| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yann S Mineur, Adetokunbo Obayemi, Mattis B Wigestrand, Gianna M Fote, Cali A Calarco, Alice M Li, Marina R Picciott. Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 9. 2013-05-02. PMID:23401542. |
to determine whether cholinergic signaling in the hippocampus could contribute to the systemic effects of cholinergic drugs, we infused physostigmine or virally delivered shrnas targeting ache into the hippocampus. |
2013-05-02 |
2023-08-12 |
mouse |
| G Lou, Q Zhang, F Xiao, Q Xiang, Z Su, L Zhang, P Yang, Y Yang, Q Zheng, Y Huan. Intranasal administration of TAT-haFGF(₁₄₋₁₅₄) attenuates disease progression in a mouse model of Alzheimer's disease. Neuroscience. vol 223. 2013-05-01. PMID:22885230. |
importantly, tat-hafgf(14-154) improved the learning and memory abilities of samp8 mice in the behavioral test, and promoted the function of cholinergic system by measuring the relevant biomarkers (acetylcholine (ach) level, acetylcholinesterase (ache) and choline acetyltransferase (chat) activities). |
2013-05-01 |
2023-08-12 |
mouse |
| Éva M Szegő, Tiago F Outeiro, Pawel Kermer, Jörg B Schul. Impairment of the septal cholinergic neurons in MPTP-treated A30P α-synuclein mice. Neurobiology of aging. vol 34. issue 2. 2013-04-29. PMID:22579457. |
we here report that the number of neurons expressing a cholinergic marker in the medial septum-diagonal band of broca complex decreases in a30p α-synuclein-expressing mice during aging, paralleled by a lower ache fiber density in the dentate gyrus and in the hippocampal ca1 field. |
2013-04-29 |
2023-08-12 |
mouse |
| Jamie K Lau, Kathleen C Brown, Brent A Thornhill, Clayton M Crabtree, Aaron M Dom, Theodore R Witte, W Elaine Hardman, Christopher A McNees, Cody A Stover, A Betts Carpenter, Haitao Luo, Yi C Chen, Brandon S Shiflett, Piyali Dasgupt. Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma. Cancer research. vol 73. issue 4. 2013-04-15. PMID:23222296. |
in this study, we show that human bacs produce acetylcholine (ach) and contain several cholinergic factors including acetylcholinesterase (ache), choline acetyltransferase (chat), choline transporter 1 (cht1, slc5a7), vesicular acetylcholine transporter (vacht, slc18a3), and nach receptors (achrs, chrnas). |
2013-04-15 |
2023-08-12 |
mouse |
| Faezeh Koohestani, Chester M Brown, Esmail Meisam. Postnatal growth hormone deficiency in growing rats causes marked decline in the activity of spinal cord acetylcholinesterase but not butyrylcholinesterase. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 7. 2013-04-03. PMID:22922167. |
the effects of growth hormone (gh) deficiency on the developmental changes in the abundance and activity of cholinesterase enzymes were studied in the developing spinal cord (sc) of postnatal rats by measuring the specific activity of acetylcholinesterase (ache), a marker for cholinergic neurons and their synaptic compartments, and butyrylcholinesterase (buche), a marker for glial cells and neurovascular cells. |
2013-04-03 |
2023-08-12 |
rat |
| Faezeh Koohestani, Chester M Brown, Esmail Meisam. Postnatal growth hormone deficiency in growing rats causes marked decline in the activity of spinal cord acetylcholinesterase but not butyrylcholinesterase. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 7. 2013-04-03. PMID:22922167. |
results imply that, in the absence of pituitary gh, the postnatal proliferation of cholinergic synapses in the rat sc, a cns structure, where ache activity is abundant, is markedly reduced during both the pre- and postweaning periods; more so in the postweaning than preweaning ages. |
