| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Nehru, R Du. The effect of dietary selenium on lead neurotoxicity. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 16. issue 1. 1997-09-03. PMID:9256932. |
along with these, a decrease in acetylcholine esterase (ache) and monoamine oxidase (mao) was seen, thus affecting both cholinergic and adrenergic neurotransmitters. |
1997-09-03 |
2023-08-12 |
rat |
| C Andres, R Beeri, A Friedman, E Lev-Lehman, S Henis, R Timberg, M Shani, H Sore. Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 15. 1997-08-27. PMID:9223334. |
to explore the possibility that overproduction of neuronal acetylcholinesterase (ache) confers changes in both cholinergic and morphogenic intercellular interactions, we studied developmental responses to neuronal ache overexpression in motoneurons and neuromuscular junctions of ache-transgenic mice. |
1997-08-27 |
2023-08-12 |
mouse |
| C Andres, R Beeri, A Friedman, E Lev-Lehman, S Henis, R Timberg, M Shani, H Sore. Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 15. 1997-08-27. PMID:9223334. |
these findings demonstrate embryonic feedback mechanisms to neuronal ache overexpression that are attributable to both cholinergic and cell-cell interaction pathways, suggesting that embryonic neurexin ibeta expression is concerted in vivo with ache levels and indicating that postnatal changes in neuronal ache-associated proteins may be involved in late-onset neuromotor pathologies. |
1997-08-27 |
2023-08-12 |
mouse |
| A Lucić, B Radić, M Peraica, M Mesić, I Primozic, Z Binenfel. Antidotal efficacy of quinuclidinium oximes against soman poisoning. Archives of toxicology. vol 71. issue 7. 1997-08-21. PMID:9209694. |
the results indicate that the in vivo effectiveness of quinuclidinium oximes against soman poisoning may not be related to reactivation or protection of ache but rather to some other mechanism of the cholinergic system. |
1997-08-21 |
2023-08-12 |
mouse |
| P G Layer, J Berger, N Kink. Cholinesterases precede "ON-OFF" channel dichotomy in the embryonic chick retina before onset of synaptogenesis. Cell and tissue research. vol 288. issue 3. 1997-08-15. PMID:9134854. |
both levels can be detected easily in the mature retina by choline acetyltransferase (chat) or by acetylcholinesterase (ache); however, the usefulness of these enzymes as developmental markers is restricted, since chat is detected too late, while ache labels not only cholinergic neuropil. |
1997-08-15 |
2023-08-12 |
chicken |
| T Fujii, Y Mori, T Tominaga, I Hayasaka, K Kawashim. Maintenance of constant blood acetylcholine content before and after feeding in young chimpanzees. Neuroscience letters. vol 227. issue 1. 1997-07-30. PMID:9178849. |
the results of the present study indicate that the blood ach of chimpanzees is distributed mainly in the blood cell fraction, and that the blood ach content is not regulated directly by cholinergic nerve activity or by plasma ache activity. |
1997-07-30 |
2023-08-12 |
chimpanzee |
| S Yamada, T Fujii, K Kawashim. Oral administration of KW-5092, a novel gastroprokinetic agent with acetylcholinesterase inhibitory and acetylcholine release enhancing activities, causes a dose-dependent increase in the blood acetylcholine content of beagle dogs. Neuroscience letters. vol 225. issue 1. 1997-07-24. PMID:9143009. |
oral administration of kw-5092 (10-30 mg/kg), a gastroprokinetic agent with acetylcholinesterase (ache) inhibitory and ach release enhancing activities, caused a dose-dependent increase in the ach content of both the blood and plasma, as well as several behavioral side effects due to peripheral cholinergic stimulation. |
1997-07-24 |
2023-08-12 |
Not clear |
| F Mennicken, R Quirio. Interleukin-2 increases choline acetyltransferase activity in septal-cell cultures. Synapse (New York, N.Y.). vol 26. issue 2. 1997-07-18. PMID:9131776. |
the effect of il-2 on the expression of the cholinergic phenotype was determined using choline acetyltransferase (chat) activity and acetylcholinesterase (ache) cytochemistry. |
1997-07-18 |
2023-08-12 |
Not clear |
| D Franco, A F Moorman, W H Lamer. Expression of the cholinergic signal-transduction pathway components during embryonic rat heart development. The Anatomical record. vol 248. issue 1. 1997-07-18. PMID:9143674. |
to establish whether other components of a cholinergic signal-transduction pathway are present in the embryonic heart, we localised the mrnas encoding choline acetyltransferase (chat), acetylcholinesterase (ache), and the muscarinic receptor isoforms (machrs; m1-m5). |
1997-07-18 |
2023-08-12 |
rat |
| J M Chemnitius, F Schahmirzadi, B D Gonska, H Kreuzer, R Zec. Indirect parasympathomimetic activity of the class III antiarrhythmic substance D/L-sotalol in vitro: reversible inhibition of cholinesterase isoenzymes from blood and the human central nervous system. Pharmacological research. vol 34. issue 5-6. 1997-06-16. PMID:9076843. |
non-competitive d/l-sotalol inhibition of caudate nucleus ache and the non-competitive component of erythrocyte ache inhibition cannot be overcome by increased concentrations of the cholinergic transmitter acetylcholine (ach). |
1997-06-16 |
2023-08-12 |
human |
