| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Sirviö, P J Riekkine. Brain and cerebrospinal fluid cholinesterases in Alzheimer's disease, Parkinson's disease and aging. A critical review of clinical and experimental studies. Journal of neural transmission. Parkinson's disease and dementia section. vol 4. 1992-11-17. PMID:1388703. |
acetylcholinesterase (ache), an enzyme responsible for the break-down of acetylcholine, is found both in cholinergic and non-cholinergic neurons in the central nervous system. |
1992-11-17 |
2023-08-11 |
Not clear |
| E E Tyrala, S V Mathews, G S Ra. Effect of intrauterine exposure to cocaine on acetylcholinesterase in primary cultures of fetal mouse brain cells. Neurotoxicology and teratology. vol 14. issue 4. 1992-10-15. PMID:1522827. |
utilizing ache as a biochemical marker, these studies have shown that in utero exposure to cocaine has an adverse effect on the normal developmental pattern of the production of acetylcholinesterase in cholinergic neurons in the fetal mouse brain. |
1992-10-15 |
2023-08-11 |
mouse |
| L E Trudeau, P Fossier, G Baux, L Tau. Xanthine derivatives IBMX and S-9977-2 potentiate transmission at an Aplysia central cholinergic synapse. Brain research. vol 586. issue 1. 1992-09-29. PMID:1380883. |
the finding that responses to the hydrolysis-resistant cholinergic analogue carbachol were unaffected by the two xanthines suggested that the observed effects were at least partly caused by an inhibition of acetylcholinesterase (ache) activity. |
1992-09-29 |
2023-08-11 |
aplysia |
| Y He, Z Yao, Y Gu, G Kuang, Y Che. Nerve growth factor promotes collateral sprouting of cholinergic fibers in the septohippocampal cholinergic system of aged rats with fimbria transection. Brain research. vol 586. issue 1. 1992-09-29. PMID:1511349. |
controls received intraventricular injections of cytochrome c. a quantitative analysis of acetylcholinesterase (ache)-positive fibers was used to evaluate whether the ngf treatment can stimulate regeneration and reinnervation of the cholinergic axons in the septohippocampal system of aged rats with fimbria transection. |
1992-09-29 |
2023-08-11 |
rat |
| J Quillfeldt, B Bolioli, C Dalmaz, S Rascovsky, C H Huang, M Dias, M B Ferreira, F Schneider, I Izquierdo, J H Medin. Biochemical and behavioral effects of intraseptal microinjection of fasciculin, an irreversible acetylcholinesterase inhibitor. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 24. issue 5. 1992-09-22. PMID:1823265. |
we examined the effect, in rats, of an intraseptal microinjection of fasciculin (fas), an irreversible peptide acetylcholinesterase (ache) inhibitor, on a) ache activity measured in septum and hippocampus, b) 3h-quinuclidinyl benzylate (3h-qnb) and 3h-oxotremorine (3h-oxo) binding to hippocampal cholinergic muscarinic receptors, c) 3h-flunitrazepam (3h-fnz) binding to hippocampal benzodiazepine receptors as a control for qnb and oxo binding, d) acquisition and retention in three different behavioral paradigms, i.e., water-finding (in which there is concomitant habituation to the apparatus), step-down inhibitory avoidance, and shuttle avoidance. |
1992-09-22 |
2023-08-11 |
rat |
| J Quillfeldt, B Bolioli, C Dalmaz, S Rascovsky, C H Huang, M Dias, M B Ferreira, F Schneider, I Izquierdo, J H Medin. Biochemical and behavioral effects of intraseptal microinjection of fasciculin, an irreversible acetylcholinesterase inhibitor. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 24. issue 5. 1992-09-22. PMID:1823265. |
the persistent inhibition of septal ache caused by fas microinjection into the septum is not sufficient to induce major changes either in hippocampal cholinergic muscarinic receptors, or in the learning or retention of behaviors regulated by the septum and/or hippocampus. |
1992-09-22 |
2023-08-11 |
rat |
| S L Minger, P Davie. Persistent innervation of the rat neocortex by basal forebrain cholinergic neurons despite the massive reduction of cortical target neurons. II. Neurochemical analysis. Experimental neurology. vol 117. issue 2. 1992-09-11. PMID:1354164. |
in this paper, neurochemical analysis of cholinergic enzymes (chat and ache) in 2-month-old offspring reveals that the basal forebrain innervates the hypocellular cortex in apparently normal fashion, despite the loss of target neurons. |
1992-09-11 |
2023-08-11 |
rat |
| M Konagaya, Y Konagaya, M Iid. [CSF acetylcholinesterase activity in central neurological diseases involving cholinergic systems]. Rinsho shinkeigaku = Clinical neurology. vol 32. issue 3. 1992-08-19. PMID:1628449. |
then, we evaluated csf ache activity in 90 cases of neurological diseases involving cholinergic system and their related disease, and 28 control cases without central organic lesions or abnormal findings in routine csf study. |
1992-08-19 |
2023-08-11 |
Not clear |
| J Kiss, A J Pate. Development of the cholinergic fibres innervating the cerebral cortex of the rat. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 10. issue 2. 1992-08-18. PMID:1632275. |
the ontogeny of innervation of the cholinergic fibres from the basal forebrain into the cingulate, frontal, parietal and piriform cortices of the rat has been examined using a modified histochemical method of acetylcholinesterase (ache). |
