| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Namba, M Iyo, K Fukushi, H Shinotoh, S Nagatsuka, T Suhara, Y Sudo, K Suzuki, T Iri. Human cerebral acetylcholinesterase activity measured with positron emission tomography: procedure, normal values and effect of age. European journal of nuclear medicine. vol 26. issue 2. 1999-04-27. PMID:9933347. |
no significant effect of age was found on ache activity of the cerebral cortex, suggesting that the ascending central cholinergic system is preserved in normal aging. |
1999-04-27 |
2023-08-12 |
human |
| C Crespo, J G Briñón, A Porteros, R Arévalo, B Rico, J Aijón, J R Alons. Distribution of acetylcholinesterase and choline acetyltransferase in the main and accessory olfactory bulbs of the hedgehog (Erinaceus europaeus). The Journal of comparative neurology. vol 403. issue 1. 1999-04-27. PMID:10075443. |
the distribution of cholinergic markers was studied in the main olfactory bulb (mob) and accessory olfactory bulb (aob) of the western european hedgehog (erinaceus europaeus) by using choline acetyltransferase (chat) immunocytochemistry and acetylcholinesterase (ache) histochemistry. |
1999-04-27 |
2023-08-12 |
Not clear |
| R C Choi, S C Yam, B Hui, D C Wan, K W Tsi. Over-expression of acetylcholinesterase stimulates the expression of agrin in NG108-15 cells. Neuroscience letters. vol 248. issue 1. 1999-03-30. PMID:9665653. |
in order to support the hypothesis, a cholinergic synapse-forming cell line ng108-15 was over-expressed with chick ache by cdna transfection. |
1999-03-30 |
2023-08-12 |
chicken |
| Z P Yang, W D Dettbar. Prevention of tolerance to the organophosphorus anticholinesterase paraoxon with carboxylesterase inhibitors. Biochemical pharmacology. vol 55. issue 9. 1999-03-30. PMID:10076534. |
daily injections (20 days) of paraoxon (0.09 mg/kg) led to a cumulative dose that was 9.0-fold higher than the acute ed50 of 0.20 mg/kg, s.c. during this period, the rats did not demonstrate visible signs of cholinergic hyperactivity nor did they die, despite the persistence of critically reduced brain acetylcholinesterase (ache) activity (20-30% of control). |
1999-03-30 |
2023-08-12 |
rat |
| Z P Yang, W D Dettbar. Prevention of tolerance to the organophosphorus anticholinesterase paraoxon with carboxylesterase inhibitors. Biochemical pharmacology. vol 55. issue 9. 1999-03-30. PMID:10076534. |
by eliminating plasma carbe (alpha-na) as potential binding sites for paraoxon with either cbdp or iso-ompa, paraoxon can exert its toxicity to a greater extent at its specific target site, the functionally important ache at cholinergic synapses. |
1999-03-30 |
2023-08-12 |
rat |
| M A Pombal, J Yáñez, O Marín, A González, R Anadó. Cholinergic and GABAergic neuronal elements in the pineal organ of lampreys, and tract-tracing observations of differential connections of pinealofugal neurons. Cell and tissue research. vol 295. issue 2. 1999-02-26. PMID:9931367. |
the putative cholinergic and gabaergic elements of the pineal organ of lampreys were investigated with immunocytochemistry to choline acetyltransferase (chat) and gamma-aminobutyric acid (gaba), and by acetylcholinesterase (ache) histochemistry. |
1999-02-26 |
2023-08-12 |
Not clear |
| A Morett. Experimental and clinical toxicology of anticholinesterase agents. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022304. |
the cholinergic syndrome appears at approximately 50% ache inhibition whereas death is believed to occur at > 90%. |
1999-02-25 |
2023-08-12 |
Not clear |
| A Morett. Experimental and clinical toxicology of anticholinesterase agents. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022304. |
op insecticides are more potent ache inhibitors rather than nte inhibitors and therefore, the dose required to cause opidp is much higher than that causing the cholinergic syndrome. |
1999-02-25 |
2023-08-12 |
Not clear |
| A P Pugovki. [Adrenergic innervation of the cerebral arteries following changes in the activity of cholinergic and monoaminergic brain systems]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 84. issue 9. 1999-01-21. PMID:9845911. |
changes in cholinesterase activity and catecholamine content in histochemically active nerves following administration of cholinesterase (ache) inhibiting agent phosphacol, seem to reflect compensatory responses to increasing dilatory cholinergic vasomotor effects under conditions of the ache activity. |
1999-01-21 |
2023-08-12 |
rat |
| R M Nitsch, S Rossner, C Albrecht, M Mayhaus, J Enderich, R Schliebs, M Wegner, T Arendt, H von der Kamme. Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter. Journal of physiology, Paris. vol 92. issue 3-4. 1999-01-13. PMID:9789819. |
in vivo studies with intraventricular infusions of the cholinergic immunotoxin 192 igg saporin showed more than 80% decrease of ache activity in cholinergic target areas of the hippocampus and brain cortex. |
1999-01-13 |
2023-08-12 |
human |
