| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasuyuki Abe, Atsushi Aoyagi, Takao Hara, Kazumi Abe, Reina Yamazaki, Yoshihiro Kumagae, Shunji Naruto, Kazuo Koyama, Shinji Marumoto, Keiko Tago, Narihiro Toda, Kazuko Takami, Naho Yamada, Mayuko Ori, Hiroshi Kogen, Tsugio Kanek. Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease. Journal of pharmacological sciences. vol 93. issue 1. 2004-07-09. PMID:14501158. |
these results suggest that both cholinergic and serotonergic systems are involved in maintaining brain arousal and that a dual inhibitor of ache and sert may be useful for the treatment of cognitive disorders associated with reduced brain activity such as in alzheimer's disease. |
2004-07-09 |
2023-08-12 |
mouse |
| Gerald B Downes, Michael Granat. Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability. Developmental biology. vol 270. issue 1. 2004-07-02. PMID:15136152. |
the enzyme acetylcholinesterase (ache) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine. |
2004-07-02 |
2023-08-12 |
zebrafish |
| Susana Nieto-Cerón, María Teresa Moral-Naranjo, Encarnación Muñoz-Delgado, Cecilio J Vidal, Francisco J Campo. Molecular properties of acetylcholinesterase in mouse spleen. Neurochemistry international. vol 45. issue 1. 2004-06-22. PMID:15082230. |
since cholinergic stimulation modulates proliferation/maturation of lymphoid cells, ache may be important for regulating the level of acetylcholine (ach) in the neighborhood of cholinergic receptors (achr) in spleen and other lymphoid tissues. |
2004-06-22 |
2023-08-12 |
mouse |
| Peter Eye. The role of oximes in the management of organophosphorus pesticide poisoning. Toxicological reviews. vol 22. issue 3. 2004-06-22. PMID:15181665. |
ops act primarily by inhibiting acetylcholinesterase (ache), thereby allowing acetylcholine to accumulate at cholinergic synapses, disturbing transmission at parasympathetic nerve endings, sympathetic ganglia, neuromuscular endplates and certain cns regions. |
2004-06-22 |
2023-08-12 |
human |
| Hideo Tsukada, Shingo Nishiyama, Dai Fukumoto, Hiroyuki Ohba, Kengo Sato, Takeharu Kakiuch. Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis. Synapse (New York, N.Y.). vol 52. issue 1. 2004-05-07. PMID:14755627. |
this study demonstrated the effects of acute acetylcholinesterase (ache) inhibition by donepezil (aricept) on the cerebral cholinergic neuronal system in the brains of young (5.2 +/- 1.1 years old) and aged (20.3 +/- 2.6 years old) monkeys (macaca mulatta) in the conscious state. |
2004-05-07 |
2023-08-12 |
monkey |
| Hideo Tsukada, Shingo Nishiyama, Dai Fukumoto, Hiroyuki Ohba, Kengo Sato, Takeharu Kakiuch. Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis. Synapse (New York, N.Y.). vol 52. issue 1. 2004-05-07. PMID:14755627. |
as evaluated by an oculomotor delayed response task, aged monkeys showed impaired working memory performance compared to young monkeys, and the impaired performance was partly improved by the administration of donepezil, due to the facilitation of the cholinergic neuronal system by ache inhibition. |
2004-05-07 |
2023-08-12 |
monkey |
| Min Li, Xiao-ping Du, Hui Y. [Protective effect of Polygonum multiflorum thunb on the cerebral cholinergic neurofibers in rats]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. vol 28. issue 4. 2004-04-28. PMID:14653117. |
to observe the number and morphological changes of cholinergic neurofibers in rats under the destruction of kainic acid, and to investigate the protective effect and the mechanism of polygonum multiflorum thunb (pmt) on acetyl-chorine esterase (ache) neurofibers. |
2004-04-28 |
2023-08-12 |
rat |
| L R Fodero, S S Mok, D Losic, L L Martin, M I Aguilar, C J Barrow, B G Livett, D H Smal. Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones. Journal of neurochemistry. vol 88. issue 5. 2004-03-30. PMID:15009674. |
although there is a loss of acetylcholinesterase (ache) from both cholinergic and non-cholinergic neurones in the brain of alzheimer patients, the level of ache is increased around amyloid plaques. |
2004-03-30 |
2023-08-12 |
mouse |
| Ann-Charlotte Granholm, Linda Sanders, Hyemyung Seo, Ling Lin, Kerstin Ford, Ole Isacso. Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome. Hippocampus. vol 13. issue 8. 2004-03-12. PMID:14750653. |
the density of the dendritic marker map2 was significantly decreased in the hippocampal formation of middle-aged trisomic mice (9-15 months old), and the density of cholinergic neurites (acetylcholinesterase [ache] histochemistry) was also decreased in specific layers of the hippocampus. |
2004-03-12 |
2023-08-12 |
mouse |
| Maria E Pereira, Andréa I H Adams, Nélson S Silv. 2,5-Hexanedione inhibits rat brain acetylcholinesterase activity in vitro. Toxicology letters. vol 146. issue 3. 2004-02-10. PMID:14687764. |
since cholinergic system seems to be affected by hexacarbon compounds, in the present study we examined the effect of 2,5-hd on ache activity of rat brain in vitro. |
