| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B P Kirby, J N P Rawlin. The role of the septo-hippocampal cholinergic projection in T-maze rewarded alternation. Behavioural brain research. vol 143. issue 1. 2003-09-09. PMID:12842294. |
administration of 192igg-saporin, a cholinergic neurotoxin, to the medial septum destroys the cell bodies from which the septo-hippocampal cholinergic projection originates, leading to reductions in both hippocampal acetylcholinesterase (ache) and choline acetyltransferase (chat). |
2003-09-09 |
2023-08-12 |
rat |
| Sultan Darvesh, David A Hopkin. Differential distribution of butyrylcholinesterase and acetylcholinesterase in the human thalamus. The Journal of comparative neurology. vol 463. issue 1. 2003-08-29. PMID:12811800. |
it has been hypothesized that acetylcholinesterase (ache) and butyrylcholinesterase (buche) are coregulators of the duration of action of acetylcholine in cholinergic neurotransmission, suggesting that buche may also have an important role in the brain. |
2003-08-29 |
2023-08-12 |
human |
| Tina M Rees, Stephen Brimijoi. The role of acetylcholinesterase in the pathogenesis of Alzheimer's disease. Drugs of today (Barcelona, Spain : 1998). vol 39. issue 1. 2003-08-01. PMID:12669110. |
additionally, numerous studies have suggested that cholinergic modulation and other functional consequences of ache inhibition may affect amyloid precursor protein processing and protect neurons against a variety of insults. |
2003-08-01 |
2023-08-12 |
Not clear |
| Véronique Bernard, Corinne Brana, Isabel Liste, Oksana Lockridge, Bertrand Bloc. Dramatic depletion of cell surface m2 muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient mice. Molecular and cellular neurosciences. vol 23. issue 1. 2003-07-28. PMID:12799142. |
we have studied the consequences of the constitutive acetylcholinesterase (ache) deficiency in knockout mice for the ache gene on the subcellular localization of the m2 receptor (m2r) and the regulation of its intraneuronal compartmentalization by the cholinergic environment, using immunohistochemistry at light and electron microscopic levels. |
2003-07-28 |
2023-08-12 |
mouse |
| Véronique Bernard, Corinne Brana, Isabel Liste, Oksana Lockridge, Bertrand Bloc. Dramatic depletion of cell surface m2 muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient mice. Molecular and cellular neurosciences. vol 23. issue 1. 2003-07-28. PMID:12799142. |
(2) in vivo and in vitro (organotypic culture) dynamic studies demonstrate that the balance between membrane and intracytoplasmic m2r can be regulated by the cholinergic influence: in ache -/- mice, m2r is translocated from the cytoplasm to the cell surface after (1) blockade of muscarinic receptors by atropine, (2) supplementation of ache -/- neurons with ache in vitro, and (3) disruption of the cortical and hippocampal cholinergic afferents in vitro. |
2003-07-28 |
2023-08-12 |
mouse |
| Tirupapuliyur V Damodaran, Katherine H Jones, Anand G Patel, Mohamed B Abou-Doni. Sarin (nerve agent GB)-induced differential expression of mRNA coding for the acetylcholinesterase gene in the rat central nervous system. Biochemical pharmacology. vol 65. issue 12. 2003-07-22. PMID:12787884. |
sarin inactivates the enzyme ache which is responsible for the breakdown of the neurotransmitter acetylcholine (ach), leading to its accumulation at ach receptors and overstimulation of the cholinergic system. |
2003-07-22 |
2023-08-12 |
rat |
| Laura A Volpicelli-Daley, Ellen G Duysen, Oksana Lockridge, Allan I Leve. Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice. Annals of neurology. vol 53. issue 6. 2003-07-09. PMID:12783426. |
a primary therapeutic strategy for alzheimer's disease includes acetylcholinesterase (ache) inhibitors with the goal of enhancing cholinergic transmission. |
2003-07-09 |
2023-08-12 |
mouse |
