| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A D Grant, M Shapira, H Sore. Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase. Cellular and molecular neurobiology. vol 21. issue 6. 2002-06-25. PMID:12043848. |
experimental evidence shows coregulation of murine ache and ars following confined swim, indicating coordinated locus response to stress, that is possibly mediated by altered cholinergic neurotransmission. |
2002-06-25 |
2023-08-12 |
Not clear |
| Gary B Quistad, Susan E Sparks, Yoffi Segall, Daniel K Nomura, John E Casid. Selective inhibitors of fatty acid amide hydrolase relative to neuropathy target esterase and acetylcholinesterase: toxicological implications. Toxicology and applied pharmacology. vol 179. issue 1. 2002-04-04. PMID:11884237. |
the overall in vivo findings with 16 compounds indicate the expected association of ache inhibition with acute or cholinergic syndrome and >70% brain nte inhibition with delayed neurotoxic action. |
2002-04-04 |
2023-08-12 |
mouse |
| E X Albuquerque, M D Santos, M Alkondon, E F Pereira, A Maelick. Modulation of nicotinic receptor activity in the central nervous system: a novel approach to the treatment of Alzheimer disease. Alzheimer disease and associated disorders. vol 15 Suppl 1. 2002-03-18. PMID:11669505. |
currently, cholinergic deficit is usually corrected by increasing the amount of acetylcholine in the synapse by inhibiting acetylcholinesterase (ache). |
2002-03-18 |
2023-08-12 |
Not clear |
| P N Tario. Maintaining cognitive function in Alzheimer disease: how effective are current treatments? Alzheimer disease and associated disorders. vol 15 Suppl 1. 2002-03-18. PMID:11669506. |
galantamine appears to be novel among marketed agents in that it inhibits ache and modulates cholinergic nicotinic receptors, perhaps increasing neurotransmission via both mechanisms. |
2002-03-18 |
2023-08-12 |
Not clear |
| T Harkany, J Mulder, K M Horvath, J Keijser, E K van der Meeberg, C Nyakas, P G Luite. Oral post-lesion administration of 5-HT(1A) receptor agonist repinotan hydrochloride (BAY x 3702) attenuates NMDA-induced delayed neuronal death in rat magnocellular nucleus basalis. Neuroscience. vol 108. issue 4. 2002-03-14. PMID:11738499. |
effects of repinotan hcl treatment on the survival of cholinergic magnocellular nucleus basalis neurons and their cortical projections were determined by quantitative acetylcholinesterase (ache) and choline-acetyltransferase (chat) histochemistry. |
2002-03-14 |
2023-08-12 |
rat |
| P Piomboni, B Baccetti, E Moretti, L Gambera, C Angelini, C Falug. Localization of molecules related to cholinergic signaling in eggs and zygotes of the sea urchin, Paracentrotus lividus. Journal of submicroscopic cytology and pathology. vol 33. issue 1-2. 2002-03-13. PMID:11686401. |
the presence of a cholinergic signaling pattern was also suggested by the presence of molecules immunologically related to acetylcholinesterase (ache), performing ache enzyme activity, detected by both immunofluorescent and histochemical methods in membranous organelles belonging to the cortical region of unfertilized eggs. |
2002-03-13 |
2023-08-12 |
Not clear |
| D Combes, Y Fedon, J P Toutant, M Arpagau. Acetylcholinesterase genes in the nematode Caenorhabditis elegans. International review of cytology. vol 209. 2002-03-04. PMID:11580201. |
acetylcholinesterase (ache, ec 3.1.1.7) is responsible for the termination of cholinergic nerve transmission. |
2002-03-04 |
2023-08-12 |
caenorhabditis_elegans |
| F Coelho, J Birk. Physostigmine for Alzheimer's disease. The Cochrane database of systematic reviews. issue 2. 2002-02-28. PMID:11405996. |
the main pharmacological approach for the treatment of alzheimer's disease (ad) has been based on the use of agents potentiating cholinergic transmission, particularly by inhibiting acetylcholinesterase (ache), the enzyme that destroys acetylcholine after it has been secreted into the synaptic clefts. |
2002-02-28 |
2023-08-12 |
Not clear |
| M Keller, A Robitzki, P G Laye. Heterologous expression of acetylcholinesterase affects proliferation and glial cytoskeleton of adherent chicken retinal cells. Cell and tissue research. vol 306. issue 2. 2002-01-22. PMID:11702230. |
besides its function at cholinergic synapses, acetylcholinesterase (ache) exerts structural functions on neural differentiation, independent of its enzymatic activity. |
2002-01-22 |
2023-08-12 |
rabbit |
| U Gies, T J Görcs, J Mulder, O Planz, L Stitz, T Bilzer, P G Luiten, T Harkan. Cortical cholinergic decline parallels the progression of Borna virus encephalitis. Neuroreport. vol 12. issue 17. 2002-01-11. PMID:11726791. |
changes in choline acetyltransferase (chat) and acetylcholinesterase (ache) activities were therefore determined in the cerebral cortex, hippocampus, striatum, amygdala and cholinergic basal forebrain nuclei (chbfn) of rats infected with bdv. |
2002-01-11 |
2023-08-12 |
rat |