2004-02-10 |
2023-08-12 |
rat |
| B Chertin, U Rolle, S Cascio, P Pur. Alterations in cholinergic and neuropeptide innervation of urinary bladder following partial bladder outlet obstruction. Pediatric surgery international. vol 19. issue 6. 2004-02-02. PMID:12756593. |
ache staining showed marked increase in cholinergic innervation density within the suburothelial region following boo. |
2004-02-02 |
2023-08-12 |
Not clear |
| Alan M Palme. Cholinergic therapies for Alzheimer's disease: progress and prospects. Current opinion in investigational drugs (London, England : 2000). vol 4. issue 7. 2004-01-22. PMID:14619403. |
there is also convincing evidence suggesting that cholinomimetic drugs (e.g., ache inhibitors and agents acting on cholinergic receptors) will have utility in the treatment of other, non-cognitive changes in behavior that are often associated with ad. |
2004-01-22 |
2023-08-12 |
Not clear |
| b' H Jagalska-Majewska, S W\\xc3\\xb3jcik, J Dziewiatkowski, A Luczy\\xc5\\x84ska, R Kurlapska, J Mory\\xc5\\x9. Postnatal development of the basolateral complex of rabbit amygdala: a stereological and histochemical study. Journal of anatomy. vol 203. issue 5. 2004-01-07. PMID:14635804.' |
reaching adult ache activity 1 month earlier than the total number of neurons in the blc may indicate a role of the cholinergic system in blc maturation. |
2004-01-07 |
2023-08-12 |
rabbit |
| P de Girolamo, C Costagliola, C Lucini, G Gargiulo, L Castald. The autonomous innervation of the buffalo (Bubalus bubalis) testis. An immunohistochemical study. European journal of histochemistry : EJH. vol 47. issue 2. 2003-12-29. PMID:12777213. |
the histochemical reaction for ache was negative, so cholinergic fibers cannot be detected in the buffalo testis. |
2003-12-29 |
2023-08-12 |
Not clear |
| Yeon-Kye Kim, Byung-Soo Koo, Dae-Jong Gong, Young-Choon Lee, Jeong-Heon Ko, Cheorl-Ho Ki. Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampus. Journal of ethnopharmacology. vol 87. issue 2-3. 2003-12-29. PMID:12860300. |
the results suggest that oral administration of ppe and tacrine increases acetylcholine concentration in the synaptic cleft of the hippocampus mostly through ache inhibition, and that ppe has a potent and long-lasting effect on the central cholinergic system. |
2003-12-29 |
2023-08-12 |
rat |
| Joy X S Jiang, Roy C Y Choi, Nina L Siow, Henry H C Lee, David C C Wan, Karl W K Tsi. Muscle induces neuronal expression of acetylcholinesterase in neuron-muscle co-culture: transcriptional regulation mediated by cAMP-dependent signaling. The Journal of biological chemistry. vol 278. issue 46. 2003-12-24. PMID:12963741. |
in order to determine the retrograde role of muscle in regulating the expression of ache in motor neuron, a chimeric co-culture of ng108-15 cell, a cholinergic cell line that resembles motor neuron, with chick myotube was established to mimic the neuromuscular contact in vitro. |
2003-12-24 |
2023-08-12 |
human |
| b' No\\xc3\\xabl A Perrier, Sonia Kh\\xc3\\xa9rif, Anselme L Perrier, Sylvie Dumas, Jacques Mallet, Jean Massouli\\xc3\\xa. Expression of PRiMA in the mouse brain: membrane anchoring and accumulation of \'tailed\' acetylcholinesterase. The European journal of neuroscience. vol 18. issue 7. 2003-12-19. PMID:14622217.' |
we compared the pattern of prima transcripts with that of ache transcripts, as well as those of choline acetyltransferase and m1 muscarinic receptors which are considered pre- and postsynaptic cholinergic markers. |
2003-12-19 |
2023-08-12 |
mouse |
| b' No\\xc3\\xabl A Perrier, Sonia Kh\\xc3\\xa9rif, Anselme L Perrier, Sylvie Dumas, Jacques Mallet, Jean Massouli\\xc3\\xa. Expression of PRiMA in the mouse brain: membrane anchoring and accumulation of \'tailed\' acetylcholinesterase. The European journal of neuroscience. vol 18. issue 7. 2003-12-19. PMID:14622217.' |
the results suggest that prima expression is predominantly or exclusively related to the cholinergic system and that anchoring of cholinesterases to cell membranes by prima represents a limiting factor for production of the ache tailed splice variant (achet)-prima complex, which represents the major ache component in the brain. |
2003-12-19 |
2023-08-12 |
mouse |
| Bin Li, Ellen G Duysen, Laura A Volpicelli-Daley, Allan I Levey, Oksana Lockridg. Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice. Pharmacology, biochemistry, and behavior. vol 74. issue 4. 2003-12-15. PMID:12667913. |
acetylcholinesterase (ache) hydrolyzes acetylcholine to terminate cholinergic neurotransmission. |
2003-12-15 |
2023-08-12 |
mouse |
| Bin Li, Ellen G Duysen, Laura A Volpicelli-Daley, Allan I Levey, Oksana Lockridg. Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice. Pharmacology, biochemistry, and behavior. vol 74. issue 4. 2003-12-15. PMID:12667913. |
in this report, we tested the hypothesis that ache-/- mice adapted to the absence of ache by downregulating cholinergic receptors. |
2003-12-15 |
2023-08-12 |
mouse |