| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Che. Organophosphate-induced brain damage: mechanisms, neuropsychiatric and neurological consequences, and potential therapeutic strategies. Neurotoxicology. vol 33. issue 3. 2012-09-18. PMID:22498093. |
organophosphate (op)-induced brain damage is defined as progressive damage to the brain, resulting from the cholinergic neuronal excitotoxicity and dysfunction induced by op-induced irreversible ache inhibition. |
2012-09-18 |
2023-08-12 |
Not clear |
| Vikas Kotagal, Martijn L T M Müller, Daniel I Kaufer, Robert A Koeppe, Nicolaas I Bohne. Thalamic cholinergic innervation is spared in Alzheimer disease compared to parkinsonian disorders. Neuroscience letters. vol 514. issue 2. 2012-09-14. PMID:22414859. |
we investigated thalamic cholinergic afferent integrity by measuring ppn-thalamic (ppn-thal) acetylcholinesterase (ache) activity via pet imaging in alzheimer (ad), parkinson disease without dementia (pd), parkinson disease with dementia (pdd) and dementia with lewy bodies (dlb). |
2012-09-14 |
2023-08-12 |
human |
| D Chand Basha, M Usha Rani, C Bhuvaneswari Devi, M Ram Kumar, G Rajarami Redd. Perinatal lead exposure alters postnatal cholinergic and aminergic system in rat brain: reversal effect of calcium co-administration. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 4. 2012-09-13. PMID:22326442. |
these alterations were greater at pnd 35 and more pronounced in the cholinergic system (ach and ache) of hippocampus and the aminergic system (epinephrine, dopamine and mao) of cerebellum. |
2012-09-13 |
2023-08-12 |
rat |
| Alexios Bimpis, Apostolos Papalois, Stylianos Tsakiris, Apostolos Zarros, Konstantinos Kalafatakis, John Botis, Vasileios Stolakis, Konstantinos M Zissis, Charis Liap. Activation of acetylcholinesterase after U-74389G administration in a porcine model of intracerebral hemorrhage. Metabolic brain disease. vol 27. issue 2. 2012-09-07. PMID:22476954. |
we, herein, report the findings of our study concerning the role of acetylcholinesterase (ache; a crucial membrane-bound enzyme involved in cholinergic neurotransmission) in a porcine model of spontaneous ich, with a focus on the first 4 and 24 h following the lesion's induction, in combination with a study of the effectiveness of the lazaroid antioxidant u-74389g administration. |
2012-09-07 |
2023-08-12 |
Not clear |
| David H Smal. Dysregulation of Ca2+ homeostasis in Alzheimer's disease: role in acetylcholinesterase production and AMPA receptor internalization. Neuro-degenerative diseases. vol 10. issue 1-4. 2012-08-29. PMID:22301681. |
as aβ-induced ca(2+) entry may increase neuronal excitability, the increase in ache and the downregulation of cell surface ampa receptors may be part of a homeostatic mechanism which maintains normal levels of cholinergic and glutamatergic signaling. |
2012-08-29 |
2023-08-12 |
Not clear |
| Mona Mehta, Abdu Adem, Marwan Sabbag. New acetylcholinesterase inhibitors for Alzheimer's disease. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22216416. |
acetylcholinesterase (ache) remains a highly viable target for the symptomatic improvement in alzheimer's disease (ad) because cholinergic deficit is a consistent and early finding in ad. |
2012-08-23 |
2023-08-12 |
Not clear |
| Katja S Kroker, Georg Rast, Riccardo Giovannini, Anelise Marti, Cornelia Dorner-Ciossek, Holger Rosenbroc. Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP. Neuropharmacology. vol 62. issue 5-6. 2012-07-23. PMID:22245562. |
it aims to compensate for the deficit in cholinergic neurotransmission by blocking acetylcholinesterase (ache) and thus increases the concentration of extracellular acetylcholine. |
2012-07-23 |
2023-08-12 |
rat |
| Guo-Jun Lang, Kun Yan Zhu, Chuan-Xi Zhan. Can acetylcholinesterase serve as a target for developing more selective insecticides? Current drug targets. vol 13. issue 4. 2012-07-23. PMID:22280346. |
because ache is expressed in all invertebrate and vertebrate animals as a key enzyme of the cholinergic system, the toxicity of anticholinesterase insecticides to mammals and non-target species such as beneficial insects has been a great concern. |
2012-07-23 |
2023-08-12 |
Not clear |
| Adriana Bolekova, Darina Kluchova, Tatiana Spakovska, Frantisek Dorko, Kvetuse Lovasov. Postnatal development of nitrergic and cholinergic structures in rat spinal cord. Archives italiennes de biologie. vol 149. issue 3. 2012-06-21. PMID:22028090. |
this work is presenting results of histochemical study of the nadph-d and ache expression (nitrergic and cholinergic neurons) in the spinal cord (sc) during various periods in its development. |
2012-06-21 |
2023-08-12 |
rat |
| Adriana Bolekova, Darina Kluchova, Tatiana Spakovska, Frantisek Dorko, Kvetuse Lovasov. Postnatal development of nitrergic and cholinergic structures in rat spinal cord. Archives italiennes de biologie. vol 149. issue 3. 2012-06-21. PMID:22028090. |
our results confirmed the presence of nitrergic and cholinergic neurons in investigated areas of the sc and indicated their fully functioning of nadph-d and ache positive structures in sc from the third postnatal week. |
2012-06-21 |
2023-08-12 |
rat |
