| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Pacheco, R Palacios-Esquivel, D E Mos. Cholinesterase inhibitors proposed for treating dementia in Alzheimer's disease: selectivity toward human brain acetylcholinesterase compared with butyrylcholinesterase. The Journal of pharmacology and experimental therapeutics. vol 274. issue 2. 1995-09-08. PMID:7636741. |
although a cholinergic deficit is not singularly responsible for symptoms of dementia, treatment strategies have been designed to facilitate cholinergic activity by inhibiting acetylcholinesterase (ache). |
1995-09-08 |
2023-08-12 |
human |
| M E Appleyar. Acetylcholinesterase induces long-term potentiation in CA1 pyramidal cells by a mechanism dependent on metabotropic glutamate receptors. Neuroscience letters. vol 190. issue 1. 1995-08-31. PMID:7624047. |
acetylcholinesterase (ache) has additional functions within the central nervous system that are unrelated to cholinergic transmission. |
1995-08-31 |
2023-08-12 |
Not clear |
| M E Appleyar. Acetylcholinesterase induces long-term potentiation in CA1 pyramidal cells by a mechanism dependent on metabotropic glutamate receptors. Neuroscience letters. vol 190. issue 1. 1995-08-31. PMID:7624047. |
because ache is also secreted from the terminal regions of cholinergic nerves within the hippocampus, this study investigates the actions of ache on synaptic transmission in guinea pig hippocampal slices. |
1995-08-31 |
2023-08-12 |
Not clear |
| L Ratnakumari, I A Qureshi, D Maysinger, R F Butterwort. Developmental deficiency of the cholinergic system in congenitally hyperammonemic spf mice: effect of acetyl-L-carnitine. The Journal of pharmacology and experimental therapeutics. vol 274. issue 1. 1995-08-18. PMID:7616428. |
we studied the effect of congenital hyperammonemia on the development of cerebral cholinergic parameters such as choline acetyltransferase (chat), acetylcholinesterase (ache) and high-affinity choline uptake (hacu) in spf mice. |
1995-08-18 |
2023-08-12 |
mouse |
| J M Palmer, T R Koc. Altered neuropeptide content and cholinergic enzymatic activity in the inflamed guinea pig jejunum during parasitism. Neuropeptides. vol 28. issue 5. 1995-08-10. PMID:7541515. |
the content of the enteric neuropeptides, substance p (sp) and vasoactive intestinal peptide (vip), and the activities of the key cholinergic enzymes, acetylcholinesterase (ache) and choline acetyltransferase (chat), were measured and compared in extracts of jejunal muscularis externa (me) obtained from uninfected jejunum and t. spiralis-inflamed jejunum. |
1995-08-10 |
2023-08-12 |
Not clear |
| E J Kimm, C E Perez, C C Yu, J Yu, R T Robertso. Reduction of transiently expressed acetylcholinesterase activity in developing thalamocortical projections does not affect the mature pattern of basal forebrain projections to visual cortex. Brain research. Developmental brain research. vol 85. issue 2. 1995-08-10. PMID:7600676. |
experiments tested the hypothesis that acetylcholinesterase (ache) activity, expressed transiently in developing thalamocortical projections, serves to limit the growth of basal forebrain cholinergic projections into thalamocortical recipient zones. |
1995-08-10 |
2023-08-12 |
rat |
| E J Kimm, C E Perez, C C Yu, J Yu, R T Robertso. Reduction of transiently expressed acetylcholinesterase activity in developing thalamocortical projections does not affect the mature pattern of basal forebrain projections to visual cortex. Brain research. Developmental brain research. vol 85. issue 2. 1995-08-10. PMID:7600676. |
these data indicate that transient ache activity in developing sensory cortex does not limit ingrowth of basal forebrain cholinergic axons. |
1995-08-10 |
2023-08-12 |
rat |
| P Piovesan, G Quatrini, L Pacifici, G Taglialatela, L Angelucc. Acetyl-L-carnitine restores choline acetyltransferase activity in the hippocampus of rats with partial unilateral fimbria-fornix transection. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 13. issue 1. 1995-07-25. PMID:7793306. |
we used choline acetyltransferase (chat) and acetyl cholinesterase (ache) as markers of central cholinergic function, and nerve growth factor (ngf) levels as indicative of the trophic regulation of the medio-septal cholinergic system. |
1995-07-25 |
2023-08-12 |
rat |
| K Ikeda, J Yamashita, T Egashira, F Takayama, Y Yamanak. [Study on the anti-dementia therapies for rats with a unilateral basal forebrain lesion--serial changes of the cholinergic markers' activities and event-related potentials after the administration of bifemelane hydrochloride or autotransplantation of the vagal nodosal ganglion]. No to shinkei = Brain and nerve. vol 47. issue 5. 1995-07-24. PMID:7786622. |
using rats with a unilateral lesion in the nucleus basalis magnocellularis (nbm), we examined electrophysiologically the therapeutic effects of bifemelane (bif) and autotransplantation of the vagal nodosal ganglion (x) on the event-related potential (p300) serially for 4 weeks, and also neurochemically their effects on cholinergic markers--the specific binding of 3h-qnb (quinuclidinyl benzilate) on muscarinic acetyl-choline receptor (machr) and the activities of acetylcholinesterase (ache) and choline acetyltransferase (cat). |
1995-07-24 |
2023-08-12 |
rat |
