| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jacques-Philippe Colletier, Didier Fournier, Harry M Greenblatt, Jure Stojan, Joel L Sussman, Giuseppe Zaccai, Israel Silman, Martin Wei. Structural insights into substrate traffic and inhibition in acetylcholinesterase. The EMBO journal. vol 25. issue 12. 2006-08-03. PMID:16763558. |
acetylcholinesterase (ache) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine. |
2006-08-03 |
2023-08-12 |
Not clear |
| Jovica Ninkovic, Anja Folchert, Yuri V Makhankov, Stephan C F Neuhauss, Inge Sillaber, Uwe Straehle, Laure Bally-Cui. Genetic identification of AChE as a positive modulator of addiction to the psychostimulant D-amphetamine in zebrafish. Journal of neurobiology. vol 66. issue 5. 2006-06-30. PMID:16470869. |
our observations demonstrate that the cholinergic system modulates drug-induced reward in zebrafish, and identify genetically ache as a promising target for systemic therapies against addiction to psychostimulants. |
2006-06-30 |
2023-08-12 |
zebrafish |
| R M Freitas, F C F Sousa, G S B Viana, M M F Fontele. Acetylcholinesterase activities in hippocampus, frontal cortex and striatum of Wistar rats after pilocarpine-induced status epilepticus. Neuroscience letters. vol 399. issue 1-2. 2006-06-30. PMID:16481111. |
experimental manipulations suggest that in vivo administration of cholinergic agonists or inhibitors of acetylcholinesterase (ache) increases the concentration of acetylcholine. |
2006-06-30 |
2023-08-12 |
rat |
| Sang-Yoon Lee, Yearn Seong Choe, Eun Kyoung Ryu, Yoichi Iimura, Yong Choi, Kyung-Han Lee, Byung-Tae Ki. Is subnanomolar binding affinity required for the in vivo imaging of acetylcholinesterase? Studies on 18F-labeled G379. Nuclear medicine and biology. vol 33. issue 1. 2006-06-19. PMID:16459263. |
acetylcholinesterase (ache) is an important cholinergic marker of alzheimer's disease (ad) and shows reduced activity in postmortem ad brain tissues. |
2006-06-19 |
2023-08-12 |
mouse |
| Andrea Contestabile, Tatiana Fila, Renata Bartesaghi, Antonio Contestabile, Elisabetta Cian. Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases. Journal of neurochemistry. vol 97. issue 2. 2006-06-08. PMID:16539660. |
we have measured in ts65dn mice the catalytic activity of the cholinergic marker, choline acetyltransferase (chat), as well as the activity of the acetylcholine-degrading enzyme acetylcholinesterase (ache), in the hippocampus and in cortical targets of basal forebrain cholinergic neurons. |
2006-06-08 |
2023-08-12 |
mouse |
| Maria Laura Bolognesi, Vincenza Andrisano, Manuela Bartolini, Andrea Cavalli, Anna Minarini, Maurizio Recanatini, Michela Rosini, Vincenzo Tumiatti, Carlo Melchiorr. Heterocyclic inhibitors of AChE acylation and peripheral sites. Farmaco (Societa chimica italiana : 1989). vol 60. issue 6-7. 2006-06-06. PMID:15878569. |
notwithstanding the criticism to the so called " cholinergic hypothesis", the therapeutic strategies for the treatment of alzheimer's disease (ad) have been mainly centered on the restoration of cholinergic functionality and, until the last year, the only drugs licensed for the management of ad were the acetycholinesterase (ache) inhibitors. |
2006-06-06 |
2023-08-12 |
Not clear |
| Eric Krejci, Isabel Martinez-Pena y Valenzuela, Rafiqa Ameziane, Mohammed Akaaboun. Acetylcholinesterase dynamics at the neuromuscular junction of live animals. The Journal of biological chemistry. vol 281. issue 15. 2006-06-05. PMID:16455662. |
at cholinergic synapses, acetylcholinesterase (ache) is critical for ensuring normal synaptic transmission. |
2006-06-05 |
2023-08-12 |
mouse |
