| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dmitriy Fayuk, Jerrel L Yake. Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons. Molecular pharmacology. vol 66. issue 3. 2004-11-03. PMID:15322258. |
therefore, drugs that target ache are likely to be important regulators of cholinergic signaling in the hippocampus. |
2004-11-03 |
2023-08-12 |
rat |
| Roger M Lane, Miia Kivipelto, Nigel H Grei. Acetylcholinesterase and its inhibition in Alzheimer disease. Clinical neuropharmacology. vol 27. issue 3. 2004-09-27. PMID:15190239. |
until recently, the only established function of acetylcholinesterase (ache) was the termination of cholinergic neurotransmission. |
2004-09-27 |
2023-08-12 |
Not clear |
| Roger M Lane, Miia Kivipelto, Nigel H Grei. Acetylcholinesterase and its inhibition in Alzheimer disease. Clinical neuropharmacology. vol 27. issue 3. 2004-09-27. PMID:15190239. |
therefore, the use of ache inhibitors to treat symptoms caused by cholinergic imbalances in alzheimer disease (ad) represented a rational approach. |
2004-09-27 |
2023-08-12 |
Not clear |
| Roger M Lane, Miia Kivipelto, Nigel H Grei. Acetylcholinesterase and its inhibition in Alzheimer disease. Clinical neuropharmacology. vol 27. issue 3. 2004-09-27. PMID:15190239. |
however, it is now clear that ache and the cholinergic system may have broader effects in ad. |
2004-09-27 |
2023-08-12 |
Not clear |
| Roger M Lane, Miia Kivipelto, Nigel H Grei. Acetylcholinesterase and its inhibition in Alzheimer disease. Clinical neuropharmacology. vol 27. issue 3. 2004-09-27. PMID:15190239. |
of particular interest may be signal transduction pathways mediated through cholinergic receptors that promote nonamyloidogenic amyloid precursor protein processing and decrease tau phosphorylation, and the role of ache in the aggregation of beta-amyloid (abeta) peptide. |
2004-09-27 |
2023-08-12 |
Not clear |
| Seyed Khosrow Tayebati, Maria Antonietta Di Tullio, Francesco Ament. Effect of treatment with the cholinesterase inhibitor rivastigmine on vesicular acetylcholine transporter and choline acetyltransferase in rat brain. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 26. issue 4. 2004-09-08. PMID:15195690. |
the observation of a greater expression of this cholinergic marker in shr suggest that ache inhibition may provide beneficial effects on cholinergic neurotransmission in an animal model of vad. |
2004-09-08 |
2023-08-12 |
rat |
| Haris Carageorgiou, Apostolos Zarros, Stylianos Tsakiri. Selegiline long-term effects on brain acetylcholinesterase, (Na+,K+)-ATPase activities, antioxidant status and learning performance of aged rats. Pharmacological research. vol 48. issue 3. 2004-07-27. PMID:12860442. |
it is concluded that: (a) mao-b inhibition and/or free radical protection on tyrosine hydroxylase by the drug may increase brain catecholamine concentrations resulting possibly in (na(+),k(+))-atpase stimulation; (b) ache and (na(+),k(+))-atpase activation by the drug could modulate brain cholinergic, catecholaminergic and serotoninergic systems as well as the neural excitability and metabolic energy production; and (c) selegiline seems to improve the learning performance of aged rats. |
2004-07-27 |
2023-08-12 |
rat |
| Donald B Hoover, Charles E Ganote, Shawn M Ferguson, Randy D Blakely, Rodney L Parson. Localization of cholinergic innervation in guinea pig heart by immunohistochemistry for high-affinity choline transporters. Cardiovascular research. vol 62. issue 1. 2004-07-20. PMID:15023558. |
previous studies have used acetylcholinesterase (ache) histochemistry to identify cholinergic nerves in the heart, but this enzyme is not a selective marker for cholinergic neurons. |
2004-07-20 |
2023-08-12 |
human |
| Stevan R Emmett, Susan A Greenfiel. A peptide derived from the C-terminal region of acetylcholinesterase modulates extracellular concentrations of acetylcholinesterase in the rat substantia nigra. Neuroscience letters. vol 358. issue 3. 2004-07-16. PMID:15039118. |
it is well established that acetylcholinesterase (ache) has 'non-classical' functions independent of cholinergic transmission. |
2004-07-16 |
2023-08-12 |
human |
| Yasuyuki Abe, Atsushi Aoyagi, Takao Hara, Kazumi Abe, Reina Yamazaki, Yoshihiro Kumagae, Shunji Naruto, Kazuo Koyama, Shinji Marumoto, Keiko Tago, Narihiro Toda, Kazuko Takami, Naho Yamada, Mayuko Ori, Hiroshi Kogen, Tsugio Kanek. Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease. Journal of pharmacological sciences. vol 93. issue 1. 2004-07-09. PMID:14501158. |
these results suggest that both cholinergic and serotonergic systems are involved in maintaining brain arousal and that a dual inhibitor of ache and sert may be useful for the treatment of cognitive disorders associated with reduced brain activity such as in alzheimer's disease. |