| G L Larsen, J Loader, D D Nguyen, G N Colasurd. Mechanisms of cholinergic dysfunction in rabbits following recurrent aspiration of cow's milk. Pediatric pulmonology. vol 32. issue 6. 2002-01-10. PMID:11747243. |
this study suggests that cholinergic hyperresponsiveness caused by repeated aspiration of milk is due to several abnormalities, including prejunctional (increase in ach release) as well as junctional (decrease in ache) mechanisms within the airways. |
2002-01-10 |
2023-08-12 |
Not clear |
| V N Tales. Acetylcholinesterase in Alzheimer's disease. Mechanisms of ageing and development. vol 122. issue 16. 2001-12-31. PMID:11589914. |
since the discovery of the cholinergic deficit in alzheimer disease (ad), acetylcholinesterase (ache) has been widely investigated in tissues involved in the disease. |
2001-12-31 |
2023-08-12 |
Not clear |
| Y K Chung, H J Heo, E K Kim, H K Kim, T L Huh, Y Lim, S K Kim, D H Shi. Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. Molecules and cells. vol 11. issue 2. 2001-12-19. PMID:11355692. |
ache inhibitors, which enhance cholinergic transmission by reducing the enzymatic degradation of acetylcholine, are the only source of compound currently approved for the treatment of alzheimer's disease (ad). |
2001-12-19 |
2023-08-12 |
Not clear |
| H von der Kammer, C Demiralay, B Andresen, C Albrecht, M Mayhaus, R M Nitsc. Regulation of gene expression by muscarinic acetylcholine receptors. Biochemical Society symposium. issue 67. 2001-12-14. PMID:11447829. |
the results also suggest a feedback mechanism where up-regulated ache expression and accelerated breakdown of acetylcholine (ach) at the cholinergic synapses limits increases in cholinergic transmission. |
2001-12-14 |
2023-08-12 |
Not clear |
| H M Dodds, L P Rivor. Comment on a published paper. The adverse cholinergic effects of the chemotherapeutic agent irinotecan (CPT-11) were unlikely to be mediated by the inhibition of acetylcholinesterase (AChE). British journal of pharmacology. vol 134. issue 2. 2001-12-04. PMID:11564665. |
the adverse cholinergic effects of the chemotherapeutic agent irinotecan (cpt-11) were unlikely to be mediated by the inhibition of acetylcholinesterase (ache). |
2001-12-04 |
2023-08-12 |
Not clear |
| E G Duysen, B Li, W Xie, L M Schopfer, R S Anderson, C A Broomfield, O Lockridg. Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality. The Journal of pharmacology and experimental therapeutics. vol 299. issue 2. 2001-12-04. PMID:11602663. |
the same cholinergic signs of toxicity were present in ache-/- mice as in wild-type mice, even though ache-/- mice have no ache whose inhibition could lead to cholinergic signs. |
2001-12-04 |
2023-08-12 |
mouse |
| M U Delmonte Corrado, H Politi, M Ognibene, C Angelini, F Trielli, P Ballarini, C Falug. Synthesis of the signal molecule acetylcholine during the developmental cycle of Paramecium primaurelia (Protista, Ciliophora) and its possible function in conjugation. The Journal of experimental biology. vol 204. issue Pt 11. 2001-09-27. PMID:11441032. |
we recently discovered, in mating-competent paramecium primaurelia, the presence of functionally related molecules of the cholinergic system: the neurotransmitter acetylcholine (ach), both its nicotinic and muscarinic receptors and its lytic enzyme acetylcholinesterase (ache). |
2001-09-27 |
2023-08-12 |
Not clear |
| K Sinha, H K Dannelly, S K Ghos. Effects of T-lymphocyte-dependent and -independent immunity on cholinergic enzyme activity in mouse lacrimal gland. Experimental physiology. vol 86. issue 2. 2001-08-23. PMID:11429631. |
to delineate the effects that immunogenic differences might have on the activities of the cholinergic enzymes, choline acetyl-transferase (chat) and acetylcholinesterase (ache) were assayed using radiolabelled substrates and measuring labelled products. |
2001-08-23 |
2023-08-12 |
mouse |
| U Krügel, V Bigl, K Eschrich, M Big. Deafferentation of the septo-hippocampal pathway in rats as a model of the metabolic events in Alzheimer's disease. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 19. issue 3. 2001-07-19. PMID:11337195. |
the deafferentation of the hippocampus results in a degeneration of cholinergic septo-hippocampal terminals accompanied by a persistent decrease of choline acetyltransferase (chat) and acetylcholine esterase (ache) activities similar to the cholinergic malfunction in ad. |
2001-07-19 |
2023-08-12 |
human |
| E W Cheon, O Kuwata, T Sait. Muscarinic acetylcholine receptors in the normal, developing and regenerating newt retinas. Brain research. Developmental brain research. vol 127. issue 1. 2001-07-12. PMID:11287060. |
like acetylcholinesterase (ache), the m2 was first detected in somata located at the most proximal level of the retina well before chat-ir cholinergic neurons appeared, while the m4 was detected at the time of appearance of chat, in both developing and regenerating retinas. |
2001-07-12 |
2023-08-12 |
Not clear |