| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S De Lacalle, C Lim, T Sobreviela, E J Mufson, L B Hersh, C B Sape. Cholinergic innervation in the human hippocampal formation including the entorhinal cortex. The Journal of comparative neurology. vol 345. issue 3. 1994-10-27. PMID:7929905. |
we studied the cholinergic innervation of the human hippocampal formation by means of immunohistochemistry with polyclonal antisera directed against acetylcholinesterase (ache), choline acetyltransferase (chat), and the low-affinity (p75) nerve growth factor receptor (ngfr). |
1994-10-27 |
2023-08-12 |
human |
| Y Ishihara, K Hirai, M Miyamoto, G Got. Central cholinergic agents. 6. Synthesis and evaluation of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepi n-8-yl)-1-propanones and their analogs as central selective acetylcholinesterase inhibitors. Journal of medicinal chemistry. vol 37. issue 15. 1994-09-12. PMID:8057278. |
among compounds with potent ache inhibition, 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1h-1- benzazepin-8-yl)-1-propanone fumarate (9a, tak-147) (ic50 of ache inhibition = 97.7 nm) inhibited the circling behavior at 3 mg/kg po, in which it had no significant effect on peripheral cholinergic effects. |
1994-09-12 |
2023-08-12 |
rat |
| H J Koponen, J Sirviö, U Lepola, E Leinonen, P J Riekkine. A long-term follow-up study of cerebrospinal fluid acetylcholinesterase in delirium. European archives of psychiatry and clinical neuroscience. vol 243. issue 6. 1994-08-31. PMID:8043620. |
the ache levels measured during the index admission correlated with the length of life after delirium, suggesting that cholinergic dysfunction may have prognostic significance in delirious patients. |
1994-08-31 |
2023-08-12 |
Not clear |
| J Berger-Sweeney, S Heckers, M M Mesulam, R G Wiley, D A Lappi, M Sharm. Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 7. 1994-08-11. PMID:8027790. |
acetylcholinesterase (ache) histochemistry and ngfr and choline acetyltransferase immunohistochemistry revealed a loss of (1) almost all ngfr-positive cholinergic neurons in the msa and ache fibers in hippocampus (msa group); (2) almost all ngfr neurons in the nbm, some in the msa, most ache fibers in neocortex and some in the hippocampus (nbm group), and (3) almost all ngfr neurons in the msa and nbm and their corresponding hippocampal and cortical ache fibers (ventricular group). |
1994-08-11 |
2023-08-12 |
rat |
| Y L Chen, D Liston, J Nielsen, D Chapin, A Dunaiskis, K Hedberg, J Ives, J Johnson, S Jone. Syntheses and anticholinesterase activity of tetrahydrobenzazepine carbamates. Journal of medicinal chemistry. vol 37. issue 13. 1994-08-09. PMID:8027982. |
the in vitro ache inhibition, cholinergic effects, acute toxicity, and elevation of brain acetylcholine levels in vivo of this series of compounds are described. |
1994-08-09 |
2023-08-12 |
mouse |
| M Yokoyama, R S Morrison, I B Black, C F Dreyfu. Septal neuron cholinergic and GABAergic functions: differential regulation by basic fibroblast growth factor and epidermal growth factor. Brain research. Developmental brain research. vol 78. issue 2. 1994-08-05. PMID:8026075. |
to determine whether increases in cat activity reflect increased enzyme activity per neuron or an increase in the number of cholinergic cells, bfgf-treated cultures were stained for acetylcholinesterase (ache) to determine numbers of cholinergic cells. |
1994-08-05 |
2023-08-12 |
cat |
| C P Heisenberg, J D Cooper, J Berke, M V Sofronie. NMDA potentiates NGF-induced sprouting of septal cholinergic fibres. Neuroreport. vol 5. issue 4. 1994-07-20. PMID:8003664. |
nerve growth factor (ngf) injected into the otherwise unlesioned adult rat septum induced sprouting of presumptive cholinergic fibres positive for p75ngfr and acetylcholinesterase (ache). |
1994-07-20 |
2023-08-12 |
rat |
| C A Kitt, C Höhmann, J T Coyle, D L Pric. Cholinergic innervation of mouse forebrain structures. The Journal of comparative neurology. vol 341. issue 1. 1994-07-15. PMID:8006218. |
using choline acetyltransferase (chat) immunocytochemistry and acetylcholinesterase (ache) histochemistry, we investigated regional and laminar differences in cholinergic innervation in the cerebral cortex, hippocampus, amygdala, and thalamus of mice. |
1994-07-15 |
2023-08-12 |
mouse |
| D S Barrett, F W Oehme, S M Kruckenberg, J E Smit. Clinical manifestations and leukocyte neurotoxic esterase and red blood cell and plasma acetylcholinesterase activities in swine following a single oral dose of tri-o-cresyl phosphate. Veterinary and human toxicology. vol 36. issue 2. 1994-06-30. PMID:8197706. |
plasma ache activities appeared to more accurately reflect the development of acute cholinergic signs observed in the 1000 mg/kg dosed swine at 3 h postdosing while red blood cell ache activities were more consistent with the delayed cholinergic signs exhibited by the 400 and 800 mg/kg dosed swine at 24 h postdosing. |
1994-06-30 |
2023-08-12 |
Not clear |
| L C Anderson, J R Garret. The effects of streptozotocin-induced diabetes on norepinephrine and cholinergic enzyme activities in rat parotid and submandibular glands. Archives of oral biology. vol 39. issue 2. 1994-06-16. PMID:8185504. |
