| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luis F Sánchez del Campo, Susana Nieto-Cerón, Julio C Morote-García, Encarnación Muñoz-Delgado, Cecilio J Vidal, Francisco J Campo. Butyrylcholinesterase activity and molecular components in thymus of healthy and merosin-deficient Lama2dy mice. Neurochemistry international. vol 50. issue 3. 2007-04-10. PMID:17178175. |
the detoxifying action of buche, its role as a backup to ache, and the relevance of the cholinergic dialogue between t cells and stromal cells for t lymphocyte proliferation, maturation and survival support a physiological function for buche in thymus. |
2007-04-10 |
2023-08-12 |
mouse |
| Carsten Eggers, Karl Herholz, Elke Kalbe, Wolf-Dieter Heis. Cortical acetylcholine esterase activity and ApoE4-genotype in Alzheimer disease. Neuroscience letters. vol 408. issue 1. 2007-04-03. PMID:16996687. |
positron emission tomography (pet) studies have demonstrated reduced acetylcholine esterase (ache) activity as an indicator of cholinergic impairment, which is a main pathogenic process in alzheimer's disease (ad). |
2007-04-03 |
2023-08-12 |
human |
| Joachim Hartmann, Cornelia Kiewert, Ellen G Duysen, Oksana Lockridge, Nigel H Greig, Jochen Klei. Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity. Journal of neurochemistry. vol 100. issue 5. 2007-04-02. PMID:17212694. |
cholinergic dysfunction is treated with inhibitors of acetylcholinesterase (ache) while the role of butyrylcholinesterase (bche) for brain cholinergic function is unclear. |
2007-04-02 |
2023-08-12 |
mouse |
| Joachim Hartmann, Cornelia Kiewert, Ellen G Duysen, Oksana Lockridge, Nigel H Greig, Jochen Klei. Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity. Journal of neurochemistry. vol 100. issue 5. 2007-04-02. PMID:17212694. |
these results point to a potential usefulness of bche inhibitors in the treatment of central cholinergic dysfunction in which brain ache activity is typically reduced. |
2007-04-02 |
2023-08-12 |
mouse |
| C M Mazzanti, R M Spanevello, L B Pereira, J F Gonçalves, R Kaizer, M Corrêa, M Ahmed, A Mazzanti, R Festugatto, D L Graça, V M Morsch, M R C Schetinge. Acetylcholinesterase activity in rats experimentally demyelinated with ethidium bromide and treated with interferon beta. Neurochemical research. vol 31. issue 8. 2007-03-22. PMID:16871442. |
our results suggest that one of the mechanisms of action of ifn-beta is through the inhibition of ache activity, and eb could be considered an inhibitor of ache activity by interfering with cholinergic neurotransmission in the different brain regions. |
2007-03-22 |
2023-08-12 |
rat |
| M Jamal, K Ameno, S Ameno, J Morishita, W Wang, M Kumihashi, U Ikuo, T Miki, I Ijir. Changes in cholinergic function in the frontal cortex and hippocampus of rat exposed to ethanol and acetaldehyde. Neuroscience. vol 144. issue 1. 2007-03-15. PMID:17045751. |
to better understand the mechanisms of etoh and ace's effects on the cholinergic system in the brain, choline acetyltransferase (chat) and acetylcholinesterase (ache) expression was examined at 40 and 240 min after a dose of etoh (1 g/kg) in the rat frontal cortex and hippocampus. |
2007-03-15 |
2023-08-12 |
rat |
| P Russo, A Catassi, A Cesario, D Serven. Development of novel therapeutic strategies for lung cancer: targeting the cholinergic system. Current medicinal chemistry. vol 13. issue 29. 2007-02-28. PMID:17168719. |
afterward, the expression of ach, ache, and cholinergic receptors in non-neuronal cells was reported in several studies [3-16]. |
2007-02-28 |
2023-08-12 |
human |
| Laura E Paraoanu, Gunnar Steinert, Janine Klaczinski, Michaela Becker-Röck, Afrim Bytyqi, Paul G Laye. On functions of cholinesterases during embryonic development. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192676. |
this means that che functioning during development fits into the classical cholinergic neurotransmitter system: acetylcholine (ach), as a signal, binds to ach receptors and then is degraded by acetylcholinesterase (ache) as the terminating enzyme. |
2007-02-23 |
2023-08-12 |
Not clear |
| Mohammad A Kamal, Peter Klein, Qian-Sheng Yu, David Tweedie, Yazhou Li, Harold W Holloway, Nigel H Grei. Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnorcymserine. Journal of Alzheimer's disease : JAD. vol 10. issue 1. 2007-02-20. PMID:16988481. |
ad, although an irreversible and progressive disorder, is currently treated with palliative, symptomatic therapy: primarily with acetylcholinesterase (ache) inhibitors to amplify remaining cholinergic activity. |
2007-02-20 |
2023-08-12 |
human |
| Natarajan Ashokkumar, Leelavinothan Pari, Kunga Mohan Ramkuma. N-Benzoyl-D-phenylalanine attenuates brain acetylcholinesterase in neonatal streptozotocin-diabetic rats. Basic & clinical pharmacology & toxicology. vol 99. issue 3. 2007-02-13. PMID:16930298. |
administration of non-sulfonylurea drug n-benzoyl-d-phenylalanine (nbdp) could protect against direct action of lipid peroxidation on brain ache and in this way it might be useful in the prevention of cholinergic neural dysfunction, which is one of the major complications in diabetes. |
2007-02-13 |
2023-08-12 |
rat |