| Kamil Kuca, Daniel Juna, Kamil Musile. Structural requirements of acetylcholinesterase reactivators. Mini reviews in medicinal chemistry. vol 6. issue 3. 2006-05-25. PMID:16515465. |
afterwards, ache is not able to serve its physiological function and intoxicated organism is died due to overstimulation of cholinergic nervous system. |
2006-05-25 |
2023-08-12 |
Not clear |
| C Bussy, P Lestaevel, B Dhieux, C Amourette, F Paquet, P Gourmelon, P Houper. Chronic ingestion of uranyl nitrate perturbs acetylcholinesterase activity and monoamine metabolism in male rat brain. Neurotoxicology. vol 27. issue 2. 2006-05-22. PMID:16325913. |
in the present study, the effects during 1.5, 6 and 9-month periods of chronic ingestion of uranyl nitrate (un) in drinking water (40 mg of uranium per litre) on cholinergic acetylcholinesterase (ache) activity and on dopaminergic and serotoninergic metabolisms were investigated in several areas of male srague dawley rat brains. |
2006-05-22 |
2023-08-12 |
rat |
| Kwan Ha Park, Young-Suk Kim, Ee-Yung Chung, Sun-Nam Choe, Jong-Jae Cho. Cardiac responses of Pacific oyster Crassostrea gigas to agents modulating cholinergic function. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 139. issue 4. 2006-05-08. PMID:15683842. |
to examine the functional effects of cholinergic modulation compounds in oyster hearts and to explore their possible use in monitoring intoxication with acetylcholine-esterase (ache) inhibitors such as organophosphates, tests were performed with in situ oyster heart preparations. |
2006-05-08 |
2023-08-12 |
Not clear |
| Kwan Ha Park, Young-Suk Kim, Ee-Yung Chung, Sun-Nam Choe, Jong-Jae Cho. Cardiac responses of Pacific oyster Crassostrea gigas to agents modulating cholinergic function. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 139. issue 4. 2006-05-08. PMID:15683842. |
the endogenous cholinergic agonist acetylcholine (ach), ache-resistant synthetic agonist carbachol, and the reversible carbamate type of ache inhibitor physostigmine, all potently depressed spontaneous cardiac contractility. |
2006-05-08 |
2023-08-12 |
Not clear |
| Kwan Ha Park, Young-Suk Kim, Ee-Yung Chung, Sun-Nam Choe, Jong-Jae Cho. Cardiac responses of Pacific oyster Crassostrea gigas to agents modulating cholinergic function. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 139. issue 4. 2006-05-08. PMID:15683842. |
the results suggest that the activation of muscarinic cholinergic receptors is coupled to inhibitory cardiac modulation, and organophosphate ache inhibitors may inhibit only an ache isozyme located at sites that are not important for control of cardiac activity in oysters. |
2006-05-08 |
2023-08-12 |
Not clear |
| Mohammad A Kamal, Abdulaziz A Al-Jafari, Qian-Sheng Yu, Nigel H Grei. Kinetic analysis of the inhibition of human butyrylcholinesterase with cymserine. Biochimica et biophysica acta. vol 1760. issue 2. 2006-04-27. PMID:16309845. |
the enzyme, acetylcholinesterase (ache), along with other elements of the cholinergic system is depleted in the ad brain. |
2006-04-27 |
2023-08-12 |
human |
| Thitiya Pung, Bradley Klein, Dennis Blodgett, Bernard Jortner, Marion Ehric. Examination of concurrent exposure to repeated stress and chlorpyrifos on cholinergic, glutamatergic, and monoamine neurotransmitter systems in rat forebrain regions. International journal of toxicology. vol 25. issue 1. 2006-04-25. PMID:16510359. |
