| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J K Marqui. Pharmacological significance of acetylcholinesterase inhibition by tetrahydroaminoacridine. Biochemical pharmacology. vol 40. issue 5. 1990-09-27. PMID:2390104. |
the kinetic analyses were also designed to determine whether chemical modification of peripheral anionic sites on ache may provide insight into mechanism for selective pharmacological alteration of cholinergic function in the brain. |
1990-09-27 |
2023-08-11 |
cattle |
| K Hozawa, R S Kimur. Cholinergic and noradrenergic nervous systems in the cynomolgus monkey cochlea. Acta oto-laryngologica. vol 110. issue 1-2. 1990-09-20. PMID:1974732. |
the cholinergic and noradrenergic nervous systems in the cochleas of cynomolgus monkeys were examined by histochemical and immunohistochemical demonstration of acetylcholinesterase (ache) and tyrosine hydroxylase (th) and/or dopamine b-hydroxylase (dbh), respectively. |
1990-09-20 |
2023-08-11 |
monkey |
| S Katayama, S Kito, Y Yamamur. Increase of muscarinic receptor following kainic acid lesions of the nucleus basalis magnocellularis in rat brain: an autoradiographic study. Research communications in chemical pathology and pharmacology. vol 68. issue 3. 1990-09-17. PMID:2385763. |
the area with decreased ache activity and increased density in 3h-qnb binding sites corresponded to the innervation of the cholinergic system arising from the nbm. |
1990-09-17 |
2023-08-11 |
rat |
| J C Szerb, A Fin. Is glutamate a co-transmitter in cortical cholinergic terminals? Effects of nucleus basalis lesion and of presynaptic muscarinic agents. Brain research. vol 515. issue 1-2. 1990-08-01. PMID:1972643. |
to obtain additional evidence in support of the co-transmitter role of glutamate in cortical cholinergic terminals proposed by docherty et al., the right nucleus basalis in rats was lesioned with ibotenic acid; resulting changes in cortical acetylcholinesterase (ache) staining, glutamate content, and the release of [3h]acetylcholine ([ 3h]ach) and glutamate from cortical slices from the two sides were compared. |
1990-08-01 |
2023-08-11 |
rat |
| M B Abou-Donia, D M Lapadul. Mechanisms of organophosphorus ester-induced delayed neurotoxicity: type I and type II. Annual review of pharmacology and toxicology. vol 30. 1990-06-26. PMID:2188574. |
most of these compounds are direct or indirect inhibitors of ache, and produce acute cholinergic effects. |
1990-06-26 |
2023-08-11 |
cattle |
| M D Kawaja, B A Flumerfelt, A W Hrycyshy. A comparison of the subnuclear and ultrastructural distribution of acetylcholinesterase and choline acetyltransferase in the rat interpeduncular nucleus. Brain research bulletin. vol 24. issue 3. 1990-06-20. PMID:2337826. |
although neuronal colocalization of chat and ache activity is not evident in the ipn, ache-positive neurons are in receipt of putative cholinergic, as well as peptidergic, afferent inputs. |
1990-06-20 |
2023-08-11 |
rat |
| E L Sutin, D M Jacobowit. Localization of substance P mRNA in cholinergic cells of the rat laterodorsal tegmental nucleus: in situ hybridization histochemistry and immunocytochemistry. Cellular and molecular neurobiology. vol 10. issue 1. 1990-06-14. PMID:1692261. |
in situ hybridization histochemical techniques in combination with immunocytochemistry and acetylcholinesterase (ache) histochemistry were used to study the colocalization of messenger rna (mrna) encoding the neuropeptide substance p (sp) in cholinergic cells of the laterodorsal tegmental nucleus (ldt) of the rat pontine brain stem. |
1990-06-14 |
2023-08-11 |
rat |
| J Sirviö, A Pitkänen, A Pääkkönen, J Partanen, P J Riekkine. Brain cholinergic enzymes and cortical EEG activity in young and old rats. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. vol 94. issue 1. 1990-05-30. PMID:2576737. |
cholinergic enzymes (chat, ache) in different areas of the brain and cortical electroencephalography (eeg) activity were investigated in young and old rats. |
1990-05-30 |
2023-08-11 |
rat |
| J Sirviö, A Pitkänen, A Pääkkönen, J Partanen, P J Riekkine. Brain cholinergic enzymes and cortical EEG activity in young and old rats. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. vol 94. issue 1. 1990-05-30. PMID:2576737. |
this decrease in ache may reflect degeneration of the cholinergic synapses. |
1990-05-30 |
2023-08-11 |
rat |
| G C Siek, L S Katz, E B Fishman, T S Korosi, J K Marqui. Molecular forms of acetylcholinesterase in subcortical areas of normal and Alzheimer disease brain. Biological psychiatry. vol 27. issue 6. 1990-05-24. PMID:2322617. |
available evidence would suggest that this form is the ache molecular form physiologically relevant at the cholinergic synapse. |
1990-05-24 |
2023-08-11 |
Not clear |
| P Tekulics, Z Rakonczay, P Szerdahelyi, P Kása, K Guly. Effects of ischemia on cholinergic neurotransmission and electrolyte content in newborn pig lumbar spinal cord. Life sciences. vol 46. issue 11. 1990-05-10. PMID:2157120. |
