| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olga A Timofeeva, Christopher J Gordo. EEG spectra, behavioral states and motor activity in rats exposed to acetylcholinesterase inhibitor chlorpyrifos. Pharmacology, biochemistry, and behavior. vol 72. issue 3. 2003-02-05. PMID:12175464. |
ops inhibit acetylcholinesterase (ache) activity, leading to a hyperactivity of the brain cholinergic systems that are involved in sleep regulation. |
2003-02-05 |
2023-08-12 |
rat |
| X J Zhang, L Yang, Q Zhao, J P Caen, H Y He, Q H Jin, L H Guo, M Alemany, L Y Zhang, Y F Sh. Induction of acetylcholinesterase expression during apoptosis in various cell types. Cell death and differentiation. vol 9. issue 8. 2003-01-31. PMID:12107822. |
acetylcholinesterase (ache) plays a key role in terminating neurotransmission at cholinergic synapses. |
2003-01-31 |
2023-08-12 |
Not clear |
| X J Zhang, L Yang, Q Zhao, J P Caen, H Y He, Q H Jin, L H Guo, M Alemany, L Y Zhang, Y F Sh. Induction of acetylcholinesterase expression during apoptosis in various cell types. Cell death and differentiation. vol 9. issue 8. 2003-01-31. PMID:12107822. |
ache is also found in tissues devoid of cholinergic responses, indicating potential functions beyond neurotransmission. |
2003-01-31 |
2023-08-12 |
Not clear |
| Ray D Beck, Michael A King, Zhi Huang, John M Petitt. Alterations in septohippocampal cholinergic neurons resulting from interleukin-2 gene knockout. Brain research. vol 955. issue 1-2. 2003-01-31. PMID:12419517. |
stereological cell counting and imaging techniques were used to compare c57bl/6-il-2(-/-) knockout and c57bl/6-il-2(+/+) wild-type mice for differences in choline acetyltransferase (chat)-positive somata in the medial septum and vertical limb of the diagonal band of broca (ms/vdb) and acetylcholine esterase (ache)-labeled cholinergic axons in hippocampal projection fields. |
2003-01-31 |
2023-08-12 |
mouse |
| Rita Moretti, Paola Torre, Rodolfo M Antonello, Giuseppe Cazzato, Antonio Bav. Rivastigmine in subcortical vascular dementia: an open 22-month study. Journal of the neurological sciences. vol 203-204. 2003-01-23. PMID:12417373. |
further to recent data indicating that patients with vascular dementia (vad) show a cholinergic deficit, we aimed to determine whether rivastigmine, a dual inhibitor of acetylcholinesterase (ache) and butyrylcholinesterase (buche), has any effects on the symptoms of vad. |
2003-01-23 |
2023-08-12 |
Not clear |
| Jenny Apelt, Ashok Kumar, Reinhard Schlieb. Impairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human beta-amyloid precursor protein. Brain research. vol 953. issue 1-2. 2003-01-10. PMID:12384234. |
to address the question of whether beta-amyloid peptides also affect cholinergic neurotransmission in vivo, brain tissue from transgenic tg2576 mice with alzheimer plaque pathology at ages ranging from 7 to 24 months were examined by immuno- and histochemical staining for choline acetyltransferase (chat) and acetycholinesterase (ache), by assaying cholinergic enzyme activities and high-affinity choline uptake as well muscarinic and nicotinic cholinergic receptor binding levels by quantitative autoradiography. |
2003-01-10 |
2023-08-12 |
mouse |
| C Flores-Flores, A Nissim, S Shochat, H Sore. Development of human antibody fragments directed towards synaptic acetylcholinesterase using a semi-synthetic phage display library. Journal of neural transmission. Supplementum. issue 62. 2003-01-10. PMID:12456061. |
current alzheimer's disease therapies suppress acetylcholine hydrolysis by inhibiting acetylcholinesterase (ache) at cholinergic synapses. |
2003-01-10 |
2023-08-12 |
human |
| Mohamed B Abou-Donia, Anjelika M Dechkovskaia, Larry B Goldstein, Deepti U Shah, Sarah L Bullman, Wasiuddin A Kha. Uranyl acetate-induced sensorimotor deficit and increased nitric oxide generation in the central nervous system in rats. Pharmacology, biochemistry, and behavior. vol 72. issue 4. 2003-01-08. PMID:12062578. |
the levels of nitric oxide as marker for increased oxidative stress, and the integrity of the cholinergic system as reflected in acetylcholinesterase (ache) activity and m2 muscarinic acetylcholine receptors ligand binding, were determined. |
2003-01-08 |
2023-08-12 |
rat |
| Matthew G Cottingham, Michael S Hollinshead, David J T Vau. Amyloid fibril formation by a synthetic peptide from a region of human acetylcholinesterase that is homologous to the Alzheimer's amyloid-beta peptide. Biochemistry. vol 41. issue 46. 2002-12-19. PMID:12427014. |
ache normally resides mainly on cholinergic neuronal membranes, but is abnormally localized to senile plaques in alzheimer's disease. |
2002-12-19 |
2023-08-12 |
human |
| Kazuo Isoma, Masago Ishikawa, Megumi Ohta, Yoichiro Ogawa, Hiroshi Hasegawa, Tadayuki Kohda, Junzo Kame. Effects of T-82, a new quinoline derivative, on cholinesterase activity and extracellular acetylcholine concentration in rat brain. Japanese journal of pharmacology. vol 88. issue 2. 2002-11-04. PMID:11928722. |
these findings suggest that t-82 activates the central cholinergic system by selectively inhibiting ache activity, while weakly affecting peripheral buche activity, and that t-82 increases the extracellular ach concentration in the brain, which is followed by inhibited ache activity. |