effects of concurrent exposure to repeated stress and chlorpyrifos on activities of acetylcholinesterase (ache), carboxylesterase, and choline acetyltransferase (chat); concentrations of excitatory amino acids, monoamines, and their metabolites; and maximum binding densities (b(max)) and equilibrium dissociation rate constants (k(d)) of glutamatergic n-methyl-d-aspartate (nmda) and total muscarinic cholinergic receptors were studied in the blood, hippocampus, cerebral cortex, or hypothalamus of adult long-evans rats. |
2006-04-25 |
2023-08-12 |
rat |
| Pedro Martínez-Moreno, Susana Nieto-Cerón, Juan Torres-Lanzas, Francisco Ruiz-Espejo, Isabel Tovar-Zapata, Pedro Martínez-Hernández, José N Rodríguez-López, Cecilio J Vidal, Juan Cabezas-Herrer. Cholinesterase activity of human lung tumours varies according to their histological classification. Carcinogenesis. vol 27. issue 3. 2006-04-04. PMID:16272577. |
the probable involvement of acetylcholinesterase (ache) and butyrylcholinesterase (bche) in cancer and the relevance of cholinergic responses for lung cancer growth prompted us to study whether cholinesterase activity of human lung is altered by malignancy. |
2006-04-04 |
2023-08-12 |
human |
| Xuan Huang, Brian Lee, Gary Johnson, John Naleway, Anthony Guzikowski, Wei Dai, Zbigniew Darzynkiewic. Novel assay utilizing fluorochrome-tagged physostigmine (Ph-F) to in situ detect active acetylcholinesterase (AChE) induced during apoptosis. Cell cycle (Georgetown, Tex.). vol 4. issue 1. 2006-03-23. PMID:15611638. |
our data on megakaryocytes and end-plates indicate that ph-f reacts with active sites of ache, and can be used to reveal the presence of this enzyme in live cells and possibly to study its expression in disorders of the neurological cholinergic system. |
2006-03-23 |
2023-08-12 |
mouse |
| J M Rollinger, P Mocka, C Zidorn, E P Ellmerer, T Langer, H Stuppne. Application of the in combo screening approach for the discovery of non-alkaloid acetylcholinesterase inhibitors from Cichorium intybus. Current drug discovery technologies. vol 2. issue 3. 2006-03-10. PMID:16472227. |
because of the direct correlation of cholinergic deficit and the severity of dementia, alzheimer's disease is preferentially treated with acetylcholinesterase (ache) inhibitors to supplement the acetylcholine level. |
2006-03-10 |
2023-08-12 |
Not clear |
| Katarina Mis, Tomaz Mars, Marko Jevsek, Helena Strasek, Marko Golicnik, Janez Brecelj, Rado Komel, Michael P King, Armand F Miranda, Zoran Grubi. Expression and distribution of acetylcholinesterase among the cellular components of the neuromuscular junction formed in human myotube in vitro. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16256091. |
ache is expressed in motor neurons and skeletal muscle at the earliest stages of their development, long before nmj starts to form and ache begins to act as a cholinergic component. |
2006-02-24 |
2023-08-12 |
human |
| Cecilio J Vida. Expression of cholinesterases in brain and non-brain tumours. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16256970. |
although the involvement of cholinesterases (ches) in the removal of acetylcholine (ach) at cholinergic synapses is firmly established, there is evidence to suggest that acetylcholinesterase (ache) and butyrylcholinesterase (buche) take part in several cellular processes. |
2006-02-24 |
2023-08-12 |
Not clear |
| Jean Massoulié, Suzanne Bon, Noël Perrier, Cinzia Falasc. The C-terminal peptides of acetylcholinesterase: cellular trafficking, oligomerization and functional anchoring. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16257397. |
the "tailed" (t) variant exists in all vertebrate cholinesterases and their c-terminal t peptides are strongly conserved; in mammals, ache(t) subunits represent the major type of acetylcholinesterase in cholinergic tissues. |
2006-02-24 |
2023-08-12 |
mouse |