| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Mennicken, R Quirio. Interleukin-2 increases choline acetyltransferase activity in septal-cell cultures. Synapse (New York, N.Y.). vol 26. issue 2. 1997-07-18. PMID:9131776. |
the effect of il-2 on the expression of the cholinergic phenotype was determined using choline acetyltransferase (chat) activity and acetylcholinesterase (ache) cytochemistry. |
1997-07-18 |
2023-08-12 |
Not clear |
| D Franco, A F Moorman, W H Lamer. Expression of the cholinergic signal-transduction pathway components during embryonic rat heart development. The Anatomical record. vol 248. issue 1. 1997-07-18. PMID:9143674. |
to establish whether other components of a cholinergic signal-transduction pathway are present in the embryonic heart, we localised the mrnas encoding choline acetyltransferase (chat), acetylcholinesterase (ache), and the muscarinic receptor isoforms (machrs; m1-m5). |
1997-07-18 |
2023-08-12 |
rat |
| J M Chemnitius, F Schahmirzadi, B D Gonska, H Kreuzer, R Zec. Indirect parasympathomimetic activity of the class III antiarrhythmic substance D/L-sotalol in vitro: reversible inhibition of cholinesterase isoenzymes from blood and the human central nervous system. Pharmacological research. vol 34. issue 5-6. 1997-06-16. PMID:9076843. |
non-competitive d/l-sotalol inhibition of caudate nucleus ache and the non-competitive component of erythrocyte ache inhibition cannot be overcome by increased concentrations of the cholinergic transmitter acetylcholine (ach). |
1997-06-16 |
2023-08-12 |
human |
| J R Delfs, D M Saroff, Y Nishida, J Friend, C Geul. Effects of NMDA and its antagonists on ventral horn cholinergic neurons in organotypic roller tube spinal cord cultures. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 1. 1997-06-16. PMID:9085191. |
neurotoxic effects of excitatory amino acid (eaa) receptor agonist n-methyl-d-aspartic acid (nmda) and its antagonists on ventral horn cholinergic neurons were studied in organotypic rollertube cultures of spinal cord (otc-scs) using biochemical assays of choline acetyltransferase (chat) and acetylcholinesterase (ache) activity, and ache histochemistry. |
1997-06-16 |
2023-08-12 |
Not clear |
| T G Beach, W G Honer, L H Hughe. Cholinergic fibre loss associated with diffuse plaques in the non-demented elderly: the preclinical stage of Alzheimer's disease? Acta neuropathologica. vol 93. issue 2. 1997-06-03. PMID:9039461. |
cholinergic fibre densities were estimated in sections stained using acetylcholinesterase (ache) enzyme histochemistry. |
1997-06-03 |
2023-08-12 |
Not clear |
| A E Reyes, D R Perez, A Alvarez, J Garrido, M K Gentry, B P Doctor, N C Inestros. A monoclonal antibody against acetylcholinesterase inhibits the formation of amyloid fibrils induced by the enzyme. Biochemical and biophysical research communications. vol 232. issue 3. 1997-05-19. PMID:9126330. |
a monoclonal antibody (mab) 25b1 directed against fetal bovine-serum acetylcholinesterase (fbs ache) was used to examine the ability of the cholinergic enzyme to promote the assembly of amyloid-beta peptides (a beta) into alzheimerś fibrils. |
1997-05-19 |
2023-08-12 |
Not clear |
| K Hirai, K Kato, T Nakayama, H Hayako, Y Ishihara, G Goto, M Miyamot. Neurochemical effects of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-b enzazepin-8-yl)-1-propanone fumarate (TAK-147), a novel acetylcholinesterase inhibitor, in rats. The Journal of pharmacology and experimental therapeutics. vol 280. issue 3. 1997-04-11. PMID:9067312. |
these results suggest that tak-147 activates the central cholinergic system by specific inhibition of ache activity without affecting peripheral butyrylcholinesterase activity, and that tak-147 also moderately activates the monoaminergic systems. |
1997-04-11 |
2023-08-12 |
rat |
| C J Gordo. Thermoregulatory aspects of environmental exposure to anticholinesterase agents. Reviews on environmental health. vol 11. issue 3. 1997-03-20. PMID:9000302. |
ache inhibition elicits cholinergic stimulation in the central nervous system and in peripheral tissues and organs, which can lead to marked dysfunction of homeostatic systems, including temperature regulation. |
1997-03-20 |
2023-08-12 |
rat |
| C J Gordo. Thermoregulatory aspects of environmental exposure to anticholinesterase agents. Reviews on environmental health. vol 11. issue 3. 1997-03-20. PMID:9000302. |
thus, the antiche-induced effects on body temperature and other physiological systems cannot be explained solely by the immediate consequences of ache inhibition and stimulation of cholinergic systems. |
1997-03-20 |
2023-08-12 |
rat |
| J Liu, C N Pop. Effects of chlorpyrifos on high-affinity choline uptake and [3H]hemicholinium-3 binding in rat brain. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 34. issue 1. 1997-03-10. PMID:8937895. |
