| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Takahata, Y Katayama, H Oshima, T Suma, M Koshinag. Transplantation of polymer-encapsulated fetal hippocampal cells into ischemic lesions of adult rat hippocampus. Cell transplantation. vol 5. issue 5 Suppl 1. 1997-01-31. PMID:8889221. |
in addition, the cholinergic fibers originated from the host brain were examined by acetylcholine esterase (ache) histochemistry. |
1997-01-31 |
2023-08-12 |
rat |
| C A Hawkins, S A Greenfiel. Comparison of the behavioural effects of infusion of carbachol and acetylcholinesterase into the rat substantia nigra. Pharmacology, biochemistry, and behavior. vol 55. issue 1. 1997-01-23. PMID:8870040. |
in this study the behavioural effects of unilateral infusion of ache and a cholinergic agonist, carbachol, were compared. |
1997-01-23 |
2023-08-12 |
rat |
| C A Hawkins, S A Greenfiel. Comparison of the behavioural effects of infusion of carbachol and acetylcholinesterase into the rat substantia nigra. Pharmacology, biochemistry, and behavior. vol 55. issue 1. 1997-01-23. PMID:8870040. |
this disparity between the effects of carbachol and ache would, therefore, suggest that ache is not exerting its long-term behavioural actions via a cholinergic mechanism, both in terms of time course of the response and the areas within the substantia nigra sensitive to these agents. |
1997-01-23 |
2023-08-12 |
rat |
| D H Small, S Michaelson, G Sbern. Non-classical actions of cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochemistry international. vol 28. issue 5-6. 1996-12-30. PMID:8792327. |
the function of ache at cholinergic synapses is to terminate cholinergic neurotransmission. |
1996-12-30 |
2023-08-12 |
Not clear |
| D H Small, S Michaelson, G Sbern. Non-classical actions of cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochemistry international. vol 28. issue 5-6. 1996-12-30. PMID:8792327. |
however, ache is expressed in tissues that are not directly innervated by cholinergic nerves. |
1996-12-30 |
2023-08-12 |
Not clear |
| D H Small, S Michaelson, G Sbern. Non-classical actions of cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochemistry international. vol 28. issue 5-6. 1996-12-30. PMID:8792327. |
acetylcholine has been shown to influence cell proliferation and neurite outgrowth through nicotinic and muscarinic receptor-mediated mechanisms and thus, that the expression of ache and bche at non-synaptic sites may be associated with a cholinergic function. |
1996-12-30 |
2023-08-12 |
Not clear |
| D M Zancan, H G Nóblega, A G Severino, M Achava. Acetylcholinesterase distribution in the central nervous system of the Megalobulimus oblongus (Gastropoda, Pulmonata). Archives d'anatomie, d'histologie et d'embryologie normales et experimentales. vol 75. 1996-12-18. PMID:8881557. |
these data provide further evidence that ache is present in neuronal bodies of the cns of this pulmonate snail, and in some areas is probably involved in cholinergic circuits. |
1996-12-18 |
2023-08-12 |
Not clear |
| S Hirokawa, M Nose, A Ishige, S Amagaya, T Oyama, Y Ogihar. Effect of Hachimi-jio-gan on scopolamine-induced memory impairment and on acetylcholine content in rat brain. Journal of ethnopharmacology. vol 50. issue 2. 1996-12-13. PMID:8866727. |
the effect of hachimi-jio-gan (hj) on scopolamine induced memory impairment was studied using a radial maze performance, the effect of hj on the central cholinergic system as measured by acetylcholine (ach) content, choline acetyltransferase (cat) and acetylcholinesterase (ache) activities was also examined. |
1996-12-13 |
2023-08-12 |
rat |
| M E Kriebel, M J Dowdall, G D Pappas, D L Downi. Detached, purified nerve terminals from skate electric organ for biochemical and physiological studies. The Biological bulletin. vol 190. issue 1. 1996-12-05. PMID:8852632. |
the activities of two cholinergic marker enzymes, choline acetyltransferase (chat) and acetylcholinesterase (ache), in extracts of whole fresh organs were much less than those reported for the electric ray torpedo, suggesting a lower volume of terminals in the organ. |
1996-12-05 |
2023-08-12 |
Not clear |
| H Schwegler, M Boldyreva, M Pyrlik-Göhlmann, R Linke, J Wu, K Zille. Genetic variation in the morphology of the septo-hippocampal cholinergic and GABAergic system in mice. I. Cholinergic and GABAergic markers. Hippocampus. vol 6. issue 2. 1996-12-03. PMID:8797015. |
in order to quantify the cholinergic innervation of various hippocampal sub-regions, we estimated the density of acetylcholinesterase (ache)-containing fibers as visualized by ache histochemistry. |
1996-12-03 |
2023-08-12 |
mouse |
| J J Hutsler, M S Gazzanig. Acetylcholinesterase staining in human auditory and language cortices: regional variation of structural features. Cerebral cortex (New York, N.Y. : 1991). vol 6. issue 2. 1996-11-27. PMID:8670655. |
