| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O A Timofeeva, C J Gordo. Changes in EEG power spectra and behavioral states in rats exposed to the acetylcholinesterase inhibitor chlorpyrifos and muscarinic agonist oxotremorine. Brain research. vol 893. issue 1-2. 2001-06-21. PMID:11223004. |
organophosphates (ops) inhibit acetylcholinesterase (ache) activity causing cholinergic stimulation in the central nervous system (cns). |
2001-06-21 |
2023-08-12 |
rat |
| V Talesa, R Romani, C Antognelli, E Giovannini, G Ros. Soluble and membrane-bound acetylcholinesterases in Mytilus galloprovincialis (Pelecypoda: Filibranchia) from the northern Adriatic sea. Chemico-biological interactions. vol 134. issue 2. 2001-05-31. PMID:11311211. |
such an ache is likely functional in cholinergic synapses. |
2001-05-31 |
2023-08-12 |
Not clear |
| N H Greig, E De Micheli, H W Holloway, Q S Yu, T Utsuki, T A Perry, A Brossi, D K Ingram, J Deutsch, D K Lahiri, T T Soncran. The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics. Acta neurologica Scandinavica. Supplementum. vol 176. 2001-05-17. PMID:11261809. |
to determine the time-dependent effects of phenserine on cholinergic function, ache activity, brain and plasma drug levels and brain extracellular acetylcholine (ach) concentrations were measured in rats before and after phenserine administration. |
2001-05-17 |
2023-08-12 |
rat |
| b' J Patocka, A Struneck\\xc3\\xa1, D R\\xc3\\xadpov\\xc3\\xa. [Cholinesterases and their importance in the etiology, diagnosis and therapy of Alzheimer\'s disease]. Ceskoslovenska fysiologie. vol 50. issue 1. 2001-05-03. PMID:11268561.' |
acetylcholinesterase (ache) plays the key role in cholinergic neurotransmission, whereas the function of butyrylcholinesterase (buche) is still unrevealed. |
2001-05-03 |
2023-08-12 |
Not clear |
| D S Woodruff-Pak, R W Vogel, G L Wen. Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172080. |
the allosterically potentiating ligand galantamine (gal) modulates nicotinic cholinergic receptors to increase acetylcholine release as well as acting as an acetylcholinesterase (ache) inhibitor. |
2001-04-19 |
2023-08-12 |
Not clear |
| H Shinotoh, A Aotsuka, K Fukushi, S Nagatsuka, N Tanaka, T Ota, S Tanada, T Iri. Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET. Neurology. vol 56. issue 3. 2001-04-05. PMID:11171913. |
all patients showed some degree of symptomatic improvement, and it was concluded that this improvement was likely caused by improved cholinergic activity by inhibition of ache in the brain. |
2001-04-05 |
2023-08-12 |
Not clear |
| A S Torrão, F M Carmona, J Lindstrom, L R Britt. Expression of cholinergic system molecules during development of the chick nervous system. Brain research. Developmental brain research. vol 124. issue 1-2. 2001-02-01. PMID:11113515. |
the results of this study reveal a developmentally regulated expression of cholinergic system-related molecules in the chick nervous system and characterize differential time-courses of expression for nachr subunits, ache, and chat during development. |
2001-02-01 |
2023-08-12 |
chicken |
| G Guidry, S C Landi. Absence of cholinergic sympathetic innervation from limb muscle vasculature in rats and mice. Autonomic neuroscience : basic & clinical. vol 82. issue 3. 2001-01-25. PMID:11023615. |
in contrast, cholinergic phenotypic markers,vacht-ir and acetylcholinesterase (ache) activity, are absent. |
2001-01-25 |
2023-08-12 |
mouse |
| M Bendayan, V Gisige. Demonstration of acetylcholinesterase molecular forms in a continuous tubular lysosomal system of rat pancreatic acinar cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 49. issue 1. 2001-01-11. PMID:11118476. |
however, the capability of the acinar cells to synthesize ache and to channel it through a tubular system is a good indication that the cells can modulate their cholinergic stimulation for optimal secretion of digestive enzymes. |
2001-01-11 |
2023-08-12 |
rat |
| A Maelick. Allosteric modulation of nicotinic receptors as a treatment strategy for Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 11 Suppl 1. 2000-12-28. PMID:10971047. |
the two most common approaches to correcting these cholinergic deficits are to increase the synaptic availability of acetylcholine (ach) by inhibiting acetylcholinesterase (ache), or to mimic the effects of ach (nicotinic agonists) by acting directly on nicotinic receptors. |
2000-12-28 |
2023-08-12 |
Not clear |
| A Das, K Kapoor, A T Sayeepriyadarshini, M Dikshit, G Palit, C Nat. Immobilization stress-induced changes in brain acetylcholinesterase activity and cognitive function in mice. Pharmacological research. vol 42. issue 3. 2000-11-03. PMID:10945925. |
