| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Srivatsa. Effects of organophosphates on cholinesterase activity and neurite regeneration in Aplysia. Chemico-biological interactions. vol 119-120. 1999-08-19. PMID:10421473. |
the effects of active site inhibited hemolymph ache was tested on large cholinergic neurons, r2 (abdominal ganglion) and lpl1 (left pleural ganglion) as well as small cholinergic neurons (buccal ganglion) of aplysia, maintained in culture. |
1999-08-19 |
2023-08-12 |
aplysia |
| M Srivatsa. Effects of organophosphates on cholinesterase activity and neurite regeneration in Aplysia. Chemico-biological interactions. vol 119-120. 1999-08-19. PMID:10421473. |
the results show that ache's catalytic action contributes to enhance neurite growth in cholinergic neurons and the effects of paraoxon appears to differ from that of echothiophate on cholinergic neurons of aplysia. |
1999-08-19 |
2023-08-12 |
aplysia |
| A Szutowicz, A Jankowska, J K Blusztajn, M Tomaszewic. Acetylcholine and acetyl-CoA metabolism in differentiating SN56 septal cell line. Journal of neuroscience research. vol 57. issue 1. 1999-08-04. PMID:10397643. |
overall, the results indicate that tra upregulates only chat expression, whereas dbcamp upregulates several features of cholinergic neurons including chat, ache, and acl. |
1999-08-04 |
2023-08-12 |
Not clear |
| U Simonsen, D Triguero, A García-Sacristán, D Priet. Cholinergic modulation of non-adrenergic, non-cholinergic relaxation in isolated, small coronary arteries from lambs. Pflugers Archiv : European journal of physiology. vol 438. issue 2. 1999-08-03. PMID:10370104. |
the presence of cholinergic innervation of small coronary arteries in the lamb was investigated by measuring choline acetyltransferase (chat) and acetylcholinesterase (ache) activities and by performing in vitro experiments in a microvascular myograph to establish whether or not there is a cholinergic component in the response to electrical field stimulation (efs). |
1999-08-03 |
2023-08-12 |
Not clear |
| H Thiermann, L Szinicz, F Eyer, F Worek, P Eyer, N Felgenhauer, T Zilke. Modern strategies in therapy of organophosphate poisoning. Toxicology letters. vol 107. issue 1-3. 1999-07-29. PMID:10414801. |
cholinergic signs soon subsided when ache was above 20% of normal, and atropine plasma levels could be kept below 7 ng/ml. |
1999-07-29 |
2023-08-12 |
Not clear |
| P G Genever, M A Birch, E Brown, T M Skerr. Osteoblast-derived acetylcholinesterase: a novel mediator of cell-matrix interactions in bone? Bone. vol 24. issue 4. 1999-07-28. PMID:10221541. |
these findings complement an increasing body of evidence which suggests that ache, in addition to its role in terminating cholinergic signaling, may be instrumental in regulating cellular differentiation and adhesion. |
1999-07-28 |
2023-08-12 |
human |
| R E Papka, H H Traurig, M Schemann, J Collins, T Copelin, K Wilso. Cholinergic neurons of the pelvic autonomic ganglia and uterus of the female rat: distribution of axons and presence of muscarinic receptors. Cell and tissue research. vol 296. issue 2. 1999-07-12. PMID:10382273. |
uterine cholinergic nerves arise from the paracervical ganglia and were, in the past, characterized based on acetylcholinesterase (ache) histochemistry. |
1999-07-12 |
2023-08-12 |
rat |
| H Tang, S M Miller, L G Ermilov, V A Lennon, S Brimijoi. Complement-mediated lesion of sympathetic ganglia in vitro with acetylcholinesterase antibodies. Journal of neuroimmunology. vol 97. issue 1-2. 1999-07-12. PMID:10408983. |
choline acetyltransferase activity (chat), an enzymatic marker of cholinergic cytoplasm in sympathetic ganglia, was largely lost after incubation with ache antibodies and serum. |
1999-07-12 |
2023-08-12 |
human |
| S Rossner, N Bakinde, U Zeitschel, R Schliebs, V Big. Cerebrospinal fluid cholinesterases--markers for loss of cholinergic basal forebrain neurons? International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 16. issue 7-8. 1999-07-07. PMID:10198815. |
to address this question enzyme activities of acetylcholinesterase (ache) and butyrylcholinesterase (bche) in both csf and parietal cortex were assayed following selective lesion of basal forebrain cholinergic neurons by a single intracerebroventricular application of the cholinergic immunotoxin 192igg-saporin. |
1999-07-07 |
2023-08-12 |
Not clear |
| S Rossner, N Bakinde, U Zeitschel, R Schliebs, V Big. Cerebrospinal fluid cholinesterases--markers for loss of cholinergic basal forebrain neurons? International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 16. issue 7-8. 1999-07-07. PMID:10198815. |
cholinergic immunolesions led to a dramatic decrease in total ache activity in parietal cortex, which was due to the specific loss of the g4 molecular form while the activity of the g1 form was increased as compared to nonlesioned animals. |