these results suggest that a reduction in hacu/acetylcholine synthesis may contribute, along with compensatory changes in cholinergic receptors, to the diminished toxicity following extensive ache inhibition by cpf. |
1997-03-10 |
2023-08-12 |
rat |
| R Schliebs, S Rossner, V Big. Immunolesion by 192IgG-saporin of rat basal forebrain cholinergic system: a useful tool to produce cortical cholinergic dysfunction. Progress in brain research. vol 109. 1997-03-07. PMID:9009714. |
nmda receptor binding was markedly reduced and ampa, kainate, and gabaa receptor binding has been significantly increased in cortical regions displaying a reduced activity of ache and decreased levels of high-affinity choline uptake sites due to immunolesion of the basal forebrain cholinergic system. |
1997-03-07 |
2023-08-12 |
rat |
| A A Al-Jafar. The inhibitory effect of the neuromuscular blocking agent, gallamine triethiodide, on camel retina acetylcholinesterase activity. Toxicology letters. vol 90. issue 1. 1997-02-27. PMID:9020401. |
the present investigation addresses the mode of inhibition of the camel retinal acetylcholinesterase (ache) activity by gallamine triethiodide, which is known to be a specific non-depolarizing neuromuscular blocking agent and polar cholinergic antagonist. |
1997-02-27 |
2023-08-12 |
Not clear |
| D Rodríguez-Ithurralde, S Olivera, A La Paz, O Vincent, A Rondea. Glycine effects on glutamate-receptor elicited acetylcholinesterase release from slices and synaptosomes of the spinal ventral horn. Journal of the neurological sciences. vol 139 Suppl. 1997-02-12. PMID:8899663. |
to study the mechanisms by which glutamate-elicited acetylcholinesterase release (gear) might play a part in the pathogenesis of excitotoxically triggered motor neurone disease, and to investigate the interaction of gear with spinal glycinergic mechanisms, we measured acetylcholinesterase (ache) and cholinergic markers, after stimulating ventral horn slices and synaptosomes from the mouse spinal cord, with both glutamate- and glycine-receptor agonists. |
1997-02-12 |
2023-08-12 |
mouse |
| T Takahata, Y Katayama, H Oshima, T Suma, M Koshinag. Transplantation of polymer-encapsulated fetal hippocampal cells into ischemic lesions of adult rat hippocampus. Cell transplantation. vol 5. issue 5 Suppl 1. 1997-01-31. PMID:8889221. |
in addition, the cholinergic fibers originated from the host brain were examined by acetylcholine esterase (ache) histochemistry. |
1997-01-31 |
2023-08-12 |
rat |
| C A Hawkins, S A Greenfiel. Comparison of the behavioural effects of infusion of carbachol and acetylcholinesterase into the rat substantia nigra. Pharmacology, biochemistry, and behavior. vol 55. issue 1. 1997-01-23. PMID:8870040. |
in this study the behavioural effects of unilateral infusion of ache and a cholinergic agonist, carbachol, were compared. |
1997-01-23 |
2023-08-12 |
rat |
| C A Hawkins, S A Greenfiel. Comparison of the behavioural effects of infusion of carbachol and acetylcholinesterase into the rat substantia nigra. Pharmacology, biochemistry, and behavior. vol 55. issue 1. 1997-01-23. PMID:8870040. |
this disparity between the effects of carbachol and ache would, therefore, suggest that ache is not exerting its long-term behavioural actions via a cholinergic mechanism, both in terms of time course of the response and the areas within the substantia nigra sensitive to these agents. |
1997-01-23 |
2023-08-12 |
rat |
| D H Small, S Michaelson, G Sbern. Non-classical actions of cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochemistry international. vol 28. issue 5-6. 1996-12-30. PMID:8792327. |
the function of ache at cholinergic synapses is to terminate cholinergic neurotransmission. |
1996-12-30 |
2023-08-12 |
Not clear |
| D H Small, S Michaelson, G Sbern. Non-classical actions of cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochemistry international. vol 28. issue 5-6. 1996-12-30. PMID:8792327. |
however, ache is expressed in tissues that are not directly innervated by cholinergic nerves. |
1996-12-30 |
2023-08-12 |
Not clear |
| D H Small, S Michaelson, G Sbern. Non-classical actions of cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochemistry international. vol 28. issue 5-6. 1996-12-30. PMID:8792327. |
acetylcholine has been shown to influence cell proliferation and neurite outgrowth through nicotinic and muscarinic receptor-mediated mechanisms and thus, that the expression of ache and bche at non-synaptic sites may be associated with a cholinergic function. |
1996-12-30 |
2023-08-12 |
Not clear |
| D M Zancan, H G Nóblega, A G Severino, M Achava. Acetylcholinesterase distribution in the central nervous system of the Megalobulimus oblongus (Gastropoda, Pulmonata). Archives d'anatomie, d'histologie et d'embryologie normales et experimentales. vol 75. 1996-12-18. PMID:8881557. |
these data provide further evidence that ache is present in neuronal bodies of the cns of this pulmonate snail, and in some areas is probably involved in cholinergic circuits. |
1996-12-18 |
2023-08-12 |
Not clear |