| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin Gyu Choi, Woong Mo Yang, Tong Ho Kang, Myung Sook O. Effects of optimized-SopungSunkiwon on memory impairment and enhancement. Neuroscience letters. vol 491. issue 2. 2011-07-05. PMID:21256184. |
acetylcholinesterase (ache) inhibition assay was performed to investigate the cholinergic antagonistic effect of oss. |
2011-07-05 |
2023-08-12 |
mouse |
| L Stan Leung, Sophie Petropoulos, Bixia Shen, Tao Luo, Ian Herrick, N Rajakumar, Jingyi M. Lesion of cholinergic neurons in nucleus basalis enhances response to general anesthetics. Experimental neurology. vol 228. issue 2. 2011-06-17. PMID:21295026. |
depletion of choline-acetyltransferase (chat)-immunoreactive cells in the nbm and decrease in optical density of acetylcholinesterase (ache) staining in the frontal and visual cortices confirmed a significant decrease in nbm cholinergic neurons in lesioned as compared to control rats. |
2011-06-17 |
2023-08-12 |
rat |
| Ramón Cacabelo. Donepezil in Alzheimer's disease: From conventional trials to pharmacogenetics. Neuropsychiatric disease and treatment. vol 3. issue 3. 2011-05-17. PMID:19300564. |
some potential effects of donepezil on the ad brain, leading to reduced cortico-hippocampal atrophy, include the following: ache inhibition, enhancement of cholinergic neurotransmission and putative modulation of other neurotransmitter systems, protection against glutamate-induced excitotoxicity, activation of neurotrophic mechanisms, promotion of non-amyloidodgenic pathways for app processing, and indirect effects on cerebrovascular function improving brain perfusion. |
2011-05-17 |
2023-08-12 |
Not clear |
| Shin-Hua Lu, Josephine W Wu, Hsuan-Liang Liu, Jian-Hua Zhao, Kung-Tien Liu, Chih-Kuang Chuang, Hsin-Yi Lin, Wei-Bor Tsai, Yih H. The discovery of potential acetylcholinesterase inhibitors: a combination of pharmacophore modeling, virtual screening, and molecular docking studies. Journal of biomedical science. vol 18. 2011-04-28. PMID:21251245. |
acetylcholinesterase (ache) plays a key role in the regulation of the cholinergic system, and hence, inhibition of ache has emerged as one of the most promising strategies for the treatment of ad. |
2011-04-28 |
2023-08-12 |
Not clear |
| Antony Sherin, Kumar T Peeyush, George Naijil, Mohan Sobhana Nandhu, Sadanandan Jayanarayanan, Paul Jes, Cheramadathikudiyil Skaria Paulos. The effects of abnormalities of glucose homeostasis on the expression and binding of muscarinic receptors in cerebral cortex of rats. European journal of pharmacology. vol 651. issue 1-3. 2011-04-11. PMID:21126518. |
in the present study, effect of insulin induced hypoglycemia and streptozotocin induced diabetes on muscarinic receptor binding, cholinergic enzymes; ache, chat expression and glut3 in the cerebral cortex of experimental rats were analysed. |
2011-04-11 |
2023-08-12 |
rat |
| Antony Sherin, Kumar T Peeyush, George Naijil, Mohan Sobhana Nandhu, Sadanandan Jayanarayanan, Paul Jes, Cheramadathikudiyil Skaria Paulos. The effects of abnormalities of glucose homeostasis on the expression and binding of muscarinic receptors in cerebral cortex of rats. European journal of pharmacology. vol 651. issue 1-3. 2011-04-11. PMID:21126518. |
increased ache and decreased chat expression is suggested to alter cortical acetylcholine metabolism in experimental rats along with altered muscarinic receptor binding in hypo/hyperglycemic rats, impair cholinergic transmission, which subsequently lead to cholinergic dysfunction thereby causing learning and memory deficits. |