2013-04-03 |
2023-08-12 |
rat |
| Faezeh Koohestani, Chester M Brown, Esmail Meisam. Differential effects of developmental hypo- and hyperthyroidism on acetylcholinesterase and butyrylcholinesterase activity in the spinal cord of developing postnatal rat pups. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 7. 2013-04-03. PMID:22982053. |
ache is a cholinergic synaptic enzyme while buche is a metabolic enzyme mainly found in glial cells and neurovascular cells. |
2013-04-03 |
2023-08-12 |
rat |
| Naouel Kamel, Hajer Attig, Alessandro Dagnino, Hamadi Boussetta, Mohamed Bann. Increased temperatures affect oxidative stress markers and detoxification response to benzo[a]pyrene exposure in mussel Mytilus galloprovincialis. Archives of environmental contamination and toxicology. vol 63. issue 4. 2013-03-26. PMID:22903631. |
the cholinergic system was evaluated using acetylcholinesterase (ache) activity. |
2013-03-26 |
2023-08-12 |
cat |
| Daniela Karlsson, Adyary Fallarero, Gerda Brunhofer, Claudia Mayer, Ohm Prakash, C Gopi Mohan, Pia Vuorela, Thomas Erke. The exploration of thienothiazines as selective butyrylcholinesterase inhibitors. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 47. issue 1. 2013-03-08. PMID:22683890. |
in the ad brain, selective bche inhibitors have been demonstrated to have a beneficial effect in vivo, probably by recovering cholinergic activity and/or by restoring ache:bche activity ratios to the levels observed in the healthy brain. |
2013-03-08 |
2023-08-12 |
human |
| Edna Blotnick, Yasmine Hamra-Amitai, Chen Wald, Talma Brenner, Lili Angliste. Changes in acetylcholinesterase in experimental autoimmune myasthenia gravis and in response to treatment with a specific antisense. The European journal of neuroscience. vol 36. issue 8. 2013-03-06. PMID:22805122. |
controlled regulation of synaptic nicotinic acetylcholine receptors (achrs) and acetylcholinesterase (ache), together with maintenance of a dynamic balance between them, is a requirement for proper function of cholinergic synapses. |
2013-03-06 |
2023-08-12 |
rat |
| Edna Blotnick, Yasmine Hamra-Amitai, Chen Wald, Talma Brenner, Lili Angliste. Changes in acetylcholinesterase in experimental autoimmune myasthenia gravis and in response to treatment with a specific antisense. The European journal of neuroscience. vol 36. issue 8. 2013-03-06. PMID:22805122. |
our findings emphasise the tight connection between achr and ache at the myasthenic nmj, and the importance of the ache/achr ratio in maintaining the required cholinergic balance. |
2013-03-06 |
2023-08-12 |
rat |
| Gulseher Sarah Sirin, Yanzi Zhou, Lee Lior-Hoffmann, Shenglong Wang, Yingkai Zhan. Aging mechanism of soman inhibited acetylcholinesterase. The journal of physical chemistry. B. vol 116. issue 40. 2013-02-25. PMID:22984913. |
acetylcholinesterase (ache) is a crucial enzyme in the cholinergic nervous system that hydrolyzes neurotransmitter acetylcholine (ach) and terminates synaptic signals. |
2013-02-25 |
2023-08-12 |
Not clear |
| Sally M Williamson, Christopher Moffat, Martha A E Gomersall, Nastja Saranzewa, Christopher N Connolly, Geraldine A Wrigh. Exposure to acetylcholinesterase inhibitors alters the physiology and motor function of honeybees. Frontiers in physiology. vol 4. 2013-02-07. PMID:23386834. |
here, we investigate the behavioral effects on honeybees of exposure to a selection of pesticides that target cholinergic signaling by inhibiting acetylcholinesterase (ache). |
2013-02-07 |
2023-08-12 |
Not clear |
