| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z P Yang, W D Dettbar. Prevention of tolerance to the organophosphorus anticholinesterase paraoxon with carboxylesterase inhibitors. Biochemical pharmacology. vol 55. issue 9. 1999-03-30. PMID:10076534. |
by eliminating plasma carbe (alpha-na) as potential binding sites for paraoxon with either cbdp or iso-ompa, paraoxon can exert its toxicity to a greater extent at its specific target site, the functionally important ache at cholinergic synapses. |
1999-03-30 |
2023-08-12 |
rat |
| M A Pombal, J Yáñez, O Marín, A González, R Anadó. Cholinergic and GABAergic neuronal elements in the pineal organ of lampreys, and tract-tracing observations of differential connections of pinealofugal neurons. Cell and tissue research. vol 295. issue 2. 1999-02-26. PMID:9931367. |
the putative cholinergic and gabaergic elements of the pineal organ of lampreys were investigated with immunocytochemistry to choline acetyltransferase (chat) and gamma-aminobutyric acid (gaba), and by acetylcholinesterase (ache) histochemistry. |
1999-02-26 |
2023-08-12 |
Not clear |
| A Morett. Experimental and clinical toxicology of anticholinesterase agents. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022304. |
the cholinergic syndrome appears at approximately 50% ache inhibition whereas death is believed to occur at > 90%. |
1999-02-25 |
2023-08-12 |
Not clear |
| A Morett. Experimental and clinical toxicology of anticholinesterase agents. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022304. |
op insecticides are more potent ache inhibitors rather than nte inhibitors and therefore, the dose required to cause opidp is much higher than that causing the cholinergic syndrome. |
1999-02-25 |
2023-08-12 |
Not clear |
| A P Pugovki. [Adrenergic innervation of the cerebral arteries following changes in the activity of cholinergic and monoaminergic brain systems]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 84. issue 9. 1999-01-21. PMID:9845911. |
changes in cholinesterase activity and catecholamine content in histochemically active nerves following administration of cholinesterase (ache) inhibiting agent phosphacol, seem to reflect compensatory responses to increasing dilatory cholinergic vasomotor effects under conditions of the ache activity. |
1999-01-21 |
2023-08-12 |
rat |
| R M Nitsch, S Rossner, C Albrecht, M Mayhaus, J Enderich, R Schliebs, M Wegner, T Arendt, H von der Kamme. Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter. Journal of physiology, Paris. vol 92. issue 3-4. 1999-01-13. PMID:9789819. |
in vivo studies with intraventricular infusions of the cholinergic immunotoxin 192 igg saporin showed more than 80% decrease of ache activity in cholinergic target areas of the hippocampus and brain cortex. |
1999-01-13 |
2023-08-12 |
human |
| R M Nitsch, S Rossner, C Albrecht, M Mayhaus, J Enderich, R Schliebs, M Wegner, T Arendt, H von der Kamme. Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter. Journal of physiology, Paris. vol 92. issue 3-4. 1999-01-13. PMID:9789819. |
the results are compatible with a combination of decreased ache activity in degenerating subcortical cholinergic projections, and additional decreases in postsynaptic ache gene expression. |
1999-01-13 |
2023-08-12 |
human |
| R M Nitsch, S Rossner, C Albrecht, M Mayhaus, J Enderich, R Schliebs, M Wegner, T Arendt, H von der Kamme. Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter. Journal of physiology, Paris. vol 92. issue 3-4. 1999-01-13. PMID:9789819. |
the results suggest a feedback mechanism by which the ache gene is activated by cholinergic neurotransmission, possibly leading to increased formation of ache protein and accelerated degradation of acetylcholine at cholinergic synapses. |
1999-01-13 |
2023-08-12 |
human |
| M Sabbatini, G Coppi, A Maggioni, V Olgiati, I Panocka, F Ament. Effect of lesions of the nucleus basalis magnocellularis and of treatment with posatirelin on cholinergic neurotransmission enzymes in the rat cerebral cortex. Mechanisms of ageing and development. vol 104. issue 2. 1999-01-07. PMID:9792196. |
the effect of 4 and 8 weeks of treatment with the thyrotropin releasing hormone (trh), analogue posatirelin (l-6-ketopiperidine-2-carbonyl-l-leucyl-proline amide), on the changes of cholinergic neurotransmission enzymes, choline acetyltransferase (chat) and acetylcholinesterase (ache), caused by lesions of the nucleus basalis magnocellularis (nbm), was investigated in the rat frontal cortex. |
1999-01-07 |
2023-08-12 |
rat |
| K J Fernandes, N R Kobayashi, B J Jasmin, W Tetzlaf. Acetylcholinesterase gene expression in axotomized rat facial motoneurons is differentially regulated by neurotrophins: correlation with trkB and trkC mRNA levels and isoforms. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 23. 1998-12-18. PMID:9822749. |
these results demonstrate that nt-4/5 and bdnf stimulate ache gene expression in motoneurons and support the concept that muscle-derived trkb ligands modulate the cholinergic phenotype of their innervating motoneurons. |
