| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ethika Tyagi, Rahul Agrawal, Chandishwar Nath, Rakesh Shukl. Effect of anti-dementia drugs on LPS induced neuroinflammation in mice. Life sciences. vol 80. issue 21. 2008-01-02. PMID:17395211. |
interleukin-2 (il-2) and isoforms of acetylcholinesterase (ache) were estimated in different brain areas as marker for neuroinflammation and cholinergic activity respectively. |
2008-01-02 |
2023-08-12 |
mouse |
| Eduardo Pacheco Rico, Denis Broock Rosemberg, Renato Dutra Dias, Mauricio Reis Bogo, Carla Denise Bona. Ethanol alters acetylcholinesterase activity and gene expression in zebrafish brain. Toxicology letters. vol 174. issue 1-3. 2007-12-18. PMID:17888594. |
these findings suggest that the alterations on zebrafish ache could reveal molecular mechanisms related to cholinergic signaling in alcoholism. |
2007-12-18 |
2023-08-12 |
zebrafish |
| Mariapaola Piccardi, Donatella Congiu, Alessio Squassina, Francesca Manconi, Paolo Francesco Putzu, Rosa Maria Mereu, Caterina Chillotti, Maria Del Zomp. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503475. |
the resulting reduction in cholinergic activity is associated with decreased levels of the neurotransmitter acetylcholine (ach), decreased activity of acetylcholinesterase (ache), choline acetyltransferase (chat), and increased butyrylcholinesterase (bche) activity. |
2007-12-06 |
2023-08-12 |
human |
| Seung-O Ko, Tak-Heun Kim, Hye Kyung Lee, Jeong-Chae Lee, Eui-Sic Ch. Temporospatial localization of acetylcholinesterase activity in the dental epithelium during mouse tooth development. Life sciences. vol 81. issue 15. 2007-12-06. PMID:17905311. |
acetylcholinesterase (ache), a principal modulator of cholinergic neurotransmission, also has been demonstrated to be involved in the morphogenetic processes of neuronal and non-neuronal tissues. |
2007-12-06 |
2023-08-12 |
mouse |
| Irene Simintzi, Kleopatra H Schulpis, Panagoula Angelogianni, Charis Liapi, Stylianos Tsakiri. The effect of aspartame on acetylcholinesterase activity in hippocampal homogenates of suckling rats. Pharmacological research. vol 56. issue 2. 2007-11-01. PMID:17580119. |
neurological disturbances have been implicated with aspartame (asp) consumption and the cholinergic system with acetylcholinesterase (ache) seems actively involved. |
2007-11-01 |
2023-08-12 |
rat |
| Marcia D Howard, Nikita Mirajkar, Subramanya Karanth, Carey N Pop. Comparative effects of oral chlorpyrifos exposure on cholinesterase activity and muscarinic receptor binding in neonatal and adult rat heart. Toxicology. vol 238. issue 2-3. 2007-10-31. PMID:17644233. |
organophosphorus (op) pesticides elicit acute toxicity by inhibiting acetylcholinesterase (ache), the enzyme responsible for inactivating acetylcholine (ach) at cholinergic synapses. |
2007-10-31 |
2023-08-12 |
rat |
| I V Coutinho-Abreu, V Q Balbino, J G Valenzuela, I V Sonoda, J M Ramalho-Ortigã. Structural characterization of acetylcholinesterase 1 from the sand fly Lutzomyia longipalpis (Diptera: Psychodidae). Journal of medical entomology. vol 44. issue 4. 2007-10-19. PMID:17695019. |
acetylcholinesterase (ache) plays a key role in cholinergic impulse transmission, and it is the target enzyme for organophosphorus and carbamate insecticides. |
2007-10-19 |
2023-08-12 |
Not clear |
| G A López-Crespo, F Carvajal, P Flores, F Sánchez-Santed, M C Sánchez-Amat. Time course of biochemical and behavioural effects of a single high dose of chlorpyrifos. Neurotoxicology. vol 28. issue 3. 2007-10-18. PMID:17350100. |
this effect is independent of the percentage of ache inhibition and therefore, of change in the cholinergic system. |
2007-10-18 |
2023-08-12 |
rat |
| Fu Ai Ling, Dong Zhao Hui, Sun Man J. Protective effect of recombinant human somatotropin on amyloid beta-peptide induced learning and memory deficits in mice. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 17. issue 4. 2007-10-18. PMID:17596983. |
toxic effects of free radicals, damages of cholinergic neurons, and increased lipid peroxidation appeared in the cerebra of abeta-treated mice, manifesting an increase of malondialdehyde (mda) and decline of glutathione (gsh) level, an increment of choline acetyltransferase (chat) and acetylcholinesterase (ache) activities, and a reduction of the acetylcholine (ach) level. |
2007-10-18 |
2023-08-12 |
mouse |
| Isabel Martinez-Pena y Valenzuela, Mohammed Akaaboun. Acetylcholinesterase mobility and stability at the neuromuscular junction of living mice. Molecular biology of the cell. vol 18. issue 8. 2007-10-17. PMID:17538015. |
acetylcholinesterase (ache) is an enzyme that terminates acetylcholine neurotransmitter function at the synaptic cleft of cholinergic synapses. |
2007-10-17 |
2023-08-12 |
mouse |
| Jin Kyung Oh, Yoon-Sang Kim, Hyun-Jung Park, Eun-Mee Lim, Kwang-Ho Pyun, Insop Shi. Antidepressant effects of Soyo-san on Immobilization stress in ovariectomized female rats. Biological & pharmaceutical bulletin. vol 30. issue 8. 2007-09-21. PMID:17666797. |
