| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z J Zhang, D A Lappi, C C Wrenn, T A Milner, R G Wile. Selective lesion of the cholinergic basal forebrain causes a loss of cortical neuropeptide Y and somatostatin neurons. Brain research. vol 800. issue 2. 1998-09-04. PMID:9685641. |
these findings indicate that: (1) cholinergic denervation of the nbm is associated with an irreversible loss of neocortical npy and ss immunoreactive neurons analogous to that observed in alzheimer's disease and aging; (2) the degree of the loss of cortical npy and ss immunoreactive neurons seems to be related to the extent of the reduction of cortical ache intensity in both toxin-injected and normal aged rats. |
1998-09-04 |
2023-08-12 |
rat |
| A Marín Burgin, L Szczupa. Basal acetylcholine release in leech ganglia depolarizes neurons through receptors with a nicotinic binding site. The Journal of experimental biology. vol 201. issue Pt 12. 1998-08-24. PMID:9722429. |
other neurons in the ganglion showed distinctive responses to the ache inhibitors that were coincident with their responses to cholinergic agonists. |
1998-08-24 |
2023-08-12 |
Not clear |
| P Taylo. Development of acetylcholinesterase inhibitors in the therapy of Alzheimer's disease. Neurology. vol 51. issue 1 Suppl 1. 1998-07-30. PMID:9674760. |
acetylcholinesterase (ache) inhibitors were first administered in europe to human subjects in the 1860s, and synthetic derivatives of the natural alkaloid inhibitors were developed in the 1930s to modulate peripheral cholinergic function. |
1998-07-30 |
2023-08-12 |
human |
| S Darvesh, D L Grantham, D A Hopkin. Distribution of butyrylcholinesterase in the human amygdala and hippocampal formation. The Journal of comparative neurology. vol 393. issue 3. 1998-07-15. PMID:9548556. |
the distribution of the major cholinergic regulatory enzyme acetylcholinesterase (ache, ec 3.1.1.7) has been extensively studied in the human brain, but the distribution of the closely related enzyme butyrylcholinesterase (buche, ec 3.1.1.8) is largely unknown. |
1998-07-15 |
2023-08-12 |
human |
| W Yao, D A Godfre. Immunohistochemical evaluation of cholinergic neurons in the rat superior olivary complex. Microscopy research and technique. vol 41. issue 3. 1998-07-02. PMID:9605344. |
the cholinergic system in the rat superior olivary complex (soc) was evaluated by immunohistochemistry for choline acetyltransferase (chat) and vesicular acetylcholine transporter (vacht) and histochemistry for acetylcholinesterase (ache). |
1998-07-02 |
2023-08-12 |
rat |
| S Gralewicz, R Soćk. Persisting behavioural and electroencephalographic effects of exposure to chlorphenvinphos, an organophosphorous pesticide, in laboratory animals. International journal of occupational medicine and environmental health. vol 10. issue 4. 1998-06-03. PMID:9575664. |
this would indicate that the changes in the cns functions after cvp exposure may be the consequence of increased cholinergic activity due to ache inhibition rather than to a direct stimulation of cholinergic muscarinic receptors by cvp. |
1998-06-03 |
2023-08-12 |
rat |
| J Aisa, M Lahoz, P J Serrano, T Castiella, C Junquera, M J Azanza, A Vera-Gi. Histochemical, immunohistochemical, and electron microscopy study of the caudal portion of the chicken intestinal nerve of Remak. Neurochemical research. vol 23. issue 6. 1998-05-29. PMID:9572673. |
we have found cholinergic cell bodies, as well as acetylcholinesterase (ache) positive neuronal fibers, forming part of the web that constitutes the i.n.r. |
1998-05-29 |
2023-08-12 |
chicken |
| E Apartis, F R Poindessous-Jazat, Y A Lamour, M H Bassan. Loss of rhythmically bursting neurons in rat medial septum following selective lesion of septohippocampal cholinergic system. Journal of neurophysiology. vol 79. issue 4. 1998-05-27. PMID:9535934. |
acetylcholinesterase (ache) histochemistry revealed a near-complete loss of cholinergic septal neurons and of cholinergic fibers in the hippocampus. |
1998-05-27 |
2023-08-12 |
rat |
| T Harkany, S O'Mahony, J P Kelly, K Soós, I Törõ, B Penke, P G Luiten, C Nyakas, K Gulya, B E Leonar. Beta-amyloid(Phe(SO3H)24)25-35 in rat nucleus basalis induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic innervation. Behavioural brain research. vol 90. issue 2. 1998-05-27. PMID:9580273. |
subsequently, acetylcholinesterase (ache) histochemistry was used to visualize alterations of parietal cortical cholinergic innervation. |
1998-05-27 |
2023-08-12 |
rat |
| J Liu, C N Pop. Comparative presynaptic neurochemical changes in rat striatum following exposure to chlorpyrifos or parathion. Journal of toxicology and environmental health. Part A. vol 53. issue 7. 1998-04-30. PMID:9561967. |
while compensatory changes in postsynaptic receptors can modulate the clinical expression of ache inhibition and lead to tolerance to these toxicants, we propose that op-selective changes in presynaptic cholinergic processes can also regulate the ultimate consequences of ache inhibition. |
1998-04-30 |
2023-08-12 |
rat |
| J Liu, C N Pop. Comparative presynaptic neurochemical changes in rat striatum following exposure to chlorpyrifos or parathion. Journal of toxicology and environmental health. Part A. vol 53. issue 7. 1998-04-30. PMID:9561967. |