1999-07-07 |
2023-08-12 |
Not clear |
| S Olivera, D Rodriguez-Ithurralde, J M Henle. Acetylcholinesterase potentiates [3H]fluorowillardiine and [3H]AMPA binding to rat cortical membranes. Neuropharmacology. vol 38. issue 4. 1999-07-02. PMID:10221754. |
in addition to its action at cholinergic synapses acetylcholinesterase (ache) has been proposed to modulate neuronal activity by mechanisms unrelated to the hydrolysis of acetylcholine. |
1999-07-02 |
2023-08-12 |
rat |
| K Kato, H Hayako, Y Ishihara, S Marui, M Iwane, M Miyamot. TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons. Neuroscience letters. vol 260. issue 1. 1999-06-18. PMID:10027686. |
tak-147, a potent acetylcholinesterase (ache) inhibitor, potentiated choline acetyltransferase (chat) activity in cultured rat septal cholinergic neurons in a concentration-dependent manner with an ec50 value of 4.47 nm. |
1999-06-18 |
2023-08-12 |
rat |
| K Kato, H Hayako, Y Ishihara, S Marui, M Iwane, M Miyamot. TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons. Neuroscience letters. vol 260. issue 1. 1999-06-18. PMID:10027686. |
these results suggest that tak-147 may have neurotrophic activity on central cholinergic neurons, not via ache inhibition but possibly via an effect on tau receptors. |
1999-06-18 |
2023-08-12 |
rat |
| L O Koskinen, M L Koch, G Pu. The neuropeptide TRH has a minor effect on the enzymatic activity of acetylcholinesterase in vitro. Peptides. vol 19. issue 10. 1999-06-15. PMID:9880071. |
we conclude that any cholinergic effect of trh observed in vivo is unlikely to be due to a direct interaction of the peptide with ache. |
1999-06-15 |
2023-08-12 |
Not clear |
| C N Pop. Organophosphorus pesticides: do they all have the same mechanism of toxicity? Journal of toxicology and environmental health. Part B, Critical reviews. vol 2. issue 2. 1999-05-18. PMID:10230392. |
it is concluded that all op anticholinesterases potentially have a mechanism of toxicity in common, that is, phosphorylation of ache causing accumulation of acetylcholine, overstimulation of cholinergic receptors, and consequent clinical signs of cholinergic toxicity. |
1999-05-18 |
2023-08-12 |
Not clear |
| L L Carlock, W L Chen, E B Gordon, J C Killeen, A Manley, L S Meyer, L S Mullin, K J Pendino, A Percy, D E Sargent, L R Seaman, N K Svanborg, R H Stanton, C I Tellone, D L Van Goethe. Regulating and assessing risks of cholinesterase-inhibiting pesticides: divergent approaches and interpretations. Journal of toxicology and environmental health. Part B, Critical reviews. vol 2. issue 2. 1999-05-18. PMID:10230391. |
when available, cholinergic effects or brain ache inhibition data should take precedence over rbc ache for determining no-observed-effect levels (noels). |
1999-05-18 |
2023-08-12 |
human |
| L L Carlock, W L Chen, E B Gordon, J C Killeen, A Manley, L S Meyer, L S Mullin, K J Pendino, A Percy, D E Sargent, L R Seaman, N K Svanborg, R H Stanton, C I Tellone, D L Van Goethe. Regulating and assessing risks of cholinesterase-inhibiting pesticides: divergent approaches and interpretations. Journal of toxicology and environmental health. Part B, Critical reviews. vol 2. issue 2. 1999-05-18. PMID:10230391. |
when available, human rbc ache inhibition or cholinergic effects data should take precedence over animal data for determining noels. |
1999-05-18 |
2023-08-12 |
human |
| L L Carlock, W L Chen, E B Gordon, J C Killeen, A Manley, L S Meyer, L S Mullin, K J Pendino, A Percy, D E Sargent, L R Seaman, N K Svanborg, R H Stanton, C I Tellone, D L Van Goethe. Regulating and assessing risks of cholinesterase-inhibiting pesticides: divergent approaches and interpretations. Journal of toxicology and environmental health. Part B, Critical reviews. vol 2. issue 2. 1999-05-18. PMID:10230391. |
due to greater potential for adversity, noels for brain ache inhibition and cholinergic effects identified in animal studies should receive a default uncertainty factor of 100x; lower uncertainty factors may be used on a case-by-case basis. |
1999-05-18 |
2023-08-12 |
human |
| Z Gu, J Yu, J R Perez-Pol. Long term changes in brain cholinergic markers and nerve growth factor levels after partial immunolesion. Brain research. vol 801. issue 1-2. 1999-05-12. PMID:9729378. |
we measured two cholinergic markers, choline acetyltransferase (chat) and acetylcholinesterase (ache) activity, and ngf protein levels at 10 days, 1, 6 and 12 months postlesion. |
1999-05-12 |
2023-08-12 |
Not clear |
| G Kryger, I Silman, J L Sussma. Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure (London, England : 1993). vol 7. issue 3. 1999-05-06. PMID:10368299. |
it significantly enhances performance in animal models of cholinergic hypofunction and has a high affinity for ache, binding to both electric eel and mouse ache in the nanomolar range. |
1999-05-06 |
2023-08-12 |
mouse |