| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenming Li, Rongbiao Pi, Hugh H N Chan, Hongjun Fu, Nelson T K Lee, Hing Wai Tsang, Yongmei Pu, Donald C Chang, Chaoying Li, Jialie Luo, Keming Xiong, Zhiwang Li, Hong Xue, Paul R Carlier, Yuanping Pang, Karl W K Tsim, Mingtao Li, Yifan Ha. Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors. The Journal of biological chemistry. vol 280. issue 18. 2005-09-02. PMID:15710623. |
however, donepezil and other ache inhibitors, even at concentrations of inhibiting ache to the similar extents as 1 mum bis(7)-tacrine, failed to prevent glutamate-induced excitotoxicity in cgns; moreover, both atropine and dihydro-beta-erythroidine, the cholinoreceptor antagonists, did not affect the anti-apoptotic properties of bis(7)-tacrine, suggesting that the neuroprotection of bis(7)-tacrine appears to be independent of inhibiting ache and cholinergic transmission. |
2005-09-02 |
2023-08-12 |
rat |
| Hidekazu Tomimoto, Ryo Ohtani, Masunari Shibata, Noriko Nakamura, Masafumi Ihar. Loss of cholinergic pathways in vascular dementia of the Binswanger type. Dementia and geriatric cognitive disorders. vol 19. issue 5-6. 2005-09-01. PMID:15785029. |
the cholinergic pathway was labeled either by histochemistry for acetylcholine esterase (ache), a degradatory enzyme of ach, or by immunohistochemistry for choline acetyltransferase, its synthetic enzyme. |
2005-09-01 |
2023-08-12 |
Not clear |
| Hidekazu Tomimoto, Ryo Ohtani, Masunari Shibata, Noriko Nakamura, Masafumi Ihar. Loss of cholinergic pathways in vascular dementia of the Binswanger type. Dementia and geriatric cognitive disorders. vol 19. issue 5-6. 2005-09-01. PMID:15785029. |
these results indicate that the cholinergic pathway is damaged not only in ad, but also in vdbt, and may further provide a pharmacological basis for treatment with ache inhibitors in vdbt. |
2005-09-01 |
2023-08-12 |
Not clear |
| Paul A Dabisch, David C Burnett, Dennis B Miller, Edward M Jakubowski, William T Muse, Jeffry S Forster, Jacqueline A Scotto, Jill R Jarvis, Emily A Davis, Stanley W Hulet, Sharon A Reutter, Robert J Mioduszewski, Sandra A Thomso. Tolerance to the miotic effect of sarin vapor in rats after multiple low-level exposures. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. vol 21. issue 3. 2005-08-26. PMID:15969635. |
inhibition of acetylcholinesterase (ache) by the organophosphorous compound sarin (gb) results in the accumulation of acetylcholine and excessive cholinergic stimulation. |
2005-08-26 |
2023-08-12 |
rat |
| Marcella Reale, Carla Iarlori, Francesco Gambi, Isabella Lucci, Mirella Salvatore, Domenico Gamb. Acetylcholinesterase inhibitors effects on oncostatin-M, interleukin-1 beta and interleukin-6 release from lymphocytes of Alzheimer's disease patients. Experimental gerontology. vol 40. issue 3. 2005-08-25. PMID:15763393. |
one strategy for treatment of ad has been to use acetylcholinesterase (ache) inhibitors to increase the levels of acetylcholine and enhancing cholinergic activity in the affected regions of the brain. |
2005-08-25 |
2023-08-12 |
Not clear |
| Kathleen M Guthrie, Amy Tran, Janie Baratta, Jen Yu, Richard T Robertso. Patterns of afferent projections to the dentate gyrus studied in organotypic co-cultures. Brain research. Developmental brain research. vol 157. issue 2. 2005-08-24. PMID:15882910. |
acetylcholinesterase (ache) histochemistry demonstrated that cholinergic axons from septum, substantia innominata, and striatum all consistently targeted the inner molecular layer of the dentate gyrus. |
2005-08-24 |
2023-08-12 |
Not clear |
| Muhammad Mubarak Hossain, Tadahiko Suzuki, Itaru Sato, Tadashi Takewaki, Koichi Suzuki, Haruo Kobayash. Neuromechanical effects of pyrethroids, allethrin, cyhalothrin and deltamethrin on the cholinergic processes in rat brain. Life sciences. vol 77. issue 7. 2005-08-08. PMID:15936353. |
