| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Maria Fossati, Simona Candiani, Marie-Therese Nödl, Luca Maragliano, Maria Pennuto, Pedro Domingues, Fabio Benfenati, Mario Pestarino, Letizia Zull. Identification and Expression of Acetylcholinesterase in Octopus vulgaris Arm Development and Regeneration: a Conserved Role for ACHE? Molecular neurobiology. vol 52. issue 1. 2016-05-17. PMID:25112677. |
this possibility is also supported by the presence in the ache sequence and model structure of both cholinergic and non-cholinergic sites. |
2016-05-17 |
2023-08-13 |
Not clear |
| A Young Min, Choon Nan Doo, Eun Jung Son, Nak Yun Sung, Kun Jong Lee, Dai-Eun Sok, Mee Ree Ki. N-palmitoyl serotonin alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of BDNF and p-CREB in mice. Chemico-biological interactions. vol 242. 2016-05-03. PMID:26408985. |
pal-5ht regulated cholinergic function by inhibiting scopolamine-induced elevation of ache activity and decline of chat activity. |
2016-05-03 |
2023-08-13 |
mouse |
| Tran Manh Hung, Joo Sang Lee, Nguyen Ngoc Chuong, Jeong Ah Kim, Sang Ho Oh, Mi Hee Woo, Jae Sue Choi, Byung Sun Mi. Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II). Chemico-biological interactions. vol 240. 2016-03-15. PMID:26297990. |
acetylcholinesterase (ache) inhibitors increase the availability of acetylcholine in central cholinergic synapses and are the most promising drugs currently available for the treatment of alzheimer's disease (ad). |
2016-03-15 |
2023-08-13 |
Not clear |
| K Petro. Macrocyclic derivatives of 6-methyluracil: New ligands of the peripheral anionic site of acetylcholinesterase. The International journal of risk & safety in medicine. vol 27 Suppl 1. 2016-03-15. PMID:26639720. |
acetylcholinesterase (ache) inhibitors are widely used in medicine for pharmacological correction of cholinergic neurotransmission pathologies such as myasthenia gravis (mg) and alzheimer's disease [1, 2]. |
2016-03-15 |
2023-08-13 |
Not clear |
| Yassine Chtourou, Brahim Gargouri, Mohammed Kebieche, Hamadi Fetou. Naringin Abrogates Cisplatin-Induced Cognitive Deficits and Cholinergic Dysfunction Through the Down-Regulation of AChE Expression and iNOS Signaling Pathways in Hippocampus of Aged Rats. Journal of molecular neuroscience : MN. vol 56. issue 2. 2016-03-14. PMID:25896911. |
naringin abrogates cisplatin-induced cognitive deficits and cholinergic dysfunction through the down-regulation of ache expression and inos signaling pathways in hippocampus of aged rats. |
2016-03-14 |
2023-08-13 |
rat |
| Pierre Bohn, Fabienne Gourand, Cyril Papamicaël, Méziane Ibazizène, Martine Dhilly, Vincent Gembus, Florent Alix, Mihaela-Liliana Ţînţaş, Francis Marsais, Louisa Barré, Vincent Levache. Dihydroquinoline Carbamate Derivatives as "Bio-oxidizable" Prodrugs for Brain Delivery of Acetylcholinesterase Inhibitors: [¹¹C] Radiosynthesis and Biological Evaluation. ACS chemical neuroscience. vol 6. issue 5. 2016-03-07. PMID:25695305. |
with the aim of improving the efficiency of marketed acetylcholinesterase (ache) inhibitors in the symptomatic treatment of alzheimer's disease, plagued by adverse effects arising from peripheral cholinergic activation, this work reports a biological evaluation of new central ache inhibitors based on an original "bio-oxidizable" prodrug strategy. |
2016-03-07 |
2023-08-13 |
mouse |
| Pierre Bohn, Fabienne Gourand, Cyril Papamicaël, Méziane Ibazizène, Martine Dhilly, Vincent Gembus, Florent Alix, Mihaela-Liliana Ţînţaş, Francis Marsais, Louisa Barré, Vincent Levache. Dihydroquinoline Carbamate Derivatives as "Bio-oxidizable" Prodrugs for Brain Delivery of Acetylcholinesterase Inhibitors: [¹¹C] Radiosynthesis and Biological Evaluation. ACS chemical neuroscience. vol 6. issue 5. 2016-03-07. PMID:25695305. |
interestingly, peripheral cholinergic activation has been shown to be limited in time, likely due to the presence of a permanent positive charge in 2a promoting rapid elimination of the ache inhibitor from the circulation of mice. |
2016-03-07 |
2023-08-13 |
mouse |
| Fen Liu, Yong Li, Rong Jiang, Cheng Nie, Zhenguo Zeng, Ning Zhao, Caixue Huang, Qiang Shao, Chengzhi Ding, Cheng Qing, Liang Xia, Erming Zeng, Kejian Qia. miR-132 inhibits lipopolysaccharide-induced inflammation in alveolar macrophages by the cholinergic anti-inflammatory pathway. Experimental lung research. vol 41. issue 5. 2016-02-26. PMID:26052826. |
we hypothesized that mir-132 attenuated lipopolysaccharide (lps)-induced inflammation of alveolar macrophages by targeting acetylcholinesterase (ache) and enhancing the acetylcholine (ach)-mediated cholinergic anti-inflammatory response. |
2016-02-26 |
2023-08-13 |
Not clear |
| Tong Li, Ying Yu, Hongliu Ca. Effects of brain-derived neurotrophic factor-pretreated neuron stem cell transplantation on Alzheimer's disease model mice. International journal of clinical and experimental medicine. vol 8. issue 11. 2016-02-17. PMID:26885166. |
the ad mouse model was constructed and effects of bdnf+nsc transplant group and traditional nsc transplant group were compared using the four indicators: conditions of learning and memory ability recovery tested by morris water maze (mwm), number of basal forebrain cholinergic neurons, expression of synaptophysin, and number of acetylcholinesterase (ache)-positive fibers detected by chemical staining. |
