| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Srinivasan, S Jayadev, D Kumaran, K F Haja Nazeer Ahamed, B Suresh, M Ramanatha. Effect of losartan and enalapril on cognitive deficit caused by Goldblatt induced hypertension. Indian journal of experimental biology. vol 43. issue 3. 2005-05-12. PMID:15816410. |
acetylcholine esterase (ache) levels in the pons medulla, hippocampus, striatum and frontal cortex were measured as a cholinergic marker of learning and memory. |
2005-05-12 |
2023-08-12 |
rat |
| Francisco Javier Gil-Bea, Mónica García-Alloza, Jon Domínguez, Beatriz Marcos, María Javier Ramíre. Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit. Neuroscience letters. vol 375. issue 1. 2005-04-18. PMID:15664119. |
in the frontal cortex of rats with a selective cholinergic lesion, all cholinergic parameters measured (ach levels, chat and ache activities, "in vitro" and "in vivo" basal ach release) were significantly reduced. |
2005-04-18 |
2023-08-12 |
rat |
| Francisco Javier Gil-Bea, Mónica García-Alloza, Jon Domínguez, Beatriz Marcos, María Javier Ramíre. Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit. Neuroscience letters. vol 375. issue 1. 2005-04-18. PMID:15664119. |
quantification of ache activity is performed by an easy and cheap method and therefore, these results suggest that determination of ache activity may be used as an effective first step method to evaluate cholinergic deficits. |
2005-04-18 |
2023-08-12 |
rat |
| Nibaldo C Inestrosa, Juan Paulo Sagal, Marcela Colombre. Acetylcholinesterase interaction with Alzheimer amyloid beta. Sub-cellular biochemistry. vol 38. 2005-04-12. PMID:15709485. |
acetylcholinesterase (ache) is an enzyme involved in cholinergic and non-cholinergic functions in both the central and peripheral nervous system, most of the ache is found as a tetrameric form bound to neuronal membranes. |
2005-04-12 |
2023-08-12 |
rat |
| R Nikolo. Alzheimer's disease therapy - an update. Drug news & perspectives. vol 11. issue 4. 2005-03-30. PMID:15616667. |
the two major pharmacological principles of cholinergic therapy are 1) reduction of acetylcholine hydrolysis by means of acetylcholinesterase (ache) inhibitors; and 2) direct stimulation of nicotinic or muscarinic receptors with selective agonists. |
2005-03-30 |
2023-08-12 |
Not clear |
| Gary Telford, Lucy J Wilkinson, Doreen S W Hooi, Vivienne Worrall, A Christopher Green, David L Cook, David I Pritchard, Gareth D Griffith. An in vitro investigation of the effects of the nerve agent pretreatment pyridostigmine bromide on human peripheral blood T-cell function. International immunopharmacology. vol 4. issue 12. 2005-03-18. PMID:15351315. |
in both cases, the therapeutic effect is mediated by inhibition of acetylcholinesterase (ache) at cholinergic synapses. |
2005-03-18 |
2023-08-12 |
human |
| Gary Telford, Lucy J Wilkinson, Doreen S W Hooi, Vivienne Worrall, A Christopher Green, David L Cook, David I Pritchard, Gareth D Griffith. An in vitro investigation of the effects of the nerve agent pretreatment pyridostigmine bromide on human peripheral blood T-cell function. International immunopharmacology. vol 4. issue 12. 2005-03-18. PMID:15351315. |
ache, acetylcholine (ach) receptors and choline acetyltransferase have been reported to be expressed by t cells, suggesting that cholinergic signalling may exert some modulatory influence on t-cell function and consequently on the immune system. |
2005-03-18 |
2023-08-12 |
human |
| Gary Telford, Lucy J Wilkinson, Doreen S W Hooi, Vivienne Worrall, A Christopher Green, David L Cook, David I Pritchard, Gareth D Griffith. An in vitro investigation of the effects of the nerve agent pretreatment pyridostigmine bromide on human peripheral blood T-cell function. International immunopharmacology. vol 4. issue 12. 2005-03-18. PMID:15351315. |
the aim of this study was to investigate the role of the t-cell cholinergic system in the immunological activation process and to examine whether inhibitors of ache such as pb affect immune function. |
2005-03-18 |
2023-08-12 |
human |
| Vincenzo Rispoli, Domenicantonio Rotiroti, Vincenzo Carelli, Felice Liberatore, Luigi Scipione, Rosario Marra, Silvano Tortorella, Barbara Di Rienz. Electroencephalographic effects induced by choline pivaloyl esters in scopolamine-treated or nucleus basalis magnocellularis lesioned rats. Pharmacology, biochemistry, and behavior. vol 78. issue 4. 2005-03-04. PMID:15301920. |
the results of the present work allow us to put forward the hypothesis that the eeg effects observed are most likely mediated through the stimulation of the cholinergic neurotransmission ensuing from enhanced cerebral levels of acetylcholine (ach) consequent upon acetylcholinesterase (ache) inhibition by choline pivaloyl esters. |
2005-03-04 |
2023-08-12 |
rat |
| N Yamada, A Hattori, T Hayashi, T Nishikawa, H Fukuda, T Fujin. Improvement of scopolamine-induced memory impairment by Z-ajoene in the water maze in mice. Pharmacology, biochemistry, and behavior. vol 78. issue 4. 2005-03-04. PMID:15301936. |