to better understand the mechanisms of their modulatory effects and also other effects on the cholinergic system in the brain, the activities of ach hydrolyzing enzyme acetylcholinesterase (ache), ach synthesizing enzyme choline acetyltransferase (chat) and ach synthesizing rate-limiting step, high-affinity choline uptake (hacu) were examined in the present study. |
2005-08-08 |
2023-08-12 |
rat |
| Yehudit Hasin, Nili Avidan, Dani Bercovich, Amos Korczyn, Israel Silman, Jacques S Beckmann, Joel L Sussma. A paradigm for single nucleotide polymorphism analysis: the case of the acetylcholinesterase gene. Human mutation. vol 24. issue 5. 2005-07-29. PMID:15459952. |
acetylcholinesterase (ache) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. |
2005-07-29 |
2023-08-12 |
human |
| Eliane Boudinot, Laurent Taysse, Sébastien Daulon, Arnaud Chatonnet, Jean Champagnat, Arthur S Fout. Effects of acetylcholinesterase and butyrylcholinesterase inhibition on breathing in mice adapted or not to reduced acetylcholinesterase. Pharmacology, biochemistry, and behavior. vol 80. issue 1. 2005-06-23. PMID:15652380. |
bche inhibition by bambuterol was ineffective in wild-type mice and heterozygotes, decreased v(t) in homozygotes adapted to null ache activity but increased v(t) in wild-type mice acutely treated with huperzine, also aggravating the cholinergic syndrome. |
2005-06-23 |
2023-08-12 |
mouse |
| Xavier Cousin, Uwe Strähle, Arnaud Chatonne. Are there non-catalytic functions of acetylcholinesterases? Lessons from mutant animal models. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 27. issue 2. 2005-05-16. PMID:15666354. |
acetylcholinesterase (ache) hydrolyses acetylcholine (ach) ensuring the fast clearance of released neurotransmitter at cholinergic synapses. |
2005-05-16 |
2023-08-12 |
Not clear |
| Lynnette J Cook, Luk W Ho, Lin Wang, Edith Terrenoire, Carol Brayne, John Grimley Evans, John Xuereb, Nigel J Cairns, Dragana Turic, Paul Hollingworth, Pamela J Moore, Luke Jehu, Nicola Archer, Sarah Walter, Catherine Foy, Amanda Edmondson, John Powell, Simon Lovestone, Julie Williams, David C Rubinsztei. Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 132B. issue 1. 2005-05-12. PMID:15690550. |
consistent deficits in the cholinergic system are evident in the brains of alzheimer's disease (ad) patients, including reductions in the activities of acetylcholine, acetylcholinesterase (ache), and choline acetyltransferase (chat), increased butyrylcholinesterase (bche) activity, and a selective loss of nicotinic acetylcholine receptors (nachrs). |
2005-05-12 |
2023-08-12 |
Not clear |
| J Srinivasan, S Jayadev, D Kumaran, K F Haja Nazeer Ahamed, B Suresh, M Ramanatha. Effect of losartan and enalapril on cognitive deficit caused by Goldblatt induced hypertension. Indian journal of experimental biology. vol 43. issue 3. 2005-05-12. PMID:15816410. |
acetylcholine esterase (ache) levels in the pons medulla, hippocampus, striatum and frontal cortex were measured as a cholinergic marker of learning and memory. |
2005-05-12 |
2023-08-12 |
rat |
| Francisco Javier Gil-Bea, Mónica García-Alloza, Jon Domínguez, Beatriz Marcos, María Javier Ramíre. Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit. Neuroscience letters. vol 375. issue 1. 2005-04-18. PMID:15664119. |
in the frontal cortex of rats with a selective cholinergic lesion, all cholinergic parameters measured (ach levels, chat and ache activities, "in vitro" and "in vivo" basal ach release) were significantly reduced. |
2005-04-18 |
2023-08-12 |
rat |