| Daniele Tomassoni, Assia Catalani, Carlo Cinque, Maria Antonietta Di Tullio, Seyed Khosrow Tayebati, Angela Cadoni, Innocent Ejike Nwankwo, Enea Traini, Francesco Ament. Effects of cholinergic enhancing drugs on cholinergic transporters in the brain and peripheral blood lymphocytes of spontaneously hypertensive rats. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:22191561. |
this study has assessed the influence of 4 week treatment with two different cholinergic enhancing drugs, the cholinergic precursor choline alphoscerate (alpha-glyceryl-phosphorylcholine) or the acetylcholinesterase (ache) inhibitor galantamine on high affinity choline uptake transporter (cht) and vesicular ach transporter (vacht) expression in the brain of spontaneously hypertensive rats (shr). |
2012-06-14 |
2023-08-12 |
rat |
| Daniele Tomassoni, Assia Catalani, Carlo Cinque, Maria Antonietta Di Tullio, Seyed Khosrow Tayebati, Angela Cadoni, Innocent Ejike Nwankwo, Enea Traini, Francesco Ament. Effects of cholinergic enhancing drugs on cholinergic transporters in the brain and peripheral blood lymphocytes of spontaneously hypertensive rats. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:22191561. |
the different activity of the cholinergic precursor and of the ache inhibitor on parameters investigated is likely related to their mechanism of action. |
2012-06-14 |
2023-08-12 |
rat |
| Daniele Tomassoni, Assia Catalani, Carlo Cinque, Maria Antonietta Di Tullio, Seyed Khosrow Tayebati, Angela Cadoni, Innocent Ejike Nwankwo, Enea Traini, Francesco Ament. Effects of cholinergic enhancing drugs on cholinergic transporters in the brain and peripheral blood lymphocytes of spontaneously hypertensive rats. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:22191561. |
differences in the activity of the cholinergic precursor and ache inhibitor investigated on cht and vacht suggests that association between choline alphoscerate and ache/cholinesterase inhibitors may represent a strategy for potentiating deficient cholinergic neurotransmission worthwhile of being investigated in clinical trials. |
2012-06-14 |
2023-08-12 |
rat |
| Astrid Vogel-Hopker, Laura E Sperling, Paul G Laye. Co-opting functions of cholinesterases in neural, limb and stem cell development. Protein and peptide letters. vol 19. issue 2. 2012-06-08. PMID:21933123. |
also, possible roles of ache in neuritic growth and of cholinergic regulations in stem cells are briefly outlined. |
2012-06-08 |
2023-08-12 |
Not clear |
| Xiaowei Shi, Zhi Zhou, Lingling Wang, Feng Yue, Mengqiang Wang, Chuanyan Yang, Linsheng Son. The immunomodulation of acetylcholinesterase in zhikong scallop Chlamys farreri. PloS one. vol 7. issue 1. 2012-06-04. PMID:22292052. |
acetycholinesterase (ache; ec 3.1.1.7) is an essential hydrolytic enzyme in the cholinergic nervous system, which plays an important role during immunomodulation in vertebrates. |
2012-06-04 |
2023-08-12 |
Not clear |
| Miroslav Pohank. Cholinesterases, a target of pharmacology and toxicology. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. vol 155. issue 3. 2012-05-23. PMID:22286807. |
of the two types, butyrylcholinesterase and acetylcholinesterase (ache), ache plays the key role in ending cholinergic neurotransmission. |
2012-05-23 |
2023-08-12 |
Not clear |
| A Sherin, J Anu, K T Peeyush, S Smijin, M Anitha, B T Roshni, C S Paulos. Cholinergic and GABAergic receptor functional deficit in the hippocampus of insulin-induced hypoglycemic and streptozotocin-induced diabetic rats. Neuroscience. vol 202. 2012-05-18. PMID:22155651. |
expression of cholinergic enzymes; acetylcholine esterase (ache) and choline acetyltransferase (chat) upregulated and downregulated, respectively, in diabetic group, which was further exacerbated by hypoglycemia. |
2012-05-18 |
2023-08-12 |
rat |
| A Sherin, K T Peeyush, S Jayanarayanan, K K Amee, C S Paulos. Decreased cholinergic receptor expression in the striatum: motor function deficit in hypoglycemic and diabetic rats. Cellular and molecular neurobiology. vol 32. issue 1. 2012-05-17. PMID:21796364. |
cholinergic enzymes: ache and chat gene expression, radioreceptor binding assay and immunohistochemistry of muscarinic m1, m3 receptors and α7nachr were carried out. |
2012-05-17 |
2023-08-12 |
rat |
| Nejat Gacar, Oguz Mutlu, Tijen Utkan, Ipek Komsuoglu Celikyurt, Semil Selcen Gocmez, Güner Ula. Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats. Pharmacology, biochemistry, and behavior. vol 99. issue 3. 2012-05-16. PMID:21624386. |
in conclusion, we suggested that resveratrol had improving effects on learning and memory by acting on muscarinic cholinergic receptors and at least in part, may reverse ache activity. |
2012-05-16 |
2023-08-12 |
rat |
| Alessandra Antunes dos Santos, Danúbia Bonfanti dos Santos, Renata Pietsch Ribeiro, Dirleise Colle, Kaite Cristiane Peres, Júlia Hermes, Anderson Machado Barbosa, Alcir Luiz Dafré, Andreza Fabro de Bem, Kamil Kuca, Marcelo Farin. Effects of K074 and pralidoxime on antioxidant and acetylcholinesterase response in malathion-poisoned mice. Neurotoxicology. vol 32. issue 6. 2012-05-02. PMID:21723318. |
the organophosphorus (op) pesticide malathion is a highly neurotoxic compound and its toxicity is primarily caused by the inhibition of acetylcholinesterase (ache), leading to cholinergic syndrome. |
2012-05-02 |
2023-08-12 |
mouse |