| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L R Vieira, A Sousa, M F Frasco, I Lima, F Morgado, L Guilhermin. Acute effects of Benzo[a]pyrene, anthracene and a fuel oil on biomarkers of the common goby Pomatoschistus microps (Teleostei, Gobiidae). The Science of the total environment. vol 395. issue 2-3. 2008-06-09. PMID:18346779. |
all the substances inhibited p. microps acetylcholinesterase (ache) indicating that they have at least one mechanism of neurotoxicity in common: the disruption of cholinergic transmission by inhibition of ache. |
2008-06-09 |
2023-08-12 |
Not clear |
| Luis M Carcoba, Miguel Santiago, Donald E Moss, Rafael Cabez. In utero methanesulfonyl fluoride differentially affects learning and maze performance in the absence of long-lasting cholinergic changes in the adult rat. Pharmacology, biochemistry, and behavior. vol 88. issue 4. 2008-05-08. PMID:17920111. |
therefore, methanesulfonyl fluoride (msf), an irreversible ache inhibitor that shows high selectivity for the cns was used to produce ache inhibition in utero to study subsequent adult behaviors, sleep, and cholinergic markers. |
2008-05-08 |
2023-08-12 |
rat |
| Anna Rostedt Punga, Mikio Sawada, Erik V Stålber. Electrophysiological signs and the prevalence of adverse effects of acetylcholinesterase inhibitors in patients with myasthenia gravis. Muscle & nerve. vol 37. issue 3. 2008-05-02. PMID:18069667. |
fourteen patients (64%) experienced daily cholinergic adverse effects, and muscarinic side effects correlated with ache activity. |
2008-05-02 |
2023-08-12 |
Not clear |
| Dongren Yang, Angela Howard, Donald Bruun, Mispa Ajua-Alemanj, Cecile Pickart, Pamela J Lei. Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase. Toxicology and applied pharmacology. vol 228. issue 1. 2008-04-28. PMID:18076960. |
a primary role of acetylcholinesterase (ache) is regulation of cholinergic neurotransmission by hydrolysis of synaptic acetylcholine. |
2008-04-28 |
2023-08-12 |
mouse |
| J E Cohen, G Zimmerman, N Melamed-Book, A Friedman, A Dori, H Sore. Transgenic inactivation of acetylcholinesterase impairs homeostasis in mouse hippocampal granule cells. Hippocampus. vol 18. issue 2. 2008-03-03. PMID:17960645. |
because cholinergic neurotransmission influences both of these functions, we hypothesized that cholinergic signaling, affected by acetylcholinesterase (ache) activity, expression level, and alternative splicing, may provide a link between these processes. |
2008-03-03 |
2023-08-12 |
mouse |
| Alexandra A Anderson, Dmitry S Ushakov, Michael A Ferenczi, Ryoichi Mori, Paul Martin, Jane L Saffel. Morphoregulation by acetylcholinesterase in fibroblasts and astrocytes. Journal of cellular physiology. vol 215. issue 1. 2008-02-19. PMID:17948252. |
acetylcholinesterase (ache) terminates neurotransmission at cholinergic synapses by hydrolysing acetylcholine, but also has non-enzymatic morphoregulatory effects on neurons such as stimulation of neurite outgrowth. |
2008-02-19 |
2023-08-12 |
mouse |
| Luis Marco, Maria do Carmo Carreira. Galanthamine, a natural product for the treatment of Alzheimer's disease. Recent patents on CNS drug discovery. vol 1. issue 1. 2008-02-15. PMID:18221196. |
galanthamine is a long-acting, selective, reversible and competitive ache inhibitor that has recently been tested in ad patients and found to be readily absorbed, to be a performance enhancer on memory tests in some patients, and to be well tolerated, although some cholinergic side effects were observed. |
2008-02-15 |
2023-08-12 |
Not clear |
| J Bajgar, K Kuca, D Jun, L Bartosova, J Fuse. Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents. Current drug metabolism. vol 8. issue 8. 2008-02-04. PMID:18220560. |
understanding the mechanism of action of organophosphates (op)/nerve agents -- irreversible acetylcholinesterase (ache, ec 3.1.1.7) inhibition at the cholinergic synapses followed by metabolic dysbalance of the organism -- two therapeutic principles for antidotal treatment are derived. |
2008-02-04 |
2023-08-12 |
Not clear |
| J Bajgar, K Kuca, D Jun, L Bartosova, J Fuse. Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents. Current drug metabolism. vol 8. issue 8. 2008-02-04. PMID:18220560. |
the main drugs are anticholinergics that antagonize the effects of accumulated acetylcholine at the cholinergic synapses and cholinesterase reactivators (oximes) reactivating inhibited ache. |
2008-02-04 |
2023-08-12 |
Not clear |
| I Swapna, K V SathyaSaikumar, Ch R K Murthy, A Dutta Gupta, B Senthilkumara. Alterations in kinetic and thermotropic properties of cerebral membrane-bound acetylcholineesterase during thioacetamide-induced hepatic encephalopathy: correlation with membrane lipid changes. Brain research. vol 1153. 2008-01-09. PMID:17482580. |