1998-12-18 |
2023-08-12 |
rat |
| S Darvesh, S E MacDonald, A M Losier, E Martin, D A Hopkins, J A Armou. Cholinesterases in cardiac ganglia and modulation of canine intrinsic cardiac neuronal activity. Journal of the autonomic nervous system. vol 71. issue 2-3. 1998-12-11. PMID:9760044. |
cholinergic neurotransmission plays a significant role in intrinsic cardiac ganglia with the action of acetylcholine being terminated by acetylcholinesterase (ache, ec 3.1.1.7). |
1998-12-11 |
2023-08-12 |
Not clear |
| O I Casanueva, P Deprez, T García-Huidobro, N C Inestros. At least two receptors of asymmetric acetylcholinesterase are present at the synaptic basal lamina of Torpedo electric organ. Biochemical and biophysical research communications. vol 250. issue 2. 1998-11-05. PMID:9753626. |
asymmetric acetylcholinesterase (ache) is anchored to the basal lamina (bl) of cholinergic synapses via its collagenic tail, yet the complement of matrix receptors involved in its attachment remains unknown. |
1998-11-05 |
2023-08-12 |
Not clear |
| B Wiedenmann, C Riedel, M John, G Ahnert-Hilger, G Stoltenburg, J Waldschmidt, K von Deimling, E O Riecken, F Schie. Qualitative and quantitative analysis of synapses in Hirschsprung's disease. Pediatric surgery international. vol 13. issue 7. 1998-11-03. PMID:9716672. |
our data also suggest that nerve endings in hd may contain high concentrations of cholinergic vesicles, paralleling the known high amounts of acetylcholine and ache found in intestinal segments of patients with hd. |
1998-11-03 |
2023-08-12 |
Not clear |
| L E Tune, T Sunderlan. New cholinergic therapies: treatment tools for the psychiatrist. The Journal of clinical psychiatry. vol 59 Suppl 13. 1998-10-20. PMID:9771828. |
the focus is on pivotal articles investigating the role of cholinergic augmentation strategies, including precursor loading and acetylcholinesterase (ache) inhibitors, in the management of cognitive and noncognitive symptoms of alzheimer's disease. |
1998-10-20 |
2023-08-12 |
Not clear |
| G Amitai, D Moorad, R Adani, B P Docto. Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon. Biochemical pharmacology. vol 56. issue 3. 1998-10-02. PMID:9744565. |
the insecticidal action of chlorpyrifos stems from inhibition of acetylcholinesterase (ache) by cpo, resulting in severe cholinergic toxicity. |
1998-10-02 |
2023-08-12 |
mouse |
| C Andres, S Seidman, R Beeri, R Timberg, H Sore. Transgenic acetylcholinesterase induces enlargement of murine neuromuscular junctions but leaves spinal cord synapses intact. Neurochemistry international. vol 32. issue 5-6. 1998-09-25. PMID:9676744. |
here we show that transgenic mice expressing human ache in their spinal cord motoneurons display primarily normal axo-dendritic spinal cord cholinergic synapses in spite of the clear excess of transgenic over host ache within these synapses. |
1998-09-25 |
2023-08-12 |
mouse |
| Z J Zhang, D A Lappi, C C Wrenn, T A Milner, R G Wile. Selective lesion of the cholinergic basal forebrain causes a loss of cortical neuropeptide Y and somatostatin neurons. Brain research. vol 800. issue 2. 1998-09-04. PMID:9685641. |
these findings indicate that: (1) cholinergic denervation of the nbm is associated with an irreversible loss of neocortical npy and ss immunoreactive neurons analogous to that observed in alzheimer's disease and aging; (2) the degree of the loss of cortical npy and ss immunoreactive neurons seems to be related to the extent of the reduction of cortical ache intensity in both toxin-injected and normal aged rats. |
1998-09-04 |
2023-08-12 |
rat |
| A Marín Burgin, L Szczupa. Basal acetylcholine release in leech ganglia depolarizes neurons through receptors with a nicotinic binding site. The Journal of experimental biology. vol 201. issue Pt 12. 1998-08-24. PMID:9722429. |
other neurons in the ganglion showed distinctive responses to the ache inhibitors that were coincident with their responses to cholinergic agonists. |
1998-08-24 |
2023-08-12 |
Not clear |
| P Taylo. Development of acetylcholinesterase inhibitors in the therapy of Alzheimer's disease. Neurology. vol 51. issue 1 Suppl 1. 1998-07-30. PMID:9674760. |
acetylcholinesterase (ache) inhibitors were first administered in europe to human subjects in the 1860s, and synthetic derivatives of the natural alkaloid inhibitors were developed in the 1930s to modulate peripheral cholinergic function. |
1998-07-30 |
2023-08-12 |
human |
| S Darvesh, D L Grantham, D A Hopkin. Distribution of butyrylcholinesterase in the human amygdala and hippocampal formation. The Journal of comparative neurology. vol 393. issue 3. 1998-07-15. PMID:9548556. |
the distribution of the major cholinergic regulatory enzyme acetylcholinesterase (ache, ec 3.1.1.7) has been extensively studied in the human brain, but the distribution of the closely related enzyme butyrylcholinesterase (buche, ec 3.1.1.8) is largely unknown. |
1998-07-15 |
2023-08-12 |
human |