| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Thiermann, L Szinicz, F Eyer, F Worek, P Eyer, N Felgenhauer, T Zilke. Modern strategies in therapy of organophosphate poisoning. Toxicology letters. vol 107. issue 1-3. 1999-07-29. PMID:10414801. |
cholinergic signs soon subsided when ache was above 20% of normal, and atropine plasma levels could be kept below 7 ng/ml. |
1999-07-29 |
2023-08-12 |
Not clear |
| P G Genever, M A Birch, E Brown, T M Skerr. Osteoblast-derived acetylcholinesterase: a novel mediator of cell-matrix interactions in bone? Bone. vol 24. issue 4. 1999-07-28. PMID:10221541. |
these findings complement an increasing body of evidence which suggests that ache, in addition to its role in terminating cholinergic signaling, may be instrumental in regulating cellular differentiation and adhesion. |
1999-07-28 |
2023-08-12 |
human |
| R E Papka, H H Traurig, M Schemann, J Collins, T Copelin, K Wilso. Cholinergic neurons of the pelvic autonomic ganglia and uterus of the female rat: distribution of axons and presence of muscarinic receptors. Cell and tissue research. vol 296. issue 2. 1999-07-12. PMID:10382273. |
uterine cholinergic nerves arise from the paracervical ganglia and were, in the past, characterized based on acetylcholinesterase (ache) histochemistry. |
1999-07-12 |
2023-08-12 |
rat |
| H Tang, S M Miller, L G Ermilov, V A Lennon, S Brimijoi. Complement-mediated lesion of sympathetic ganglia in vitro with acetylcholinesterase antibodies. Journal of neuroimmunology. vol 97. issue 1-2. 1999-07-12. PMID:10408983. |
choline acetyltransferase activity (chat), an enzymatic marker of cholinergic cytoplasm in sympathetic ganglia, was largely lost after incubation with ache antibodies and serum. |
1999-07-12 |
2023-08-12 |
human |
| S Rossner, N Bakinde, U Zeitschel, R Schliebs, V Big. Cerebrospinal fluid cholinesterases--markers for loss of cholinergic basal forebrain neurons? International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 16. issue 7-8. 1999-07-07. PMID:10198815. |
to address this question enzyme activities of acetylcholinesterase (ache) and butyrylcholinesterase (bche) in both csf and parietal cortex were assayed following selective lesion of basal forebrain cholinergic neurons by a single intracerebroventricular application of the cholinergic immunotoxin 192igg-saporin. |
1999-07-07 |
2023-08-12 |
Not clear |
| S Rossner, N Bakinde, U Zeitschel, R Schliebs, V Big. Cerebrospinal fluid cholinesterases--markers for loss of cholinergic basal forebrain neurons? International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 16. issue 7-8. 1999-07-07. PMID:10198815. |
cholinergic immunolesions led to a dramatic decrease in total ache activity in parietal cortex, which was due to the specific loss of the g4 molecular form while the activity of the g1 form was increased as compared to nonlesioned animals. |
1999-07-07 |
2023-08-12 |
Not clear |
| S Olivera, D Rodriguez-Ithurralde, J M Henle. Acetylcholinesterase potentiates [3H]fluorowillardiine and [3H]AMPA binding to rat cortical membranes. Neuropharmacology. vol 38. issue 4. 1999-07-02. PMID:10221754. |
in addition to its action at cholinergic synapses acetylcholinesterase (ache) has been proposed to modulate neuronal activity by mechanisms unrelated to the hydrolysis of acetylcholine. |
1999-07-02 |
2023-08-12 |
rat |
| K Kato, H Hayako, Y Ishihara, S Marui, M Iwane, M Miyamot. TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons. Neuroscience letters. vol 260. issue 1. 1999-06-18. PMID:10027686. |
tak-147, a potent acetylcholinesterase (ache) inhibitor, potentiated choline acetyltransferase (chat) activity in cultured rat septal cholinergic neurons in a concentration-dependent manner with an ec50 value of 4.47 nm. |
1999-06-18 |
2023-08-12 |
rat |
| K Kato, H Hayako, Y Ishihara, S Marui, M Iwane, M Miyamot. TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons. Neuroscience letters. vol 260. issue 1. 1999-06-18. PMID:10027686. |
these results suggest that tak-147 may have neurotrophic activity on central cholinergic neurons, not via ache inhibition but possibly via an effect on tau receptors. |
1999-06-18 |
2023-08-12 |
rat |
| L O Koskinen, M L Koch, G Pu. The neuropeptide TRH has a minor effect on the enzymatic activity of acetylcholinesterase in vitro. Peptides. vol 19. issue 10. 1999-06-15. PMID:9880071. |
we conclude that any cholinergic effect of trh observed in vivo is unlikely to be due to a direct interaction of the peptide with ache. |
1999-06-15 |
2023-08-12 |
Not clear |
| C N Pop. Organophosphorus pesticides: do they all have the same mechanism of toxicity? Journal of toxicology and environmental health. Part B, Critical reviews. vol 2. issue 2. 1999-05-18. PMID:10230392. |
it is concluded that all op anticholinesterases potentially have a mechanism of toxicity in common, that is, phosphorylation of ache causing accumulation of acetylcholine, overstimulation of cholinergic receptors, and consequent clinical signs of cholinergic toxicity. |