| Takatoshi Hikida, Yasuji Kitabatake, Ira Pastan, Shigetada Nakanish. Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 10. 2003-07-01. PMID:12721372. |
these results demonstrate that centrally active ache inhibitors prevent long-lasting behavioral abnormalities associated with cocaine and morphine addictions by potentiating the actions of ach released from the nac cholinergic neurons. |
2003-07-01 |
2023-08-12 |
Not clear |
| H Shinotoh, K Fukushi, S Nagatsuka, N Tanaka, A Aotsuka, T Ota, H Namba, S Tanada, T Iri. The amygdala and Alzheimer's disease: positron emission tomographic study of the cholinergic system. Annals of the New York Academy of Sciences. vol 985. 2003-06-17. PMID:12724174. |
we measured brain acetylcholinesterase (ache) activity in 54 patients with ad and in 22 normal controls by positron emission tomography and n-[(11)c]methylpiperidin-4-yl acetate to characterize the cholinergic pathology in ad. |
2003-06-17 |
2023-08-12 |
Not clear |
| Vladimir V Malygin, Vladimir B Sokolov, Rudy J Richardson, Galina F Makhaev. Quantitative structure-activity relationships predict the delayed neurotoxicity potential of a series of O-alkyl-O-methylchloroformimino phenylphosphonates. Journal of toxicology and environmental health. Part A. vol 66. issue 7. 2003-06-02. PMID:12746136. |
inhibition of acetylcholinesterase (ache) versus inhibition and aging of neuropathy target esterase (nte) by organophosphorus (op) compounds in vivo can give rise to distinct neurological consequences: acute cholinergic toxicity versus op compound-induced delayed neurotoxicity (opidn). |
2003-06-02 |
2023-08-12 |
Not clear |
| Qi-Huang Jin, Yu-Fang Shi, Heng-Yi He, Kelvin K W Ng, Hua Jiang, Lei Yang, Zi-Qing Jiang, Xue-Jun Zhan. Isolation of acetylcholinesterase from apoptotic human lung fibroblast cells by antibody affinity chromatography. BioTechniques. vol Suppl. 2003-04-25. PMID:12395932. |
acetylcholinesterase (ache; ec3.1.1.7) is well known for its role in the hydrolysis of acetylcholine at cholinergic synapses to terminate neurotransmission. |
2003-04-25 |
2023-08-12 |
human |
| H Sugimot. Donepezil hydrochloride: a treatment drug for Alzheimer's disease. Chemical record (New York, N.Y.). vol 1. issue 1. 2003-04-22. PMID:11893059. |
the role of the cholinergic system with respect to cognitive deficits characteristic of alzheimer's disease (ad) has led to a number of studies focusing on the development of acetylcholinesterase (ache) inhibitors as a drug for treating this disease. |
2003-04-22 |
2023-08-12 |
Not clear |
| Tjerk J H Bueters, Marloes J A Joosen, Herman P M van Helden, Ad P Ijzerman, Meindert Danho. Adenosine A1 receptor agonist N6-cyclopentyladenosine affects the inactivation of acetylcholinesterase in blood and brain by sarin. The Journal of pharmacology and experimental therapeutics. vol 304. issue 3. 2003-04-21. PMID:12604711. |
a correlation between the residual ache activity in the brain and the incidence of cholinergic symptoms could be established with logistic regression analysis: lower inhibition of ache in the brain precluded the onset of critical symptoms. |
2003-04-21 |
2023-08-12 |
rat |
| E S Tsai, S J Haraldson, J Baratta, A D Lander, J Yu, R T Robertso. Basal forebrain cholinergic cell attachment and neurite outgrowth on organotypic slice cultures of hippocampal formation. Neuroscience. vol 115. issue 3. 2003-04-07. PMID:12435420. |
cultures processed for acetylcholinesterase (ache) histochemistry demonstrated non-random patterns of cholinergic cells and their neurites. |
2003-04-07 |
2023-08-12 |
mouse |
| Valtteri Kaasinen, Kjell Någren, Tarja Järvenpää, Anne Roivainen, Meixiang Yu, Vesa Oikonen, Timo Kurki, Juha O Rinn. Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer's disease. Journal of clinical psychopharmacology. vol 22. issue 6. 2003-03-31. PMID:12454562. |
