| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hideo Tsukada, Shingo Nishiyama, Dai Fukumoto, Hiroyuki Ohba, Kengo Sato, Takeharu Kakiuch. Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis. Synapse (New York, N.Y.). vol 52. issue 1. 2004-05-07. PMID:14755627. |
this study demonstrated the effects of acute acetylcholinesterase (ache) inhibition by donepezil (aricept) on the cerebral cholinergic neuronal system in the brains of young (5.2 +/- 1.1 years old) and aged (20.3 +/- 2.6 years old) monkeys (macaca mulatta) in the conscious state. |
2004-05-07 |
2023-08-12 |
monkey |
| Hideo Tsukada, Shingo Nishiyama, Dai Fukumoto, Hiroyuki Ohba, Kengo Sato, Takeharu Kakiuch. Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis. Synapse (New York, N.Y.). vol 52. issue 1. 2004-05-07. PMID:14755627. |
as evaluated by an oculomotor delayed response task, aged monkeys showed impaired working memory performance compared to young monkeys, and the impaired performance was partly improved by the administration of donepezil, due to the facilitation of the cholinergic neuronal system by ache inhibition. |
2004-05-07 |
2023-08-12 |
monkey |
| Min Li, Xiao-ping Du, Hui Y. [Protective effect of Polygonum multiflorum thunb on the cerebral cholinergic neurofibers in rats]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. vol 28. issue 4. 2004-04-28. PMID:14653117. |
to observe the number and morphological changes of cholinergic neurofibers in rats under the destruction of kainic acid, and to investigate the protective effect and the mechanism of polygonum multiflorum thunb (pmt) on acetyl-chorine esterase (ache) neurofibers. |
2004-04-28 |
2023-08-12 |
rat |
| L R Fodero, S S Mok, D Losic, L L Martin, M I Aguilar, C J Barrow, B G Livett, D H Smal. Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones. Journal of neurochemistry. vol 88. issue 5. 2004-03-30. PMID:15009674. |
although there is a loss of acetylcholinesterase (ache) from both cholinergic and non-cholinergic neurones in the brain of alzheimer patients, the level of ache is increased around amyloid plaques. |
2004-03-30 |
2023-08-12 |
mouse |
| Ann-Charlotte Granholm, Linda Sanders, Hyemyung Seo, Ling Lin, Kerstin Ford, Ole Isacso. Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome. Hippocampus. vol 13. issue 8. 2004-03-12. PMID:14750653. |
the density of the dendritic marker map2 was significantly decreased in the hippocampal formation of middle-aged trisomic mice (9-15 months old), and the density of cholinergic neurites (acetylcholinesterase [ache] histochemistry) was also decreased in specific layers of the hippocampus. |
2004-03-12 |
2023-08-12 |
mouse |
| Maria E Pereira, Andréa I H Adams, Nélson S Silv. 2,5-Hexanedione inhibits rat brain acetylcholinesterase activity in vitro. Toxicology letters. vol 146. issue 3. 2004-02-10. PMID:14687764. |
since cholinergic system seems to be affected by hexacarbon compounds, in the present study we examined the effect of 2,5-hd on ache activity of rat brain in vitro. |
2004-02-10 |
2023-08-12 |
rat |
| B Chertin, U Rolle, S Cascio, P Pur. Alterations in cholinergic and neuropeptide innervation of urinary bladder following partial bladder outlet obstruction. Pediatric surgery international. vol 19. issue 6. 2004-02-02. PMID:12756593. |
ache staining showed marked increase in cholinergic innervation density within the suburothelial region following boo. |
2004-02-02 |
2023-08-12 |
Not clear |
| Alan M Palme. Cholinergic therapies for Alzheimer's disease: progress and prospects. Current opinion in investigational drugs (London, England : 2000). vol 4. issue 7. 2004-01-22. PMID:14619403. |
there is also convincing evidence suggesting that cholinomimetic drugs (e.g., ache inhibitors and agents acting on cholinergic receptors) will have utility in the treatment of other, non-cognitive changes in behavior that are often associated with ad. |
2004-01-22 |
2023-08-12 |
Not clear |
| b' H Jagalska-Majewska, S W\\xc3\\xb3jcik, J Dziewiatkowski, A Luczy\\xc5\\x84ska, R Kurlapska, J Mory\\xc5\\x9. Postnatal development of the basolateral complex of rabbit amygdala: a stereological and histochemical study. Journal of anatomy. vol 203. issue 5. 2004-01-07. PMID:14635804.' |
reaching adult ache activity 1 month earlier than the total number of neurons in the blc may indicate a role of the cholinergic system in blc maturation. |
2004-01-07 |
2023-08-12 |
rabbit |
| P de Girolamo, C Costagliola, C Lucini, G Gargiulo, L Castald. The autonomous innervation of the buffalo (Bubalus bubalis) testis. An immunohistochemical study. European journal of histochemistry : EJH. vol 47. issue 2. 2003-12-29. PMID:12777213. |
the histochemical reaction for ache was negative, so cholinergic fibers cannot be detected in the buffalo testis. |
2003-12-29 |
2023-08-12 |
Not clear |
| Yeon-Kye Kim, Byung-Soo Koo, Dae-Jong Gong, Young-Choon Lee, Jeong-Heon Ko, Cheorl-Ho Ki. Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampus. Journal of ethnopharmacology. vol 87. issue 2-3. 2003-12-29. PMID:12860300. |
