| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B R Capacio, C E Byers, D R Anderson, R L Matthews, D E Brow. The effect of ondansetron on pyridostigmine-induced blood acetylcholinesterase inhibition in the guinea pig. Drug and chemical toxicology. vol 19. issue 1-2. 1996-10-16. PMID:8804550. |
the significance of these findings is that the increased ache inhibition resulting from simultaneous oral administration of both component could result in undesirable cholinergic toxicities and subsequent perform decrements. |
1996-10-16 |
2023-08-12 |
Not clear |
| Z P Yang, J Morrow, A Wu, L J Roberts, W D Dettbar. Diisopropylphosphorofluoridate-induced muscle hyperactivity associated with enhanced lipid peroxidation in vivo. Biochemical pharmacology. vol 52. issue 2. 1996-08-26. PMID:8694861. |
it is suggested that the ache inhibitor-induced cholinergic hyperactivity initiates that accumulation of free radicals leading to lipid peroxidation, which may be the initiator of the ache inhibitor-induced cell injury. |
1996-08-26 |
2023-08-12 |
rat |
| G M Bores, F P Huger, W Petko, A E Mutlib, F Camacho, D K Rush, D E Selk, V Wolf, R W Kosley, L Davis, H M Varga. Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine. The Journal of pharmacology and experimental therapeutics. vol 277. issue 2. 1996-06-27. PMID:8627552. |
p11012 and p11149 were found to be potent, competitive and selective inhibitors of ache, demonstrating central cholinergic activity, behavioral efficacy and safety. |
1996-06-27 |
2023-08-12 |
rat |
| G M Bores, F P Huger, W Petko, A E Mutlib, F Camacho, D K Rush, D E Selk, V Wolf, R W Kosley, L Davis, H M Varga. Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine. The Journal of pharmacology and experimental therapeutics. vol 277. issue 2. 1996-06-27. PMID:8627552. |
like gal, both p11012 and p11149 showed central cholinergic activity biochemically, by significantly inhibiting rat brain ache; physiologically, by causing hypothermia; and behaviorally, by attenuating scopolamine-induced deficits in passive avoidance. |
1996-06-27 |
2023-08-12 |
rat |
| P DeBoer, E D Abercrombi. Physiological release of striatal acetylcholine in vivo: modulation by D1 and D2 dopamine receptor subtypes. The Journal of pharmacology and experimental therapeutics. vol 277. issue 2. 1996-06-27. PMID:8627558. |
the degree to which the dopaminergic modulation of striatal cholinergic neurons might vary as a function of local extracellular ach level also was examined by application of varying concentrations of the acetylcholinesterase (ache), inhibitor neostigmine (neo) in the microdialysis perfusate. |
1996-06-27 |
2023-08-12 |
rat |
| N C Inestrosa, A Alvarez, C A Pérez, R D Moreno, M Vicente, C Linker, O I Casanueva, C Soto, J Garrid. Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme. Neuron. vol 16. issue 4. 1996-05-28. PMID:8608006. |
acetylcholinesterase (ache), an important component of cholinergic synapses, colocalizes with amyloid-beta peptide (a beta) deposits of alzheimer's brain. |
1996-05-28 |
2023-08-12 |
mouse |
| N C Inestrosa, A Alvarez, C A Pérez, R D Moreno, M Vicente, C Linker, O I Casanueva, C Soto, J Garrid. Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme. Neuron. vol 16. issue 4. 1996-05-28. PMID:8608006. |
thus, in addition to its role in cholinergic synapses, ache may function by accelerating a beta formation and could play a role during amyloid deposition in alzheimer's brain. |
1996-05-28 |
2023-08-12 |
mouse |
| W Yao, D A Godfre. Immunohistochemistry of muscarinic acetylcholine receptors in rat cochlear nucleus. Hearing research. vol 89. issue 1-2. 1996-04-30. PMID:8600134. |
to investigate the distribution of machrs and the correlation of pre- and post-synaptic cholinergic markers in cn, we used a monoclonal anti-machr antibody (m35) and a monoclonal antibody against choline acetyltransferase (chat) to perform immunohistochemistry on rat brain sections, and we also carried out histochemistry for acetylcholinesterase (ache) activity. |
1996-04-30 |
2023-08-12 |
rat |
| J T Laitinen, K S Laitinen, T Kokkol. Cholinergic signaling in the rat pineal gland. Cellular and molecular neurobiology. vol 15. issue 2. 1996-03-25. PMID:8590450. |
cholinergic signaling in the rat pineal gland is suggested based on the localization of choline acetyltransferase (chat) and acetylcholinesterase (ache), as well as muscarinic and nicotinic ach binding sites in the gland. |
1996-03-25 |
2023-08-12 |
rat |
| W Tong, E R Collantes, Y Chen, W J Wels. A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors. Journal of medicinal chemistry. vol 39. issue 2. 1996-02-28. PMID:8558505. |
