| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mathilde M Triquigneaux, Marilyn Ehrenshaft, Esther Roth, Israel Silman, Yakov Ashani, Ronald P Mason, Lev Weiner, Leesa J Deterdin. Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue. The Biochemical journal. vol 448. issue 1. 2013-01-14. PMID:22888904. |
the principal role of ache (acetylcholinesterase) is termination of impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine. |
2013-01-14 |
2023-08-12 |
Not clear |
| Rômulo Pillon Barcelos, Rafael de Lima Portella, Thiago Henrique Lugokenski, Edovando José Flores da Rosa, Guilherme Pires Amaral, Luiz Filipe Machado Garcia, Leandro Bresolin, Vanessa Carratu, Félix Alexandre Antunes Soares, Nilda Berenice de Vargas Barbos. Isatin-3-N4-benzilthiosemicarbazone, a non-toxic thiosemicarbazone derivative, protects and reactivates rat and human cholinesterases inhibited by methamidophos in vitro and in silico. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 6. 2013-01-04. PMID:22542756. |
the inactivation of ache results in the accumulation of acetylcholine at cholinergic receptor sites, causing a cholinergic crisis that can lead to death. |
2013-01-04 |
2023-08-12 |
mouse |
| Lev Pavlovsky, Yifat Bitan, Hadar Shalev, Yonatan Serlin, Alon Friedma. Stress-induced altered cholinergic-glutamatergic interactions in the mouse hippocampus. Brain research. vol 1472. 2013-01-02. PMID:22796599. |
stress-related behavioral modulation via central cholinergic pathways was enhanced by the central ache inhibitor, physostigmine, thus further supporting the notion that stress is associated with long lasting hypersensitivity to acetylcholine. |
2013-01-02 |
2023-08-12 |
mouse |
| Dong-Young Choi, Young-Jung Lee, Sun Young Lee, Yoot Mo Lee, Hyun Hee Lee, Im Seop Choi, Ki-Wan Oh, Sang Bae Han, Sang-Yoon Nam, Jin Tae Hon. Attenuation of scopolamine-induced cognitive dysfunction by obovatol. Archives of pharmacal research. vol 35. issue 7. 2012-12-18. PMID:22864751. |
the disease is pathologically characterized by extracellular deposition of beta-amyloid peptide (aβ), cholinergic neurodegeneration and elevation of acetylcholine esterase (ache) activity in the affected regions. |
2012-12-18 |
2023-08-12 |
Not clear |
| Pradeep Kumar Kamat, Santoshkumar Tota, Shivika Rai, Rakesh Shukla, Shakir Ali, Abul Kalam Najmi, Chandishwar Nat. Okadaic acid induced neurotoxicity leads to central cholinergic dysfunction in rats. European journal of pharmacology. vol 690. issue 1-3. 2012-12-17. PMID:22749976. |
in the present study, we investigated effect of oka (i.c.v) on cholinergic function by observing acetylcholine level (ach), acetylcholinestrase (ache) activity, and mrna expression of acetylcholinestrase and α7nicotinic receptor (α7-nachr) as a cholinergic markers in brain areas (cerebellum, striatum cortex and hippocampus). |
2012-12-17 |
2023-08-12 |
rat |
| Pradeep Kumar Kamat, Santoshkumar Tota, Shivika Rai, Rakesh Shukla, Shakir Ali, Abul Kalam Najmi, Chandishwar Nat. Okadaic acid induced neurotoxicity leads to central cholinergic dysfunction in rats. European journal of pharmacology. vol 690. issue 1-3. 2012-12-17. PMID:22749976. |
pretreatment with anti-dementic drugs donepezil (ache inhibitor; 5mg/kg, p.o) and memantine (nmda receptor antagonist; 10mg/kg, p.o) daily for 13 day prevented cholinergic dysfunction and neuronal loss in cortex and hippocampus of oka treated rat. |
2012-12-17 |
2023-08-12 |
rat |
| Ian R Macdonald, Earl Martin, Terrone L Rosenberry, Sultan Darves. Probing the peripheral site of human butyrylcholinesterase. Biochemistry. vol 51. issue 36. 2012-12-04. PMID:22901043. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) catalyze the hydrolysis of the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. |
2012-12-04 |
2023-08-12 |
human |
| Miroslav Pohank. Acetylcholinesterase inhibitors: a patent review (2008 - present). Expert opinion on therapeutic patents. vol 22. issue 8. 2012-11-27. PMID:22768972. |
ache is an important part of the cholinergic nervous system taking place in the central and peripheral nervous system. |
2012-11-27 |
2023-08-12 |
Not clear |
| Wilson K W Luk, Vicky P Chen, Roy C Y Choi, Karl W K Tsi. N-linked glycosylation of dimeric acetylcholinesterase in erythrocytes is essential for enzyme maturation and membrane targeting. The FEBS journal. vol 279. issue 17. 2012-11-08. PMID:22805525. |
acetylcholinesterase (ache) is well-known for its cholinergic functions in the nervous system; however, this enzyme is also found in other tissues where its function is still not understood. |
2012-11-08 |
2023-08-12 |
human |
| Jeandre Augusto dos Santos Jaques, João Felipe Peres Rezer, Fabiano Barbosa Carvalho, Michelle Melgarejo da Rosa, Jessié Martins Gutierres, Jamile Fabbrin Gonçalves, Roberta Schmatz, André Valle de Bairros, Cinthia Melazzo Mazzanti, Maribel Antonello Rubin, Maria Rosa Chitolina Schetinger, Daniela Bitencourt Rosa Lea. Curcumin protects against cigarette smoke-induced cognitive impairment and increased acetylcholinesterase activity in rats. Physiology & behavior. vol 106. issue 5. 2012-11-07. PMID:22579739. |
