| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Marcho. [The fasciculin-acetylcholinesterase interaction]. Journal de la Societe de biologie. vol 193. issue 6. 2000-06-19. PMID:10783708. |
acetylcholinesterase (ache) terminates the action of the neurotransmitter acetylcholine at cholinergic synapses in the central and peripheral nervous systems. |
2000-06-19 |
2023-08-12 |
mouse |
| H N Nigg, J B Knaa. Blood cholinesterases as human biomarkers of organophosphorus pesticide exposure. Reviews of environmental contamination and toxicology. vol 163. 2000-05-03. PMID:10771584. |
ops exert their insecticidal action by their ability to inhibit ache at the cholinergic synapse, resulting in the accumulation of acetylcholine. |
2000-05-03 |
2023-08-12 |
human |
| G L Wenk, G Quack, H J Moebius, W Danys. No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use. Life sciences. vol 66. issue 12. 2000-03-31. PMID:10737358. |
new drug therapies have been designed to either enhance cholinergic function by inhibition acetylcholinesterase (ache), e.g. |
2000-03-31 |
2023-08-12 |
Not clear |
| Y Ishihara, G Goto, M Miyamot. Central selective acetylcholinesterase inhibitor with neurotrophic activity: structure-activity relationships of TAK-147 and related compounds. Current medicinal chemistry. vol 7. issue 3. 2000-03-30. PMID:10637368. |
furthermore, tak-147 was revealed to have ngf-like neurotrophic activity on central cholinergic neurons at concentrations where it inhibits ache activity. |
2000-03-30 |
2023-08-12 |
Not clear |
| Y Li, L Liu, J Kang, J G Sheng, S W Barger, R E Mrak, W S Griffi. Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 1. 2000-01-27. PMID:10627591. |
cholinergic dysfunction in alzheimer's disease has been attributed to stress-induced increases in acetylcholinesterase (ache) activity. |
2000-01-27 |
2023-08-12 |
rat |
| K Ojika, S Mitake, N Tohdoh, S H Appel, Y Otsuka, E Katada, N Matsukaw. Hippocampal cholinergic neurostimulating peptides (HCNP). Progress in neurobiology. vol 60. issue 1. 2000-01-20. PMID:10622376. |
one of these components, originally purified from young rat hippocampus, is a novel undecapeptide (hippocampal cholinergic neurostimulating peptide; hcnp); this enhances the production of chat, but not of ache. |
2000-01-20 |
2023-08-12 |
rat |
| T Arendt, K Lehmann, G Seeger, U Gärtne. Synergistic effects of tetrahydroaminoacridine and lithium on cholinergic function after excitotoxic basal forebrain lesions in rat. Pharmacopsychiatry. vol 32. issue 6. 2000-01-12. PMID:10599934. |
rats received ibotenic acid lesions of cholinergic basal forebrain nuclei resulting in a 30% to 40% depletion of both cortical choline acetyltransferase (chat) and acetylcholinesterase (ache) activity. |
2000-01-12 |
2023-08-12 |
rat |
| b' E Krejci, C Legay, S Thomine, J Sketelj, J Massouli\\xc3\\xa. Differences in expression of acetylcholinesterase and collagen Q control the distribution and oligomerization of the collagen-tailed forms in fast and slow muscles. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 24. 2000-01-06. PMID:10594051.' |
collagen-tailed ache represents the first evidence that synaptic components involved in cholinergic transmission may be differently regulated in fast and slow muscles. |
2000-01-06 |
2023-08-12 |
rat |
| H M Dodds, L P Rivor. The mechanism for the inhibition of acetylcholinesterases by irinotecan (CPT-11). Molecular pharmacology. vol 56. issue 6. 1999-12-17. PMID:10570064. |
the rapid reversibility of the inhibition of ache by cpt-11 and the lower activity of the carboxylate form are likely reasons for the transient nature of the cholinergic toxicity observed clinically. |
1999-12-17 |
2023-08-12 |
human |
| E B Abdelsala. Neurotoxic potential of six organophosphorus compounds in adult hens. Veterinary and human toxicology. vol 41. issue 5. 1999-11-26. PMID:10509429. |
with the exception of leptophos, all compounds produced severe cholinergic signs associated with > 80% inhibition of brain ache at 24 h. on the other hand, brain nte activity was 86% inhibited by leptophos and to lesser extents by trichlorfon (76%), phosphamidon (74%), coumaphos (70%) and dichlorvos (70%). |
1999-11-26 |
2023-08-12 |
Not clear |
| T Kosasa, Y Kuriya, K Matsui, Y Yamanish. Effect of donepezil hydrochloride (E2020) on basal concentration of extracellular acetylcholine in the hippocampus of rats. European journal of pharmacology. vol 380. issue 2-3. 1999-11-01. PMID:10513568. |
these results suggest that oral administration of donepezil, tacrine and ena-713 increases acetylcholine concentration in the synaptic cleft of the hippocampus mostly through ache inhibition, and that donepezil has a more potent activity than tacrine and a longer-lasting effect than ena-713 on the central cholinergic system. |