the results suggest that oral administration of ppe and tacrine increases acetylcholine concentration in the synaptic cleft of the hippocampus mostly through ache inhibition, and that ppe has a potent and long-lasting effect on the central cholinergic system. |
2003-12-29 |
2023-08-12 |
rat |
| Joy X S Jiang, Roy C Y Choi, Nina L Siow, Henry H C Lee, David C C Wan, Karl W K Tsi. Muscle induces neuronal expression of acetylcholinesterase in neuron-muscle co-culture: transcriptional regulation mediated by cAMP-dependent signaling. The Journal of biological chemistry. vol 278. issue 46. 2003-12-24. PMID:12963741. |
in order to determine the retrograde role of muscle in regulating the expression of ache in motor neuron, a chimeric co-culture of ng108-15 cell, a cholinergic cell line that resembles motor neuron, with chick myotube was established to mimic the neuromuscular contact in vitro. |
2003-12-24 |
2023-08-12 |
human |
| b' No\\xc3\\xabl A Perrier, Sonia Kh\\xc3\\xa9rif, Anselme L Perrier, Sylvie Dumas, Jacques Mallet, Jean Massouli\\xc3\\xa. Expression of PRiMA in the mouse brain: membrane anchoring and accumulation of \'tailed\' acetylcholinesterase. The European journal of neuroscience. vol 18. issue 7. 2003-12-19. PMID:14622217.' |
we compared the pattern of prima transcripts with that of ache transcripts, as well as those of choline acetyltransferase and m1 muscarinic receptors which are considered pre- and postsynaptic cholinergic markers. |
2003-12-19 |
2023-08-12 |
mouse |
| b' No\\xc3\\xabl A Perrier, Sonia Kh\\xc3\\xa9rif, Anselme L Perrier, Sylvie Dumas, Jacques Mallet, Jean Massouli\\xc3\\xa. Expression of PRiMA in the mouse brain: membrane anchoring and accumulation of \'tailed\' acetylcholinesterase. The European journal of neuroscience. vol 18. issue 7. 2003-12-19. PMID:14622217.' |
the results suggest that prima expression is predominantly or exclusively related to the cholinergic system and that anchoring of cholinesterases to cell membranes by prima represents a limiting factor for production of the ache tailed splice variant (achet)-prima complex, which represents the major ache component in the brain. |
2003-12-19 |
2023-08-12 |
mouse |
| Bin Li, Ellen G Duysen, Laura A Volpicelli-Daley, Allan I Levey, Oksana Lockridg. Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice. Pharmacology, biochemistry, and behavior. vol 74. issue 4. 2003-12-15. PMID:12667913. |
acetylcholinesterase (ache) hydrolyzes acetylcholine to terminate cholinergic neurotransmission. |
2003-12-15 |
2023-08-12 |
mouse |
| Bin Li, Ellen G Duysen, Laura A Volpicelli-Daley, Allan I Levey, Oksana Lockridg. Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice. Pharmacology, biochemistry, and behavior. vol 74. issue 4. 2003-12-15. PMID:12667913. |
in this report, we tested the hypothesis that ache-/- mice adapted to the absence of ache by downregulating cholinergic receptors. |
2003-12-15 |
2023-08-12 |
mouse |
| Bin Li, Ellen G Duysen, Laura A Volpicelli-Daley, Allan I Levey, Oksana Lockridg. Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice. Pharmacology, biochemistry, and behavior. vol 74. issue 4. 2003-12-15. PMID:12667913. |
these results indicate that one adaptation to the absence of ache is downregulation of muscarinic receptors, thus reducing response to cholinergic stimulation. |
2003-12-15 |
2023-08-12 |
mouse |
| Min Wu, Samuel S Newton, Joshua B Atkins, Changqing Xu, Ronald S Duman, Meenakshi Alrej. Acetylcholinesterase inhibitors activate septohippocampal GABAergic neurons via muscarinic but not nicotinic receptors. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12966162. |
using electrophysiological recordings and fluorescent labeling techniques to identify living septohippocampal neurons in rat brain slices, we report that ache inhibitors, in the absence of exogenous ach, produce a profound excitation in 94% of septohippocampal gabaergic neurons and an inhibition in 24% of septohippocampal cholinergic neurons. |
2003-12-10 |
2023-08-12 |
rat |
| Min Wu, Samuel S Newton, Joshua B Atkins, Changqing Xu, Ronald S Duman, Meenakshi Alrej. Acetylcholinesterase inhibitors activate septohippocampal GABAergic neurons via muscarinic but not nicotinic receptors. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12966162. |
the inhibitory and excitatory effects of ache inhibitors, presumably, occur due to accumulation of ach that is released locally within the msdb via axon collaterals of septohippocampal cholinergic neurons. |
2003-12-10 |
2023-08-12 |
rat |
| Yoffi Segall, Gary B Quistad, Susan E Sparks, John E Casid. Major intermediates in organophosphate synthesis (PCl3, POCl3, PSCl3, and their diethyl esters) are anticholinesterase agents directly or on activation. Chemical research in toxicology. vol 16. issue 3. 2003-10-14. PMID:12641435. |
pcl(3) and pocl(3) produce cholinergic poisoning signs on ip administration to mice, and all three phosphotrichlorides give marked in vivo inhibition of serum bche but not brain ache activity. |
2003-10-14 |
2023-08-12 |
mouse |