| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vladimir V Malygin, Vladimir B Sokolov, Rudy J Richardson, Galina F Makhaev. Quantitative structure-activity relationships predict the delayed neurotoxicity potential of a series of O-alkyl-O-methylchloroformimino phenylphosphonates. Journal of toxicology and environmental health. Part A. vol 66. issue 7. 2003-06-02. PMID:12746136. |
inhibition of acetylcholinesterase (ache) versus inhibition and aging of neuropathy target esterase (nte) by organophosphorus (op) compounds in vivo can give rise to distinct neurological consequences: acute cholinergic toxicity versus op compound-induced delayed neurotoxicity (opidn). |
2003-06-02 |
2023-08-12 |
Not clear |
| Qi-Huang Jin, Yu-Fang Shi, Heng-Yi He, Kelvin K W Ng, Hua Jiang, Lei Yang, Zi-Qing Jiang, Xue-Jun Zhan. Isolation of acetylcholinesterase from apoptotic human lung fibroblast cells by antibody affinity chromatography. BioTechniques. vol Suppl. 2003-04-25. PMID:12395932. |
acetylcholinesterase (ache; ec3.1.1.7) is well known for its role in the hydrolysis of acetylcholine at cholinergic synapses to terminate neurotransmission. |
2003-04-25 |
2023-08-12 |
human |
| H Sugimot. Donepezil hydrochloride: a treatment drug for Alzheimer's disease. Chemical record (New York, N.Y.). vol 1. issue 1. 2003-04-22. PMID:11893059. |
the role of the cholinergic system with respect to cognitive deficits characteristic of alzheimer's disease (ad) has led to a number of studies focusing on the development of acetylcholinesterase (ache) inhibitors as a drug for treating this disease. |
2003-04-22 |
2023-08-12 |
Not clear |
| Tjerk J H Bueters, Marloes J A Joosen, Herman P M van Helden, Ad P Ijzerman, Meindert Danho. Adenosine A1 receptor agonist N6-cyclopentyladenosine affects the inactivation of acetylcholinesterase in blood and brain by sarin. The Journal of pharmacology and experimental therapeutics. vol 304. issue 3. 2003-04-21. PMID:12604711. |
a correlation between the residual ache activity in the brain and the incidence of cholinergic symptoms could be established with logistic regression analysis: lower inhibition of ache in the brain precluded the onset of critical symptoms. |
2003-04-21 |
2023-08-12 |
rat |
| E S Tsai, S J Haraldson, J Baratta, A D Lander, J Yu, R T Robertso. Basal forebrain cholinergic cell attachment and neurite outgrowth on organotypic slice cultures of hippocampal formation. Neuroscience. vol 115. issue 3. 2003-04-07. PMID:12435420. |
cultures processed for acetylcholinesterase (ache) histochemistry demonstrated non-random patterns of cholinergic cells and their neurites. |
2003-04-07 |
2023-08-12 |
mouse |
| Valtteri Kaasinen, Kjell Någren, Tarja Järvenpää, Anne Roivainen, Meixiang Yu, Vesa Oikonen, Timo Kurki, Juha O Rinn. Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer's disease. Journal of clinical psychopharmacology. vol 22. issue 6. 2003-03-31. PMID:12454562. |
donepezil and rivastigmine are acetylcholinesterase (ache) inhibitors used to improve cholinergic neurotransmission and cognitive function in alzheimer's disease (ad). |
2003-03-31 |
2023-08-12 |
human |
| Udo Rolle, Boris Chertin, Laszlo Nemeth, Prem Pur. Demonstration of nitrergic and cholinergic innervation in whole-mount preparations of rabbit, pig, and human upper urinary tract. Pediatric surgery international. vol 18. issue 5-6. 2003-03-21. PMID:12415346. |
to investigate the distribution of nitrergic and cholinergic innervation in rabbit, pig, and human upper urinary tract, (uut) whole-mount preparations and frozen sections were stained with nicotinamide adenine dinucleotide phosphate (nadph)-diaphorase and acetylcholinesterase (ache) histochemistry. |
2003-03-21 |
2023-08-12 |
human |