| J R Delfs, D M Saroff, Y Nishida, J Friend, C Geul. Effects of NMDA and its antagonists on ventral horn cholinergic neurons in organotypic roller tube spinal cord cultures. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 1. 1997-06-16. PMID:9085191. |
neurotoxic effects of excitatory amino acid (eaa) receptor agonist n-methyl-d-aspartic acid (nmda) and its antagonists on ventral horn cholinergic neurons were studied in organotypic rollertube cultures of spinal cord (otc-scs) using biochemical assays of choline acetyltransferase (chat) and acetylcholinesterase (ache) activity, and ache histochemistry. |
1997-06-16 |
2023-08-12 |
Not clear |
| T G Beach, W G Honer, L H Hughe. Cholinergic fibre loss associated with diffuse plaques in the non-demented elderly: the preclinical stage of Alzheimer's disease? Acta neuropathologica. vol 93. issue 2. 1997-06-03. PMID:9039461. |
cholinergic fibre densities were estimated in sections stained using acetylcholinesterase (ache) enzyme histochemistry. |
1997-06-03 |
2023-08-12 |
Not clear |
| A E Reyes, D R Perez, A Alvarez, J Garrido, M K Gentry, B P Doctor, N C Inestros. A monoclonal antibody against acetylcholinesterase inhibits the formation of amyloid fibrils induced by the enzyme. Biochemical and biophysical research communications. vol 232. issue 3. 1997-05-19. PMID:9126330. |
a monoclonal antibody (mab) 25b1 directed against fetal bovine-serum acetylcholinesterase (fbs ache) was used to examine the ability of the cholinergic enzyme to promote the assembly of amyloid-beta peptides (a beta) into alzheimerś fibrils. |
1997-05-19 |
2023-08-12 |
Not clear |
| K Hirai, K Kato, T Nakayama, H Hayako, Y Ishihara, G Goto, M Miyamot. Neurochemical effects of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-b enzazepin-8-yl)-1-propanone fumarate (TAK-147), a novel acetylcholinesterase inhibitor, in rats. The Journal of pharmacology and experimental therapeutics. vol 280. issue 3. 1997-04-11. PMID:9067312. |
these results suggest that tak-147 activates the central cholinergic system by specific inhibition of ache activity without affecting peripheral butyrylcholinesterase activity, and that tak-147 also moderately activates the monoaminergic systems. |
1997-04-11 |
2023-08-12 |
rat |
| C J Gordo. Thermoregulatory aspects of environmental exposure to anticholinesterase agents. Reviews on environmental health. vol 11. issue 3. 1997-03-20. PMID:9000302. |
ache inhibition elicits cholinergic stimulation in the central nervous system and in peripheral tissues and organs, which can lead to marked dysfunction of homeostatic systems, including temperature regulation. |
1997-03-20 |
2023-08-12 |
rat |
| C J Gordo. Thermoregulatory aspects of environmental exposure to anticholinesterase agents. Reviews on environmental health. vol 11. issue 3. 1997-03-20. PMID:9000302. |
thus, the antiche-induced effects on body temperature and other physiological systems cannot be explained solely by the immediate consequences of ache inhibition and stimulation of cholinergic systems. |
1997-03-20 |
2023-08-12 |
rat |
| J Liu, C N Pop. Effects of chlorpyrifos on high-affinity choline uptake and [3H]hemicholinium-3 binding in rat brain. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 34. issue 1. 1997-03-10. PMID:8937895. |
these results suggest that a reduction in hacu/acetylcholine synthesis may contribute, along with compensatory changes in cholinergic receptors, to the diminished toxicity following extensive ache inhibition by cpf. |
1997-03-10 |
2023-08-12 |
rat |
| R Schliebs, S Rossner, V Big. Immunolesion by 192IgG-saporin of rat basal forebrain cholinergic system: a useful tool to produce cortical cholinergic dysfunction. Progress in brain research. vol 109. 1997-03-07. PMID:9009714. |
nmda receptor binding was markedly reduced and ampa, kainate, and gabaa receptor binding has been significantly increased in cortical regions displaying a reduced activity of ache and decreased levels of high-affinity choline uptake sites due to immunolesion of the basal forebrain cholinergic system. |
1997-03-07 |
2023-08-12 |
rat |
| A A Al-Jafar. The inhibitory effect of the neuromuscular blocking agent, gallamine triethiodide, on camel retina acetylcholinesterase activity. Toxicology letters. vol 90. issue 1. 1997-02-27. PMID:9020401. |
the present investigation addresses the mode of inhibition of the camel retinal acetylcholinesterase (ache) activity by gallamine triethiodide, which is known to be a specific non-depolarizing neuromuscular blocking agent and polar cholinergic antagonist. |
1997-02-27 |
2023-08-12 |
Not clear |
| D Rodríguez-Ithurralde, S Olivera, A La Paz, O Vincent, A Rondea. Glycine effects on glutamate-receptor elicited acetylcholinesterase release from slices and synaptosomes of the spinal ventral horn. Journal of the neurological sciences. vol 139 Suppl. 1997-02-12. PMID:8899663. |
to study the mechanisms by which glutamate-elicited acetylcholinesterase release (gear) might play a part in the pathogenesis of excitotoxically triggered motor neurone disease, and to investigate the interaction of gear with spinal glycinergic mechanisms, we measured acetylcholinesterase (ache) and cholinergic markers, after stimulating ventral horn slices and synaptosomes from the mouse spinal cord, with both glutamate- and glycine-receptor agonists. |
1997-02-12 |
2023-08-12 |
mouse |