| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Rodríguez-Ithurralde, O Vincen. Excitotoxicity and cholinergic chemical markers during programmed motor neurone death. Journal of the neurological sciences. vol 124 Suppl. 1995-02-02. PMID:7807141. |
we measured cholinergic markers and acetylcholinesterase (ache) molecular forms after glutamate receptor stimulation of superfused slices of mouse spinal cord at different developmental ages. |
1995-02-02 |
2023-08-12 |
mouse |
| J De Bleecker, D Lison, K Van Den Abeele, J Willems, J De Reuc. Acute and subacute organophosphate poisoning in the rat. Neurotoxicology. vol 15. issue 2. 1995-01-12. PMID:7991223. |
marked differences are noted in the duration of cholinergic symptoms and of ache inhibition after either paraoxon and mipafox, or fenthion poisoning. |
1995-01-12 |
2023-08-12 |
rat |
| E A Van der Zee, P G Luite. Cholinergic and GABAergic neurons in the rat medial septum express muscarinic acetylcholine receptors. Brain research. vol 652. issue 2. 1994-12-29. PMID:7953739. |
the cholinergic transmitter nature of the machr-positive cells was studied using adjacent 8 microns thick serial sections stained immunocytochemically for choline acetyltransferase (chat), or histochemically for acetylcholinesterase (ache). |
1994-12-29 |
2023-08-12 |
rat |
| T Egashir. [Experimental techniques for developing new drugs acting on dementia (4)--Aged rats]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 14. issue 4. 1994-12-16. PMID:7975929. |
the changes in choline acetyltransferase (chat), acetylcholinesterase (ache), muscarinic receptor binding (machr) and na(+)-dependent high affinity choline uptake (hacu) are generally consistent with age-dependent declines in cholinergic neurotransmission, although these decreases may include differences in strain/species, sex, tissue sampling and assay procedures. |
1994-12-16 |
2023-08-12 |
rat |
| Z X She. Acetylcholinesterase provides deeper insights into Alzheimer's disease. Medical hypotheses. vol 43. issue 1. 1994-12-07. PMID:7968717. |
this article reviews the considerable evidence which rejects the cholinergic hypothesis of alzheimer's disease (ad) and proposes that it is the ache system of which the lightly stained neurons are located in the entorhinal cortex, the ca1/subiculum of the hippocampus and the amygdala which are the most vulnerable and are the earliest affected in the pathological processes of ad. |
1994-12-07 |
2023-08-12 |
Not clear |
| D Nonner, J N Barret. Changes in the response of cultured septal cholinergic neurons to nerve growth factor exposure and deprivation during the first postnatal month. Brain research. Developmental brain research. vol 79. issue 2. 1994-11-30. PMID:7955320. |
to determine whether this increase was due to enhanced survival of cholinergic neurons or simply to enhanced ache expression, we examined cultures to which ngf was added only after an initial 1-2-week exposure to anti-ngf antibody. |
1994-11-30 |
2023-08-12 |
rat |
| R C Gupta, J T Goad, W L Kade. Cholinergic and noncholinergic changes in skeletal muscles by carbofuran and methyl parathion. Journal of toxicology and environmental health. vol 43. issue 3. 1994-11-29. PMID:7966439. |
the objective of this investigation was to determine the distribution of cholinergic (acetyl-cholinesterase, ache) and noncholinergic markers in slow-, fast-, and mixed-fiber containing muscles (soleus, sol; extensor digitorum longus, edl; and diaphragm, dia, respectively). |
1994-11-29 |
2023-08-12 |
rat |
| R C Gupta, J T Goad, W L Kade. Cholinergic and noncholinergic changes in skeletal muscles by carbofuran and methyl parathion. Journal of toxicology and environmental health. vol 43. issue 3. 1994-11-29. PMID:7966439. |
rats receiving either insecticide showed cholinergic signs with maximal severity including muscle fasciculations and convulsions within 15-30 min that lasted for about 2 h. at 1 h postinsecticide injection, when ache was maximally inhibited (81-96%), significant depletion of atp and pcr was evident in muscles (dia > sol > edl), and activities of ck-mm and ldh were elevated in muscles and consequently in serum. |
1994-11-29 |
2023-08-12 |
rat |
| O Stewar. Cholinergic sprouting is blocked by repeated induction of electroconvulsive seizures, a manipulation that induces a persistent reactive state in astrocytes. Experimental neurology. vol 129. issue 1. 1994-11-16. PMID:7925832. |
quantitative densitometric analyses revealed that the increase in ache staining that is indicative of cholinergic sprouting was essentially eliminated in the animals that experienced daily ecs. |
1994-11-16 |
2023-08-12 |
mouse |
| S De Lacalle, C Lim, T Sobreviela, E J Mufson, L B Hersh, C B Sape. Cholinergic innervation in the human hippocampal formation including the entorhinal cortex. The Journal of comparative neurology. vol 345. issue 3. 1994-10-27. PMID:7929905. |
we studied the cholinergic innervation of the human hippocampal formation by means of immunohistochemistry with polyclonal antisera directed against acetylcholinesterase (ache), choline acetyltransferase (chat), and the low-affinity (p75) nerve growth factor receptor (ngfr). |
1994-10-27 |
2023-08-12 |
human |