1999-05-18 |
2023-08-12 |
Not clear |
| L L Carlock, W L Chen, E B Gordon, J C Killeen, A Manley, L S Meyer, L S Mullin, K J Pendino, A Percy, D E Sargent, L R Seaman, N K Svanborg, R H Stanton, C I Tellone, D L Van Goethe. Regulating and assessing risks of cholinesterase-inhibiting pesticides: divergent approaches and interpretations. Journal of toxicology and environmental health. Part B, Critical reviews. vol 2. issue 2. 1999-05-18. PMID:10230391. |
when available, cholinergic effects or brain ache inhibition data should take precedence over rbc ache for determining no-observed-effect levels (noels). |
1999-05-18 |
2023-08-12 |
human |
| L L Carlock, W L Chen, E B Gordon, J C Killeen, A Manley, L S Meyer, L S Mullin, K J Pendino, A Percy, D E Sargent, L R Seaman, N K Svanborg, R H Stanton, C I Tellone, D L Van Goethe. Regulating and assessing risks of cholinesterase-inhibiting pesticides: divergent approaches and interpretations. Journal of toxicology and environmental health. Part B, Critical reviews. vol 2. issue 2. 1999-05-18. PMID:10230391. |
when available, human rbc ache inhibition or cholinergic effects data should take precedence over animal data for determining noels. |
1999-05-18 |
2023-08-12 |
human |
| L L Carlock, W L Chen, E B Gordon, J C Killeen, A Manley, L S Meyer, L S Mullin, K J Pendino, A Percy, D E Sargent, L R Seaman, N K Svanborg, R H Stanton, C I Tellone, D L Van Goethe. Regulating and assessing risks of cholinesterase-inhibiting pesticides: divergent approaches and interpretations. Journal of toxicology and environmental health. Part B, Critical reviews. vol 2. issue 2. 1999-05-18. PMID:10230391. |
due to greater potential for adversity, noels for brain ache inhibition and cholinergic effects identified in animal studies should receive a default uncertainty factor of 100x; lower uncertainty factors may be used on a case-by-case basis. |
1999-05-18 |
2023-08-12 |
human |
| Z Gu, J Yu, J R Perez-Pol. Long term changes in brain cholinergic markers and nerve growth factor levels after partial immunolesion. Brain research. vol 801. issue 1-2. 1999-05-12. PMID:9729378. |
we measured two cholinergic markers, choline acetyltransferase (chat) and acetylcholinesterase (ache) activity, and ngf protein levels at 10 days, 1, 6 and 12 months postlesion. |
1999-05-12 |
2023-08-12 |
Not clear |
| G Kryger, I Silman, J L Sussma. Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure (London, England : 1993). vol 7. issue 3. 1999-05-06. PMID:10368299. |
it significantly enhances performance in animal models of cholinergic hypofunction and has a high affinity for ache, binding to both electric eel and mouse ache in the nanomolar range. |
1999-05-06 |
2023-08-12 |
mouse |
| H Namba, M Iyo, K Fukushi, H Shinotoh, S Nagatsuka, T Suhara, Y Sudo, K Suzuki, T Iri. Human cerebral acetylcholinesterase activity measured with positron emission tomography: procedure, normal values and effect of age. European journal of nuclear medicine. vol 26. issue 2. 1999-04-27. PMID:9933347. |
no significant effect of age was found on ache activity of the cerebral cortex, suggesting that the ascending central cholinergic system is preserved in normal aging. |
1999-04-27 |
2023-08-12 |
human |
| C Crespo, J G Briñón, A Porteros, R Arévalo, B Rico, J Aijón, J R Alons. Distribution of acetylcholinesterase and choline acetyltransferase in the main and accessory olfactory bulbs of the hedgehog (Erinaceus europaeus). The Journal of comparative neurology. vol 403. issue 1. 1999-04-27. PMID:10075443. |
the distribution of cholinergic markers was studied in the main olfactory bulb (mob) and accessory olfactory bulb (aob) of the western european hedgehog (erinaceus europaeus) by using choline acetyltransferase (chat) immunocytochemistry and acetylcholinesterase (ache) histochemistry. |
1999-04-27 |
2023-08-12 |
Not clear |
| R C Choi, S C Yam, B Hui, D C Wan, K W Tsi. Over-expression of acetylcholinesterase stimulates the expression of agrin in NG108-15 cells. Neuroscience letters. vol 248. issue 1. 1999-03-30. PMID:9665653. |
in order to support the hypothesis, a cholinergic synapse-forming cell line ng108-15 was over-expressed with chick ache by cdna transfection. |
1999-03-30 |
2023-08-12 |
chicken |
| Z P Yang, W D Dettbar. Prevention of tolerance to the organophosphorus anticholinesterase paraoxon with carboxylesterase inhibitors. Biochemical pharmacology. vol 55. issue 9. 1999-03-30. PMID:10076534. |
daily injections (20 days) of paraoxon (0.09 mg/kg) led to a cumulative dose that was 9.0-fold higher than the acute ed50 of 0.20 mg/kg, s.c. during this period, the rats did not demonstrate visible signs of cholinergic hyperactivity nor did they die, despite the persistence of critically reduced brain acetylcholinesterase (ache) activity (20-30% of control). |
1999-03-30 |
2023-08-12 |
rat |