2016-02-17 |
2023-08-13 |
mouse |
| Kiranpreet Kaur, Marit Jørgensen Bakke, Frank Nilsen, Tor Einar Horsber. Identification and Molecular Characterization of Two Acetylcholinesterases from the Salmon Louse, Lepeophtheirus salmonis. PloS one. vol 10. issue 5. 2016-02-03. PMID:25938836. |
acetylcholinesterase (ache) is an important enzyme in cholinergic synapses. |
2016-02-03 |
2023-08-13 |
Not clear |
| Iwa Lee, Per Eriksson, Anders Fredriksson, Sonja Buratovic, Henrik Viber. Developmental neurotoxic effects of two pesticides: Behavior and biomolecular studies on chlorpyrifos and carbaryl. Toxicology and applied pharmacology. vol 288. issue 3. 2016-01-19. PMID:26314619. |
the results also indicate that the developmental neurotoxic effects induced are not related to the classical mechanism of acute cholinergic hyperstimulation, as the ache inhibition level (8-12%) remained below the threshold for causing systemic toxicity. |
2016-01-19 |
2023-08-13 |
mouse |
| Fan-Shiu Tsai, Lung-Yuan Wu, Shu-Er Yang, Hao-Yuan Cheng, Chin-Chuan Tsai, Chi-Rei Wu, Li-Wei Li. Ferulic acid reverses the cognitive dysfunction caused by amyloid β peptide 1-40 through anti-oxidant activity and cholinergic activation in rats. The American journal of Chinese medicine. vol 43. issue 2. 2016-01-14. PMID:25807957. |
this study also elucidates the role of anti-oxidant enzymes and cholinergic marker acetylcholinesterase (ache) in the reversal of fa from aβ1-40-induced cognitive deficits in rats. |
2016-01-14 |
2023-08-13 |
rat |
| Rafał Sokołowski, Tadeusz Płus. [Today's threat of use of organophosphorus compounds]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 39. issue 231. 2015-12-31. PMID:26449583. |
inhibition of ache activity leads to the accumulation of large amounts of acetylcholine and hyperactivity of the cholinergic system by stimulating acetylcholine receptors - muscarinic and nicotinic. |
2015-12-31 |
2023-08-13 |
Not clear |
| Zongming Ren, Xu Zhang, Xiaoguang Wang, Pingping Qi, Biao Zhang, Yang Zeng, Rongshu Fu, Mingsheng Mia. AChE inhibition: one dominant factor for swimming behavior changes of Daphnia magna under DDVP exposure. Chemosphere. vol 120. 2015-12-18. PMID:25112705. |
as a key enzyme that hydrolyzes the neurotransmitter acetylcholine in cholinergic synapses of both vertebrates and invertebrates, acetylcholinesterase (ache) is strongly inhibited by organophosphates. |
2015-12-18 |
2023-08-13 |
Not clear |
| Javier del Pino, Paula Moyano, María José Anadon, José Manuel García, María Jesús Díaz, Jimena García, María Teresa Frej. Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Toxicology. vol 336. 2015-12-15. PMID:26210949. |
acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through ache variants alteration. |
2015-12-15 |
2023-08-13 |
Not clear |
| Javier del Pino, Paula Moyano, María José Anadon, José Manuel García, María Jesús Díaz, Jimena García, María Teresa Frej. Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Toxicology. vol 336. 2015-12-15. PMID:26210949. |
in this regard, it has been reported that cpf can affect cholinergic transmission, and alter ache variants, which have been shown to be related with basal forebrain cholinergic neuronal loss. |
2015-12-15 |
2023-08-13 |
Not clear |
| Javier del Pino, Paula Moyano, María José Anadon, José Manuel García, María Jesús Díaz, Jimena García, María Teresa Frej. Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Toxicology. vol 336. 2015-12-15. PMID:26210949. |
according to these data, we hypothesized that cpf could induce basal forebrain cholinergic neuronal loss through cholinergic transmission and ache variants alteration. |
2015-12-15 |
2023-08-13 |
Not clear |
| Javier del Pino, Paula Moyano, María José Anadon, José Manuel García, María Jesús Díaz, Jimena García, María Teresa Frej. Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Toxicology. vol 336. 2015-12-15. PMID:26210949. |
this study shows that cpf impaired cholinergic transmission, induced ache inhibition and, only after long-term exposure, increased cht expression, which suggests that acetylcholine levels alteration could be mediated by these actions. |
2015-12-15 |
2023-08-13 |
Not clear |
| Javier del Pino, Paula Moyano, María José Anadon, José Manuel García, María Jesús Díaz, Jimena García, María Teresa Frej. Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Toxicology. vol 336. 2015-12-15. PMID:26210949. |
moreover, cpf induces, after acute and long-term exposure, cell death in cholinergic neurons in the basal forebrain and this effect is independent of ache inhibition and acetylcholine alteration, but was mediated partially by ache variants alteration. |
2015-12-15 |
2023-08-13 |
Not clear |
| Jing Liu, Carey Pop. The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats. Neurotoxicology. vol 46. 2015-11-12. PMID:25447325. |
organophosphorus anticholinesterases (ops) elicit acute toxicity by inhibiting acetylcholinesterase (ache), leading to acetylcholine accumulation and overstimulation of cholinergic receptors. |
2015-11-12 |
2023-08-13 |
rat |