| Reinhard Schliebs, Kristin Heidel, Jenny Apelt, Magdalena Gniezdzinska, Ludmil Kirazov, Andrzej Szutowic. Interaction of interleukin-1beta with muscarinic acetylcholine receptor-mediated signaling cascade in cholinergically differentiated SH-SY5Y cells. Brain research. vol 1122. issue 1. 2007-01-30. PMID:17026971. |
to reveal whether il-1beta affects muscarinic acetylcholine receptor (machr)-mediated intracellular signaling, cholinergically differentiated sh-sy5y cells were exposed to il-1beta for various periods of time followed by stimulation of machr with carbachol for 1 h, and key molecules of cholinergic signaling cascades were determined including phosphoinositide hydrolysis, dna-binding capacity of nfkappab and ap-1, and activity of acetylcholinesterase (ache). |
2007-01-30 |
2023-08-12 |
Not clear |
| R T Robertson, J Baratta, J Yu, K M Guthri. A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex. Neuroscience. vol 143. issue 2. 2007-01-26. PMID:17049175. |
patterns of expression of nt-3 (defined by beta-galactosidase reporter expression in heterozygous offspring of transgenic nt-3(laczneo/+) mice) revealed that limbic cortical regions (including frontal, cingulate, and insular cortex, as well as the dentate gyrus) express nt-3 and that these cortical regions receive early and relatively dense cholinergic axons (stained for acetylcholinesterase, ache). |
2007-01-26 |
2023-08-12 |
mouse |
| R T Robertson, J Baratta, J Yu, K M Guthri. A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex. Neuroscience. vol 143. issue 2. 2007-01-26. PMID:17049175. |
using the dentate gyrus as a model system, studies revealed that expression of the nt-3 reporter parallels, and precedes by approximately 2 days, the ingrowth of ache positive cholinergic axons. |
2007-01-26 |
2023-08-12 |
mouse |
| Gabriel Zimmerman, Hermona Sore. Termination and beyond: acetylcholinesterase as a modulator of synaptic transmission. Cell and tissue research. vol 326. issue 2. 2007-01-23. PMID:16802134. |
this unique termination mechanism makes acetylcholinesterase (ache), the enzyme in charge of executing acetylcholine breakdown, a key component of cholinergic signaling. |
2007-01-23 |
2023-08-12 |
Not clear |
| Carlos H T P da Silva, Vanessa Leiria Campo, Ivone Carvalho, Carlton A Taf. Molecular modeling, docking and ADMET studies applied to the design of a novel hybrid for treatment of Alzheimer's disease. Journal of molecular graphics & modelling. vol 25. issue 2. 2007-01-08. PMID:16413803. |
some of the drugs currently used in the treatment of ad are capable of increasing the cholinergic transmission through the ache inhibition. |
2007-01-08 |
2023-08-12 |
human |
| Karin U Schallreuter, Nicholas C J Gibbons, Carsten Zothner, Souna M Elwary, Hartmut Rokos, John M Woo. Butyrylcholinesterase is present in the human epidermis and is regulated by H2O2: more evidence for oxidative stress in vitiligo. Biochemical and biophysical research communications. vol 349. issue 3. 2006-11-07. PMID:16962996. |
based on our results we conclude that h(2)o(2) is a major player in the regulation of the cholinergic signal via both ache and bche and this signal is severely affected in the epidermis of patients with active vitiligo. |
2006-11-07 |
2023-08-12 |
human |
| Cinthia M Mazzanti, Roselia M Spanevello, Adriana Obregon, Luciane B Pereira, Cristiane A Streher, Mushtaq Ahmed, Alexandre Mazzanti, Dominguita L Graça, Vera M Morsch, Maria Rosa C Schetinge. Ethidium bromide inhibits rat brain acetylcholinesterase activity in vitro. Chemico-biological interactions. vol 162. issue 2. 2006-10-30. PMID:16839531. |
these data indicate that etbr should be considered a strong inhibitor of ache activity demonstrating that there is an interaction between this compound and the cholinergic system. |
2006-10-30 |
2023-08-12 |
rat |
| L Gandía, R M Alvarez, J M Hernández-Guijo, J M González-Rubio, R de Pascual, J Rojo, L Tapi. [Anticholinesterases in the treatment of Alzheimer's disease]. Revista de neurologia. vol 42. issue 8. 2006-10-18. PMID:16625509. |
this led to the formulation of the so-called cholinergic theory of alzheimer, which provides the rationale behind the use of the drugs that are currently available to treat this disease, namely, acetylcholine esterase (ache) inhibitors (rivastigmine, donepezil and galanthamine). |
2006-10-18 |
2023-08-12 |
Not clear |
| Deqiang Zhang, J Andrew McCammo. The association of tetrameric acetylcholinesterase with ColQ tail: a block normal mode analysis. PLoS computational biology. vol 1. issue 6. 2006-09-29. PMID:16299589. |
acetylcholinesterase (ache) rapidly hydrolyzes acetylcholine in the neuromuscular junctions and other cholinergic synapses to terminate the neuronal signal. |
2006-09-29 |
2023-08-12 |
mouse |
| Y Ben-Shaul, L Benmoyal-Segal, S Ben-Ari, H Bergman, H Sore. Adaptive acetylcholinesterase splicing patterns attenuate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice. The European journal of neuroscience. vol 23. issue 11. 2006-09-28. PMID:16819980. |
our findings highlight the functional differences between individual ache variants and indicate that a naturally occurring stress or ache inhibitor-induced splicing shift can act to minimize dopaminergic cholinergic imbalances. |
2006-09-28 |
2023-08-12 |
mouse |