| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Weinstock, M Razin, M Chorev, A En. Pharmacological evaluation of phenyl-carbamates as CNS-selective acetylcholinesterase inhibitors. Journal of neural transmission. Supplementum. vol 43. 1995-04-13. PMID:7884403. |
sdz ena 713 produced a 10-fold greater inhibition of ache in the hippocampus and cortex than in the heart and skeletal muscle, which explains its relatively low toxicity and freedom from cholinergic side effects. |
1995-04-13 |
2023-08-12 |
human |
| Y Ishii, J Kojima, N Ikeda, K Kawashim. Effect of NIK-247 on basal concentrations of extracellular acetylcholine in the cerebral cortex of conscious, freely moving rats. Japanese journal of pharmacology. vol 66. issue 3. 1995-03-30. PMID:7869615. |
these findings demonstrate that nik-247 increases extracellular ach concentration and inhibits ache activity in the cerebral cortex after oral administration, and they suggest that nik-247 facilitates central cholinergic transmission. |
1995-03-30 |
2023-08-12 |
rat |
| F Yufu, T Egashira, Y Yamanak. Age-related changes of cholinergic markers in the rat brain. Japanese journal of pharmacology. vol 66. issue 2. 1995-03-29. PMID:7869609. |
to evaluate whether any degenerative changes affect the brain cholinergic systems during natural aging, we compared various cholinergic biochemical markers (number of muscarinic receptors, machr; choline acetyltransferase activity, chat; acetylcholinesterase activity, ache; and sodium-dependent high affinity choline uptake) in the cortical (cr) and subcortical (ss) regions of the brains of aged (24 month) and young (2 month) rats. |
1995-03-29 |
2023-08-12 |
rat |
| I A Alonso, J C Prieto, E Arill. Effect of acute and chronic diisopropylfluorophosphate and atropine administration on somatostatin binding in the rat frontoparietal cortex and hippocampus. Psychopharmacology. vol 110. issue 1-2. 1995-03-29. PMID:7870867. |
the acute and chronic administration of diisopropylfluorophosphate (dfp), an inhibitor of acetylcholinesterase (ache), and of atropine, a blocker of muscarinic cholinergic receptors, did not affect somatostatin-like immunoreactivity (sli) content in the frontoparietal cortex and hippocampus of rats. |
1995-03-29 |
2023-08-12 |
rat |
| R J Richardso. Assessment of the neurotoxic potential of chlorpyrifos relative to other organophosphorus compounds: a critical review of the literature. Journal of toxicology and environmental health. vol 44. issue 2. 1995-03-16. PMID:7531775. |
because chlorpyrifos and other op insecticides are designed to produce acute cholinergic effects through inhibition of acetylcholinesterase (ache) and some op compounds can cause op compound-induced delayed neurotoxicity (opidn) via chemical modification of neurotoxic esterase (neuropathy target esterase, nte), this review focuses on the capacity of chlorpyrifos to precipitate these and other adverse neurological consequences. |
1995-03-16 |
2023-08-12 |
rat |
| Y Dimberg, L Lärkfor. Effects of irradiation on cholinergic neurons and nerve growth factor mRNA in mouse foetal brain aggregation cultures. International journal of radiation biology. vol 66. issue 6. 1995-02-06. PMID:7814978. |
the level of a neuronal marker for cholinergic neurons, namely acetylcholine esterase (ache), increased linearly with the dose of irradiation after 10 days in vitro. |
1995-02-06 |
2023-08-12 |
mouse |
| Y Dimberg, L Lärkfor. Effects of irradiation on cholinergic neurons and nerve growth factor mRNA in mouse foetal brain aggregation cultures. International journal of radiation biology. vol 66. issue 6. 1995-02-06. PMID:7814978. |
thus, we showed that cholinergic and morphological markers are affected by irradiation and the alteration in ache activity induced by irradiation correlated well with the changes in ngf mrna. |
1995-02-06 |
2023-08-12 |
mouse |
| D Rodríguez-Ithurralde, O Vincen. Excitotoxicity and cholinergic chemical markers during programmed motor neurone death. Journal of the neurological sciences. vol 124 Suppl. 1995-02-02. PMID:7807141. |
we measured cholinergic markers and acetylcholinesterase (ache) molecular forms after glutamate receptor stimulation of superfused slices of mouse spinal cord at different developmental ages. |
1995-02-02 |
2023-08-12 |
mouse |
| J De Bleecker, D Lison, K Van Den Abeele, J Willems, J De Reuc. Acute and subacute organophosphate poisoning in the rat. Neurotoxicology. vol 15. issue 2. 1995-01-12. PMID:7991223. |
marked differences are noted in the duration of cholinergic symptoms and of ache inhibition after either paraoxon and mipafox, or fenthion poisoning. |
1995-01-12 |
2023-08-12 |
rat |
| E A Van der Zee, P G Luite. Cholinergic and GABAergic neurons in the rat medial septum express muscarinic acetylcholine receptors. Brain research. vol 652. issue 2. 1994-12-29. PMID:7953739. |
the cholinergic transmitter nature of the machr-positive cells was studied using adjacent 8 microns thick serial sections stained immunocytochemically for choline acetyltransferase (chat), or histochemically for acetylcholinesterase (ache). |
1994-12-29 |
2023-08-12 |
rat |
| T Egashir. [Experimental techniques for developing new drugs acting on dementia (4)--Aged rats]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 14. issue 4. 1994-12-16. PMID:7975929. |