2011-04-11 |
2023-08-12 |
rat |
| David Hicks, Danielle John, Natalia Z Makova, Zaineb Henderson, Natalia N Nalivaeva, Anthony J Turne. Membrane targeting, shedding and protein interactions of brain acetylcholinesterase. Journal of neurochemistry. vol 116. issue 5. 2011-03-30. PMID:21214569. |
furthermore, ache is secreted ('shed') from membranes and this shedding is stimulated by cholinergic agonists. |
2011-03-30 |
2023-08-12 |
rat |
| David Hicks, Danielle John, Natalia Z Makova, Zaineb Henderson, Natalia N Nalivaeva, Anthony J Turne. Membrane targeting, shedding and protein interactions of brain acetylcholinesterase. Journal of neurochemistry. vol 116. issue 5. 2011-03-30. PMID:21214569. |
a strong association of ache with the membrane via prima seems therefore to be a specific requirement of forebrain cholinergic neurons. |
2011-03-30 |
2023-08-12 |
rat |
| V C Moser, S Padill. Esterase metabolism of cholinesterase inhibitors using rat liver in vitro. Toxicology. vol 281. issue 1-3. 2011-03-25. PMID:21237238. |
a variety of chemicals, such as organophosphate (op) and carbamate pesticides, nerve agents, and industrial chemicals, inhibit acetylcholinesterase (ache) leading to overstimulation of the cholinergic nervous system. |
2011-03-25 |
2023-08-12 |
rat |
| Nitin Bansal, Milind Parl. Soybean supplementation helps reverse age- and scopolamine-induced memory deficits in mice. Journal of medicinal food. vol 13. issue 6. 2011-03-24. PMID:20954807. |
soybean administration also resulted in diminished brain ache activity, decrease in brain tbars, and increase in gsh levels, thereby indicating facilitated cholinergic transmission, reduced free radical generation, and enhanced scavenging of free radicals. |
2011-03-24 |
2023-08-12 |
mouse |
| Yingjun Zhao, Xiaoying Wang, Tao Wang, Xin Hu, Xin Hui, Mingxia Yan, Qiang Gao, Taoyang Chen, Jinjun Li, Ming Yao, Dafang Wan, Jianren Gu, Jia Fan, Xianghuo H. Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitization. Hepatology (Baltimore, Md.). vol 53. issue 2. 2011-03-18. PMID:21274871. |
acetylcholinesterase (ache) plays important roles in the cholinergic system, and its dysregulation is involved in a variety of human diseases. |
2011-03-18 |
2023-08-12 |
human |
| Aleksandro S Da Silva, Silvia G Monteiro, Jamile F Gonçalves, Rosélia Spanevello, Roberta Schmatz, Camila B Oliveira, Marcio M Costa, Raqueli T França, Jeandre A S Jaques, Maria Rosa C Schetinger, Cinthia M Mazzanti, Sonia T A Lope. Trypanosoma evansi: immune response and acetylcholinesterase activity in lymphocytes from infected rats. Experimental parasitology. vol 127. issue 2. 2011-02-15. PMID:21036170. |
therefore, the infection by t. evansi influences ache activity in lymphocytes of rats indicating changes in the responses of cholinergic system in acute phase, possibly due to immune functions performed by these enzymes. |
2011-02-15 |
2023-08-12 |
rat |
| O Soukup, Z Kristofikova, J Proska, G Tobin, J Patocka, J Marek, D Jun, J Fusek, D Ripova, K Kuc. Novel acetylcholinesterase reactivator K112 and its cholinergic properties. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 64. issue 8. 2011-02-09. PMID:20634031. |
its cholinergic properties could be of importance at op poisoning and are not related to the ache reactivation that has been studied. |
2011-02-09 |
2023-08-12 |
rat |
