| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gerd Bicker, Mario Naujock, Annely Haas. Cellular expression patterns of acetylcholinesterase activity during grasshopper development. Cell and tissue research. vol 317. issue 2. 2005-02-03. PMID:15221439. |
in a third phase (after 45%), the somata of certain identified mechanosensory neurons started to express ache activity, presumably reflecting cholinergic differentiation. |
2005-02-03 |
2023-08-12 |
Not clear |
| Colette A Inkson, Alex C Brabbs, Tarlochan S Grewal, Timothy M Skerry, Paul G Geneve. Characterization of acetylcholinesterase expression and secretion during osteoblast differentiation. Bone. vol 35. issue 4. 2005-02-02. PMID:15454088. |
although best known for its role in cholinergic signalling, a substantial body of evidence suggests that acetylcholinesterase (ache) has multiple biological functions. |
2005-02-02 |
2023-08-12 |
Not clear |
| Thomas C Chou, Stephen R Rotman, Clifford B Sape. Lateral hypothalamic acetylcholinesterase-immunoreactive neurons co-express either orexin or melanin concentrating hormone. Neuroscience letters. vol 370. issue 2-3. 2005-01-31. PMID:15488307. |
the lateral hypothalamic area (lha) contains a large population of neurons that express the enzyme acetylcholinesterase (ache), but are not themselves cholinergic. |
2005-01-31 |
2023-08-12 |
Not clear |
| Marie M Svedberg, Ivan Bednar, Agneta Nordber. Effect of subchronic galantamine treatment on neuronal nicotinic and muscarinic receptor subtypes in transgenic mice overexpressing human acetylcholinesterase. Neuropharmacology. vol 47. issue 4. 2005-01-18. PMID:15380373. |
overexpression of acetylcholinesterase (ache) in mice causes cholinergic deficits with memory impairment. |
2005-01-18 |
2023-08-12 |
mouse |
| Haiheng Dong, Yun-Yan Xiang, Noa Farchi, William Ju, Yaojiong Wu, Liwen Chen, Yutian Wang, Binyamin Hochner, Burton Yang, Hermona Soreq, Wei-Yang L. Excessive expression of acetylcholinesterase impairs glutamatergic synaptogenesis in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 41. 2005-01-12. PMID:15483114. |
chronic blockade of the pas of ache with specific inhibitors selectively impaired glutamatergic functions and excitatory synaptic structures independently of cholinergic activation, while inducing ache overexpression. |
2005-01-12 |
2023-08-12 |
Not clear |
| Sang-Yoon Lee, Yearn Seong Choe, Yu Ri Kim, Jin-Young Paik, Byoung Wook Choi, Sang Eun Kim, Kyung-Han Lee, Yong Choi, Byung-Tae Ki. Synthesis and evaluation of 5,7-dihydro-3-[2-[1-(4-[18F]-fluorobenzyl)-4-piperidinyl]ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one for in vivo mapping of acetylcholinesterase. Nuclear medicine communications. vol 25. issue 6. 2004-12-20. PMID:15167519. |
acetylcholinesterase (ache) is an important cholinergic marker for the diagnosis of alzheimer's disease (ad). |
2004-12-20 |
2023-08-12 |
Not clear |
| Jirí Bajga. Organophosphates/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment. Advances in clinical chemistry. vol 38. 2004-12-06. PMID:15521192. |
they are characterized according to their action as compounds influencing cholinergic nerve transmission via inhibition of ache. |
2004-12-06 |
2023-08-12 |
Not clear |
| Dmitriy Fayuk, Jerrel L Yake. Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons. Molecular pharmacology. vol 66. issue 3. 2004-11-03. PMID:15322258. |
therefore, drugs that target ache are likely to be important regulators of cholinergic signaling in the hippocampus. |
2004-11-03 |
2023-08-12 |
rat |
| Roger M Lane, Miia Kivipelto, Nigel H Grei. Acetylcholinesterase and its inhibition in Alzheimer disease. Clinical neuropharmacology. vol 27. issue 3. 2004-09-27. PMID:15190239. |
until recently, the only established function of acetylcholinesterase (ache) was the termination of cholinergic neurotransmission. |
2004-09-27 |
2023-08-12 |
Not clear |
| Roger M Lane, Miia Kivipelto, Nigel H Grei. Acetylcholinesterase and its inhibition in Alzheimer disease. Clinical neuropharmacology. vol 27. issue 3. 2004-09-27. PMID:15190239. |
therefore, the use of ache inhibitors to treat symptoms caused by cholinergic imbalances in alzheimer disease (ad) represented a rational approach. |
2004-09-27 |
2023-08-12 |
Not clear |
| Roger M Lane, Miia Kivipelto, Nigel H Grei. Acetylcholinesterase and its inhibition in Alzheimer disease. Clinical neuropharmacology. vol 27. issue 3. 2004-09-27. PMID:15190239. |
however, it is now clear that ache and the cholinergic system may have broader effects in ad. |
2004-09-27 |
2023-08-12 |
Not clear |
