| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marco Racchi, Michela Mazzucchelli, S Carolina Lenzken, Emanuela Porrello, Cristina Lanni, Stefano Govon. Role of acetylcholinesterase inhibitors in the regulation of amyloid beta precursor protein (AbetaPP) metabolism. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16297899. |
in this paper we review the evidence that these drugs, albeit with different quantitative and qualitative effects, can modulate the metabolism and expression of abetapp, through mechanism that involve either an indirect cholinergic mechanism or effects that do not involve the canonical pharmacological activity of ache inhibitors. |
2006-02-24 |
2023-08-12 |
Not clear |
| Susan Greenfiel. A peptide derived from acetylcholinesterase is a pivotal signalling molecule in neurodegeneration. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16297900. |
it is now widely accepted that acetylcholinesterase (ache) also displays non-cholinergic functions, completely independent of cholinergic transmission. |
2006-02-24 |
2023-08-12 |
Not clear |
| J Espinosa Raya, J Correa-Basurto, J I Vázquez Alcántara, J G Trujillo-Ferrar. Effects of succinic acid derivatives on ex vivo acetylcholinesterase activity. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16429502. |
although the magnitude of the cholinergic effects observed with the two succinic acid derivatives was similar to that seen with tacrine and other ache inhibitors, the toxicity study showed that the new inhibitors have less adverse side effects. |
2006-02-24 |
2023-08-12 |
Not clear |
| Mrinalini Muralidharan, Hermona Soreq, Tsafrir S Mo. Characterizing pea acetylcholinesterase. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16429548. |
although the best-defined role of acetylcholinesterase (ache) is to terminate cholinergic transmission signals, the presence of the enzyme and its substrate is not limited to the metazoan nervous system. |
2006-02-24 |
2023-08-12 |
Not clear |
| L Sánchez del Campo, S Nieto-Cerón, E Muñoz-Delgado, C J Vidal, F J Campo. Muscular dystrophy with laminin deficiency decreases acetylcholinesterase activity in thymus of dystrophic Lama2dy mice. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16429580. |
the drop in ache activity in dystrophic animals could affect the amount of ach reaching cholinergic receptors in cells of lymphoid organs. |
2006-02-24 |
2023-08-12 |
mouse |
| Ora Kofman, Guy Ben-Basha. Diisopropylfluorophosphate administration in the pre-weanling period induces long-term changes in anxiety behavior and passive avoidance in adult mice. Psychopharmacology. vol 183. issue 4. 2006-01-31. PMID:16283257. |
the developing brain may be particularly vulnerable to exposure to acetylcholinesterase (ache) inhibitors because of the role of ache on neuronal development and the effects of cholinergic pathways in mediating behavioral and hormonal responses to stress. |
2006-01-31 |
2023-08-12 |
mouse |
| Debra Toiber, Hermona Sore. Cellular stress reactions as putative cholinergic links in Alzheimer's disease. Neurochemical research. vol 30. issue 6-7. 2006-01-30. PMID:16187225. |
here, we present evidence to the fact that these two distinct phenomena both associate with specific changes in acetylcholinesterase (ache) gene expression within cholinergic neurons. |
2006-01-30 |
2023-08-12 |
Not clear |
| Debra Toiber, Hermona Sore. Cellular stress reactions as putative cholinergic links in Alzheimer's disease. Neurochemical research. vol 30. issue 6-7. 2006-01-30. PMID:16187225. |
under chronic cellular stress, aberrant ache regulation may thus facilitate apoptotic pathways, promoting plaque formation, cognitive impairments and degeneration of cholinergic nerve cells. |
2006-01-30 |
2023-08-12 |
Not clear |
| Yehudit Hasin, Nili Avidan, Dani Bercovich, Amos D Korczyn, Israel Silman, Jacques S Beckmann, Joel L Sussma. Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations. Current Alzheimer research. vol 2. issue 2. 2006-01-18. PMID:15974920. |
acetylcholinesterase (ache) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. |
2006-01-18 |
2023-08-12 |
human |
| Amitava Das, Deepak Rai, Madhu Dikshit, Gautam Palit, Chandishwar Nat. Nature of stress: differential effects on brain acetylcholinesterase activity and memory in rats. Life sciences. vol 77. issue 18. 2006-01-05. PMID:16098992. |
in acute and chronic-predictable groups the decreased ache activity in the hippocampal ds fraction during learning may be responsible to maintain cognitive function by enhancing the cholinergic activity. |
2006-01-05 |
2023-08-12 |
rat |
| Jan Mulder, Tibor Harkany, Katalin Czollner, Thomas I F H Cremers, Jan N Keijser, Csaba Nyakas, Paul G M Luite. Galantamine-induced behavioral recovery after sublethal excitotoxic lesions to the rat medial septum. Behavioural brain research. vol 163. issue 1. 2005-12-07. PMID:15951032. |