| Y Ishihara, K Hirai, M Miyamoto, G Got. Central cholinergic agents. 6. Synthesis and evaluation of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepi n-8-yl)-1-propanones and their analogs as central selective acetylcholinesterase inhibitors. Journal of medicinal chemistry. vol 37. issue 15. 1994-09-12. PMID:8057278. |
among compounds with potent ache inhibition, 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1h-1- benzazepin-8-yl)-1-propanone fumarate (9a, tak-147) (ic50 of ache inhibition = 97.7 nm) inhibited the circling behavior at 3 mg/kg po, in which it had no significant effect on peripheral cholinergic effects. |
1994-09-12 |
2023-08-12 |
rat |
| H J Koponen, J Sirviö, U Lepola, E Leinonen, P J Riekkine. A long-term follow-up study of cerebrospinal fluid acetylcholinesterase in delirium. European archives of psychiatry and clinical neuroscience. vol 243. issue 6. 1994-08-31. PMID:8043620. |
the ache levels measured during the index admission correlated with the length of life after delirium, suggesting that cholinergic dysfunction may have prognostic significance in delirious patients. |
1994-08-31 |
2023-08-12 |
Not clear |
| J Berger-Sweeney, S Heckers, M M Mesulam, R G Wiley, D A Lappi, M Sharm. Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 7. 1994-08-11. PMID:8027790. |
acetylcholinesterase (ache) histochemistry and ngfr and choline acetyltransferase immunohistochemistry revealed a loss of (1) almost all ngfr-positive cholinergic neurons in the msa and ache fibers in hippocampus (msa group); (2) almost all ngfr neurons in the nbm, some in the msa, most ache fibers in neocortex and some in the hippocampus (nbm group), and (3) almost all ngfr neurons in the msa and nbm and their corresponding hippocampal and cortical ache fibers (ventricular group). |
1994-08-11 |
2023-08-12 |
rat |
| Y L Chen, D Liston, J Nielsen, D Chapin, A Dunaiskis, K Hedberg, J Ives, J Johnson, S Jone. Syntheses and anticholinesterase activity of tetrahydrobenzazepine carbamates. Journal of medicinal chemistry. vol 37. issue 13. 1994-08-09. PMID:8027982. |
the in vitro ache inhibition, cholinergic effects, acute toxicity, and elevation of brain acetylcholine levels in vivo of this series of compounds are described. |
1994-08-09 |
2023-08-12 |
mouse |
| M Yokoyama, R S Morrison, I B Black, C F Dreyfu. Septal neuron cholinergic and GABAergic functions: differential regulation by basic fibroblast growth factor and epidermal growth factor. Brain research. Developmental brain research. vol 78. issue 2. 1994-08-05. PMID:8026075. |
to determine whether increases in cat activity reflect increased enzyme activity per neuron or an increase in the number of cholinergic cells, bfgf-treated cultures were stained for acetylcholinesterase (ache) to determine numbers of cholinergic cells. |
1994-08-05 |
2023-08-12 |
cat |
| C P Heisenberg, J D Cooper, J Berke, M V Sofronie. NMDA potentiates NGF-induced sprouting of septal cholinergic fibres. Neuroreport. vol 5. issue 4. 1994-07-20. PMID:8003664. |
nerve growth factor (ngf) injected into the otherwise unlesioned adult rat septum induced sprouting of presumptive cholinergic fibres positive for p75ngfr and acetylcholinesterase (ache). |
1994-07-20 |
2023-08-12 |
rat |
| C A Kitt, C Höhmann, J T Coyle, D L Pric. Cholinergic innervation of mouse forebrain structures. The Journal of comparative neurology. vol 341. issue 1. 1994-07-15. PMID:8006218. |
using choline acetyltransferase (chat) immunocytochemistry and acetylcholinesterase (ache) histochemistry, we investigated regional and laminar differences in cholinergic innervation in the cerebral cortex, hippocampus, amygdala, and thalamus of mice. |
1994-07-15 |
2023-08-12 |
mouse |
| D S Barrett, F W Oehme, S M Kruckenberg, J E Smit. Clinical manifestations and leukocyte neurotoxic esterase and red blood cell and plasma acetylcholinesterase activities in swine following a single oral dose of tri-o-cresyl phosphate. Veterinary and human toxicology. vol 36. issue 2. 1994-06-30. PMID:8197706. |
plasma ache activities appeared to more accurately reflect the development of acute cholinergic signs observed in the 1000 mg/kg dosed swine at 3 h postdosing while red blood cell ache activities were more consistent with the delayed cholinergic signs exhibited by the 400 and 800 mg/kg dosed swine at 24 h postdosing. |
1994-06-30 |
2023-08-12 |
Not clear |
| L C Anderson, J R Garret. The effects of streptozotocin-induced diabetes on norepinephrine and cholinergic enzyme activities in rat parotid and submandibular glands. Archives of oral biology. vol 39. issue 2. 1994-06-16. PMID:8185504. |
therefore, glandular levels of the adrenergic neurotransmitter, norepinephrine (ne) and two cholinergic enzymes, choline acetyltransferase (chat) and acetylcholinesterase (ache), were investigated in 6-month streptozotocin-diabetic rats. |
1994-06-16 |
2023-08-12 |
rat |
| I Aubert, J Poirier, S Gauthier, R Quirio. Multiple cholinergic markers are unexpectedly not altered in the rat dentate gyrus following entorhinal cortex lesions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 5 Pt 1. 1994-06-14. PMID:8182423. |
in this regard, it has been shown that lesions of the entorhinal cortex, which sends glutamatergic projections to the hippocampus, promote the sprouting and plasticity of presumptive cholinergic septohippocampal fibers in the dentate gyrus, as revealed by ache histochemistry. |
1994-06-14 |
2023-08-12 |
rat |