan Maiti, Preeti Solanki, Alpesh Kumar Sharma, Amitabh, Shashi Bala Singh, Dipti Prasad, Govindasamy Ilavazhaga. Acetylcholinesterase inhibitors enhance cognitive functions in rats following hypobaric hypoxia. Behavioural brain research. vol 203. issue 1. 2009-08-31. PMID:19446892. |
cholinergic markers like acetylcholine (ach) and acetylcholinesterase (ache) were evaluated in hippocampus and cortex of rats. |
2009-08-31 |
2023-08-12 |
rat |
| Sangu Muthuraju, Panchanan Maiti, Preeti Solanki, Alpesh Kumar Sharma, Amitabh, Shashi Bala Singh, Dipti Prasad, Govindasamy Ilavazhaga. Acetylcholinesterase inhibitors enhance cognitive functions in rats following hypobaric hypoxia. Behavioural brain research. vol 203. issue 1. 2009-08-31. PMID:19446892. |
the acheis were able to improve the cholinergic activity by restoring the level of ach by blocking the ache activity. |
2009-08-31 |
2023-08-12 |
rat |