1999-11-01 |
2023-08-12 |
rat |
| I Niebrój-Dobosz, I Domitrz, A Mickielewic. Cytotoxic activity of serum and cerebrospinal fluid of amyotrophic lateral sclerosis (ALS) patients against acetylcholinesterase. Folia neuropathologica. vol 37. issue 2. 1999-10-29. PMID:10464429. |
the ache activity in serum and csf is the consequence of the enzyme leakage from brain, degenerating cholinergic neurons and neuromuscular junctions. |
1999-10-29 |
2023-08-12 |
human |
| X Cousin, C Bo. Acetylcholinesterase from snake venom as a model for its nerve and muscle counterpart. Journal of natural toxins. vol 8. issue 2. 1999-10-18. PMID:10410339. |
acetylcholinesterase (ache) plays a key role in cholinergic transmission. |
1999-10-18 |
2023-08-12 |
Not clear |
| X Cousin, C Bo. Acetylcholinesterase from snake venom as a model for its nerve and muscle counterpart. Journal of natural toxins. vol 8. issue 2. 1999-10-18. PMID:10410339. |
the presence of ache in tissues devoid of cholinergic function is also well known and raises the question of its role. |
1999-10-18 |
2023-08-12 |
Not clear |
| E W Cheon, T Sait. Choline acetyltransferase and acetylcholinesterase in the normal, developing and regenerating newt retinas. Brain research. Developmental brain research. vol 116. issue 1. 1999-10-07. PMID:10446351. |
to elucidate whether retinal regeneration follows the same sequence of cellular differentiation steps that occur in retinal development, we examined the time course of appearance of the cholinergic neurons and ache activity in both developing and regenerating retinas. |
1999-10-07 |
2023-08-12 |
Not clear |
| H Shinoto. [PET study of cholinergic system in the brain]. Rinsho shinkeigaku = Clinical neurology. vol 39. issue 1. 1999-09-15. PMID:10377794. |
recently, we have developed a method to measure acetylcholinesterase (ache) activity, a functional marker for cholinergic system, by positron emission tomography (pet) and carbon-11 labeled n-methyl-4-piperidyl acetate. |
1999-09-15 |
2023-08-12 |
human |
| D I Mitsur. [Changes of the aluminum and silicon contents and cholinergic activity of the blood depending on the course of the gastroduodenal ulcer]. Klinichna khirurhiia. issue 5. 1999-09-08. PMID:10429395. |
in 37 patients with gastroduodenal ulcer disease were revealed the changes of concentration of aluminium and silicon in blood, of acetylcholine in erythrocytes and plasma, the cholinesterase (ache) activity depending on the disease clinical course, the ulcer size; the interconnection between the blood cholinergic activity and the contents of aluminium and silicon; the influence of aluminium and silicon ions on the ache activity of plasma and erythrocytes, what is confirmed by the correlational analysis data and gives and arguments for application of chemical compounds with aluminium and silicon in treatment and prophylaxis of an ulcer disease recurrence. |
1999-09-08 |
2023-08-12 |
Not clear |
| C A Nurse, M Zhan. Acetylcholine contributes to hypoxic chemotransmission in co-cultures of rat type 1 cells and petrosal neurons. Respiration physiology. vol 115. issue 2. 1999-08-27. PMID:10385033. |
recent evidence has strengthened the case for acetylcholine (ach) as a co-released transmitter: (i) cultured type 1 cells express several cholinergic markers including the vesicular ach transporter (vacht), intracellular acetylcholinesterase (ache), and occasional clear cored vesicles (approximately 50 nm diameter); (ii) the frequency of spontaneous synaptic activity, as well as the hypoxia-induced depolarization recorded in 'juxtaposed' pn in co-culture, were partially suppressed by the nicotinic ach receptor (nachr) blocker, mecamylamine (2 microm); (iii) consistent with the presence of extracellular ache, ach-mediated membrane noise in type 1 cells as well as the hypoxia-evoked pn response in co-culture were potentiated in a few cases by the ache inhibitor, eserine (100 microm). |
1999-08-27 |
2023-08-12 |
rat |
| M Srivatsa. Effects of organophosphates on cholinesterase activity and neurite regeneration in Aplysia. Chemico-biological interactions. vol 119-120. 1999-08-19. PMID:10421473. |
in aplysia, a marine mollusc, acetylcholinesterase (ache) is present in cholinergic and non-cholinergic neurons and in hemolymph. |
1999-08-19 |
2023-08-12 |
aplysia |
| M Srivatsa. Effects of organophosphates on cholinesterase activity and neurite regeneration in Aplysia. Chemico-biological interactions. vol 119-120. 1999-08-19. PMID:10421473. |
in order to test whether ache's site-specific neurotrophic action varies with the neuronal phenotype, we investigated the effects of active-site inhibited hemolymph ache on neurite growth of cholinergic neurons of aplysia in primary culture. |
1999-08-19 |
2023-08-12 |
aplysia |