| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Javier del Pino, Paula Moyano, María José Anadon, José Manuel García, María Jesús Díaz, Jimena García, María Teresa Frej. Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Toxicology. vol 336. 2015-12-15. PMID:26210949. |
acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through ache variants alteration. |
2015-12-15 |
2023-08-13 |
Not clear |
| Javier del Pino, Paula Moyano, María José Anadon, José Manuel García, María Jesús Díaz, Jimena García, María Teresa Frej. Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Toxicology. vol 336. 2015-12-15. PMID:26210949. |
in this regard, it has been reported that cpf can affect cholinergic transmission, and alter ache variants, which have been shown to be related with basal forebrain cholinergic neuronal loss. |
2015-12-15 |
2023-08-13 |
Not clear |
| Javier del Pino, Paula Moyano, María José Anadon, José Manuel García, María Jesús Díaz, Jimena García, María Teresa Frej. Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Toxicology. vol 336. 2015-12-15. PMID:26210949. |
according to these data, we hypothesized that cpf could induce basal forebrain cholinergic neuronal loss through cholinergic transmission and ache variants alteration. |
2015-12-15 |
2023-08-13 |
Not clear |
| Javier del Pino, Paula Moyano, María José Anadon, José Manuel García, María Jesús Díaz, Jimena García, María Teresa Frej. Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Toxicology. vol 336. 2015-12-15. PMID:26210949. |
this study shows that cpf impaired cholinergic transmission, induced ache inhibition and, only after long-term exposure, increased cht expression, which suggests that acetylcholine levels alteration could be mediated by these actions. |
2015-12-15 |
2023-08-13 |
Not clear |
| Javier del Pino, Paula Moyano, María José Anadon, José Manuel García, María Jesús Díaz, Jimena García, María Teresa Frej. Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Toxicology. vol 336. 2015-12-15. PMID:26210949. |
moreover, cpf induces, after acute and long-term exposure, cell death in cholinergic neurons in the basal forebrain and this effect is independent of ache inhibition and acetylcholine alteration, but was mediated partially by ache variants alteration. |
2015-12-15 |
2023-08-13 |
Not clear |
| Jing Liu, Carey Pop. The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats. Neurotoxicology. vol 46. 2015-11-12. PMID:25447325. |
organophosphorus anticholinesterases (ops) elicit acute toxicity by inhibiting acetylcholinesterase (ache), leading to acetylcholine accumulation and overstimulation of cholinergic receptors. |
2015-11-12 |
2023-08-13 |
rat |
| Roger M Lane, Taher Darreh-Shor. Understanding the beneficial and detrimental effects of donepezil and rivastigmine to improve their therapeutic value. Journal of Alzheimer's disease : JAD. vol 44. issue 4. 2015-11-09. PMID:25408210. |
inhibition of acetylcholinesterase (ache) in damaged but functional cholinergic synapses in the brains of dementia patients increases intrasynaptic ach. |
2015-11-09 |
2023-08-13 |
Not clear |
| Benedikt Zujalovic, Eberhard Bart. Delirium Accompanied by Cholinergic Deficiency and Organ Failure in a 73-Year-Old Critically Ill Patient: Physostigmine as a Therapeutic Option. Case reports in critical care. vol 2015. 2015-11-09. PMID:26550498. |
using the possibility of bedside determination of the acetylcholinesterase activity (ache activity), we assumed to objectify the cholinergic homeostasis within minutes. |
2015-11-09 |
2023-08-13 |
Not clear |
| Matthew O Parker, Alistair J Brock, Ari Sudwarts, Muy-Teck Teh, Fraser J Combe, Caroline H Brenna. Developmental role of acetylcholinesterase in impulse control in zebrafish. Frontiers in behavioral neuroscience. vol 9. 2015-11-03. PMID:26528153. |
assessment of expression of cholinergic (nachr), serotonergic (5-ht), and dopamine (dr) receptor mrna in both adult and larval (9 dpf) ache (sb55/+) revealed significant downregulation of chrna2, chrna5, and drd2 mrna in ache (sb55/+) larvae, but no differences in adults. |
2015-11-03 |
2023-08-13 |
zebrafish |
| Robert Alan Mans, Brian A Warmus, Caroline C Smith, Lori L McMaho. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats. Journal of neurophysiology. vol 112. issue 10. 2015-10-19. PMID:25143547. |
acetylcholinesterase (ache) inhibitors are commonly prescribed to enhance cholinergic signaling in alzheimer's disease in hopes of rescuing cognitive function, caused, in part, by degeneration of cholinergic innervation to the hippocampus and cortex. |
2015-10-19 |
2023-08-13 |
rat |
| José L Domínguez, Fernando Fernández-Nieto, Marian Castro, Marco Catto, M Rita Paleo, Silvia Porto, F Javier Sardina, José M Brea, Angelo Carotti, M Carmen Villaverde, Fredy Sussma. Computer-aided structure-based design of multitarget leads for Alzheimer's disease. Journal of chemical information and modeling. vol 55. issue 1. 2015-10-19. PMID:25483751. |