| Francesco Amenta, Maria Antonietta Di Tullio, Daniele Tomasson. The cholinergic approach for the treatment of vascular dementia: evidence from pre-clinical and clinical studies. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 24. issue 7-8. 2003-03-12. PMID:12450245. |
these positive results should be regarded with caution due to the small number of patients included in controlled clinical trials using cholinergic precursors and to the limited number and sample size of trials with ache and che inhibitors. |
2003-03-12 |
2023-08-12 |
Not clear |
| Angelo Moretto, Marcello Lott. The relationship between isofenphos cholinergic toxicity and the development of polyneuropathy in hens and humans. Archives of toxicology. vol 76. issue 5-6. 2003-03-04. PMID:12107655. |
to explain this difference the following hypotheses were tested: (1) phoxim is a promoter of isofenphos-induced opidp; (2) whereas neuropathy target esterase (nte) is thought to be the target of opidp, activation of isofenphos by liver microsomes causes the formation of more potent nte inhibitor(s) in humans than in hens; (3) in contrast to hen nte, the sensitivity of the human enzyme to such inhibitor(s) is higher than that of acetylcholinesterase (ache), the target of cholinergic toxicity. |
2003-03-04 |
2023-08-12 |
human |
| Talma Brenner, Yasmine Hamra-Amitay, Tama Evron, Neli Boneva, Shlomo Seidman, Hermona Sore. The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 2. 2003-02-28. PMID:12554700. |
the efficacy of targeting only one ache splicing variant highlights potential advantages of mrna-targeted therapeutics for chronic cholinergic malfunctioning. |
2003-02-28 |
2023-08-12 |
rat |
| R F Villa, A Gorini, S Hoye. ATPases of synaptic plasma membranes from hippocampus after ischemia and recovery during ageing. Neurochemical research. vol 27. issue 9. 2003-02-06. PMID:12396096. |
this in vivo study of recovery time-course from 15 mins of cerebral ischemia indicated specific biochemical assessments of functional meaning: (a) na+k(+)-atpase of synaptic plasma membranes in adult and aged animals is stimulated by ischemia; (b) this "hyperactivity" is more markedly related to adult than to aged animals; (c) these abnormalities still persist after 72 and 96 h during the recirculation times, indicating the delayed postischemic suffering of the brain; (d) specific mg(2+)-atpase enzyme system possess a lower catalytic power in aged animals than in adult ones, but remained unaltered in adult animals by ischemia and reperfusion; (e) mg(2+)-atpase is stimulated in aged animals by ischemia, further increasing during reperfusion up to 72-96 h, indicating the delayed hyperactivity of hippocampus; (f) the increased metabolic activity of hippocampus is indicated by the increased activity of cholinergic system; (g) integrity of synaptic plasma membranes seems not to be altered by 15 min ischemia to a critical extent to compromise their catalytic functionality during reperfusion; (h) ache activity increases in both adult and aged at some survival times. |
2003-02-06 |
2023-08-12 |
rat |
| Olga A Timofeeva, Christopher J Gordo. EEG spectra, behavioral states and motor activity in rats exposed to acetylcholinesterase inhibitor chlorpyrifos. Pharmacology, biochemistry, and behavior. vol 72. issue 3. 2003-02-05. PMID:12175464. |
ops inhibit acetylcholinesterase (ache) activity, leading to a hyperactivity of the brain cholinergic systems that are involved in sleep regulation. |
2003-02-05 |
2023-08-12 |
rat |
| X J Zhang, L Yang, Q Zhao, J P Caen, H Y He, Q H Jin, L H Guo, M Alemany, L Y Zhang, Y F Sh. Induction of acetylcholinesterase expression during apoptosis in various cell types. Cell death and differentiation. vol 9. issue 8. 2003-01-31. PMID:12107822. |
acetylcholinesterase (ache) plays a key role in terminating neurotransmission at cholinergic synapses. |
2003-01-31 |
2023-08-12 |
Not clear |