thus this study shows that acute immobilization stress may enhance cognitive function in mice which may be attributed to a decrease in ache activity leading to an increase in cholinergic activity in the brain. |
2000-11-03 |
2023-08-12 |
mouse |
| E Lev-Lehman, T Evron, R S Broide, E Meshorer, I Ariel, S Seidman, H Sore. Synaptogenesis and myopathy under acetylcholinesterase overexpression. Journal of molecular neuroscience : MN. vol 14. issue 1-2. 2000-10-17. PMID:10854041. |
our findings demonstrate common transcriptional responses to cholinergic nmj stress of diverse origin, and implicate deregulated ache expression in excessive neurite outgrowth, uncontrolled synaptogenesis, and myopathology. |
2000-10-17 |
2023-08-12 |
mouse |
| R C Gupta, J T Goad, D Milatovic, W D Dettbar. Cholinergic and noncholinergic brain biomarkers of insecticide exposure and effects. Human & experimental toxicology. vol 19. issue 5. 2000-09-07. PMID:10918524. |
in controls, analyses of the brain regions revealed a wide variability in the values of cholinergic (acetylcholinesterase, ache) and noncholinergic (creatine kinase, ck; and lactic dehydrogenase, ldh, and their isoenzymes) biomarkers. |
2000-09-07 |
2023-08-12 |
rat |
| X Sun, X B Liu, J R Martinez, G H Zhan. Effects of low concentrations of paraoxon on Ca(2+) mobilization in a human parotid salivary cell-line HSY. Archives of oral biology. vol 45. issue 8. 2000-08-18. PMID:10869474. |
inhibition of acetylcholinesterase (ache) by ops leads to a decrease in acetylcholine (ach) breakdown that results in overstimulation of muscarinic cholinergic receptors (mchr). |
2000-08-18 |
2023-08-12 |
human |
| H Soreq, S Seidma. Anti-sense approach to anticholinesterase therapeutics. The Israel Medical Association journal : IMAJ. vol 2 Suppl. 2000-08-09. PMID:10909423. |
in light of the likely role(s) of specific ache variants in various diseases affecting cholinergic neurotransmission, the potential contribution that anti-sense technology can make towards improved approaches to anti-ache therapeutics deserves serious attention. |
2000-08-09 |
2023-08-12 |
Not clear |
| F Monnet-Tschudi, M G Zurich, B Schilter, L G Costa, P Honegge. Maturation-dependent effects of chlorpyrifos and parathion and their oxygen analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures. Toxicology and applied pharmacology. vol 165. issue 3. 2000-08-08. PMID:10873710. |
toxic effects, assessed by measuring protein content as an index of general cytotoxicity, and various enzyme activities as cell-type-specific neuronal and glial markers (chat and gad, for cholinergic and gabaergic neurons, respectively, and gs and cnp, for astrocytes and oligodendrocytes, respectively) were only found at more than 70% of ache inhibition. |
2000-08-08 |
2023-08-12 |
rat |
| J W Bigbee, K V Sharma, J J Gupta, J L Dupre. Morphogenic role for acetylcholinesterase in axonal outgrowth during neural development. Environmental health perspectives. vol 107 Suppl 1. 2000-07-27. PMID:10229710. |
acetylcholinesterase (ache) is the enzyme that hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses and neuromuscular junctions. |
2000-07-27 |
2023-08-12 |
Not clear |
| G Jeyarasasingam, M Yeluashvili, M Qui. Tacrine, a reversible acetylcholinesterase inhibitor, induces myopathy. Neuroreport. vol 11. issue 6. 2000-07-17. PMID:10817586. |
tacrine, an acetylcholinesterase (ache) inhibitor that has been used in the treatment of alzheimer's disease, increases available acetylcholine (ach) levels in the synaptic cleft thereby enhancing the activity of cholinergic pathways. |
2000-07-17 |
2023-08-12 |
rat |
| M Pakaski, Z Rakonczay, I Fakla, H Papp, P Kas. In vitro effects of metrifonate on neuronal amyloid precursor protein processing and protein kinase C level. Brain research. vol 863. issue 1-2. 2000-07-14. PMID:10773217. |
it has been suggested that acetylcholinesterase (ache) inhibitors, which promote the cholinergic function and consequently improve the cognitive deficits, may also exert a neuroprotective effect by activating normal app processing. |
2000-07-14 |
2023-08-12 |
Not clear |
| W Xie, J A Stribley, A Chatonnet, P J Wilder, A Rizzino, R D McComb, P Taylor, S H Hinrichs, O Lockridg. Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase. The Journal of pharmacology and experimental therapeutics. vol 293. issue 3. 2000-07-14. PMID:10869390. |
acetylcholinesterase (ache; ec 3.1.1.7) is the primary terminator of nerve impulse transmission at cholinergic synapses and is believed to play an important role in neural development. |
2000-07-14 |
2023-08-12 |
mouse |