| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Erdogan Orhan, G Orhan, E Gurka. An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production. Mini reviews in medicinal chemistry. vol 11. issue 10. 2012-02-15. PMID:21762104. |
cholinesterase enzyme family consisting of acetylcholinesterase (ache) and butrylcholinesterase (bche) is important in pathogenesis of alzheimer's disease (ad), explained by "cholinergic hypothesis". |
2012-02-15 |
2023-08-12 |
Not clear |
| Rita Romani, Roberta Galeazzi, Gabriella Rosi, Rosamaria Fiorini, Irene Pirisinu, Annarina Ambrosini, Giovanna Zoles. Anandamide and its congeners inhibit human plasma butyrylcholinesterase. Possible new roles for these endocannabinoids? Biochimie. vol 93. issue 9. 2012-02-03. PMID:21664223. |
butyrylcholinesterase (bche), a serine hydrolase biochemically related to the cholinergic enzyme acetylcholinesterase (ache), is found in many mammalian tissues, such as serum and central nervous system, but its physiological role is still unclear. |
2012-02-03 |
2023-08-12 |
human |
| Kasim Abass Askar, A Caleb Kudi, A John Mood. Purification of soluble acetylcholinesterase from sheep liver by affinity chromatography. Applied biochemistry and biotechnology. vol 165. issue 1. 2012-02-02. PMID:21499785. |
a further aim was to study whether the edrophonium's pharmacologic action is due primarily to the inhibition or inactivation of ache at sites of cholinergic transmission. |
2012-02-02 |
2023-08-12 |
Not clear |
| Kasim Abass Askar, A Caleb Kudi, A John Mood. Purification of soluble acetylcholinesterase from sheep liver by affinity chromatography. Applied biochemistry and biotechnology. vol 165. issue 1. 2012-02-02. PMID:21499785. |
ache is a pivotal enzyme in the cholinergic nervous system. |
2012-02-02 |
2023-08-12 |
Not clear |
| Aleksandro S da Silva, Silvia G Monteiro, Jamile F Gonçalves, Rosélia Spanevello, Camila B Oliveira, Marcio M Costa, Jeandre A S Jaques, Vera M Morsch, Maria Rosa C Schetinger, Cinthia M Mazzanti, Sonia T A Lope. Acetylcholinesterase activity and lipid peroxidation in the brain and spinal cord of rats infected with Trypanosoma evansi. Veterinary parasitology. vol 175. issue 3-4. 2012-02-01. PMID:21055876. |
based on the results, we conclude that the changes in ache activity and lipid peroxidation in the cns are induced by infection with t. evansi, suggesting that the parasite interferes with the cholinergic neurotransmission in this experimental condition. |
2012-02-01 |
2023-08-12 |
rat |
| M Sánchez-Guerra, N Pérez-Herrera, B Quintanilla-Veg. Organophosphorous pesticides research in Mexico: epidemiological and experimental approaches. Toxicology mechanisms and methods. vol 21. issue 9. 2012-01-30. PMID:22003926. |
studies in agricultural workers from several regions of the country reported moderate to severe cholinergic symptoms, including decreased acetylcholinesterase (ache) activity (the main acute op toxic effect that causes an over accumulation of the neurotransmitter acetylcholine), revealing the potential risk of intoxication of mexican farmers. |
2012-01-30 |
2023-08-12 |
human |
| Daniel P Holschneider, Yumei Guo, Margareth Roch, Keith M Norman, Oscar U Scremi. Acetylcholinesterase inhibition and locomotor function after motor-sensory cortex impact injury. Journal of neurotrauma. vol 28. issue 9. 2012-01-16. PMID:21787180. |
the hypothesis that enhancement of cholinergic function by inhibition of acetylcholinesterase (ache) improves locomotion following tbi was tested in sprague-dawley male rats after a unilateral controlled cortical impact (cci) injury of the motor-sensory cortex. |
2012-01-16 |
2023-08-12 |
rat |
| G RamaRao, B K Bhattacharya, Subodh Kumar, C K Waghmar. Gene expression and phosphoprotein profile of certain key neuronal signaling proteins following soman intoxication. Toxicology. vol 290. issue 2-3. 2012-01-12. PMID:21971501. |
nerve agents irreversibly inhibit acetylcholinesterase (ache), leading to cholinergic crisis and death at acute exposure levels. |
2012-01-12 |
2023-08-12 |
Not clear |
| David O Kennedy, Fiona L Dodd, Bernadette C Robertson, Edward J Okello, Jonathon L Reay, Andrew B Scholey, Crystal F Haskel. Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults. Journal of psychopharmacology (Oxford, England). vol 25. issue 8. 2011-12-13. PMID:20937617. |
these results extend previous observations of improved cognitive performance and mood following ache inhibitory sage extracts and suggest that the ability of well-tolerated terpenoid-containing extracts to beneficially modulate cholinergic function and cognitive performance deserves further attention. |
2011-12-13 |
2023-08-12 |
human |
| Joaquim Cerejeira, Pedro Batista, Vasco Nogueira, Horácio Firmino, Adriano Vaz-Serra, Elizabeta B Mukaetova-Ladinsk. Low preoperative plasma cholinesterase activity as a risk marker of postoperative delirium in elderly patients. Age and ageing. vol 40. issue 5. 2011-12-09. PMID:21576115. |
cholinergic dysfunction has been implicated in delirium pathophysiology and plasmatic acetylcholinesterase (ache) and butyrylcholinesterase (buche) activities are suppressed in patients with delirium. |