| X J Zhang, L Yang, Q Zhao, J P Caen, H Y He, Q H Jin, L H Guo, M Alemany, L Y Zhang, Y F Sh. Induction of acetylcholinesterase expression during apoptosis in various cell types. Cell death and differentiation. vol 9. issue 8. 2003-01-31. PMID:12107822. |
ache is also found in tissues devoid of cholinergic responses, indicating potential functions beyond neurotransmission. |
2003-01-31 |
2023-08-12 |
Not clear |
| Ray D Beck, Michael A King, Zhi Huang, John M Petitt. Alterations in septohippocampal cholinergic neurons resulting from interleukin-2 gene knockout. Brain research. vol 955. issue 1-2. 2003-01-31. PMID:12419517. |
stereological cell counting and imaging techniques were used to compare c57bl/6-il-2(-/-) knockout and c57bl/6-il-2(+/+) wild-type mice for differences in choline acetyltransferase (chat)-positive somata in the medial septum and vertical limb of the diagonal band of broca (ms/vdb) and acetylcholine esterase (ache)-labeled cholinergic axons in hippocampal projection fields. |
2003-01-31 |
2023-08-12 |
mouse |
| Rita Moretti, Paola Torre, Rodolfo M Antonello, Giuseppe Cazzato, Antonio Bav. Rivastigmine in subcortical vascular dementia: an open 22-month study. Journal of the neurological sciences. vol 203-204. 2003-01-23. PMID:12417373. |
further to recent data indicating that patients with vascular dementia (vad) show a cholinergic deficit, we aimed to determine whether rivastigmine, a dual inhibitor of acetylcholinesterase (ache) and butyrylcholinesterase (buche), has any effects on the symptoms of vad. |
2003-01-23 |
2023-08-12 |
Not clear |
| Jenny Apelt, Ashok Kumar, Reinhard Schlieb. Impairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human beta-amyloid precursor protein. Brain research. vol 953. issue 1-2. 2003-01-10. PMID:12384234. |
to address the question of whether beta-amyloid peptides also affect cholinergic neurotransmission in vivo, brain tissue from transgenic tg2576 mice with alzheimer plaque pathology at ages ranging from 7 to 24 months were examined by immuno- and histochemical staining for choline acetyltransferase (chat) and acetycholinesterase (ache), by assaying cholinergic enzyme activities and high-affinity choline uptake as well muscarinic and nicotinic cholinergic receptor binding levels by quantitative autoradiography. |
2003-01-10 |
2023-08-12 |
mouse |
| C Flores-Flores, A Nissim, S Shochat, H Sore. Development of human antibody fragments directed towards synaptic acetylcholinesterase using a semi-synthetic phage display library. Journal of neural transmission. Supplementum. issue 62. 2003-01-10. PMID:12456061. |
current alzheimer's disease therapies suppress acetylcholine hydrolysis by inhibiting acetylcholinesterase (ache) at cholinergic synapses. |
2003-01-10 |
2023-08-12 |
human |
| Mohamed B Abou-Donia, Anjelika M Dechkovskaia, Larry B Goldstein, Deepti U Shah, Sarah L Bullman, Wasiuddin A Kha. Uranyl acetate-induced sensorimotor deficit and increased nitric oxide generation in the central nervous system in rats. Pharmacology, biochemistry, and behavior. vol 72. issue 4. 2003-01-08. PMID:12062578. |
the levels of nitric oxide as marker for increased oxidative stress, and the integrity of the cholinergic system as reflected in acetylcholinesterase (ache) activity and m2 muscarinic acetylcholine receptors ligand binding, were determined. |
2003-01-08 |
2023-08-12 |
rat |
| Matthew G Cottingham, Michael S Hollinshead, David J T Vau. Amyloid fibril formation by a synthetic peptide from a region of human acetylcholinesterase that is homologous to the Alzheimer's amyloid-beta peptide. Biochemistry. vol 41. issue 46. 2002-12-19. PMID:12427014. |
ache normally resides mainly on cholinergic neuronal membranes, but is abnormally localized to senile plaques in alzheimer's disease. |
2002-12-19 |
2023-08-12 |
human |