| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Li, Ellen G Duysen, Laura A Volpicelli-Daley, Allan I Levey, Oksana Lockridg. Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice. Pharmacology, biochemistry, and behavior. vol 74. issue 4. 2003-12-15. PMID:12667913. |
these results indicate that one adaptation to the absence of ache is downregulation of muscarinic receptors, thus reducing response to cholinergic stimulation. |
2003-12-15 |
2023-08-12 |
mouse |
| Min Wu, Samuel S Newton, Joshua B Atkins, Changqing Xu, Ronald S Duman, Meenakshi Alrej. Acetylcholinesterase inhibitors activate septohippocampal GABAergic neurons via muscarinic but not nicotinic receptors. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12966162. |
using electrophysiological recordings and fluorescent labeling techniques to identify living septohippocampal neurons in rat brain slices, we report that ache inhibitors, in the absence of exogenous ach, produce a profound excitation in 94% of septohippocampal gabaergic neurons and an inhibition in 24% of septohippocampal cholinergic neurons. |
2003-12-10 |
2023-08-12 |
rat |
| Min Wu, Samuel S Newton, Joshua B Atkins, Changqing Xu, Ronald S Duman, Meenakshi Alrej. Acetylcholinesterase inhibitors activate septohippocampal GABAergic neurons via muscarinic but not nicotinic receptors. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12966162. |
the inhibitory and excitatory effects of ache inhibitors, presumably, occur due to accumulation of ach that is released locally within the msdb via axon collaterals of septohippocampal cholinergic neurons. |
2003-12-10 |
2023-08-12 |
rat |
| Yoffi Segall, Gary B Quistad, Susan E Sparks, John E Casid. Major intermediates in organophosphate synthesis (PCl3, POCl3, PSCl3, and their diethyl esters) are anticholinesterase agents directly or on activation. Chemical research in toxicology. vol 16. issue 3. 2003-10-14. PMID:12641435. |
pcl(3) and pocl(3) produce cholinergic poisoning signs on ip administration to mice, and all three phosphotrichlorides give marked in vivo inhibition of serum bche but not brain ache activity. |
2003-10-14 |
2023-08-12 |
mouse |
| B P Kirby, J N P Rawlin. The role of the septo-hippocampal cholinergic projection in T-maze rewarded alternation. Behavioural brain research. vol 143. issue 1. 2003-09-09. PMID:12842294. |
administration of 192igg-saporin, a cholinergic neurotoxin, to the medial septum destroys the cell bodies from which the septo-hippocampal cholinergic projection originates, leading to reductions in both hippocampal acetylcholinesterase (ache) and choline acetyltransferase (chat). |
2003-09-09 |
2023-08-12 |
rat |
| Sultan Darvesh, David A Hopkin. Differential distribution of butyrylcholinesterase and acetylcholinesterase in the human thalamus. The Journal of comparative neurology. vol 463. issue 1. 2003-08-29. PMID:12811800. |
it has been hypothesized that acetylcholinesterase (ache) and butyrylcholinesterase (buche) are coregulators of the duration of action of acetylcholine in cholinergic neurotransmission, suggesting that buche may also have an important role in the brain. |
2003-08-29 |
2023-08-12 |
human |
| Tina M Rees, Stephen Brimijoi. The role of acetylcholinesterase in the pathogenesis of Alzheimer's disease. Drugs of today (Barcelona, Spain : 1998). vol 39. issue 1. 2003-08-01. PMID:12669110. |
additionally, numerous studies have suggested that cholinergic modulation and other functional consequences of ache inhibition may affect amyloid precursor protein processing and protect neurons against a variety of insults. |
2003-08-01 |
2023-08-12 |
Not clear |
| Véronique Bernard, Corinne Brana, Isabel Liste, Oksana Lockridge, Bertrand Bloc. Dramatic depletion of cell surface m2 muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient mice. Molecular and cellular neurosciences. vol 23. issue 1. 2003-07-28. PMID:12799142. |
we have studied the consequences of the constitutive acetylcholinesterase (ache) deficiency in knockout mice for the ache gene on the subcellular localization of the m2 receptor (m2r) and the regulation of its intraneuronal compartmentalization by the cholinergic environment, using immunohistochemistry at light and electron microscopic levels. |
2003-07-28 |
2023-08-12 |
mouse |
| Véronique Bernard, Corinne Brana, Isabel Liste, Oksana Lockridge, Bertrand Bloc. Dramatic depletion of cell surface m2 muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient mice. Molecular and cellular neurosciences. vol 23. issue 1. 2003-07-28. PMID:12799142. |
(2) in vivo and in vitro (organotypic culture) dynamic studies demonstrate that the balance between membrane and intracytoplasmic m2r can be regulated by the cholinergic influence: in ache -/- mice, m2r is translocated from the cytoplasm to the cell surface after (1) blockade of muscarinic receptors by atropine, (2) supplementation of ache -/- neurons with ache in vitro, and (3) disruption of the cortical and hippocampal cholinergic afferents in vitro. |
2003-07-28 |
2023-08-12 |
mouse |
| Tirupapuliyur V Damodaran, Katherine H Jones, Anand G Patel, Mohamed B Abou-Doni. Sarin (nerve agent GB)-induced differential expression of mRNA coding for the acetylcholinesterase gene in the rat central nervous system. Biochemical pharmacology. vol 65. issue 12. 2003-07-22. PMID:12787884. |