2011-12-09 |
2023-08-12 |
Not clear |
| Bombi Lee, Insop Shim, Hyejung Lee, Dae-Hyun Hah. Rehmannia glutinosa ameliorates scopolamine-induced learning and memory impairment in rats. Journal of microbiology and biotechnology. vol 21. issue 8. 2011-12-05. PMID:21876380. |
changes in cholinergic system reactivity were also examined by measuring the immunoreactive neurons of choline acetyltransferase (chat) and the reactivity of acetylcholinesterase (ache) in the hippocampus. |
2011-12-05 |
2023-08-12 |
rat |
| Songmi Kim, Yuno Lee, Prettina Lazar, Minky Son, Ayoung Baek, Sundarapandian Thangapandian, Na Young Jeong, Young Hyun Yoo, Keun Woo Le. Binding conformation prediction between human acetylcholinesterase and cytochrome c using molecular modeling methods. Journal of molecular graphics & modelling. vol 29. issue 8. 2011-12-01. PMID:21570330. |
the acetylcholinesterase (ache) is important to terminate acetylcholine-mediated neurotransmission at cholinergic synapses. |
2011-12-01 |
2023-08-12 |
human |
| Renato Scacchi, Maria Ruggeri, Rosa Maria Corb. Variation of the butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) genes in coronary artery disease. Clinica chimica acta; international journal of clinical chemistry. vol 412. issue 15-16. 2011-09-30. PMID:21473860. |
butyrylcholinesterase (bche) and acetylcholinesterase (ache) are two enzymes of the cholinergic system putatively involved in coronary artery disease (cad). |
2011-09-30 |
2023-08-12 |
human |
| Csaba Nyakas, Ivica Granic, László G Halmy, Pradeep Banerjee, Paul G M Luite. The basal forebrain cholinergic system in aging and dementia. Rescuing cholinergic neurons from neurotoxic amyloid-β42 with memantine. Behavioural brain research. vol 221. issue 2. 2011-09-09. PMID:20553766. |
the evidence pointing to cholinergic impairments come from studies that report a decline in the activity of choline acetyltransferase (chat) and acetylcholine esterase (ache), acetylcholine (ach) release and the levels of nicotinic and muscarinic receptors, and loss of cholinergic basal forebrain neurons in the ad brain. |
2011-09-09 |
2023-08-12 |
rat |
| Anne M Valle, Zoran Radic, Brinda K Rana, Vafa Mahboubi, Jennifer Wessel, Pei-an Betty Shih, Fangwen Rao, Daniel T O'Connor, Palmer Taylo. Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits. The Journal of pharmacology and experimental therapeutics. vol 338. issue 1. 2011-08-30. PMID:21493754. |
cholinergic neurotransmission in the central and autonomic nervous systems regulates immediate variations in and longer-term maintenance of cardiovascular function with acetylcholinesterase (ache) activity that is critical to temporal responsiveness. |
2011-08-30 |
2023-08-12 |
human |
| Dong Hyun Kim, Yearn Seong Choe, Joon Young Choi, Kyung-Han Lee, Byung-Tae Ki. Binding of 2-[18F]fluoro-CP-118,954 to mouse acetylcholinesterase: microPET and ex vivo Cerenkov luminescence imaging studies. Nuclear medicine and biology. vol 38. issue 4. 2011-08-23. PMID:21531291. |
acetylcholinesterase (ache) has been an important cholinergic factor for the diagnosis of alzheimer's disease (ad), because of reduced ache activity in the postmortem brains of ad patients. |
2011-08-23 |
2023-08-12 |
mouse |
| Hong Yang, Guifang Jin, Dongdong Ren, Sijing Luo, Tianhong Zho. Mechanism of isoflavone aglycone's effect on cognitive performance of senescence-accelerated mice. Brain and cognition. vol 76. issue 1. 2011-08-15. PMID:21463916. |
data suggested that ia could indirectly increase concentration of the cholinergic neural transmitter ach through regulation of ache, therefore improving the central cholinergic function and enhancing the learning and memory ability. |
2011-08-15 |
2023-08-12 |
mouse |
| Mohd Imran Khan, Abbas Ali Mahdi, Najmul Islam, Subodh Kumar Rastogi, M P S Neg. Assessment of erythrocyte acetylcholine esterase activities in painters. Indian journal of occupational and environmental medicine. vol 13. issue 1. 2011-07-14. PMID:20165609. |
the marked reduction observed in both rbc and plasma ache activity may account for disruption of cholinergic function and result in neurotoxicity among the painters. |
2011-07-14 |
2023-08-12 |
Not clear |
| Deepika Sharma, Munish Puri, Ashok K Tiwary, Nirmal Singh, Amteshwar Singh Jagg. Antiamnesic effect of stevioside in scopolamine-treated rats. Indian journal of pharmacology. vol 42. issue 3. 2011-07-14. PMID:20871768. |
brain acetylcholinestrase enzyme (ache) activity was measured to assess the central cholinergic activity. |
2011-07-14 |
2023-08-12 |
rat |
| Véronique Bernard, Emmanuelle Girard, Anna Hrabovska, Shelley Camp, Palmer Taylor, Benoit Plaud, Eric Krejc. Distinct localization of collagen Q and PRiMA forms of acetylcholinesterase at the neuromuscular junction. Molecular and cellular neurosciences. vol 46. issue 1. 2011-07-05. PMID:20883790. |
acetylcholinesterase (ache) terminates the action of acetylcholine at cholinergic synapses thereby preventing rebinding of acetylcholine to nicotinic postsynaptic receptors at the neuromuscular junction. |
2011-07-05 |
2023-08-12 |
mouse |