the biochemical changes of the elements of cholinergic neurotransmission (choline acetyltransferase, chat; acetylcholinesterase, ache; butyrylcholinesterase, buche; and muscarinic cholinergic receptors, machr) as well as the electrolyte content were studied in ischemic lumbar spinal cord segments of newborn pigs. |
1990-05-10 |
2023-08-11 |
Not clear |
| L R Williams, M R Donald, K S Jodeli. Optimal parameters for the histochemical demonstration of acetylcholinesterase in plastic sections of rat brain. Stain technology. vol 64. issue 4. 1990-03-21. PMID:2623674. |
demonstration of ache enzyme activity in the cholinergic projection from the rat basal forebrain to the ipsilateral hippocampus exemplifies the usefulness of the technique. |
1990-03-21 |
2023-08-11 |
rat |
| L R Williams, M R Donald, K S Jodeli. Optimal parameters for the histochemical demonstration of acetylcholinesterase in plastic sections of rat brain. Stain technology. vol 64. issue 4. 1990-03-21. PMID:2623674. |
this procedure offers a convenient method for analysis of cholinergic neurons that avoids potential artifacts inherent in other ache histochemical procedures. |
1990-03-21 |
2023-08-11 |
rat |
| D J Clarke, A Björklun. Restoration of cholinergic circuitry in the hippocampus by foetal grafts. EXS. vol 57. 1990-03-15. PMID:2533098. |
however, we have demonstrated that this restoration of both ache and chat fibre density represents a specific mechanism and that the source of the foetal cholinergic neurons is crucial to the extent of reinnervation and pattern of connectivity achieved. |
1990-03-15 |
2023-08-11 |
rat |
| G Raivich, G W Kreutzber. Topography of beta NGF receptor-positive and AChE-reactive neurons in the central nervous system. EXS. vol 57. 1990-03-15. PMID:2558908. |
to learn more about the action of beta ngf in the central nervous system we have mapped the distribution of beta ngf receptors and compared it with that of acetylcholinesterase (ache), a sensitive enzyme marker for cholinergic neurons. |
1990-03-15 |
2023-08-11 |
Not clear |
| T N Robinson, R J De Souza, A J Cross, A R Gree. The mechanism of tetrahydroaminoacridine-evoked release of endogenous 5-hydroxytryptamine and dopamine from rat brain tissue prisms. British journal of pharmacology. vol 98. issue 4. 1990-03-14. PMID:2611486. |
1 tetrahydroaminoacridine (tha) is an acetylcholinesterase (ache) inhibitor which may have a greater therapeutic effect in alzheimer-type dementia (atd) than other cholinergic agents. |
1990-03-14 |
2023-08-11 |
rat |
| L T Robertson, N Roma. Distribution of acetylcholinesterase in the granular layer of the cerebellum of the rhesus monkey (Macaca mulatta). Brain, behavior and evolution. vol 34. issue 6. 1990-03-08. PMID:2611640. |
the high levels of ache activity in the flocculonodular lobe and lobule ix may correspond to cholinergic mossy fiber transmission, but the high levels of ache activity in other cerebellar regions probably involve noncholinergic functions. |
1990-03-08 |
2023-08-11 |
monkey |
| N J Woolf, L L Butche. Cholinergic systems in the rat brain: IV. Descending projections of the pontomesencephalic tegmentum. Brain research bulletin. vol 23. issue 6. 1990-03-08. PMID:2611694. |
descending projections from cholinergic neurons in the pedunculopontine and laterodorsal tegmental nuclei, collectively referred to as the pontomesencephalotegmental (pmt) cholinergic complex, were studied by use of the fluorescent retrograde tracers fluorogold, true blue, or evans blue in combination with choline acetyltransferase (chat) immunohistochemistry of acetylcholinesterase (ache) pharmacohistochemistry. |
1990-03-08 |
2023-08-11 |
rat |
| N J Woolf, L L Butche. Cholinergic systems in the rat brain: IV. Descending projections of the pontomesencephalic tegmentum. Brain research bulletin. vol 23. issue 6. 1990-03-08. PMID:2611694. |
fluorescent tracers used in combination with ache pharmacohistochemistry corroborated these projections and, in addition, provided evidence for cholinergic pontomesencephalic projections to the lateral reticular nucleus and inferior olive. |
1990-03-08 |
2023-08-11 |
rat |
| J A Nielsen, E E Mena, I H Williams, M R Nocerini, D Listo. Correlation of brain levels of 9-amino-1,2,3,4-tetrahydroacridine (THA) with neurochemical and behavioral changes. European journal of pharmacology. vol 173. issue 1. 1990-02-22. PMID:2606156. |
we conclude that brain ache inhibition by tha is sufficient to explain its purported therapeutic activity in alzheimer's disease and that its favorable brain/plasma distribution in vivo may account for its central cholinergic action without inducing the severe peripheral cholinergic effects typically seen with other ache inhibitors. |
1990-02-22 |
2023-08-11 |
mouse |