the assay results revealed that the designed inhibitors had improved affinities for bace-1 by more than 3 orders of magnitude and also displayed amyloid aggregation inhibition and affinity for ache and buche, a result that led us to a group of multitarget amyloid cascade inhibitors that also could have a positive effect at the cholinergic level. |
2015-10-19 |
2023-08-13 |
Not clear |
| Zhi-Hong Ji, Chao Liu, Hong Zhao, Xin-Yu Y. Neuroprotective effect of biatractylenolide against memory impairment in D-galactose-induced aging mice. Journal of molecular neuroscience : MN. vol 55. issue 3. 2015-10-15. PMID:25173400. |
the potential mechanisms underlying the neuroprotective effect of biatractylenolide in d-galactose-treated mice might be (i) attenuating oxidative damage via decreasing ros formation, (ii) restoring cholinergic neurotransmission via decreasing ache activity, and (iii) increasing the expression of memory-related proteins (synapsin i and pkc). |
2015-10-15 |
2023-08-13 |
mouse |
| Ashok Kumar, Sorabh Sharma, Ashwani Prashar, Rahul Deshmuk. Effect of licofelone--a dual COX/5-LOX inhibitor in intracerebroventricular streptozotocin-induced behavioral and biochemical abnormalities in rats. Journal of molecular neuroscience : MN. vol 55. issue 3. 2015-10-15. PMID:25204299. |
levels of malondialdehyde (mda), nitrite, reduced glutathione (gsh), and acetylcholinesterase (ache) activity were determined to check oxidative stress and cholinergic function. |
2015-10-15 |
2023-08-13 |
rat |
| Jun Chen, Hongna Pan, Cynthia Chen, Wei Wu, Kevin Iskandar, Jeffrey He, Tetsade Piermartiri, David M Jacobowitz, Qian-Sheng Yu, John H McDonough, Nigel H Greig, Ann M Marin. (-)-Phenserine attenuates soman-induced neuropathology. PloS one. vol 9. issue 6. 2015-10-13. PMID:24955574. |
the irreversible inhibition of the critical cholinergic degradative enzyme acetylcholinesterase (ache) by op nerve agents leads to cholinergic crisis. |
2015-10-13 |
2023-08-13 |
rat |
| Maria-Letizia Campanari, María-Salud García-Ayllón, Olivia Belbin, Joan Galcerán, Alberto Lleó, Javier Sáez-Valer. Acetylcholinesterase modulates presenilin-1 levels and γ-secretase activity. Journal of Alzheimer's disease : JAD. vol 41. issue 3. 2015-09-18. PMID:24699279. |
the cholinergic enzyme acetylcholinesterase (ache) and the catalytic component of the γ-secretase complex, presenilin-1 (ps1), are known to interact. |
2015-09-18 |
2023-08-13 |
human |
| Franciele Martini, César Augusto Bruning, Suelen Mendonca Soares, Cristina Wayne Nogueira, Gilson Zen. Inhibitory effect of ebselen on cerebral acetylcholinesterase activity in vitro: kinetics and reversibility of inhibition. Current pharmaceutical design. vol 21. issue 7. 2015-09-11. PMID:25312723. |
there is evidence that ebselen inhibits acetylcholinesterase (ache) activity, an enzyme that plays a key role in the cholinergic system by hydrolyzing acetylcholine (ach), in vitro and ex vivo. |
2015-09-11 |
2023-08-13 |
Not clear |
| Robert Zdanowski, Małgorzata Krzyżowska, Sławomir Lewicki, Piotr Rutkowski, Monika Leśniak, Marek Saracyn, Marcin Niemcewicz, Aleksander Michalski, Marek Kowalczy. Effect of isopropyl methylphosphonofluoridate (IMPF) poisoning on selected immunological parameters of angiogenesis. Annals of agricultural and environmental medicine : AAEM. vol 21. issue 4. 2015-08-28. PMID:25528912. |
acetylcholinesterase (ache) and cholinergic receptors play an important role in the immune system, including lymphocyte-induced angiogenesis. |
2015-08-28 |
2023-08-13 |
mouse |
| Mohamed A Elnasharty, Ahmed Sayed-Ahme. Expression and localization of pChAT as a novel method to study cholinergic innervation of rat adrenal gland. Acta histochemica. vol 116. issue 8. 2015-08-20. PMID:25239149. |
cholinergic innervation of the rat adrenal gland has been analyzed previously using cholinergic markers including acetylcholinesterase (ache), choline acetyltransferase (chat) and vesicular acetylcholine transporter (vacht). |
2015-08-20 |
2023-08-13 |
rat |
| Panit Yamchuen, Sathid Aimjongjun, Nanteetip Limpeancho. Oxidized low density lipoprotein increases acetylcholinesterase activity correlating with reactive oxygen species production. Neurochemistry international. vol 78. 2015-08-17. PMID:25111460. |
these findings support the notion that oxidized ldls are cytotoxic and that their action on ache may reduce central cholinergic transmission in ad and affirm ache as a continued rational for anticholinesterase therapy but in conjunction with antioxidant/antihyperlipidemic cotreatments. |
2015-08-17 |
2023-08-13 |
human |
| Hui-Jun Xi, Ren-Pei Wu, Jing-Jing Liu, Ling-Juan Zhang, Zhao-Shen L. Role of acetylcholinesterase in lung cancer. Thoracic cancer. vol 6. issue 4. 2015-08-14. PMID:26273392. |
acetylcholinesterase (ache) plays a key role in catalytic hydrolysis of cholinergic neurotransmitters. |
2015-08-14 |
2023-08-13 |
Not clear |