| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I V Coutinho-Abreu, V Q Balbino, J G Valenzuela, I V Sonoda, J M Ramalho-Ortigã. Structural characterization of acetylcholinesterase 1 from the sand fly Lutzomyia longipalpis (Diptera: Psychodidae). Journal of medical entomology. vol 44. issue 4. 2007-10-19. PMID:17695019. |
acetylcholinesterase (ache) plays a key role in cholinergic impulse transmission, and it is the target enzyme for organophosphorus and carbamate insecticides. |
2007-10-19 |
2023-08-12 |
Not clear |
| G A López-Crespo, F Carvajal, P Flores, F Sánchez-Santed, M C Sánchez-Amat. Time course of biochemical and behavioural effects of a single high dose of chlorpyrifos. Neurotoxicology. vol 28. issue 3. 2007-10-18. PMID:17350100. |
this effect is independent of the percentage of ache inhibition and therefore, of change in the cholinergic system. |
2007-10-18 |
2023-08-12 |
rat |
| Fu Ai Ling, Dong Zhao Hui, Sun Man J. Protective effect of recombinant human somatotropin on amyloid beta-peptide induced learning and memory deficits in mice. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 17. issue 4. 2007-10-18. PMID:17596983. |
toxic effects of free radicals, damages of cholinergic neurons, and increased lipid peroxidation appeared in the cerebra of abeta-treated mice, manifesting an increase of malondialdehyde (mda) and decline of glutathione (gsh) level, an increment of choline acetyltransferase (chat) and acetylcholinesterase (ache) activities, and a reduction of the acetylcholine (ach) level. |
2007-10-18 |
2023-08-12 |
mouse |
| Isabel Martinez-Pena y Valenzuela, Mohammed Akaaboun. Acetylcholinesterase mobility and stability at the neuromuscular junction of living mice. Molecular biology of the cell. vol 18. issue 8. 2007-10-17. PMID:17538015. |
acetylcholinesterase (ache) is an enzyme that terminates acetylcholine neurotransmitter function at the synaptic cleft of cholinergic synapses. |
2007-10-17 |
2023-08-12 |
mouse |
| Jin Kyung Oh, Yoon-Sang Kim, Hyun-Jung Park, Eun-Mee Lim, Kwang-Ho Pyun, Insop Shi. Antidepressant effects of Soyo-san on Immobilization stress in ovariectomized female rats. Biological & pharmaceutical bulletin. vol 30. issue 8. 2007-09-21. PMID:17666797. |
we assessed the changes in the reactivity of the cholinergic system by measuring the immunoreactive neurons of choline acetyltransferase (chat) and reactivity of acetylcholinesterase (ache) in the hippocampus, and the serum levels of corticosterone were assessed after behavioral testing. |
2007-09-21 |
2023-08-12 |
rat |
| Carlos H T P da Silva, Ivone Carvalho, C A Taf. Virtual screening, molecular interaction field, molecular dynamics, docking, density functional, and ADMET properties of novel AChE inhibitors in Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 24. issue 6. 2007-09-18. PMID:17508773. |
many drugs currently used for the treatment of the ad are based on the improvement of cholinergic neurotransmission achieved by acetylcholinesterase (ache) inhibition, the enzyme responsible for acetylcholine hydrolysis. |
2007-09-18 |
2023-08-12 |
Not clear |
| b' Zbyn\\xc4\\x95k Svoboda, Jaroslav Kv\\xc4\\x95tina, Josef Herink, Jir\\xc3\\xad Bajgar, Lucie Bartosov\\xc3\\xa1, Vladim\\xc3\\xadr Palicka, Pavel Zivn\\xc3\\xb. Galantamine antiacetylcholinesterase activity in rat brain influenced by L-carnitine. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. vol 149. issue 2. 2007-08-28. PMID:16601783.' |
galantamine (gal) is a selective, competitive and reversible acetylcholinesterase (ache) inhibitor, which increases the activity of the cholinergic system and hence gives rise to an improvement of cognitive functions in patients suffering from dementia of alzheimer type. |
2007-08-28 |
2023-08-12 |
rat |
| Kamil Kuca, Jirí Cabal, Daniel Jun, Jirí Kassa, Lucie Bartosová, Gabriela Kunesová, Vlastimil Dohna. Strategy for the development of new acetylcholinesterase reactivators - antidotes used for treatment of nerve agent poisonings. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. vol 149. issue 2. 2007-08-28. PMID:16601804. |
the mechanism of intoxication with organophosphorus compounds, including highly toxic nerve agents, is based on the formation of irreversibly inhibited acetylcholinesterase (ache; ec 3.1.1.7) that could be followed by a generalized cholinergic crisis. |
2007-08-28 |
2023-08-12 |
Not clear |
| Md Badiul Bhuiyan, Ferid Murad, Michael E Fan. The placental cholinergic system: localization to the cytotrophoblast and modulation of nitric oxide. Cell communication and signaling : CCS. vol 4. 2007-08-01. PMID:16686954. |
the human placenta, a non-neuronal tissue, contains an active cholinergic system comprised of acetylcholine (ach), choline acetyltransferase (chat), acetylcholinesterase (ache), and high affinity muscarinic receptors. |
2007-08-01 |
2023-08-12 |
human |
| Adi Gilboa-Geffen, Paul P Lacoste, Lilach Soreq, Geraldine Cizeron-Clairac, Rozen Le Panse, Frederique Truffault, Iftach Shaked, Hermona Soreq, Sonia Berrih-Akni. The thymic theme of acetylcholinesterase splice variants in myasthenia gravis. Blood. vol 109. issue 10. 2007-07-12. PMID:17272501. |
cholinergic signaling and acetylcholinesterase (ache) influence immune response and inflammation. |