| Hemant Kumar, Byung-Wook Kim, Soo-Yeol Song, Jun-Soo Kim, In-Su Kim, Young-Sook Kwon, Sushruta Koppula, Dong-Kug Cho. Cognitive enhancing effects of alpha asarone in amnesic mice by influencing cholinergic and antioxidant defense mechanisms. Bioscience, biotechnology, and biochemistry. vol 76. issue 8. 2013-02-04. PMID:22878197. |
these results suggest that α-asarone has a beneficial effect in cognitive impairment induced by dysfunction of cholinergic system in brain through inhibition of ache activity and by influencing the antioxidant defense mechanism. |
2013-02-04 |
2023-08-12 |
mouse |
| Hai-Yan Zhan. New insights into huperzine A for the treatment of Alzheimer's disease. Acta pharmacologica Sinica. vol 33. issue 9. 2013-01-29. PMID:22941287. |
in addition to its ache inhibitory effect, potent multifaceted neuroprotective effect through activating cholinergic system and directly acting on mitochondria have been explored. |
2013-01-29 |
2023-08-12 |
Not clear |
| Laura E Sperling, Janine Klaczinski, Corina Schütz, Lydia Rudolph, Paul G Laye. Mouse acetylcholinesterase enhances neurite outgrowth of rat R28 cells through interaction with laminin-1. PloS one. vol 7. issue 5. 2013-01-24. PMID:22570738. |
the enzyme acetylcholinesterase (ache) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine, but can also exert 'non-classical', morpho-regulatory effects on developing neurons such as stimulation of neurite outgrowth. |
2013-01-24 |
2023-08-12 |
mouse |
| Vera Lucia Sardá Ribeiro, Cláudia Vanzella, Felipe dos Santos Moysés, Jaqueline Campiol Dos Santos, João Ricardo Souza Martins, Gilsane Lino von Poser, Ionara Rodrigues Siqueir. Effect of Calea serrata Less. n-hexane extract on acetylcholinesterase of larvae ticks and brain Wistar rats. Veterinary parasitology. vol 189. issue 2-4. 2013-01-24. PMID:22608349. |
acetylcholinesterase (ache), an enzyme that hydrolyses acetylcholine (ach) at cholinergic synapses, is a target for pesticides and its inhibition by organophosphates leads to paralysis and death of arthropods. |
2013-01-24 |
2023-08-12 |
rat |
| Dharam Paul Attrey, Amrit Kumar Singh, Tanveer Naved, Balgangadhar Ro. Effect of seabuckthorn extract on scopolamine induced cognitive impairment. Indian journal of experimental biology. vol 50. issue 10. 2013-01-22. PMID:23214261. |
the results suggest that sbt leaf extract has potential effects against scopolamine induced cognitive impairment by regulating cholinergic marker enzyme activity (ache activity) and promoting the antioxidant system and may be explored for its use in cognitive disorders. |
2013-01-22 |
2023-08-12 |
rat |
| Shazi Shakil, Rosina Khan, Shams Tabrez, Qamre Alam, Nasimudeen R Jabir, Mansour I Sulaiman, Nigel H Greig, Mohammad A Kama. Interaction of human brain acetylcholinesterase with cyclophosphamide: a molecular modeling and docking study. CNS & neurological disorders drug targets. vol 10. issue 7. 2013-01-21. PMID:21999734. |
this study describes the interaction between human acetylcholinesterase (ache), a key regulator of central and peripheral cholinergic function, and the widely used nitrogen mustard alkylating agent, cyclophosphamide (cp). |
2013-01-21 |
2023-08-12 |
human |
| Tatimah Peth-Nui, Jintanaporn Wattanathorn, Supaporn Muchimapura, Terdthai Tong-Un, Nawanant Piyavhatkul, Poonsri Rangseekajee, Kornkanok Ingkaninan, Sakchai Vittaya-Areeku. Effects of 12-Week Bacopa monnieri Consumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2013-01-16. PMID:23320031. |
the cholinergic and monoaminergic systems functions were determined using ache and mao activities. |
2013-01-16 |
2023-08-12 |
human |