| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Hirokawa, M Nose, A Ishige, S Amagaya, T Oyama, Y Ogihar. Effect of Hachimi-jio-gan on scopolamine-induced memory impairment and on acetylcholine content in rat brain. Journal of ethnopharmacology. vol 50. issue 2. 1996-12-13. PMID:8866727. |
the effect of hachimi-jio-gan (hj) on scopolamine induced memory impairment was studied using a radial maze performance, the effect of hj on the central cholinergic system as measured by acetylcholine (ach) content, choline acetyltransferase (cat) and acetylcholinesterase (ache) activities was also examined. |
1996-12-13 |
2023-08-12 |
rat |
| M E Kriebel, M J Dowdall, G D Pappas, D L Downi. Detached, purified nerve terminals from skate electric organ for biochemical and physiological studies. The Biological bulletin. vol 190. issue 1. 1996-12-05. PMID:8852632. |
the activities of two cholinergic marker enzymes, choline acetyltransferase (chat) and acetylcholinesterase (ache), in extracts of whole fresh organs were much less than those reported for the electric ray torpedo, suggesting a lower volume of terminals in the organ. |
1996-12-05 |
2023-08-12 |
Not clear |
| H Schwegler, M Boldyreva, M Pyrlik-Göhlmann, R Linke, J Wu, K Zille. Genetic variation in the morphology of the septo-hippocampal cholinergic and GABAergic system in mice. I. Cholinergic and GABAergic markers. Hippocampus. vol 6. issue 2. 1996-12-03. PMID:8797015. |
in order to quantify the cholinergic innervation of various hippocampal sub-regions, we estimated the density of acetylcholinesterase (ache)-containing fibers as visualized by ache histochemistry. |
1996-12-03 |
2023-08-12 |
mouse |
| J J Hutsler, M S Gazzanig. Acetylcholinesterase staining in human auditory and language cortices: regional variation of structural features. Cerebral cortex (New York, N.Y. : 1991). vol 6. issue 2. 1996-11-27. PMID:8670655. |
acetylcholinesterase (ache), the enzyme responsible for deactivating acetylcholine, is found within both cholinergic axons arising from the basal forebrain and a subgroup of pyramidal cells in layers iii and v of the cerebral cortex. |
1996-11-27 |
2023-08-12 |
human |
| Y Reiss, S Kröger, J Grassi, K W Tsim, E Willbold, P G Laye. Extracellular and asymmetric forms of acetylcholinesterase are expressed on cholinergic and noncholinergic terminal neuropil of the developing chick retina. Cell and tissue research. vol 286. issue 1. 1996-11-21. PMID:8781208. |
only two out of four major acetylcholinesterase (ache) subbands in the inner plexiform layer (ipl) of vertebrate retinae correspond to sites of cholinergic synaptic transmission, as has been shown by the co-distribution of ache and choline acetyltransferase (chat) staining. |
1996-11-21 |
2023-08-12 |
chicken |
| Y Reiss, S Kröger, J Grassi, K W Tsim, E Willbold, P G Laye. Extracellular and asymmetric forms of acetylcholinesterase are expressed on cholinergic and noncholinergic terminal neuropil of the developing chick retina. Cell and tissue research. vol 286. issue 1. 1996-11-21. PMID:8781208. |
thus, extracellular and asymmetric forms of ache are predominantly found on the terminal arbor neuropil of both cholinergic and non-cholinergic ipl subbands. |
1996-11-21 |
2023-08-12 |
chicken |
| M Srivatsan, B Peret. Effect of acetylcholinesterase inhibition on behavior is age-dependent in freely moving Aplysia. Behavioural brain research. vol 77. issue 1-2. 1996-11-18. PMID:8762162. |
comparisons of the results of ache inhibition which would elevate acetylcholine (ach) levels with those of carbachol administration revealed that ache inhibition affects both cholinergic and non-cholinergic mechanisms underlying the two behaviors. |
1996-11-18 |
2023-08-12 |
aplysia |
| S Jianmongkol, C E Berkman, C M Thompson, R J Richardso. Relative potencies of the four stereoisomers of isomalathion for inhibition of hen brain acetylcholinesterase and neurotoxic esterase in vitro. Toxicology and applied pharmacology. vol 139. issue 2. 1996-10-28. PMID:8806851. |
the cholinergic toxicity of malathion is exacerbated by its isomerization product, isomalathion, which inhibits detoxifying carboxylesterases as well as target acetylcholinesterase (ache). |
1996-10-28 |
2023-08-12 |
rat |
| M Weinstoc. The pharmacotherapy of Alzheimer's disease based on the cholinergic hypothesis: an update. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 4. issue 4. 1996-10-24. PMID:8846227. |
current pharmacological strategies, aimed at increasing cholinergic activity include acetylcholinesterase (ache) inhibitors, cholinergic agonists, acetylcholine (ach) releasers and stimulants of nerve growth factors (ngf). |
1996-10-24 |
2023-08-12 |
Not clear |
| B R Capacio, C E Byers, D R Anderson, R L Matthews, D E Brow. The effect of ondansetron on pyridostigmine-induced blood acetylcholinesterase inhibition in the guinea pig. Drug and chemical toxicology. vol 19. issue 1-2. 1996-10-16. PMID:8804550. |
the significance of these findings is that the increased ache inhibition resulting from simultaneous oral administration of both component could result in undesirable cholinergic toxicities and subsequent perform decrements. |