| O Soukup, Z Kristofikova, J Proska, G Tobin, J Patocka, J Marek, D Jun, J Fusek, D Ripova, K Kuc. Novel acetylcholinesterase reactivator K112 and its cholinergic properties. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 64. issue 8. 2011-02-09. PMID:20634031. |
these cholinergic effects include a weak inhibition of ache (ic(50)=43.8 ± 4.88 μm), inhibition of binding to the porcine muscarinic m2 receptor (ic(50)=4.36 μm) and finally, the inhibition of hacu (68.4 ± 9.9%), a key regulatory step in the synthesis of ach. |
2011-02-09 |
2023-08-12 |
rat |
| Pravinkumar Bhutada, Yogita Mundhada, Kuldeep Bansod, Chetan Bhutada, Santosh Tawari, Pankaj Dixit, Dharmendra Mundhad. Ameliorative effect of quercetin on memory dysfunction in streptozotocin-induced diabetic rats. Neurobiology of learning and memory. vol 94. issue 3. 2011-01-27. PMID:20620214. |
diabetes-related cognitive dysfunction is a consequence of changes within the central nervous system that are secondary to chronic hyperglycemia, oxidative stress, and cholinergic dysfunction, and probably therefore anti-diabetics, anti-oxidants, and acetylcholine esterase (ache) inhibitors were found to have beneficial effects in animal models. |
2011-01-27 |
2023-08-12 |
rat |
| Houjuan Xing, Ying Han, Shu Li, Jintao Wang, Xu Wang, Shiwen X. Alterations in mRNA expression of acetylcholinesterase in brain and muscle of common carp exposed to atrazine and chlorpyrifos. Ecotoxicology and environmental safety. vol 73. issue 7. 2011-01-24. PMID:20696475. |
alteration in transcription of ache caused by atr, cpf, and their mixture could reveal the toxic mechanisms related to cholinergic signaling. |
2011-01-24 |
2023-08-12 |
Not clear |
| Hajer Attig, Alessandro Dagnino, Alessandro Negri, Jamel Jebali, Hamadi Boussetta, Aldo Viarengo, Francesco Dondero, Mohamed Bann. Uptake and biochemical responses of mussels Mytilus galloprovincialis exposed to sublethal nickel concentrations. Ecotoxicology and environmental safety. vol 73. issue 7. 2011-01-24. PMID:20800282. |
the cholinergic system was evaluated using the acetylcholinesterase activity (ache). |
2011-01-24 |
2023-08-12 |
Not clear |
| Mohammad A Kamal, M Reale, Abdulaziz A Al-Jafar. Multiple approaches to analyse the data for rat brain acetylcholinesterase inhibition by cyclophosphamide. Neurochemical research. vol 35. issue 10. 2011-01-18. PMID:20652634. |
acetylcholinesterase (ache) is an externally oriented membrane-bound enzyme and its main physiological role is termination of chemical transmission at cholinergic synapses and secretory organs by rapid hydrolysis of the neurotransmitter acetylcholine (ach). |
2011-01-18 |
2023-08-12 |
rat |
| Zaineb Henderson, Nazia Matto, Danielle John, Natalia N Nalivaeva, Anthony J Turne. Co-localization of PRiMA with acetylcholinesterase in cholinergic neurons of rat brain: an immunocytochemical study. Brain research. vol 1344. 2011-01-10. PMID:20471375. |
previously it has been found that principal cholinergic neurons in the brain express high concentrations of ache enzymic activity at their neuronal membranes. |
2011-01-10 |
2023-08-12 |
rat |
| Zaineb Henderson, Nazia Matto, Danielle John, Natalia N Nalivaeva, Anthony J Turne. Co-localization of PRiMA with acetylcholinesterase in cholinergic neurons of rat brain: an immunocytochemical study. Brain research. vol 1344. 2011-01-10. PMID:20471375. |
a strong association of ache with prima at the plasma membrane is therefore a feature specific to principal cholinergic neurons that innervate the central nervous system. |
2011-01-10 |
2023-08-12 |
rat |