| Roger M Lane, Miia Kivipelto, Nigel H Grei. Acetylcholinesterase and its inhibition in Alzheimer disease. Clinical neuropharmacology. vol 27. issue 3. 2004-09-27. PMID:15190239. |
of particular interest may be signal transduction pathways mediated through cholinergic receptors that promote nonamyloidogenic amyloid precursor protein processing and decrease tau phosphorylation, and the role of ache in the aggregation of beta-amyloid (abeta) peptide. |
2004-09-27 |
2023-08-12 |
Not clear |
| Seyed Khosrow Tayebati, Maria Antonietta Di Tullio, Francesco Ament. Effect of treatment with the cholinesterase inhibitor rivastigmine on vesicular acetylcholine transporter and choline acetyltransferase in rat brain. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 26. issue 4. 2004-09-08. PMID:15195690. |
the observation of a greater expression of this cholinergic marker in shr suggest that ache inhibition may provide beneficial effects on cholinergic neurotransmission in an animal model of vad. |
2004-09-08 |
2023-08-12 |
rat |
| Haris Carageorgiou, Apostolos Zarros, Stylianos Tsakiri. Selegiline long-term effects on brain acetylcholinesterase, (Na+,K+)-ATPase activities, antioxidant status and learning performance of aged rats. Pharmacological research. vol 48. issue 3. 2004-07-27. PMID:12860442. |
it is concluded that: (a) mao-b inhibition and/or free radical protection on tyrosine hydroxylase by the drug may increase brain catecholamine concentrations resulting possibly in (na(+),k(+))-atpase stimulation; (b) ache and (na(+),k(+))-atpase activation by the drug could modulate brain cholinergic, catecholaminergic and serotoninergic systems as well as the neural excitability and metabolic energy production; and (c) selegiline seems to improve the learning performance of aged rats. |
2004-07-27 |
2023-08-12 |
rat |
| Donald B Hoover, Charles E Ganote, Shawn M Ferguson, Randy D Blakely, Rodney L Parson. Localization of cholinergic innervation in guinea pig heart by immunohistochemistry for high-affinity choline transporters. Cardiovascular research. vol 62. issue 1. 2004-07-20. PMID:15023558. |
previous studies have used acetylcholinesterase (ache) histochemistry to identify cholinergic nerves in the heart, but this enzyme is not a selective marker for cholinergic neurons. |
2004-07-20 |
2023-08-12 |
human |
| Stevan R Emmett, Susan A Greenfiel. A peptide derived from the C-terminal region of acetylcholinesterase modulates extracellular concentrations of acetylcholinesterase in the rat substantia nigra. Neuroscience letters. vol 358. issue 3. 2004-07-16. PMID:15039118. |
it is well established that acetylcholinesterase (ache) has 'non-classical' functions independent of cholinergic transmission. |
2004-07-16 |
2023-08-12 |
human |
| Yasuyuki Abe, Atsushi Aoyagi, Takao Hara, Kazumi Abe, Reina Yamazaki, Yoshihiro Kumagae, Shunji Naruto, Kazuo Koyama, Shinji Marumoto, Keiko Tago, Narihiro Toda, Kazuko Takami, Naho Yamada, Mayuko Ori, Hiroshi Kogen, Tsugio Kanek. Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease. Journal of pharmacological sciences. vol 93. issue 1. 2004-07-09. PMID:14501158. |
these results suggest that both cholinergic and serotonergic systems are involved in maintaining brain arousal and that a dual inhibitor of ache and sert may be useful for the treatment of cognitive disorders associated with reduced brain activity such as in alzheimer's disease. |
2004-07-09 |
2023-08-12 |
mouse |
| Gerald B Downes, Michael Granat. Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability. Developmental biology. vol 270. issue 1. 2004-07-02. PMID:15136152. |
the enzyme acetylcholinesterase (ache) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine. |
2004-07-02 |
2023-08-12 |
zebrafish |
| Susana Nieto-Cerón, María Teresa Moral-Naranjo, Encarnación Muñoz-Delgado, Cecilio J Vidal, Francisco J Campo. Molecular properties of acetylcholinesterase in mouse spleen. Neurochemistry international. vol 45. issue 1. 2004-06-22. PMID:15082230. |
since cholinergic stimulation modulates proliferation/maturation of lymphoid cells, ache may be important for regulating the level of acetylcholine (ach) in the neighborhood of cholinergic receptors (achr) in spleen and other lymphoid tissues. |
2004-06-22 |
2023-08-12 |
mouse |
| Peter Eye. The role of oximes in the management of organophosphorus pesticide poisoning. Toxicological reviews. vol 22. issue 3. 2004-06-22. PMID:15181665. |
ops act primarily by inhibiting acetylcholinesterase (ache), thereby allowing acetylcholine to accumulate at cholinergic synapses, disturbing transmission at parasympathetic nerve endings, sympathetic ganglia, neuromuscular endplates and certain cns regions. |
2004-06-22 |
2023-08-12 |
human |