sarin inactivates the enzyme ache which is responsible for the breakdown of the neurotransmitter acetylcholine (ach), leading to its accumulation at ach receptors and overstimulation of the cholinergic system. |
2003-07-22 |
2023-08-12 |
rat |
| Laura A Volpicelli-Daley, Ellen G Duysen, Oksana Lockridge, Allan I Leve. Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice. Annals of neurology. vol 53. issue 6. 2003-07-09. PMID:12783426. |
a primary therapeutic strategy for alzheimer's disease includes acetylcholinesterase (ache) inhibitors with the goal of enhancing cholinergic transmission. |
2003-07-09 |
2023-08-12 |
mouse |
| Takatoshi Hikida, Yasuji Kitabatake, Ira Pastan, Shigetada Nakanish. Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 10. 2003-07-01. PMID:12721372. |
these results demonstrate that centrally active ache inhibitors prevent long-lasting behavioral abnormalities associated with cocaine and morphine addictions by potentiating the actions of ach released from the nac cholinergic neurons. |
2003-07-01 |
2023-08-12 |
Not clear |
| H Shinotoh, K Fukushi, S Nagatsuka, N Tanaka, A Aotsuka, T Ota, H Namba, S Tanada, T Iri. The amygdala and Alzheimer's disease: positron emission tomographic study of the cholinergic system. Annals of the New York Academy of Sciences. vol 985. 2003-06-17. PMID:12724174. |
we measured brain acetylcholinesterase (ache) activity in 54 patients with ad and in 22 normal controls by positron emission tomography and n-[(11)c]methylpiperidin-4-yl acetate to characterize the cholinergic pathology in ad. |
2003-06-17 |
2023-08-12 |
Not clear |
| Vladimir V Malygin, Vladimir B Sokolov, Rudy J Richardson, Galina F Makhaev. Quantitative structure-activity relationships predict the delayed neurotoxicity potential of a series of O-alkyl-O-methylchloroformimino phenylphosphonates. Journal of toxicology and environmental health. Part A. vol 66. issue 7. 2003-06-02. PMID:12746136. |
inhibition of acetylcholinesterase (ache) versus inhibition and aging of neuropathy target esterase (nte) by organophosphorus (op) compounds in vivo can give rise to distinct neurological consequences: acute cholinergic toxicity versus op compound-induced delayed neurotoxicity (opidn). |
2003-06-02 |
2023-08-12 |
Not clear |
| Qi-Huang Jin, Yu-Fang Shi, Heng-Yi He, Kelvin K W Ng, Hua Jiang, Lei Yang, Zi-Qing Jiang, Xue-Jun Zhan. Isolation of acetylcholinesterase from apoptotic human lung fibroblast cells by antibody affinity chromatography. BioTechniques. vol Suppl. 2003-04-25. PMID:12395932. |
acetylcholinesterase (ache; ec3.1.1.7) is well known for its role in the hydrolysis of acetylcholine at cholinergic synapses to terminate neurotransmission. |
2003-04-25 |
2023-08-12 |
human |
| H Sugimot. Donepezil hydrochloride: a treatment drug for Alzheimer's disease. Chemical record (New York, N.Y.). vol 1. issue 1. 2003-04-22. PMID:11893059. |
the role of the cholinergic system with respect to cognitive deficits characteristic of alzheimer's disease (ad) has led to a number of studies focusing on the development of acetylcholinesterase (ache) inhibitors as a drug for treating this disease. |
2003-04-22 |
2023-08-12 |
Not clear |
| Tjerk J H Bueters, Marloes J A Joosen, Herman P M van Helden, Ad P Ijzerman, Meindert Danho. Adenosine A1 receptor agonist N6-cyclopentyladenosine affects the inactivation of acetylcholinesterase in blood and brain by sarin. The Journal of pharmacology and experimental therapeutics. vol 304. issue 3. 2003-04-21. PMID:12604711. |
a correlation between the residual ache activity in the brain and the incidence of cholinergic symptoms could be established with logistic regression analysis: lower inhibition of ache in the brain precluded the onset of critical symptoms. |
2003-04-21 |
2023-08-12 |
rat |
| E S Tsai, S J Haraldson, J Baratta, A D Lander, J Yu, R T Robertso. Basal forebrain cholinergic cell attachment and neurite outgrowth on organotypic slice cultures of hippocampal formation. Neuroscience. vol 115. issue 3. 2003-04-07. PMID:12435420. |
cultures processed for acetylcholinesterase (ache) histochemistry demonstrated non-random patterns of cholinergic cells and their neurites. |
2003-04-07 |
2023-08-12 |
mouse |
| Valtteri Kaasinen, Kjell Någren, Tarja Järvenpää, Anne Roivainen, Meixiang Yu, Vesa Oikonen, Timo Kurki, Juha O Rinn. Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer's disease. Journal of clinical psychopharmacology. vol 22. issue 6. 2003-03-31. PMID:12454562. |
donepezil and rivastigmine are acetylcholinesterase (ache) inhibitors used to improve cholinergic neurotransmission and cognitive function in alzheimer's disease (ad). |
2003-03-31 |
2023-08-12 |
human |
| Udo Rolle, Boris Chertin, Laszlo Nemeth, Prem Pur. Demonstration of nitrergic and cholinergic innervation in whole-mount preparations of rabbit, pig, and human upper urinary tract. Pediatric surgery international. vol 18. issue 5-6. 2003-03-21. PMID:12415346. |
to investigate the distribution of nitrergic and cholinergic innervation in rabbit, pig, and human upper urinary tract, (uut) whole-mount preparations and frozen sections were stained with nicotinamide adenine dinucleotide phosphate (nadph)-diaphorase and acetylcholinesterase (ache) histochemistry. |
2003-03-21 |
2023-08-12 |
human |