| R M Nitsch, S Rossner, C Albrecht, M Mayhaus, J Enderich, R Schliebs, M Wegner, T Arendt, H von der Kamme. Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter. Journal of physiology, Paris. vol 92. issue 3-4. 1999-01-13. PMID:9789819. |
the results are compatible with a combination of decreased ache activity in degenerating subcortical cholinergic projections, and additional decreases in postsynaptic ache gene expression. |
1999-01-13 |
2023-08-12 |
human |
| R M Nitsch, S Rossner, C Albrecht, M Mayhaus, J Enderich, R Schliebs, M Wegner, T Arendt, H von der Kamme. Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter. Journal of physiology, Paris. vol 92. issue 3-4. 1999-01-13. PMID:9789819. |
the results suggest a feedback mechanism by which the ache gene is activated by cholinergic neurotransmission, possibly leading to increased formation of ache protein and accelerated degradation of acetylcholine at cholinergic synapses. |
1999-01-13 |
2023-08-12 |
human |
| M Sabbatini, G Coppi, A Maggioni, V Olgiati, I Panocka, F Ament. Effect of lesions of the nucleus basalis magnocellularis and of treatment with posatirelin on cholinergic neurotransmission enzymes in the rat cerebral cortex. Mechanisms of ageing and development. vol 104. issue 2. 1999-01-07. PMID:9792196. |
the effect of 4 and 8 weeks of treatment with the thyrotropin releasing hormone (trh), analogue posatirelin (l-6-ketopiperidine-2-carbonyl-l-leucyl-proline amide), on the changes of cholinergic neurotransmission enzymes, choline acetyltransferase (chat) and acetylcholinesterase (ache), caused by lesions of the nucleus basalis magnocellularis (nbm), was investigated in the rat frontal cortex. |
1999-01-07 |
2023-08-12 |
rat |
| K J Fernandes, N R Kobayashi, B J Jasmin, W Tetzlaf. Acetylcholinesterase gene expression in axotomized rat facial motoneurons is differentially regulated by neurotrophins: correlation with trkB and trkC mRNA levels and isoforms. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 23. 1998-12-18. PMID:9822749. |
these results demonstrate that nt-4/5 and bdnf stimulate ache gene expression in motoneurons and support the concept that muscle-derived trkb ligands modulate the cholinergic phenotype of their innervating motoneurons. |
1998-12-18 |
2023-08-12 |
rat |
| S Darvesh, S E MacDonald, A M Losier, E Martin, D A Hopkins, J A Armou. Cholinesterases in cardiac ganglia and modulation of canine intrinsic cardiac neuronal activity. Journal of the autonomic nervous system. vol 71. issue 2-3. 1998-12-11. PMID:9760044. |
cholinergic neurotransmission plays a significant role in intrinsic cardiac ganglia with the action of acetylcholine being terminated by acetylcholinesterase (ache, ec 3.1.1.7). |
1998-12-11 |
2023-08-12 |
Not clear |
| O I Casanueva, P Deprez, T García-Huidobro, N C Inestros. At least two receptors of asymmetric acetylcholinesterase are present at the synaptic basal lamina of Torpedo electric organ. Biochemical and biophysical research communications. vol 250. issue 2. 1998-11-05. PMID:9753626. |
asymmetric acetylcholinesterase (ache) is anchored to the basal lamina (bl) of cholinergic synapses via its collagenic tail, yet the complement of matrix receptors involved in its attachment remains unknown. |
1998-11-05 |
2023-08-12 |
Not clear |
| B Wiedenmann, C Riedel, M John, G Ahnert-Hilger, G Stoltenburg, J Waldschmidt, K von Deimling, E O Riecken, F Schie. Qualitative and quantitative analysis of synapses in Hirschsprung's disease. Pediatric surgery international. vol 13. issue 7. 1998-11-03. PMID:9716672. |
our data also suggest that nerve endings in hd may contain high concentrations of cholinergic vesicles, paralleling the known high amounts of acetylcholine and ache found in intestinal segments of patients with hd. |
1998-11-03 |
2023-08-12 |
Not clear |
| L E Tune, T Sunderlan. New cholinergic therapies: treatment tools for the psychiatrist. The Journal of clinical psychiatry. vol 59 Suppl 13. 1998-10-20. PMID:9771828. |
the focus is on pivotal articles investigating the role of cholinergic augmentation strategies, including precursor loading and acetylcholinesterase (ache) inhibitors, in the management of cognitive and noncognitive symptoms of alzheimer's disease. |
1998-10-20 |
2023-08-12 |
Not clear |
| G Amitai, D Moorad, R Adani, B P Docto. Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon. Biochemical pharmacology. vol 56. issue 3. 1998-10-02. PMID:9744565. |
the insecticidal action of chlorpyrifos stems from inhibition of acetylcholinesterase (ache) by cpo, resulting in severe cholinergic toxicity. |
1998-10-02 |
2023-08-12 |
mouse |
| C Andres, S Seidman, R Beeri, R Timberg, H Sore. Transgenic acetylcholinesterase induces enlargement of murine neuromuscular junctions but leaves spinal cord synapses intact. Neurochemistry international. vol 32. issue 5-6. 1998-09-25. PMID:9676744. |
here we show that transgenic mice expressing human ache in their spinal cord motoneurons display primarily normal axo-dendritic spinal cord cholinergic synapses in spite of the clear excess of transgenic over host ache within these synapses. |
1998-09-25 |
2023-08-12 |
mouse |