2007-07-12 |
2023-08-12 |
mouse |
| Chi-Rei Wu, Chia-Lin Chang, Ping-Ying Hsieh, Li-Wei Lin, Hui Chin. Psoralen and isopsoralen, two coumarins of Psoraleae Fructus, can alleviate scopolamine-induced amnesia in rats. Planta medica. vol 73. issue 3. 2007-06-20. PMID:17318785. |
the results suggest that psoralen and isopsoralen are the major active ingredients of psoraleae fructus responsible for the progressive reversal of scopolamine-induced amnesia, whose effects are partially associated with inhibition of ache activity and hence activation of the central cholinergic neuronal system. |
2007-06-20 |
2023-08-12 |
rat |
| M H Bazalakova, R D Blakel. The high-affinity choline transporter: a critical protein for sustaining cholinergic signaling as revealed in studies of genetically altered mice. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722248. |
studies in various mouse models of cholinergic dysfunction, including acetylcholinesterase (ache) transgenic and knockout mice, choline acetyltransferase (chat) heterozygote mice, muscarinic (machr) and nicotinic (machr) receptor knockout mice, as well as cht knockout and heterozygote mice, have revealed new information about the role of cht expression and regulation in response to long-term alterations in cholinergic neurotransmission. |
2007-05-23 |
2023-08-12 |
mouse |
| Sultan Darvesh, Ryan Walsh, Earl Marti. Homocysteine thiolactone and human cholinesterases. Cellular and molecular neurobiology. vol 27. issue 1. 2007-05-22. PMID:16955366. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) are serine hydrolase enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine, a key process in the regulation of the cholinergic system. |
2007-05-22 |
2023-08-12 |
human |
| Peter Melzer, Laura Mineo, Ford F Ebne. Optic nerve transection affects development and use-dependent plasticity in neocortex of the rat: Quantitative acetylcholinesterase imaging. Brain research. vol 1139. 2007-05-08. PMID:17280650. |
the laminar distribution of the ache reaction product suggests that the observed changes in ache activity were mainly related to cholinergic basal forebrain afferents. |
2007-05-08 |
2023-08-12 |
rat |
| M Dumont, R Lalonde, J-F Ghersi-Egea, K Fukuchi, C Straziell. Regional acetylcholinesterase activity and its correlation with behavioral performances in 15-month old transgenic mice expressing the human C99 fragment of APP. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 9. 2007-05-02. PMID:16362638. |
in the present investigation, the cholinergic innervation in forebrain regions of transgenic mice (tg13592) expressing the human betaapp c99 fragment was compared to that of non-transgenic controls by measuring the activity of the non-specific catabolic enzyme, acetylcholinesterase (ache). |
2007-05-02 |
2023-08-12 |
mouse |
| M Dumont, R Lalonde, J-F Ghersi-Egea, K Fukuchi, C Straziell. Regional acetylcholinesterase activity and its correlation with behavioral performances in 15-month old transgenic mice expressing the human C99 fragment of APP. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 9. 2007-05-02. PMID:16362638. |
in particular, ache activity was upregulated in three basal forebrain regions containing cholinergic cell bodies, prelimbic cortex, anterior subiculum, and paraventricular thalamus, but downregulated in lateral septum and reticular thalamus. |
2007-05-02 |
2023-08-12 |
mouse |
| Ruth R Jameson, Frederic J Seidler, Theodore A Slotki. Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon. Environmental health perspectives. vol 115. issue 1. 2007-05-02. PMID:17366821. |
organophosphate pesticides affect mammalian brain development through mechanisms separable from the inhibition of acetylcholinesterase (ache) enzymatic activity and resultant cholinergic hyperstimulation. |
2007-05-02 |
2023-08-12 |
Not clear |
| Minjeong Sun, C Justin Lee, Hee-Sup Shi. Reduced nicotinic receptor function in sympathetic ganglia is responsible for the hypothermia in the acetylcholinesterase knockout mouse. The Journal of physiology. vol 578. issue Pt 3. 2007-04-26. PMID:17038428. |
paradoxically, acetylcholinesterase (ache) inhibitors, which should enhance cholinergic signalling, induce hypothermia. |
2007-04-26 |
2023-08-12 |
mouse |
| Minjeong Sun, C Justin Lee, Hee-Sup Shi. Reduced nicotinic receptor function in sympathetic ganglia is responsible for the hypothermia in the acetylcholinesterase knockout mouse. The Journal of physiology. vol 578. issue Pt 3. 2007-04-26. PMID:17038428. |
to understand the mechanism of how cholinergic signalling in the sg controls thermoregulation, we analysed infant ache knockout mice, which are known to show hypothermia by postnatal day 15. |
2007-04-26 |
2023-08-12 |
mouse |
| Timothy C Marrs, Paul Rice, J Allister Val. The role of oximes in the treatment of nerve agent poisoning in civilian casualties. Toxicological reviews. vol 25. issue 4. 2007-04-17. PMID:17288500. |
nerve agents phosphonylate a serine hydroxyl group in the active site of the enzyme, acetylcholinesterase (ache), which results in accumulation of acetylcholine and, in turn, causes enhancement and prolongation of cholinergic effects and depolarisation blockade. |
2007-04-17 |
2023-08-12 |
Not clear |