infusion of n-methyl-d-aspartate (nmda; 30nmol/1microl) in the medial septum resulted in spatial learning deficits associated with significant shrinkage of cholinergic neurons and reduced ache activity in the hippocampus at 7 days post-lesion. |
2005-12-07 |
2023-08-12 |
rat |
| Jeffrey S Thinschmidt, Charles J Frazier, Michael A King, Edwin M Meyer, Roger L Papk. Septal innervation regulates the function of alpha7 nicotinic receptors in CA1 hippocampal interneurons. Experimental neurology. vol 195. issue 2. 2005-11-21. PMID:16000197. |
ms/db injections of the selective cholinergic neurotoxin 192 igg-saporin did not affect alpha7 receptor currents, although ms/db chat and hippocampal ache immunolabeling were significantly reduced. |
2005-11-21 |
2023-08-12 |
Not clear |
| Jirí Bajga. Complex view on poisoning with nerve agents and organophosphates. Acta medica (Hradec Kralove). vol 48. issue 1. 2005-11-03. PMID:16080378. |
they are characterized according to their action as compounds influencing cholinergic nerve transmission via inhibition of ache. |
2005-11-03 |
2023-08-12 |
human |
| Donna M Byers, Louis N Irwin, Donald E Moss, Isabel C Sumaya, Christine F Hohman. Prenatal exposure to the acetylcholinesterase inhibitor methanesulfonyl fluoride alters forebrain morphology and gene expression. Brain research. Developmental brain research. vol 158. issue 1-2. 2005-10-27. PMID:15964079. |
the changes observed in cortical morphology and gene expression suggest a critical developmental role for ache in the fetal nervous system, most likely through its effect on cholinergic neurotransmission. |
2005-10-27 |
2023-08-12 |
rat |
| b' J Cabal, K Kuca, D Jun, J Bajgar, M Hrabinov\\xc3\\xa. [A comparison of the efficacy of the reactivators of acetylcholinesterase inhibited with tabun]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti. vol 54. issue 4. 2005-10-27. PMID:16124202.' |
afterwards, ache is not able to fulfil its role in the organism and subsequently cholinergic crisis occurs. |
2005-10-27 |
2023-08-12 |
Not clear |
| Israel Silman, Joel L Sussma. Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology. Current opinion in pharmacology. vol 5. issue 3. 2005-09-08. PMID:15907917. |
the synaptic enzyme acetylcholinesterase (ache) terminates transmission at cholinergic synapses by rapidly hydrolysing acetylcholine. |
2005-09-08 |
2023-08-12 |
Not clear |
| Wenming Li, Rongbiao Pi, Hugh H N Chan, Hongjun Fu, Nelson T K Lee, Hing Wai Tsang, Yongmei Pu, Donald C Chang, Chaoying Li, Jialie Luo, Keming Xiong, Zhiwang Li, Hong Xue, Paul R Carlier, Yuanping Pang, Karl W K Tsim, Mingtao Li, Yifan Ha. Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors. The Journal of biological chemistry. vol 280. issue 18. 2005-09-02. PMID:15710623. |
however, donepezil and other ache inhibitors, even at concentrations of inhibiting ache to the similar extents as 1 mum bis(7)-tacrine, failed to prevent glutamate-induced excitotoxicity in cgns; moreover, both atropine and dihydro-beta-erythroidine, the cholinoreceptor antagonists, did not affect the anti-apoptotic properties of bis(7)-tacrine, suggesting that the neuroprotection of bis(7)-tacrine appears to be independent of inhibiting ache and cholinergic transmission. |
2005-09-02 |
2023-08-12 |
rat |
| Hidekazu Tomimoto, Ryo Ohtani, Masunari Shibata, Noriko Nakamura, Masafumi Ihar. Loss of cholinergic pathways in vascular dementia of the Binswanger type. Dementia and geriatric cognitive disorders. vol 19. issue 5-6. 2005-09-01. PMID:15785029. |
the cholinergic pathway was labeled either by histochemistry for acetylcholine esterase (ache), a degradatory enzyme of ach, or by immunohistochemistry for choline acetyltransferase, its synthetic enzyme. |
2005-09-01 |
2023-08-12 |
Not clear |
| Hidekazu Tomimoto, Ryo Ohtani, Masunari Shibata, Noriko Nakamura, Masafumi Ihar. Loss of cholinergic pathways in vascular dementia of the Binswanger type. Dementia and geriatric cognitive disorders. vol 19. issue 5-6. 2005-09-01. PMID:15785029. |
these results indicate that the cholinergic pathway is damaged not only in ad, but also in vdbt, and may further provide a pharmacological basis for treatment with ache inhibitors in vdbt. |
2005-09-01 |
2023-08-12 |
Not clear |
| Paul A Dabisch, David C Burnett, Dennis B Miller, Edward M Jakubowski, William T Muse, Jeffry S Forster, Jacqueline A Scotto, Jill R Jarvis, Emily A Davis, Stanley W Hulet, Sharon A Reutter, Robert J Mioduszewski, Sandra A Thomso. Tolerance to the miotic effect of sarin vapor in rats after multiple low-level exposures. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. vol 21. issue 3. 2005-08-26. PMID:15969635. |
inhibition of acetylcholinesterase (ache) by the organophosphorous compound sarin (gb) results in the accumulation of acetylcholine and excessive cholinergic stimulation. |
2005-08-26 |
2023-08-12 |
rat |