acetylcholinesterase (ache) is an important peripheral membrane-bound enzyme, crucial for cholinergic neurotransmission. |
2008-01-09 |
2023-08-12 |
rat |
| Ethika Tyagi, Rahul Agrawal, Chandishwar Nath, Rakesh Shukl. Effect of anti-dementia drugs on LPS induced neuroinflammation in mice. Life sciences. vol 80. issue 21. 2008-01-02. PMID:17395211. |
interleukin-2 (il-2) and isoforms of acetylcholinesterase (ache) were estimated in different brain areas as marker for neuroinflammation and cholinergic activity respectively. |
2008-01-02 |
2023-08-12 |
mouse |
| Eduardo Pacheco Rico, Denis Broock Rosemberg, Renato Dutra Dias, Mauricio Reis Bogo, Carla Denise Bona. Ethanol alters acetylcholinesterase activity and gene expression in zebrafish brain. Toxicology letters. vol 174. issue 1-3. 2007-12-18. PMID:17888594. |
these findings suggest that the alterations on zebrafish ache could reveal molecular mechanisms related to cholinergic signaling in alcoholism. |
2007-12-18 |
2023-08-12 |
zebrafish |
| Mariapaola Piccardi, Donatella Congiu, Alessio Squassina, Francesca Manconi, Paolo Francesco Putzu, Rosa Maria Mereu, Caterina Chillotti, Maria Del Zomp. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503475. |
the resulting reduction in cholinergic activity is associated with decreased levels of the neurotransmitter acetylcholine (ach), decreased activity of acetylcholinesterase (ache), choline acetyltransferase (chat), and increased butyrylcholinesterase (bche) activity. |
2007-12-06 |
2023-08-12 |
human |
| Seung-O Ko, Tak-Heun Kim, Hye Kyung Lee, Jeong-Chae Lee, Eui-Sic Ch. Temporospatial localization of acetylcholinesterase activity in the dental epithelium during mouse tooth development. Life sciences. vol 81. issue 15. 2007-12-06. PMID:17905311. |
acetylcholinesterase (ache), a principal modulator of cholinergic neurotransmission, also has been demonstrated to be involved in the morphogenetic processes of neuronal and non-neuronal tissues. |
2007-12-06 |
2023-08-12 |
mouse |
| Irene Simintzi, Kleopatra H Schulpis, Panagoula Angelogianni, Charis Liapi, Stylianos Tsakiri. The effect of aspartame on acetylcholinesterase activity in hippocampal homogenates of suckling rats. Pharmacological research. vol 56. issue 2. 2007-11-01. PMID:17580119. |
neurological disturbances have been implicated with aspartame (asp) consumption and the cholinergic system with acetylcholinesterase (ache) seems actively involved. |
2007-11-01 |
2023-08-12 |
rat |
| Marcia D Howard, Nikita Mirajkar, Subramanya Karanth, Carey N Pop. Comparative effects of oral chlorpyrifos exposure on cholinesterase activity and muscarinic receptor binding in neonatal and adult rat heart. Toxicology. vol 238. issue 2-3. 2007-10-31. PMID:17644233. |
organophosphorus (op) pesticides elicit acute toxicity by inhibiting acetylcholinesterase (ache), the enzyme responsible for inactivating acetylcholine (ach) at cholinergic synapses. |
2007-10-31 |
2023-08-12 |
rat |
| I V Coutinho-Abreu, V Q Balbino, J G Valenzuela, I V Sonoda, J M Ramalho-Ortigã. Structural characterization of acetylcholinesterase 1 from the sand fly Lutzomyia longipalpis (Diptera: Psychodidae). Journal of medical entomology. vol 44. issue 4. 2007-10-19. PMID:17695019. |
acetylcholinesterase (ache) plays a key role in cholinergic impulse transmission, and it is the target enzyme for organophosphorus and carbamate insecticides. |
2007-10-19 |
2023-08-12 |
Not clear |
| G A López-Crespo, F Carvajal, P Flores, F Sánchez-Santed, M C Sánchez-Amat. Time course of biochemical and behavioural effects of a single high dose of chlorpyrifos. Neurotoxicology. vol 28. issue 3. 2007-10-18. PMID:17350100. |
this effect is independent of the percentage of ache inhibition and therefore, of change in the cholinergic system. |
2007-10-18 |
2023-08-12 |
rat |
| Fu Ai Ling, Dong Zhao Hui, Sun Man J. Protective effect of recombinant human somatotropin on amyloid beta-peptide induced learning and memory deficits in mice. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 17. issue 4. 2007-10-18. PMID:17596983. |
toxic effects of free radicals, damages of cholinergic neurons, and increased lipid peroxidation appeared in the cerebra of abeta-treated mice, manifesting an increase of malondialdehyde (mda) and decline of glutathione (gsh) level, an increment of choline acetyltransferase (chat) and acetylcholinesterase (ache) activities, and a reduction of the acetylcholine (ach) level. |
2007-10-18 |
2023-08-12 |
mouse |
| Isabel Martinez-Pena y Valenzuela, Mohammed Akaaboun. Acetylcholinesterase mobility and stability at the neuromuscular junction of living mice. Molecular biology of the cell. vol 18. issue 8. 2007-10-17. PMID:17538015. |
acetylcholinesterase (ache) is an enzyme that terminates acetylcholine neurotransmitter function at the synaptic cleft of cholinergic synapses. |
2007-10-17 |
2023-08-12 |
mouse |