the changes in choline acetyltransferase (chat), acetylcholinesterase (ache), muscarinic receptor binding (machr) and na(+)-dependent high affinity choline uptake (hacu) are generally consistent with age-dependent declines in cholinergic neurotransmission, although these decreases may include differences in strain/species, sex, tissue sampling and assay procedures. |
1994-12-16 |
2023-08-12 |
rat |
| Z X She. Acetylcholinesterase provides deeper insights into Alzheimer's disease. Medical hypotheses. vol 43. issue 1. 1994-12-07. PMID:7968717. |
this article reviews the considerable evidence which rejects the cholinergic hypothesis of alzheimer's disease (ad) and proposes that it is the ache system of which the lightly stained neurons are located in the entorhinal cortex, the ca1/subiculum of the hippocampus and the amygdala which are the most vulnerable and are the earliest affected in the pathological processes of ad. |
1994-12-07 |
2023-08-12 |
Not clear |
| D Nonner, J N Barret. Changes in the response of cultured septal cholinergic neurons to nerve growth factor exposure and deprivation during the first postnatal month. Brain research. Developmental brain research. vol 79. issue 2. 1994-11-30. PMID:7955320. |
to determine whether this increase was due to enhanced survival of cholinergic neurons or simply to enhanced ache expression, we examined cultures to which ngf was added only after an initial 1-2-week exposure to anti-ngf antibody. |
1994-11-30 |
2023-08-12 |
rat |
| R C Gupta, J T Goad, W L Kade. Cholinergic and noncholinergic changes in skeletal muscles by carbofuran and methyl parathion. Journal of toxicology and environmental health. vol 43. issue 3. 1994-11-29. PMID:7966439. |
the objective of this investigation was to determine the distribution of cholinergic (acetyl-cholinesterase, ache) and noncholinergic markers in slow-, fast-, and mixed-fiber containing muscles (soleus, sol; extensor digitorum longus, edl; and diaphragm, dia, respectively). |
1994-11-29 |
2023-08-12 |
rat |
| R C Gupta, J T Goad, W L Kade. Cholinergic and noncholinergic changes in skeletal muscles by carbofuran and methyl parathion. Journal of toxicology and environmental health. vol 43. issue 3. 1994-11-29. PMID:7966439. |
rats receiving either insecticide showed cholinergic signs with maximal severity including muscle fasciculations and convulsions within 15-30 min that lasted for about 2 h. at 1 h postinsecticide injection, when ache was maximally inhibited (81-96%), significant depletion of atp and pcr was evident in muscles (dia > sol > edl), and activities of ck-mm and ldh were elevated in muscles and consequently in serum. |
1994-11-29 |
2023-08-12 |
rat |
| O Stewar. Cholinergic sprouting is blocked by repeated induction of electroconvulsive seizures, a manipulation that induces a persistent reactive state in astrocytes. Experimental neurology. vol 129. issue 1. 1994-11-16. PMID:7925832. |
quantitative densitometric analyses revealed that the increase in ache staining that is indicative of cholinergic sprouting was essentially eliminated in the animals that experienced daily ecs. |
1994-11-16 |
2023-08-12 |
mouse |
| S De Lacalle, C Lim, T Sobreviela, E J Mufson, L B Hersh, C B Sape. Cholinergic innervation in the human hippocampal formation including the entorhinal cortex. The Journal of comparative neurology. vol 345. issue 3. 1994-10-27. PMID:7929905. |
we studied the cholinergic innervation of the human hippocampal formation by means of immunohistochemistry with polyclonal antisera directed against acetylcholinesterase (ache), choline acetyltransferase (chat), and the low-affinity (p75) nerve growth factor receptor (ngfr). |
1994-10-27 |
2023-08-12 |
human |
| Y Ishihara, K Hirai, M Miyamoto, G Got. Central cholinergic agents. 6. Synthesis and evaluation of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepi n-8-yl)-1-propanones and their analogs as central selective acetylcholinesterase inhibitors. Journal of medicinal chemistry. vol 37. issue 15. 1994-09-12. PMID:8057278. |
among compounds with potent ache inhibition, 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1h-1- benzazepin-8-yl)-1-propanone fumarate (9a, tak-147) (ic50 of ache inhibition = 97.7 nm) inhibited the circling behavior at 3 mg/kg po, in which it had no significant effect on peripheral cholinergic effects. |
1994-09-12 |
2023-08-12 |
rat |
| H J Koponen, J Sirviö, U Lepola, E Leinonen, P J Riekkine. A long-term follow-up study of cerebrospinal fluid acetylcholinesterase in delirium. European archives of psychiatry and clinical neuroscience. vol 243. issue 6. 1994-08-31. PMID:8043620. |
the ache levels measured during the index admission correlated with the length of life after delirium, suggesting that cholinergic dysfunction may have prognostic significance in delirious patients. |
1994-08-31 |
2023-08-12 |
Not clear |
| J Berger-Sweeney, S Heckers, M M Mesulam, R G Wiley, D A Lappi, M Sharm. Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 7. 1994-08-11. PMID:8027790. |
acetylcholinesterase (ache) histochemistry and ngfr and choline acetyltransferase immunohistochemistry revealed a loss of (1) almost all ngfr-positive cholinergic neurons in the msa and ache fibers in hippocampus (msa group); (2) almost all ngfr neurons in the nbm, some in the msa, most ache fibers in neocortex and some in the hippocampus (nbm group), and (3) almost all ngfr neurons in the msa and nbm and their corresponding hippocampal and cortical ache fibers (ventricular group). |
1994-08-11 |
2023-08-12 |
rat |