| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Kato, H Hayako, Y Ishihara, S Marui, M Iwane, M Miyamot. TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons. Neuroscience letters. vol 260. issue 1. 1999-06-18. PMID:10027686. |
tak-147, a potent acetylcholinesterase (ache) inhibitor, potentiated choline acetyltransferase (chat) activity in cultured rat septal cholinergic neurons in a concentration-dependent manner with an ec50 value of 4.47 nm. |
1999-06-18 |
2023-08-12 |
rat |
| K Kato, H Hayako, Y Ishihara, S Marui, M Iwane, M Miyamot. TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons. Neuroscience letters. vol 260. issue 1. 1999-06-18. PMID:10027686. |
these results suggest that tak-147 may have neurotrophic activity on central cholinergic neurons, not via ache inhibition but possibly via an effect on tau receptors. |
1999-06-18 |
2023-08-12 |
rat |
| L O Koskinen, M L Koch, G Pu. The neuropeptide TRH has a minor effect on the enzymatic activity of acetylcholinesterase in vitro. Peptides. vol 19. issue 10. 1999-06-15. PMID:9880071. |
we conclude that any cholinergic effect of trh observed in vivo is unlikely to be due to a direct interaction of the peptide with ache. |
1999-06-15 |
2023-08-12 |
Not clear |
| C N Pop. Organophosphorus pesticides: do they all have the same mechanism of toxicity? Journal of toxicology and environmental health. Part B, Critical reviews. vol 2. issue 2. 1999-05-18. PMID:10230392. |
it is concluded that all op anticholinesterases potentially have a mechanism of toxicity in common, that is, phosphorylation of ache causing accumulation of acetylcholine, overstimulation of cholinergic receptors, and consequent clinical signs of cholinergic toxicity. |
1999-05-18 |
2023-08-12 |
Not clear |
| L L Carlock, W L Chen, E B Gordon, J C Killeen, A Manley, L S Meyer, L S Mullin, K J Pendino, A Percy, D E Sargent, L R Seaman, N K Svanborg, R H Stanton, C I Tellone, D L Van Goethe. Regulating and assessing risks of cholinesterase-inhibiting pesticides: divergent approaches and interpretations. Journal of toxicology and environmental health. Part B, Critical reviews. vol 2. issue 2. 1999-05-18. PMID:10230391. |
when available, cholinergic effects or brain ache inhibition data should take precedence over rbc ache for determining no-observed-effect levels (noels). |
1999-05-18 |
2023-08-12 |
human |
| L L Carlock, W L Chen, E B Gordon, J C Killeen, A Manley, L S Meyer, L S Mullin, K J Pendino, A Percy, D E Sargent, L R Seaman, N K Svanborg, R H Stanton, C I Tellone, D L Van Goethe. Regulating and assessing risks of cholinesterase-inhibiting pesticides: divergent approaches and interpretations. Journal of toxicology and environmental health. Part B, Critical reviews. vol 2. issue 2. 1999-05-18. PMID:10230391. |
when available, human rbc ache inhibition or cholinergic effects data should take precedence over animal data for determining noels. |
1999-05-18 |
2023-08-12 |
human |
| L L Carlock, W L Chen, E B Gordon, J C Killeen, A Manley, L S Meyer, L S Mullin, K J Pendino, A Percy, D E Sargent, L R Seaman, N K Svanborg, R H Stanton, C I Tellone, D L Van Goethe. Regulating and assessing risks of cholinesterase-inhibiting pesticides: divergent approaches and interpretations. Journal of toxicology and environmental health. Part B, Critical reviews. vol 2. issue 2. 1999-05-18. PMID:10230391. |
due to greater potential for adversity, noels for brain ache inhibition and cholinergic effects identified in animal studies should receive a default uncertainty factor of 100x; lower uncertainty factors may be used on a case-by-case basis. |
1999-05-18 |
2023-08-12 |
human |
| Z Gu, J Yu, J R Perez-Pol. Long term changes in brain cholinergic markers and nerve growth factor levels after partial immunolesion. Brain research. vol 801. issue 1-2. 1999-05-12. PMID:9729378. |
we measured two cholinergic markers, choline acetyltransferase (chat) and acetylcholinesterase (ache) activity, and ngf protein levels at 10 days, 1, 6 and 12 months postlesion. |
1999-05-12 |
2023-08-12 |
Not clear |
| G Kryger, I Silman, J L Sussma. Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure (London, England : 1993). vol 7. issue 3. 1999-05-06. PMID:10368299. |
it significantly enhances performance in animal models of cholinergic hypofunction and has a high affinity for ache, binding to both electric eel and mouse ache in the nanomolar range. |
1999-05-06 |
2023-08-12 |
mouse |
| H Namba, M Iyo, K Fukushi, H Shinotoh, S Nagatsuka, T Suhara, Y Sudo, K Suzuki, T Iri. Human cerebral acetylcholinesterase activity measured with positron emission tomography: procedure, normal values and effect of age. European journal of nuclear medicine. vol 26. issue 2. 1999-04-27. PMID:9933347. |
no significant effect of age was found on ache activity of the cerebral cortex, suggesting that the ascending central cholinergic system is preserved in normal aging. |