these compounds have been found to inhibit the metabolic breakdown of the neurotransmitter acetylcholine (ach) by the enzyme acetylcholinesterase (ache) and hence alleviate memory deficits in patients with alzheimer's disease by potentiating cholinergic transmission. |
1996-02-28 |
2023-08-12 |
human |
| H Schwegle. Transient postnatal thyroxine treatment leads to an increased number of cholinergic neurons in the medial septum and to a higher density of cholinergic fibers in hippocampal CA3 in rats. Neuroscience letters. vol 198. issue 3. 1996-02-21. PMID:8552320. |
at the age of 12 weeks, the number of immunocytochemically labeled cholinergic neuronal profiles in the medial septum/diagonal band (ms/vdb) was counted, and the density of acetylcholinesterase (ache)-positive fibers in four hippocampal subregions was measured. |
1996-02-21 |
2023-08-12 |
rat |
| S P Mahadik, S Mukherje. Monosialoganglioside cotreatment prevents haloperidol treatment-associated loss of cholinergic enzymes in rat brain. Biological psychiatry. vol 38. issue 4. 1996-02-20. PMID:8547447. |
effects of monosialoganglioside (gm1 ganglioside) cotreatment with haloperidol (hal) were studied in rat on the haloperidol treatment-associated changes in cholinergic enzymes, choline acetyltransferase (chat), and acetylcholinesterase (ache) in three brain regions of interest: striatum, hippocampus, and cerebral cortex. |
1996-02-20 |
2023-08-12 |
rat |
| K Ikeda, T Egashira, J Yamashita, S Okoyam. Effect of vagal autotransplantation and bifemelane hydrochloride on cholinergic markers and event-related potentials in rats with lesions of the nucleus basalis magnocellularis. Brain research. vol 688. issue 1-2. 1996-02-14. PMID:8542304. |
in addition, the effects on cholinergic markers were assessed by determining the specific binding of [3h]qnb (quinuclidinyl benzilate) to the muscarinic acetylcholine receptor (machr) as well as the activity of choline acetyltransferase (chat) and acetylcholinesterase (ache). |
1996-02-14 |
2023-08-12 |
rat |
| C Geula, M M Mesula. Cholinesterases and the pathology of Alzheimer disease. Alzheimer disease and associated disorders. vol 9 Suppl 2. 1996-02-07. PMID:8534419. |
alzheimer disease (ad) is accompanied by a marked loss of acetylcholinesterase (ache) activity associated with cortical cholinergic axons and cholinoceptive neurons. |
1996-02-07 |
2023-08-12 |
Not clear |
| S Nochi, N Asakawa, T Sat. Kinetic study on the inhibition of acetylcholinesterase by 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (E2020). Biological & pharmaceutical bulletin. vol 18. issue 8. 1996-02-05. PMID:8535413. |
its mechanism of action is to increase central cholinergic activity by inhibiting acetylcholinesterase (ache) in the brain. |
1996-02-05 |
2023-08-12 |
Not clear |
| N Senanayake, P S Sanmuganatha. Extrapyramidal manifestations complicating organophosphorus insecticide poisoning. Human & experimental toxicology. vol 14. issue 7. 1995-12-28. PMID:7576821. |
the human extrapyramidal system is rich in cholinergic neurons and acetylcholinesterase (ache). |
1995-12-28 |
2023-08-12 |
human |
| J Bajgar, G M Bisso, H Michale. Differential inhibition of rat brain acetylcholinesterase molecular forms by 7-methoxytacrine in vitro. Toxicology letters. vol 80. issue 1-3. 1995-12-14. PMID:7482577. |
the differential inhibition of ache molecular forms by 7-meota is discussed in relation to its possible clinical application for treatment of disorders such as alzheimer's disease, in which a reduction of brain cholinergic neurotransmission is believed to play a role. |
1995-12-14 |
2023-08-12 |
rat |
| C Legay, M Huchet, J Massoulié, J P Changeu. Developmental regulation of acetylcholinesterase transcripts in the mouse diaphragm: alternative splicing and focalization. The European journal of neuroscience. vol 7. issue 8. 1995-11-28. PMID:7582132. |
this suggests that a common control mechanism ensures the synaptic focalization of mrnas encoding the cholinergic proteins ache and acetylcholine receptor during muscle development. |
1995-11-28 |
2023-08-12 |
mouse |
| G Sánchez-Chávez, C J Vidal, R Salced. Acetyl- and butyrylcholinesterase activities in the rat retina and retinal pigment epithelium. Journal of neuroscience research. vol 41. issue 5. 1995-11-09. PMID:7563246. |
the ache in the neural retina might be involved in cholinergic actions. |
1995-11-09 |
2023-08-12 |
rat |
| T Nonomura, C Nishio, R M Lindsay, H Hatanak. Cultured basal forebrain cholinergic neurons from postnatal rats show both overlapping and non-overlapping responses to the neurotrophins. Brain research. vol 683. issue 1. 1995-11-03. PMID:7552337. |
we have addressed this issue in cultures of basal forebrain neurons derived from 2-week-old postnatal rats, using choline acetyltransferase (chat) and acetylcholinesterase (ache) as cholinergic markers. |
1995-11-03 |
2023-08-12 |
rat |