2002-11-04 |
2023-08-12 |
human |
| Ho-Jin Heo, Seong-Chan Hong, Hong-Yon Cho, Bumshik Hong, Hye-Kyung Kim, Eun-Ki Kim, Dong-Hoon Shi. Inhibitory effect of zeatin, isolated from Fiatoua villosa, on acetylcholinesterase activity from PC12 cells. Molecules and cells. vol 13. issue 1. 2002-10-10. PMID:11911460. |
acetylcholinesterase (ache) inhibitors, which enhance cholinergic transmission by reducing the enzymatic degradation of acetylcholine, are the only source of the compound that is currently approved for the treatment of alzheimer's disease (ad). |
2002-10-10 |
2023-08-12 |
Not clear |
| P Tario. Current status and new developments with galantamine in the treatment of Alzheimer's disease. Expert opinion on pharmacotherapy. vol 2. issue 12. 2002-09-26. PMID:11825333. |
galantamine is a newly available cholinergic drug that offsets reductions in central cholinergic neurotransmission in alzheimer's disease (ad) by specifically and reversibly inhibiting acetylcholinesterase (ache) and by allosterically modulating nicotinic cholinergic receptors. |
2002-09-26 |
2023-08-12 |
Not clear |
| Katsumi Sugasawa, Kōichi Andō, Takayuki Mōr. Noradrenergic and cholinergic nerves in the uterus of the Japanese long-fingered bat, Miniopterus schreibersii fuliginosus, change with reproductive cycle. Zoological science. vol 19. issue 4. 2002-09-23. PMID:12130815. |
the significant change in the innervation pattern of uterine na and ache nerves in the pregnant bats under and after hibernation, and in the postpartum bat must be considered in relation to the adrenergic and cholinergic controlling mechanisms on the uterine function that is matched for the unique reproductive cycle of this bat. |
2002-09-23 |
2023-08-12 |
Not clear |
| Sławomir Gralewicz, Piotr Lutz, Tadeusz Toma. Behavioural responsiveness to amphetamine or scopolamine following repeated exposure to chlorphenvinphos in rats. Acta neurobiologiae experimentalis. vol 62. issue 2. 2002-09-12. PMID:12201035. |
a number of reports indicate that exposure to organophosphates (ops), inhibitors of acetylcholinesterase (ache), may result in long-lasting neurobehavioural alterations suggestive of an increased cholinergic tone. |
2002-09-12 |
2023-08-12 |
rat |
| L Frölic. The cholinergic pathology in Alzheimer's disease--discrepancies between clinical experience and pathophysiological findings. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 7-8. 2002-09-06. PMID:12111437. |
new studies on the pathophysiology of the cholinergic system in ad suggest 1. that the cholinergic deficit occurs only late in the disease, 2. that at the earliest stages there even is an upregulation of cholinergic activity in the brain, and 3. that an increased activity of ache may develop under therapy with ache-i's. |
2002-09-06 |
2023-08-12 |
Not clear |
| Ezio Giacobini, R Spiegel, A Enz, A E Veroff, N R Cutle. Inhibition of acetyl- and butyryl-cholinesterase in the cerebrospinal fluid of patients with Alzheimer's disease by rivastigmine: correlation with cognitive benefit. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 7-8. 2002-09-06. PMID:12111443. |
these results indicate that cognitive improvement with rivastigmine in ad is associated with central inhibition of ches and support a role for central buche in addition to ache inhibition in modulating cholinergic function in ad. |
2002-09-06 |
2023-08-12 |
Not clear |
| A D Grant, M Shapira, H Sore. Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase. Cellular and molecular neurobiology. vol 21. issue 6. 2002-06-25. PMID:12043848. |
experimental evidence shows coregulation of murine ache and ars following confined swim, indicating coordinated locus response to stress, that is possibly mediated by altered cholinergic neurotransmission. |
2002-06-25 |
2023-08-12 |
Not clear |
| Gary B Quistad, Susan E Sparks, Yoffi Segall, Daniel K Nomura, John E Casid. Selective inhibitors of fatty acid amide hydrolase relative to neuropathy target esterase and acetylcholinesterase: toxicological implications. Toxicology and applied pharmacology. vol 179. issue 1. 2002-04-04. PMID:11884237. |
the overall in vivo findings with 16 compounds indicate the expected association of ache inhibition with acute or cholinergic syndrome and >70% brain nte inhibition with delayed neurotoxic action. |
2002-04-04 |
2023-08-12 |
mouse |
| E X Albuquerque, M D Santos, M Alkondon, E F Pereira, A Maelick. Modulation of nicotinic receptor activity in the central nervous system: a novel approach to the treatment of Alzheimer disease. Alzheimer disease and associated disorders. vol 15 Suppl 1. 2002-03-18. PMID:11669505. |
currently, cholinergic deficit is usually corrected by increasing the amount of acetylcholine in the synapse by inhibiting acetylcholinesterase (ache). |
2002-03-18 |
2023-08-12 |
Not clear |
| P N Tario. Maintaining cognitive function in Alzheimer disease: how effective are current treatments? Alzheimer disease and associated disorders. vol 15 Suppl 1. 2002-03-18. PMID:11669506. |
galantamine appears to be novel among marketed agents in that it inhibits ache and modulates cholinergic nicotinic receptors, perhaps increasing neurotransmission via both mechanisms. |
2002-03-18 |
2023-08-12 |
Not clear |