1992-08-18 |
2023-08-11 |
rat |
| J Kiss, A J Pate. Development of the cholinergic fibres innervating the cerebral cortex of the rat. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 10. issue 2. 1992-08-18. PMID:1632275. |
within the dispersed ache fibre network in the cerebral cortex, three bands of relatively enriched cholinergic processes, namely the deep cortical, mid-cortical and superficial layers, developed in an 'inside-out' fashion. |
1992-08-18 |
2023-08-11 |
rat |
| E K Perry, M Johnson, J M Kerwin, M A Piggott, J A Court, P J Shaw, P G Ince, A Brown, R H Perr. Convergent cholinergic activities in aging and Alzheimer's disease. Neurobiology of aging. vol 13. issue 3. 1992-08-12. PMID:1625768. |
a similar trend was apparent with respect to acetylcholinesterase (ache) histochemical activity associated with fibers and terminals (predominantly cholinergic and concentrated in ca3 and 4 of the hippocampus) but not with reactive perikarya (considered to be noncholinergic) present in both hippocampus and cortex. |
1992-08-12 |
2023-08-11 |
human |
| R P Gaykema, C Nyakas, E Horvath, L B Hersh, C Majtenyi, P G Luite. Cholinergic fiber aberrations in nucleus basalis lesioned rat and Alzheimer's disease. Neurobiology of aging. vol 13. issue 3. 1992-08-12. PMID:1625774. |
innervation density and morphological aberrations of cholinergic fibers were studied with choline acetyltransferase (chat) immunocytochemistry and acetylcholinesterase (ache) histochemistry in 30-35 month-old aged rats and rats with long-term bilateral lesions of the magnocellular basal nucleus (mbn). |
1992-08-12 |
2023-08-11 |
human |
| H M Hwang, M Y Min, Y S Fuh, T H Chi. Effects of cholinergic depletion by medial septal area lesions on synaptic responses in CA1 area of hippocampal slices. The Chinese journal of physiology. vol 34. issue 4. 1992-08-10. PMID:1820845. |
it was found that bilateral lesions of the medial septal area (msa) by microinjection of kainic acid produced a dramatic reduction of acetylcholinesterase-positive (ache(+)) fibers, presumably cholinergic, in most of hippocampal areas. |
1992-08-10 |
2023-08-11 |
Not clear |
| H Soreq, Y Lapidot-Lifson, H Zaku. A role for cholinesterases in tumorigenesis? Cancer cells (Cold Spring Harbor, N.Y. : 1989). vol 3. issue 12. 1992-08-06. PMID:1820094. |
hydrolysis of the neurotransmitter acetylcholine by acetylcholinesterase (ache) and butyrylcholinesterase (bche) is the rate-limiting step in the termination of cholinergic signaling at neuromuscular junctions. |
1992-08-06 |
2023-08-11 |
human |
| D K Getman, J H Eubanks, S Camp, G A Evans, P Taylo. The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7. American journal of human genetics. vol 51. issue 1. 1992-07-23. PMID:1609795. |
acetylcholinesterase (ache) is a secreted enzyme essential for regulating cholinergic neurotransmission at neuronal and neuromuscular synapses. |
1992-07-23 |
2023-08-11 |
human |
| G Braun, G Bicke. Habituation of an appetitive reflex in the honeybee. Journal of neurophysiology. vol 67. issue 3. 1992-06-10. PMID:1578245. |
application of an acetylcholine esterase (ache) inhibitor and a cholinergic receptor blocker confirmed histochemical data that implicate cholinergic transmission in the reflex pathways. |
1992-06-10 |
2023-08-11 |
bee |
| G X. [Further investigation into the recurrent causes of post-vidian neurectomy and the feasibility of treating vasomotor rhinitis by surgery]. Zhonghua er bi yan hou ke za zhi. vol 26. issue 5. 1992-06-10. PMID:1811678. |
the authors had found that there were parasympathetic nerve fibres in the anterior ethmoid nerve and also cholinergic microganglia were present in the inferior turbinate of humans by the histochemical method of acetylcholinesterase (ache). |
1992-06-10 |
2023-08-11 |
Not clear |
| K Kobayashi, K Miyazu, Y Fukutani, I Nakamura, N Yamaguch. Morphometric study on the CH4 of the nucleus basalis of Meynert in Alzheimer's disease. Molecular and chemical neuropathology. vol 15. issue 3. 1992-05-18. PMID:1725482. |
the cholinergic neurons were identified as positive reaction products of ache in the perikarya. |
1992-05-18 |
2023-08-11 |
Not clear |
| T G Beach, E G McGee. Senile plaques, amyloid beta-protein, and acetylcholinesterase fibres: laminar distributions in Alzheimer's disease striate cortex. Acta neuropathologica. vol 83. issue 3. 1992-05-06. PMID:1373024. |
the results indicate that enhanced silver methods may not reveal the complete distribution of a beta p. the codistribution of a beta p-immunoreactive diffuse amyloid deposits and ache fibres to the same cortical laminae is consistent with the possibility that these deposits may be formed from degenerating cholinergic elements. |
1992-05-06 |
2023-08-11 |
Not clear |
| J W Sowell, Y Tang, M J Valli, J M Chapman, L A Usher, C M Vaughan, J W Kos. Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine. Journal of medicinal chemistry. vol 35. issue 6. 1992-04-28. PMID:1552502. |
in an effort to develop novel, nonquaternary ache inhibitors capable of penetrating into the cns and alleviating the cholinergic deficit characteristic of alzheimer's disease, a series of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine has been synthesized. |
1992-04-28 |
2023-08-11 |
mouse |