2004-07-09 |
2023-08-12 |
mouse |
| Gerald B Downes, Michael Granat. Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability. Developmental biology. vol 270. issue 1. 2004-07-02. PMID:15136152. |
the enzyme acetylcholinesterase (ache) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine. |
2004-07-02 |
2023-08-12 |
zebrafish |
| Susana Nieto-Cerón, María Teresa Moral-Naranjo, Encarnación Muñoz-Delgado, Cecilio J Vidal, Francisco J Campo. Molecular properties of acetylcholinesterase in mouse spleen. Neurochemistry international. vol 45. issue 1. 2004-06-22. PMID:15082230. |
since cholinergic stimulation modulates proliferation/maturation of lymphoid cells, ache may be important for regulating the level of acetylcholine (ach) in the neighborhood of cholinergic receptors (achr) in spleen and other lymphoid tissues. |
2004-06-22 |
2023-08-12 |
mouse |
| Peter Eye. The role of oximes in the management of organophosphorus pesticide poisoning. Toxicological reviews. vol 22. issue 3. 2004-06-22. PMID:15181665. |
ops act primarily by inhibiting acetylcholinesterase (ache), thereby allowing acetylcholine to accumulate at cholinergic synapses, disturbing transmission at parasympathetic nerve endings, sympathetic ganglia, neuromuscular endplates and certain cns regions. |
2004-06-22 |
2023-08-12 |
human |
| Hideo Tsukada, Shingo Nishiyama, Dai Fukumoto, Hiroyuki Ohba, Kengo Sato, Takeharu Kakiuch. Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis. Synapse (New York, N.Y.). vol 52. issue 1. 2004-05-07. PMID:14755627. |
this study demonstrated the effects of acute acetylcholinesterase (ache) inhibition by donepezil (aricept) on the cerebral cholinergic neuronal system in the brains of young (5.2 +/- 1.1 years old) and aged (20.3 +/- 2.6 years old) monkeys (macaca mulatta) in the conscious state. |
2004-05-07 |
2023-08-12 |
monkey |
| Hideo Tsukada, Shingo Nishiyama, Dai Fukumoto, Hiroyuki Ohba, Kengo Sato, Takeharu Kakiuch. Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis. Synapse (New York, N.Y.). vol 52. issue 1. 2004-05-07. PMID:14755627. |
as evaluated by an oculomotor delayed response task, aged monkeys showed impaired working memory performance compared to young monkeys, and the impaired performance was partly improved by the administration of donepezil, due to the facilitation of the cholinergic neuronal system by ache inhibition. |
2004-05-07 |
2023-08-12 |
monkey |
| Min Li, Xiao-ping Du, Hui Y. [Protective effect of Polygonum multiflorum thunb on the cerebral cholinergic neurofibers in rats]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. vol 28. issue 4. 2004-04-28. PMID:14653117. |
to observe the number and morphological changes of cholinergic neurofibers in rats under the destruction of kainic acid, and to investigate the protective effect and the mechanism of polygonum multiflorum thunb (pmt) on acetyl-chorine esterase (ache) neurofibers. |
2004-04-28 |
2023-08-12 |
rat |
| L R Fodero, S S Mok, D Losic, L L Martin, M I Aguilar, C J Barrow, B G Livett, D H Smal. Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones. Journal of neurochemistry. vol 88. issue 5. 2004-03-30. PMID:15009674. |
although there is a loss of acetylcholinesterase (ache) from both cholinergic and non-cholinergic neurones in the brain of alzheimer patients, the level of ache is increased around amyloid plaques. |
2004-03-30 |
2023-08-12 |
mouse |
| Ann-Charlotte Granholm, Linda Sanders, Hyemyung Seo, Ling Lin, Kerstin Ford, Ole Isacso. Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome. Hippocampus. vol 13. issue 8. 2004-03-12. PMID:14750653. |
the density of the dendritic marker map2 was significantly decreased in the hippocampal formation of middle-aged trisomic mice (9-15 months old), and the density of cholinergic neurites (acetylcholinesterase [ache] histochemistry) was also decreased in specific layers of the hippocampus. |
2004-03-12 |
2023-08-12 |
mouse |
| Maria E Pereira, Andréa I H Adams, Nélson S Silv. 2,5-Hexanedione inhibits rat brain acetylcholinesterase activity in vitro. Toxicology letters. vol 146. issue 3. 2004-02-10. PMID:14687764. |
since cholinergic system seems to be affected by hexacarbon compounds, in the present study we examined the effect of 2,5-hd on ache activity of rat brain in vitro. |
2004-02-10 |
2023-08-12 |
rat |
| B Chertin, U Rolle, S Cascio, P Pur. Alterations in cholinergic and neuropeptide innervation of urinary bladder following partial bladder outlet obstruction. Pediatric surgery international. vol 19. issue 6. 2004-02-02. PMID:12756593. |
ache staining showed marked increase in cholinergic innervation density within the suburothelial region following boo. |
2004-02-02 |
2023-08-12 |
Not clear |