these results suggest that different ops may selectively modify presynaptic cholinergic processes and that early, op-selective changes in hacu/ach synthesis may contribute to the differential toxicity noted following extensive ache inhibition by either cpf or ps. |
1998-04-30 |
2023-08-12 |
rat |
| J M Cermak, T Holler, D A Jackson, J K Blusztaj. Prenatal availability of choline modifies development of the hippocampal cholinergic system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 12. issue 3. 1998-03-31. PMID:9506479. |
to characterize the neurochemical mechanisms that may mediate this effect, we investigated the development of indices of the cholinergic system in the hippocampus: choline acetyltransferase (chat), acetylcholinesterase (ache), synthesis of acetylcholine (ach) from choline transported by high-affinity choline uptake (hacu), and potassium-evoked ach release. |
1998-03-31 |
2023-08-12 |
rat |
| L Coniglio, A Morale, C Angelini, C Falug. Cholinergic activation of settlement in Ciona intestinalis metamorphosing larvae. The Journal of experimental zoology. vol 280. issue 4. 1998-03-27. PMID:9493350. |
in free-swimming tadpoles, ache activity was localized by histochemical methods at the cell surface of the adhesive papillae, suggesting the possible presence of a cholinergic system in these structures. |
1998-03-27 |
2023-08-12 |
Not clear |
| M Brank, K Zajc-Kreft, S Kreft, R Komel, Z Grubi. Biogenesis of acetylcholinesterase is impaired, although its mRNA level remains normal, in the glucocorticoid-treated rat skeletal muscle. European journal of biochemistry. vol 251. issue 1-2. 1998-03-23. PMID:9492307. |
acetylcholinesterase (ache) is responsible for the hydrolysis of acetylcholine in the neuromuscular junction and other cholinergic synapses. |
1998-03-23 |
2023-08-12 |
rat |
| S Gralewic. [Possible consequences of AChE inhibition in organophosphate poisoning. A new approach to an old problem]. Medycyna pracy. vol 48. issue 4. 1998-02-18. PMID:9471495. |
since a long time it has been known, however, that in the nervous system the localization pattern of ache does not overlap the localization of cholinergic neurons, and several recent findings show that apart from being the ach hydrolyzing enzyme, ache is also a neuromodulator participating in the phenomenon of neuronal plasticity i.e. |
1998-02-18 |
2023-08-12 |
Not clear |
| S Gralewic. [Possible consequences of AChE inhibition in organophosphate poisoning. A new approach to an old problem]. Medycyna pracy. vol 48. issue 4. 1998-02-18. PMID:9471495. |
it is likely then, that out of the known effects of op poisoning regarded as results of cholinergic hyperactivity some are due to the loss of the nonenzymatic, neuromodulatory role of ache. |
1998-02-18 |
2023-08-12 |
Not clear |
| M Grifman, A Arbel, D Ginzberg, D Glick, S Elgavish, B Shaanan, H Sore. In vitro phosphorylation of acetylcholinesterase at non-consensus protein kinase A sites enhances the rate of acetylcholine hydrolysis. Brain research. Molecular brain research. vol 51. issue 1-2. 1998-02-17. PMID:9427520. |
in vivo suppression of the acetylcholine hydrolyzing activity of ache and consequent impairment in cholinergic neurotransmission occur under exposure to both natural and pharmacological compounds, including organophosphate and carbamate insecticides and chemical warfare agents. |
1998-02-17 |
2023-08-12 |
human |
| M Grifman, A Arbel, D Ginzberg, D Glick, S Elgavish, B Shaanan, H Sore. In vitro phosphorylation of acetylcholinesterase at non-consensus protein kinase A sites enhances the rate of acetylcholine hydrolysis. Brain research. Molecular brain research. vol 51. issue 1-2. 1998-02-17. PMID:9427520. |
phosphorylation of ache may possibly offer a rapid feedback mechanism that can compensate for impairments in cholinergic neurotransmission, modulating the hydrolytic activity of this enzyme and enabling acetylcholine hydrolysis to proceed under such challenges. |
1998-02-17 |
2023-08-12 |
human |
| M Grifman, H Sore. Differentiation intensifies the susceptibility of pheochromocytoma cells to antisense oligodeoxynucleotide-dependent suppression of acetylcholinesterase activity. Antisense & nucleic acid drug development. vol 7. issue 4. 1998-02-05. PMID:9303187. |
our findings demonstrate a differentiation-related increase in the susceptibility of pc12 cells to inhibition by specific as-odns, suggesting the use of this model system to select as-odns for suppression of ache levels in the treatment of neurodegenerative diseases associated with cholinergic malfunction. |
1998-02-05 |
2023-08-12 |
rat |
| Y Zhang, P L Carlen, L Zhan. Kinetics of muscarinic reduction of IsAHP in hippocampal neurons: effects of acetylcholinesterase inhibitors. Journal of neurophysiology. vol 78. issue 6. 1998-02-05. PMID:9405519. |
the present experiments were designed to elucidate the time frame in which an evoked cholinergic impulse decreases the ca2+-dependent k+ current (isahp) in hippocampal ca1 neurons, and to determine to what extent acetylcholinesterase (ache) inhibitors enhance the efficacy of the cholinergic impulse. |
1998-02-05 |
2023-08-12 |
rat |