| K Ikeda, J Yamashita, T Egashira, F Takayama, Y Yamanak. [Study on the anti-dementia therapies for rats with a unilateral basal forebrain lesion--serial changes of the cholinergic markers' activities and event-related potentials after the administration of bifemelane hydrochloride or autotransplantation of the vagal nodosal ganglion]. No to shinkei = Brain and nerve. vol 47. issue 5. 1995-07-24. PMID:7786622. |
these results might indicate as follows: 1) compensatory postsynaptic process such as cortical machr increase and ache decrease occurred after acute cholinergic depletion. |
1995-07-24 |
2023-08-12 |
rat |
| K Ikeda, J Yamashita, T Egashira, F Takayama, Y Yamanak. [Study on the anti-dementia therapies for rats with a unilateral basal forebrain lesion--serial changes of the cholinergic markers' activities and event-related potentials after the administration of bifemelane hydrochloride or autotransplantation of the vagal nodosal ganglion]. No to shinkei = Brain and nerve. vol 47. issue 5. 1995-07-24. PMID:7786622. |
2) administration of bif and x autotransplantation recovered cortical cat and ache levels and normalized cholinergic neuronal activity of p300. |
1995-07-24 |
2023-08-12 |
rat |
| J B Hutchins, J M Bernanke, V E Jefferso. Acetylcholinesterase in the developing ferret retina. Experimental eye research. vol 60. issue 2. 1995-07-14. PMID:7781740. |
the function of acetylcholinesterase (ache) is to terminate the action of acetylcholine at the cholinergic synapse. |
1995-07-14 |
2023-08-12 |
Not clear |
| C V Borlongan, T K Koutouzis, T S Randall, T B Freeman, D W Cahill, P R Sanber. Systemic 3-nitropropionic acid: behavioral deficits and striatal damage in adult rats. Brain research bulletin. vol 36. issue 6. 1995-06-29. PMID:7538873. |
results revealed striatal glial infiltration, loss of intrinsic striatal cholinergic neurons, but some sparing of large ache positive neurons, minimal damage of nadph-diaphorase-containing neurons, and very slight, if any, alterations in cytochrome oxidase activity. |
1995-06-29 |
2023-08-12 |
rat |
| W F Li, C E Furlong, L G Cost. Paraoxonase protects against chlorpyrifos toxicity in mice. Toxicology letters. vol 76. issue 3. 1995-06-27. PMID:7539166. |
administration of paraoxonase 30 min after this exposure abolished cholinergic signs and significantly protected against ache inhibition. |
1995-06-27 |
2023-08-12 |
mouse |
| B Buwalda, L de Groote, E A Van der Zee, T Matsuyama, P G Luite. Immunocytochemical demonstration of developmental distribution of muscarinic acetylcholine receptors in rat parietal cortex. Brain research. Developmental brain research. vol 84. issue 2. 1995-06-14. PMID:7743637. |
the development of m35-ir in the cortex appeared to antedate that of its cholinergic afferentation as indicated by ache histochemical study. |
1995-06-14 |
2023-08-12 |
rat |
| H Kobayashi, Y Wang, H Hirakawa, D S O'Briain, P Pur. Intraoperative evaluation of extent of aganglionosis by a rapid acetylcholinesterase histochemical technique. Journal of pediatric surgery. vol 30. issue 2. 1995-06-07. PMID:7738746. |
using a supplemental oxidation step, the authors modified the acetylcholinesterase (ache) histochemistry technique of karnovsky and roots to produce staining of cholinergic nerve fibers in 10 minutes rather than in 2 hours, as required with the conventional ache technique. |
1995-06-07 |
2023-08-12 |
Not clear |
| S Rossner, R Schliebs, V Big. Ibotenic acid lesion of nucleus basalis magnocellularis differentially affects cholinergic, glutamatergic and GABAergic markers in cortical rat brain regions. Brain research. vol 668. issue 1-2. 1995-05-10. PMID:7704621. |
in cortical regions displaying a reduced activity of ache and decreased levels of high-affinity choline uptake sites due to forebrain cholinergic lesion, nmda receptor binding was markedly reduced in comparison to the unlesioned brain side whereas ampa and kainate binding has been significantly increased in these regions. |
1995-05-10 |
2023-08-12 |
rat |
| H Namba, T Irie, K Fukushi, M Iy. In vivo measurement of acetylcholinesterase activity in the brain with a radioactive acetylcholine analog. Brain research. vol 667. issue 2. 1995-05-03. PMID:7697367. |
the method would be applicable for in vivo studies of human brain ache activity in disorders of central cholinergic systems such as alzheimer's disease. |
1995-05-03 |
2023-08-12 |
human |
| T W Farris, L L Butcher, J D Oh, N J Wool. Trophic-factor modulation of cortical acetylcholinesterase reappearance following transection of the medial cholinergic pathway in the adult rat. Experimental neurology. vol 131. issue 2. 1995-04-27. PMID:7895819. |
laminar patterns of cortical acetylcholinesterase (ache) activity are reestablished in the adult, pharmacologically unmanipulated rat following axotomy of the medial cholinergic pathway. |
1995-04-27 |
2023-08-12 |
rat |
| K Tanaka, N Ogawa, M Asanuma, Y Kondo, A Mor. Chronic administration of acetylcholinesterase inhibitor in the senescent rat brain. Neurobiology of aging. vol 15. issue 6. 1995-04-18. PMID:7891827. |
the effects of chronic administration of ena-713, an acetylcholinesterase (ache) inhibitor, on pre- and postsynaptic cholinergic indices were examined in the senescent rat brain. |
1995-04-18 |
2023-08-12 |
rat |