1999-04-27 |
2023-08-12 |
human |
| C Crespo, J G Briñón, A Porteros, R Arévalo, B Rico, J Aijón, J R Alons. Distribution of acetylcholinesterase and choline acetyltransferase in the main and accessory olfactory bulbs of the hedgehog (Erinaceus europaeus). The Journal of comparative neurology. vol 403. issue 1. 1999-04-27. PMID:10075443. |
the distribution of cholinergic markers was studied in the main olfactory bulb (mob) and accessory olfactory bulb (aob) of the western european hedgehog (erinaceus europaeus) by using choline acetyltransferase (chat) immunocytochemistry and acetylcholinesterase (ache) histochemistry. |
1999-04-27 |
2023-08-12 |
Not clear |
| R C Choi, S C Yam, B Hui, D C Wan, K W Tsi. Over-expression of acetylcholinesterase stimulates the expression of agrin in NG108-15 cells. Neuroscience letters. vol 248. issue 1. 1999-03-30. PMID:9665653. |
in order to support the hypothesis, a cholinergic synapse-forming cell line ng108-15 was over-expressed with chick ache by cdna transfection. |
1999-03-30 |
2023-08-12 |
chicken |
| Z P Yang, W D Dettbar. Prevention of tolerance to the organophosphorus anticholinesterase paraoxon with carboxylesterase inhibitors. Biochemical pharmacology. vol 55. issue 9. 1999-03-30. PMID:10076534. |
daily injections (20 days) of paraoxon (0.09 mg/kg) led to a cumulative dose that was 9.0-fold higher than the acute ed50 of 0.20 mg/kg, s.c. during this period, the rats did not demonstrate visible signs of cholinergic hyperactivity nor did they die, despite the persistence of critically reduced brain acetylcholinesterase (ache) activity (20-30% of control). |
1999-03-30 |
2023-08-12 |
rat |
| Z P Yang, W D Dettbar. Prevention of tolerance to the organophosphorus anticholinesterase paraoxon with carboxylesterase inhibitors. Biochemical pharmacology. vol 55. issue 9. 1999-03-30. PMID:10076534. |
by eliminating plasma carbe (alpha-na) as potential binding sites for paraoxon with either cbdp or iso-ompa, paraoxon can exert its toxicity to a greater extent at its specific target site, the functionally important ache at cholinergic synapses. |
1999-03-30 |
2023-08-12 |
rat |
| M A Pombal, J Yáñez, O Marín, A González, R Anadó. Cholinergic and GABAergic neuronal elements in the pineal organ of lampreys, and tract-tracing observations of differential connections of pinealofugal neurons. Cell and tissue research. vol 295. issue 2. 1999-02-26. PMID:9931367. |
the putative cholinergic and gabaergic elements of the pineal organ of lampreys were investigated with immunocytochemistry to choline acetyltransferase (chat) and gamma-aminobutyric acid (gaba), and by acetylcholinesterase (ache) histochemistry. |
1999-02-26 |
2023-08-12 |
Not clear |
| A Morett. Experimental and clinical toxicology of anticholinesterase agents. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022304. |
the cholinergic syndrome appears at approximately 50% ache inhibition whereas death is believed to occur at > 90%. |
1999-02-25 |
2023-08-12 |
Not clear |
| A Morett. Experimental and clinical toxicology of anticholinesterase agents. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022304. |
op insecticides are more potent ache inhibitors rather than nte inhibitors and therefore, the dose required to cause opidp is much higher than that causing the cholinergic syndrome. |
1999-02-25 |
2023-08-12 |
Not clear |
| A P Pugovki. [Adrenergic innervation of the cerebral arteries following changes in the activity of cholinergic and monoaminergic brain systems]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 84. issue 9. 1999-01-21. PMID:9845911. |
changes in cholinesterase activity and catecholamine content in histochemically active nerves following administration of cholinesterase (ache) inhibiting agent phosphacol, seem to reflect compensatory responses to increasing dilatory cholinergic vasomotor effects under conditions of the ache activity. |
1999-01-21 |
2023-08-12 |
rat |
| R M Nitsch, S Rossner, C Albrecht, M Mayhaus, J Enderich, R Schliebs, M Wegner, T Arendt, H von der Kamme. Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter. Journal of physiology, Paris. vol 92. issue 3-4. 1999-01-13. PMID:9789819. |
in vivo studies with intraventricular infusions of the cholinergic immunotoxin 192 igg saporin showed more than 80% decrease of ache activity in cholinergic target areas of the hippocampus and brain cortex. |
1999-01-13 |
2023-08-12 |
human |
| R M Nitsch, S Rossner, C Albrecht, M Mayhaus, J Enderich, R Schliebs, M Wegner, T Arendt, H von der Kamme. Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter. Journal of physiology, Paris. vol 92. issue 3-4. 1999-01-13. PMID:9789819. |
the results are compatible with a combination of decreased ache activity in degenerating subcortical cholinergic projections, and additional decreases in postsynaptic ache gene expression. |
1999-01-13 |
2023-08-12 |
human |