1996-10-16 |
2023-08-12 |
Not clear |
| Z P Yang, J Morrow, A Wu, L J Roberts, W D Dettbar. Diisopropylphosphorofluoridate-induced muscle hyperactivity associated with enhanced lipid peroxidation in vivo. Biochemical pharmacology. vol 52. issue 2. 1996-08-26. PMID:8694861. |
it is suggested that the ache inhibitor-induced cholinergic hyperactivity initiates that accumulation of free radicals leading to lipid peroxidation, which may be the initiator of the ache inhibitor-induced cell injury. |
1996-08-26 |
2023-08-12 |
rat |
| G M Bores, F P Huger, W Petko, A E Mutlib, F Camacho, D K Rush, D E Selk, V Wolf, R W Kosley, L Davis, H M Varga. Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine. The Journal of pharmacology and experimental therapeutics. vol 277. issue 2. 1996-06-27. PMID:8627552. |
p11012 and p11149 were found to be potent, competitive and selective inhibitors of ache, demonstrating central cholinergic activity, behavioral efficacy and safety. |
1996-06-27 |
2023-08-12 |
rat |
| G M Bores, F P Huger, W Petko, A E Mutlib, F Camacho, D K Rush, D E Selk, V Wolf, R W Kosley, L Davis, H M Varga. Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine. The Journal of pharmacology and experimental therapeutics. vol 277. issue 2. 1996-06-27. PMID:8627552. |
like gal, both p11012 and p11149 showed central cholinergic activity biochemically, by significantly inhibiting rat brain ache; physiologically, by causing hypothermia; and behaviorally, by attenuating scopolamine-induced deficits in passive avoidance. |
1996-06-27 |
2023-08-12 |
rat |
| P DeBoer, E D Abercrombi. Physiological release of striatal acetylcholine in vivo: modulation by D1 and D2 dopamine receptor subtypes. The Journal of pharmacology and experimental therapeutics. vol 277. issue 2. 1996-06-27. PMID:8627558. |
the degree to which the dopaminergic modulation of striatal cholinergic neurons might vary as a function of local extracellular ach level also was examined by application of varying concentrations of the acetylcholinesterase (ache), inhibitor neostigmine (neo) in the microdialysis perfusate. |
1996-06-27 |
2023-08-12 |
rat |
| N C Inestrosa, A Alvarez, C A Pérez, R D Moreno, M Vicente, C Linker, O I Casanueva, C Soto, J Garrid. Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme. Neuron. vol 16. issue 4. 1996-05-28. PMID:8608006. |
acetylcholinesterase (ache), an important component of cholinergic synapses, colocalizes with amyloid-beta peptide (a beta) deposits of alzheimer's brain. |
1996-05-28 |
2023-08-12 |
mouse |
| N C Inestrosa, A Alvarez, C A Pérez, R D Moreno, M Vicente, C Linker, O I Casanueva, C Soto, J Garrid. Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme. Neuron. vol 16. issue 4. 1996-05-28. PMID:8608006. |
thus, in addition to its role in cholinergic synapses, ache may function by accelerating a beta formation and could play a role during amyloid deposition in alzheimer's brain. |
1996-05-28 |
2023-08-12 |
mouse |
| W Yao, D A Godfre. Immunohistochemistry of muscarinic acetylcholine receptors in rat cochlear nucleus. Hearing research. vol 89. issue 1-2. 1996-04-30. PMID:8600134. |
to investigate the distribution of machrs and the correlation of pre- and post-synaptic cholinergic markers in cn, we used a monoclonal anti-machr antibody (m35) and a monoclonal antibody against choline acetyltransferase (chat) to perform immunohistochemistry on rat brain sections, and we also carried out histochemistry for acetylcholinesterase (ache) activity. |
1996-04-30 |
2023-08-12 |
rat |
| J T Laitinen, K S Laitinen, T Kokkol. Cholinergic signaling in the rat pineal gland. Cellular and molecular neurobiology. vol 15. issue 2. 1996-03-25. PMID:8590450. |
cholinergic signaling in the rat pineal gland is suggested based on the localization of choline acetyltransferase (chat) and acetylcholinesterase (ache), as well as muscarinic and nicotinic ach binding sites in the gland. |
1996-03-25 |
2023-08-12 |
rat |
| W Tong, E R Collantes, Y Chen, W J Wels. A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors. Journal of medicinal chemistry. vol 39. issue 2. 1996-02-28. PMID:8558505. |
these compounds have been found to inhibit the metabolic breakdown of the neurotransmitter acetylcholine (ach) by the enzyme acetylcholinesterase (ache) and hence alleviate memory deficits in patients with alzheimer's disease by potentiating cholinergic transmission. |
1996-02-28 |
2023-08-12 |
human |
| H Schwegle. Transient postnatal thyroxine treatment leads to an increased number of cholinergic neurons in the medial septum and to a higher density of cholinergic fibers in hippocampal CA3 in rats. Neuroscience letters. vol 198. issue 3. 1996-02-21. PMID:8552320. |
at the age of 12 weeks, the number of immunocytochemically labeled cholinergic neuronal profiles in the medial septum/diagonal band (ms/vdb) was counted, and the density of acetylcholinesterase (ache)-positive fibers in four hippocampal subregions was measured. |
1996-02-21 |
2023-08-12 |
rat |