these results suggest that z-ajoene may act on the cholinergic system and on memory impairment caused by excess activity of ache. |
2005-03-04 |
2023-08-12 |
mouse |
| Hideo Tsukad. [Pre-clinical evaluation of effects of acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: PET study in conscious monkeys]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 124. issue 3. 2005-03-01. PMID:15333988. |
the present review described the effects of acetylcholinesterase (ache) inhibition on the cerebral cholinergic neuronal system in the conscious monkey brains with pet. |
2005-03-01 |
2023-08-12 |
monkey |
| Hideo Tsukad. [Pre-clinical evaluation of effects of acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: PET study in conscious monkeys]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 124. issue 3. 2005-03-01. PMID:15333988. |
as evaluated by an oculomotor delayed response task, aged monkeys showed impaired working memory performance compared to young monkeys, and the impaired performance was partly improved by the administration of donepezil, due to the facilitation of the cholinergic neuronal system by ache inhibition by donepezil. |
2005-03-01 |
2023-08-12 |
monkey |
| Marco Racchi, Michela Mazzucchelli, Emanuela Porrello, Cristina Lanni, Stefano Govon. Acetylcholinesterase inhibitors: novel activities of old molecules. Pharmacological research. vol 50. issue 4. 2005-02-04. PMID:15304241. |
the therapeutic approach for improving the cognitive function in patients with alzheimer's disease (ad) is mainly based on the potentiation of central cholinergic activity and is achieved clinically by the use of acetylcholinesterase (ache) inhibitors such as tacrine, donepezil, rivastigmine, galantamine and other drugs currently in clinical trials. |
2005-02-04 |
2023-08-12 |
Not clear |
| Gerd Bicker, Mario Naujock, Annely Haas. Cellular expression patterns of acetylcholinesterase activity during grasshopper development. Cell and tissue research. vol 317. issue 2. 2005-02-03. PMID:15221439. |
in a third phase (after 45%), the somata of certain identified mechanosensory neurons started to express ache activity, presumably reflecting cholinergic differentiation. |
2005-02-03 |
2023-08-12 |
Not clear |
| Colette A Inkson, Alex C Brabbs, Tarlochan S Grewal, Timothy M Skerry, Paul G Geneve. Characterization of acetylcholinesterase expression and secretion during osteoblast differentiation. Bone. vol 35. issue 4. 2005-02-02. PMID:15454088. |
although best known for its role in cholinergic signalling, a substantial body of evidence suggests that acetylcholinesterase (ache) has multiple biological functions. |
2005-02-02 |
2023-08-12 |
Not clear |
| Thomas C Chou, Stephen R Rotman, Clifford B Sape. Lateral hypothalamic acetylcholinesterase-immunoreactive neurons co-express either orexin or melanin concentrating hormone. Neuroscience letters. vol 370. issue 2-3. 2005-01-31. PMID:15488307. |
the lateral hypothalamic area (lha) contains a large population of neurons that express the enzyme acetylcholinesterase (ache), but are not themselves cholinergic. |
2005-01-31 |
2023-08-12 |
Not clear |
| Marie M Svedberg, Ivan Bednar, Agneta Nordber. Effect of subchronic galantamine treatment on neuronal nicotinic and muscarinic receptor subtypes in transgenic mice overexpressing human acetylcholinesterase. Neuropharmacology. vol 47. issue 4. 2005-01-18. PMID:15380373. |
overexpression of acetylcholinesterase (ache) in mice causes cholinergic deficits with memory impairment. |
2005-01-18 |
2023-08-12 |
mouse |
| Haiheng Dong, Yun-Yan Xiang, Noa Farchi, William Ju, Yaojiong Wu, Liwen Chen, Yutian Wang, Binyamin Hochner, Burton Yang, Hermona Soreq, Wei-Yang L. Excessive expression of acetylcholinesterase impairs glutamatergic synaptogenesis in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 41. 2005-01-12. PMID:15483114. |
chronic blockade of the pas of ache with specific inhibitors selectively impaired glutamatergic functions and excitatory synaptic structures independently of cholinergic activation, while inducing ache overexpression. |
2005-01-12 |
2023-08-12 |
Not clear |
| Sang-Yoon Lee, Yearn Seong Choe, Yu Ri Kim, Jin-Young Paik, Byoung Wook Choi, Sang Eun Kim, Kyung-Han Lee, Yong Choi, Byung-Tae Ki. Synthesis and evaluation of 5,7-dihydro-3-[2-[1-(4-[18F]-fluorobenzyl)-4-piperidinyl]ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one for in vivo mapping of acetylcholinesterase. Nuclear medicine communications. vol 25. issue 6. 2004-12-20. PMID:15167519. |
acetylcholinesterase (ache) is an important cholinergic marker for the diagnosis of alzheimer's disease (ad). |
2004-12-20 |
2023-08-12 |
Not clear |
| Jirí Bajga. Organophosphates/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment. Advances in clinical chemistry. vol 38. 2004-12-06. PMID:15521192. |
they are characterized according to their action as compounds influencing cholinergic nerve transmission via inhibition of ache. |
2004-12-06 |
2023-08-12 |
Not clear |