therefore, glandular levels of the adrenergic neurotransmitter, norepinephrine (ne) and two cholinergic enzymes, choline acetyltransferase (chat) and acetylcholinesterase (ache), were investigated in 6-month streptozotocin-diabetic rats. |
1994-06-16 |
2023-08-12 |
rat |
| I Aubert, J Poirier, S Gauthier, R Quirio. Multiple cholinergic markers are unexpectedly not altered in the rat dentate gyrus following entorhinal cortex lesions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 5 Pt 1. 1994-06-14. PMID:8182423. |
in this regard, it has been shown that lesions of the entorhinal cortex, which sends glutamatergic projections to the hippocampus, promote the sprouting and plasticity of presumptive cholinergic septohippocampal fibers in the dentate gyrus, as revealed by ache histochemistry. |
1994-06-14 |
2023-08-12 |
rat |
| K Tanaka, N Ogawa, K Mizukawa, M Asanuma, Y Kondo, S Nishibayashi, A Mor. Acetylcholinesterase inhibitor ENA-713 protects against ischemia-induced decrease in pre- and postsynaptic cholinergic indices in the gerbil brain following transient ischemia. Neurochemical research. vol 19. issue 2. 1994-06-14. PMID:8183420. |
the effects of pre-treatment with ena-713, an acetylcholinesterase (ache) inhibitor, on changes in pre- and postsynaptic cholinergic indices in gerbil brain following transient ischemia were studied at 4 and 14 days after recirculation. |
1994-06-14 |
2023-08-12 |
Not clear |
| E Girardi, P Schneider, G Rodriguez De Lores Arnai. Area-specific modification of acetylcholinesterase activity following 3-mercaptopropionic acid-induced seizures. Molecular and chemical neuropathology. vol 21. issue 1. 1994-06-10. PMID:8179769. |
to conclude, ache sensitivity to convulsant and saline administration is tissue-specific and not restricted to cholinergic areas. |
1994-06-10 |
2023-08-12 |
rat |
| D S Barrett, F W Oehm. The effect of a single oral dose of tri-o-cresyl phosphate on neurotoxic esterase and acetylcholinesterase activities in the central nervous system, erythrocytes and plasma. Veterinary and human toxicology. vol 36. issue 1. 1994-05-12. PMID:8154093. |
based on the data provided by this study, a threshold inhibition of erythrocyte ache between 59 and 74% is required for production of acute cholinergic signs. |
1994-05-12 |
2023-08-12 |
Not clear |
| N Bogdanovic, A Islam, L Nilsson, L Bergström, B Winblad, A Ade. Effects of nucleus basalis lesion on muscarinic receptor subtypes. Experimental brain research. vol 97. issue 2. 1994-05-09. PMID:8150042. |
acetylcholinesterase (ache) histochemistry showed a loss of cortical ache-containing neurons, and choline acetyltransferase (chat) immunohistochemistry demonstrated a loss of cholinergic cells in nbm. |
1994-05-09 |
2023-08-12 |
human |
| A H Mohamme. Effects of cholinesterase inhibitors on learning and memory in rats: a brief review with special reference to THA. Acta neurologica Scandinavica. Supplementum. vol 149. 1994-04-14. PMID:8128832. |
research on memory enhancing effects of acetylcholinesterase (ache) inhibitors was stimulated by the finding of diminished cholinergic markers in patients with alzheimer's disease, and the correlation of cognitive impairment to cholinergic deficits in these patients. |
1994-04-14 |
2023-08-12 |
rat |
| A H Mohamme. Effects of cholinesterase inhibitors on learning and memory in rats: a brief review with special reference to THA. Acta neurologica Scandinavica. Supplementum. vol 149. 1994-04-14. PMID:8128832. |
these findings are compatible with the view that ache inhibitors can be efficacious in "restoration" of some cholinergic functions. |
1994-04-14 |
2023-08-12 |
rat |
| J I Nagy, T Yamamoto, L M Jorda. Evidence for the cholinergic nature of C-terminals associated with subsurface cisterns in alpha-motoneurons of rat. Synapse (New York, N.Y.). vol 15. issue 1. 1994-03-17. PMID:8310422. |
here we have used this anti-ssc antibody in combination with antibodies against choline acetyltransferase (chat) and acetylcholinesterase (ache) to determine whether c-terminals on motoneurons contain these cholinergic enzyme markers. |
1994-03-17 |
2023-08-12 |
rat |
| b' M Mi\\xc4\\x87i\\xc4\\x87, G Leposavi\\xc4\\x87, N Ugresi\\xc4\\x8. Relationships between monoaminergic and cholinergic innervation of the rat thymus during aging. Journal of neuroimmunology. vol 49. issue 1-2. 1994-03-03. PMID:8294558.' |
the aged rat thymus seemed to be able to maintain its cholinergic innervation in terms of density and pattern of distribution, while the density of cells with intracytoplasmic acetylcholinesterase (ache) staining even increased. |
1994-03-03 |
2023-08-12 |
rat |
| C N Svendsen, J N Kew, K Staley, M V Sofronie. Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 1. 1994-02-16. PMID:8283253. |
cholinergic neurons identified by staining for ache, chat, and p75ngfr could be maintained in serum-free, ngf-supplemented medium for over 40 d. when ngf was removed and ngf antibodies added to 14-d-old cultures, less than 30% of cholinergic neurons survived a further 4 d, but when ngf was similarly withdrawn from 35-d-old cultures, over 75% of cholinergic neurons survived. |
1994-02-16 |
2023-08-12 |
Not clear |