we assessed the changes in the reactivity of the cholinergic system by measuring the immunoreactive neurons of choline acetyltransferase (chat) and reactivity of acetylcholinesterase (ache) in the hippocampus, and the serum levels of corticosterone were assessed after behavioral testing. |
2007-09-21 |
2023-08-12 |
rat |
| Carlos H T P da Silva, Ivone Carvalho, C A Taf. Virtual screening, molecular interaction field, molecular dynamics, docking, density functional, and ADMET properties of novel AChE inhibitors in Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 24. issue 6. 2007-09-18. PMID:17508773. |
many drugs currently used for the treatment of the ad are based on the improvement of cholinergic neurotransmission achieved by acetylcholinesterase (ache) inhibition, the enzyme responsible for acetylcholine hydrolysis. |
2007-09-18 |
2023-08-12 |
Not clear |
| b' Zbyn\\xc4\\x95k Svoboda, Jaroslav Kv\\xc4\\x95tina, Josef Herink, Jir\\xc3\\xad Bajgar, Lucie Bartosov\\xc3\\xa1, Vladim\\xc3\\xadr Palicka, Pavel Zivn\\xc3\\xb. Galantamine antiacetylcholinesterase activity in rat brain influenced by L-carnitine. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. vol 149. issue 2. 2007-08-28. PMID:16601783.' |
galantamine (gal) is a selective, competitive and reversible acetylcholinesterase (ache) inhibitor, which increases the activity of the cholinergic system and hence gives rise to an improvement of cognitive functions in patients suffering from dementia of alzheimer type. |
2007-08-28 |
2023-08-12 |
rat |
| Kamil Kuca, Jirí Cabal, Daniel Jun, Jirí Kassa, Lucie Bartosová, Gabriela Kunesová, Vlastimil Dohna. Strategy for the development of new acetylcholinesterase reactivators - antidotes used for treatment of nerve agent poisonings. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. vol 149. issue 2. 2007-08-28. PMID:16601804. |
the mechanism of intoxication with organophosphorus compounds, including highly toxic nerve agents, is based on the formation of irreversibly inhibited acetylcholinesterase (ache; ec 3.1.1.7) that could be followed by a generalized cholinergic crisis. |
2007-08-28 |
2023-08-12 |
Not clear |
| Md Badiul Bhuiyan, Ferid Murad, Michael E Fan. The placental cholinergic system: localization to the cytotrophoblast and modulation of nitric oxide. Cell communication and signaling : CCS. vol 4. 2007-08-01. PMID:16686954. |
the human placenta, a non-neuronal tissue, contains an active cholinergic system comprised of acetylcholine (ach), choline acetyltransferase (chat), acetylcholinesterase (ache), and high affinity muscarinic receptors. |
2007-08-01 |
2023-08-12 |
human |
| Adi Gilboa-Geffen, Paul P Lacoste, Lilach Soreq, Geraldine Cizeron-Clairac, Rozen Le Panse, Frederique Truffault, Iftach Shaked, Hermona Soreq, Sonia Berrih-Akni. The thymic theme of acetylcholinesterase splice variants in myasthenia gravis. Blood. vol 109. issue 10. 2007-07-12. PMID:17272501. |
cholinergic signaling and acetylcholinesterase (ache) influence immune response and inflammation. |
2007-07-12 |
2023-08-12 |
mouse |
| Chi-Rei Wu, Chia-Lin Chang, Ping-Ying Hsieh, Li-Wei Lin, Hui Chin. Psoralen and isopsoralen, two coumarins of Psoraleae Fructus, can alleviate scopolamine-induced amnesia in rats. Planta medica. vol 73. issue 3. 2007-06-20. PMID:17318785. |
the results suggest that psoralen and isopsoralen are the major active ingredients of psoraleae fructus responsible for the progressive reversal of scopolamine-induced amnesia, whose effects are partially associated with inhibition of ache activity and hence activation of the central cholinergic neuronal system. |
2007-06-20 |
2023-08-12 |
rat |
| M H Bazalakova, R D Blakel. The high-affinity choline transporter: a critical protein for sustaining cholinergic signaling as revealed in studies of genetically altered mice. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722248. |
studies in various mouse models of cholinergic dysfunction, including acetylcholinesterase (ache) transgenic and knockout mice, choline acetyltransferase (chat) heterozygote mice, muscarinic (machr) and nicotinic (machr) receptor knockout mice, as well as cht knockout and heterozygote mice, have revealed new information about the role of cht expression and regulation in response to long-term alterations in cholinergic neurotransmission. |
2007-05-23 |
2023-08-12 |
mouse |
| Sultan Darvesh, Ryan Walsh, Earl Marti. Homocysteine thiolactone and human cholinesterases. Cellular and molecular neurobiology. vol 27. issue 1. 2007-05-22. PMID:16955366. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) are serine hydrolase enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine, a key process in the regulation of the cholinergic system. |
2007-05-22 |
2023-08-12 |
human |
| Peter Melzer, Laura Mineo, Ford F Ebne. Optic nerve transection affects development and use-dependent plasticity in neocortex of the rat: Quantitative acetylcholinesterase imaging. Brain research. vol 1139. 2007-05-08. PMID:17280650. |
the laminar distribution of the ache reaction product suggests that the observed changes in ache activity were mainly related to cholinergic basal forebrain afferents. |
2007-05-08 |
2023-08-12 |
rat |