donepezil and rivastigmine are acetylcholinesterase (ache) inhibitors used to improve cholinergic neurotransmission and cognitive function in alzheimer's disease (ad). |
2003-03-31 |
2023-08-12 |
human |
| Udo Rolle, Boris Chertin, Laszlo Nemeth, Prem Pur. Demonstration of nitrergic and cholinergic innervation in whole-mount preparations of rabbit, pig, and human upper urinary tract. Pediatric surgery international. vol 18. issue 5-6. 2003-03-21. PMID:12415346. |
to investigate the distribution of nitrergic and cholinergic innervation in rabbit, pig, and human upper urinary tract, (uut) whole-mount preparations and frozen sections were stained with nicotinamide adenine dinucleotide phosphate (nadph)-diaphorase and acetylcholinesterase (ache) histochemistry. |
2003-03-21 |
2023-08-12 |
human |
| Francesco Amenta, Maria Antonietta Di Tullio, Daniele Tomasson. The cholinergic approach for the treatment of vascular dementia: evidence from pre-clinical and clinical studies. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 24. issue 7-8. 2003-03-12. PMID:12450245. |
these positive results should be regarded with caution due to the small number of patients included in controlled clinical trials using cholinergic precursors and to the limited number and sample size of trials with ache and che inhibitors. |
2003-03-12 |
2023-08-12 |
Not clear |
| Angelo Moretto, Marcello Lott. The relationship between isofenphos cholinergic toxicity and the development of polyneuropathy in hens and humans. Archives of toxicology. vol 76. issue 5-6. 2003-03-04. PMID:12107655. |
to explain this difference the following hypotheses were tested: (1) phoxim is a promoter of isofenphos-induced opidp; (2) whereas neuropathy target esterase (nte) is thought to be the target of opidp, activation of isofenphos by liver microsomes causes the formation of more potent nte inhibitor(s) in humans than in hens; (3) in contrast to hen nte, the sensitivity of the human enzyme to such inhibitor(s) is higher than that of acetylcholinesterase (ache), the target of cholinergic toxicity. |
2003-03-04 |
2023-08-12 |
human |
| Talma Brenner, Yasmine Hamra-Amitay, Tama Evron, Neli Boneva, Shlomo Seidman, Hermona Sore. The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 2. 2003-02-28. PMID:12554700. |
the efficacy of targeting only one ache splicing variant highlights potential advantages of mrna-targeted therapeutics for chronic cholinergic malfunctioning. |
2003-02-28 |
2023-08-12 |
rat |
| R F Villa, A Gorini, S Hoye. ATPases of synaptic plasma membranes from hippocampus after ischemia and recovery during ageing. Neurochemical research. vol 27. issue 9. 2003-02-06. PMID:12396096. |
this in vivo study of recovery time-course from 15 mins of cerebral ischemia indicated specific biochemical assessments of functional meaning: (a) na+k(+)-atpase of synaptic plasma membranes in adult and aged animals is stimulated by ischemia; (b) this "hyperactivity" is more markedly related to adult than to aged animals; (c) these abnormalities still persist after 72 and 96 h during the recirculation times, indicating the delayed postischemic suffering of the brain; (d) specific mg(2+)-atpase enzyme system possess a lower catalytic power in aged animals than in adult ones, but remained unaltered in adult animals by ischemia and reperfusion; (e) mg(2+)-atpase is stimulated in aged animals by ischemia, further increasing during reperfusion up to 72-96 h, indicating the delayed hyperactivity of hippocampus; (f) the increased metabolic activity of hippocampus is indicated by the increased activity of cholinergic system; (g) integrity of synaptic plasma membranes seems not to be altered by 15 min ischemia to a critical extent to compromise their catalytic functionality during reperfusion; (h) ache activity increases in both adult and aged at some survival times. |
2003-02-06 |
2023-08-12 |
rat |