acetylcholinesterase (ache), the enzyme responsible for deactivating acetylcholine, is found within both cholinergic axons arising from the basal forebrain and a subgroup of pyramidal cells in layers iii and v of the cerebral cortex. |
1996-11-27 |
2023-08-12 |
human |
| Y Reiss, S Kröger, J Grassi, K W Tsim, E Willbold, P G Laye. Extracellular and asymmetric forms of acetylcholinesterase are expressed on cholinergic and noncholinergic terminal neuropil of the developing chick retina. Cell and tissue research. vol 286. issue 1. 1996-11-21. PMID:8781208. |
only two out of four major acetylcholinesterase (ache) subbands in the inner plexiform layer (ipl) of vertebrate retinae correspond to sites of cholinergic synaptic transmission, as has been shown by the co-distribution of ache and choline acetyltransferase (chat) staining. |
1996-11-21 |
2023-08-12 |
chicken |
| Y Reiss, S Kröger, J Grassi, K W Tsim, E Willbold, P G Laye. Extracellular and asymmetric forms of acetylcholinesterase are expressed on cholinergic and noncholinergic terminal neuropil of the developing chick retina. Cell and tissue research. vol 286. issue 1. 1996-11-21. PMID:8781208. |
thus, extracellular and asymmetric forms of ache are predominantly found on the terminal arbor neuropil of both cholinergic and non-cholinergic ipl subbands. |
1996-11-21 |
2023-08-12 |
chicken |
| M Srivatsan, B Peret. Effect of acetylcholinesterase inhibition on behavior is age-dependent in freely moving Aplysia. Behavioural brain research. vol 77. issue 1-2. 1996-11-18. PMID:8762162. |
comparisons of the results of ache inhibition which would elevate acetylcholine (ach) levels with those of carbachol administration revealed that ache inhibition affects both cholinergic and non-cholinergic mechanisms underlying the two behaviors. |
1996-11-18 |
2023-08-12 |
aplysia |
| S Jianmongkol, C E Berkman, C M Thompson, R J Richardso. Relative potencies of the four stereoisomers of isomalathion for inhibition of hen brain acetylcholinesterase and neurotoxic esterase in vitro. Toxicology and applied pharmacology. vol 139. issue 2. 1996-10-28. PMID:8806851. |
the cholinergic toxicity of malathion is exacerbated by its isomerization product, isomalathion, which inhibits detoxifying carboxylesterases as well as target acetylcholinesterase (ache). |
1996-10-28 |
2023-08-12 |
rat |
| M Weinstoc. The pharmacotherapy of Alzheimer's disease based on the cholinergic hypothesis: an update. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 4. issue 4. 1996-10-24. PMID:8846227. |
current pharmacological strategies, aimed at increasing cholinergic activity include acetylcholinesterase (ache) inhibitors, cholinergic agonists, acetylcholine (ach) releasers and stimulants of nerve growth factors (ngf). |
1996-10-24 |
2023-08-12 |
Not clear |
| B R Capacio, C E Byers, D R Anderson, R L Matthews, D E Brow. The effect of ondansetron on pyridostigmine-induced blood acetylcholinesterase inhibition in the guinea pig. Drug and chemical toxicology. vol 19. issue 1-2. 1996-10-16. PMID:8804550. |
the significance of these findings is that the increased ache inhibition resulting from simultaneous oral administration of both component could result in undesirable cholinergic toxicities and subsequent perform decrements. |
1996-10-16 |
2023-08-12 |
Not clear |
| Z P Yang, J Morrow, A Wu, L J Roberts, W D Dettbar. Diisopropylphosphorofluoridate-induced muscle hyperactivity associated with enhanced lipid peroxidation in vivo. Biochemical pharmacology. vol 52. issue 2. 1996-08-26. PMID:8694861. |
it is suggested that the ache inhibitor-induced cholinergic hyperactivity initiates that accumulation of free radicals leading to lipid peroxidation, which may be the initiator of the ache inhibitor-induced cell injury. |
1996-08-26 |
2023-08-12 |
rat |
| G M Bores, F P Huger, W Petko, A E Mutlib, F Camacho, D K Rush, D E Selk, V Wolf, R W Kosley, L Davis, H M Varga. Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine. The Journal of pharmacology and experimental therapeutics. vol 277. issue 2. 1996-06-27. PMID:8627552. |
p11012 and p11149 were found to be potent, competitive and selective inhibitors of ache, demonstrating central cholinergic activity, behavioral efficacy and safety. |
1996-06-27 |
2023-08-12 |
rat |
| G M Bores, F P Huger, W Petko, A E Mutlib, F Camacho, D K Rush, D E Selk, V Wolf, R W Kosley, L Davis, H M Varga. Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine. The Journal of pharmacology and experimental therapeutics. vol 277. issue 2. 1996-06-27. PMID:8627552. |
like gal, both p11012 and p11149 showed central cholinergic activity biochemically, by significantly inhibiting rat brain ache; physiologically, by causing hypothermia; and behaviorally, by attenuating scopolamine-induced deficits in passive avoidance. |
1996-06-27 |
2023-08-12 |
rat |