| Francisco Javier Gil-Bea, Mónica García-Alloza, Jon Domínguez, Beatriz Marcos, María Javier Ramíre. Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit. Neuroscience letters. vol 375. issue 1. 2005-04-18. PMID:15664119. |
quantification of ache activity is performed by an easy and cheap method and therefore, these results suggest that determination of ache activity may be used as an effective first step method to evaluate cholinergic deficits. |
2005-04-18 |
2023-08-12 |
rat |
| Nibaldo C Inestrosa, Juan Paulo Sagal, Marcela Colombre. Acetylcholinesterase interaction with Alzheimer amyloid beta. Sub-cellular biochemistry. vol 38. 2005-04-12. PMID:15709485. |
acetylcholinesterase (ache) is an enzyme involved in cholinergic and non-cholinergic functions in both the central and peripheral nervous system, most of the ache is found as a tetrameric form bound to neuronal membranes. |
2005-04-12 |
2023-08-12 |
rat |
| R Nikolo. Alzheimer's disease therapy - an update. Drug news & perspectives. vol 11. issue 4. 2005-03-30. PMID:15616667. |
the two major pharmacological principles of cholinergic therapy are 1) reduction of acetylcholine hydrolysis by means of acetylcholinesterase (ache) inhibitors; and 2) direct stimulation of nicotinic or muscarinic receptors with selective agonists. |
2005-03-30 |
2023-08-12 |
Not clear |
| Gary Telford, Lucy J Wilkinson, Doreen S W Hooi, Vivienne Worrall, A Christopher Green, David L Cook, David I Pritchard, Gareth D Griffith. An in vitro investigation of the effects of the nerve agent pretreatment pyridostigmine bromide on human peripheral blood T-cell function. International immunopharmacology. vol 4. issue 12. 2005-03-18. PMID:15351315. |
in both cases, the therapeutic effect is mediated by inhibition of acetylcholinesterase (ache) at cholinergic synapses. |
2005-03-18 |
2023-08-12 |
human |
| Gary Telford, Lucy J Wilkinson, Doreen S W Hooi, Vivienne Worrall, A Christopher Green, David L Cook, David I Pritchard, Gareth D Griffith. An in vitro investigation of the effects of the nerve agent pretreatment pyridostigmine bromide on human peripheral blood T-cell function. International immunopharmacology. vol 4. issue 12. 2005-03-18. PMID:15351315. |
ache, acetylcholine (ach) receptors and choline acetyltransferase have been reported to be expressed by t cells, suggesting that cholinergic signalling may exert some modulatory influence on t-cell function and consequently on the immune system. |
2005-03-18 |
2023-08-12 |
human |
| Gary Telford, Lucy J Wilkinson, Doreen S W Hooi, Vivienne Worrall, A Christopher Green, David L Cook, David I Pritchard, Gareth D Griffith. An in vitro investigation of the effects of the nerve agent pretreatment pyridostigmine bromide on human peripheral blood T-cell function. International immunopharmacology. vol 4. issue 12. 2005-03-18. PMID:15351315. |
the aim of this study was to investigate the role of the t-cell cholinergic system in the immunological activation process and to examine whether inhibitors of ache such as pb affect immune function. |
2005-03-18 |
2023-08-12 |
human |
| Vincenzo Rispoli, Domenicantonio Rotiroti, Vincenzo Carelli, Felice Liberatore, Luigi Scipione, Rosario Marra, Silvano Tortorella, Barbara Di Rienz. Electroencephalographic effects induced by choline pivaloyl esters in scopolamine-treated or nucleus basalis magnocellularis lesioned rats. Pharmacology, biochemistry, and behavior. vol 78. issue 4. 2005-03-04. PMID:15301920. |
the results of the present work allow us to put forward the hypothesis that the eeg effects observed are most likely mediated through the stimulation of the cholinergic neurotransmission ensuing from enhanced cerebral levels of acetylcholine (ach) consequent upon acetylcholinesterase (ache) inhibition by choline pivaloyl esters. |
2005-03-04 |
2023-08-12 |
rat |