these ache alterations could suggest a role in the memory impairment promoted by cigarette smoke-exposure and point toward the potential of cur to modulate cholinergic neurotransmission and, consequently, improve cognition deficits induced by smoke. |
2012-11-07 |
2023-08-12 |
rat |
| Caterina Ciacci, Cristina Barmo, Gabriella Gallo, Maria Maisano, Tiziana Cappello, Alessia D'Agata, Claudio Leonzio, Angela Mauceri, Salvatore Fasulo, Laura Canes. Effects of sublethal, environmentally relevant concentrations of hexavalent chromium in the gills of Mytilus galloprovincialis. Aquatic toxicology (Amsterdam, Netherlands). vol 120-121. 2012-10-17. PMID:22673405. |
gill morphology and immunolocalization of gsh-transferase (gst), of components involved in cholinergic (ache and chat), adrenergic (th) and serotoninergic (5-ht(3) receptor) systems, regulating gill motility, were evaluated. |
2012-10-17 |
2023-08-12 |
Not clear |
| C Falugi, C Davol. Localization of putative biochemical messengers during Eisenia foetida (Annelida, Oligochaeta) development. Tissue & cell. vol 25. issue 3. 2012-10-02. PMID:18621234. |
this histochemical-immunohistochemical study was performed on the earthworm eisenia foetida at different developmental stages, to investigate the presence and distribution of cholinergic molecules (ache, buche, alpha-bungarotoxin-binding sites), several biogenic amines (5ht and catecholamines), and some immunologically-related peptides (somatostatin. |
2012-10-02 |
2023-08-12 |
Not clear |
| C I Fernández, J Bergado, K De La Cuétara, N Nunez, O Castellanos, O González, A Torres, R Macías, L Alvarez, H Molin. Brain aging and neurotransplantation. II. Effects of septal cell suspension grafts to hippocampus of aged rodents on learning and memory impairments. Archives of gerontology and geriatrics. vol 19 Suppl 1. 2012-10-02. PMID:18649844. |
acetylcholine esterase (ache) histochemistry demonstrated the survival of cholinergic cells within the transplant. |
2012-10-02 |
2023-08-12 |
human |
| N Morel, P Dreyfu. Association of acetylcholinesterase with the external surface of the presynaptic plasma membrane in Torpedo electric organ. Neurochemistry international. vol 4. issue 4. 2012-10-02. PMID:20487879. |
a high acetylcholinesterase (ache) activity was found associated with pure cholinergic synaptosomes prepared from torpedo electric organ. |
2012-10-02 |
2023-08-12 |
Not clear |
| A Barat, J Gómez-Barriocanal, G Ramíre. Two classes of collagen-tailed, asymmetric molecular forms of acetylcholinesterase in skeletal muscle: differential effects of denervation. Neurochemistry international. vol 6. issue 3. 2012-10-02. PMID:20488062. |
skeletal muscles of different vertebrate species contain, as it is the case in other cholinergic tissues, two classes of collagen-tailed, asymmetric forms (a-forms) of acetylcholinesterase (ache). |
2012-10-02 |
2023-08-12 |
rat |
| A Barat, J Gómez-Barriocanal, G Ramíre. Two classes of collagen-tailed, asymmetric molecular forms of acetylcholinesterase in skeletal muscle: differential effects of denervation. Neurochemistry international. vol 6. issue 3. 2012-10-02. PMID:20488062. |
it is expected that this further example of ache polymorphism will contribute to a better understanding of cholinergic transmission in skeletal muscle and, more specially, of nerve-muscle interactions. |
2012-10-02 |
2023-08-12 |
rat |
| J W Swisher, J A Doebler, A Anthon. Soman intoxication in hypothyroid rats: alterations in brain neuronal RNA, acetylcholinesterase and survival. Neurochemistry international. vol 8. issue 1. 2012-10-02. PMID:20493025. |
resistance to soman observed with thyroid deficiency may be due in large part to increased binding to plasma enzymes and diminished delivery of soman to ache in vital cholinergic sites. |
2012-10-02 |
2023-08-12 |
rat |
| B Earley, A Biegon, B E Leonar. Quantitative autoradiographic analysis of muscarinic receptors and quantitative histochemistry of acetylcholinesterase in the rat brain after trimethyltin intoxication. Neurochemistry international. vol 15. issue 4. 2012-10-02. PMID:20504522. |
the influence of trimethyl tin (tmt) intoxication on muscarinic cholinergic receptors and histochemistry of acetylcholinesterase (ache) in the rat brain 21 days after treatment was studied. |
2012-10-02 |
2023-08-12 |
rat |
| B Earley, A Biegon, B E Leonar. Quantitative autoradiographic analysis of muscarinic receptors and quantitative histochemistry of acetylcholinesterase in the rat brain after trimethyltin intoxication. Neurochemistry international. vol 15. issue 4. 2012-10-02. PMID:20504522. |
the effect on ache content was confined to cholinergic terminal areas, e.g. |
2012-10-02 |
2023-08-12 |
rat |
| A Szabó, J Nemcsók, P Kása, K Guly. Muscarinic cholinergic components in the carp brain. Neurochemistry international. vol 15. issue 4. 2012-10-02. PMID:20504527. |
the activity of the muscarinic cholinergic system (acetylcholine, ach; acetylcholinesterase, ache; choline acetyltransferase, chat; muscarinic acetylcholine receptors) was studied in the carp brain. |
2012-10-02 |
2023-08-12 |
Not clear |