| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Koneni V Sashidhara, Ram K Modukuri, Pooja Jadiya, Ranga Prasad Dodda, Manoj Kumar, Balasubramaniam Sridhar, Vikash Kumar, Rizwanul Haque, Mohammad Imran Siddiqi, Aamir Nazi. Benzofuran-chalcone hybrids as potential multifunctional agents against Alzheimer's disease: synthesis and in vivo studies with transgenic Caenorhabditis elegans. ChemMedChem. vol 9. issue 12. 2015-07-24. PMID:25251917. |
these compounds were also found to decrease acetylcholinesterase (ache) levels, reduce oxidative stress in the worms, lower lipid content, and to provide protection against chemically induced cholinergic neurodegeneration. |
2015-07-24 |
2023-08-13 |
human |
| Ian R Macdonald, Kenneth Rockwood, Earl Martin, Sultan Darves. Cholinesterase inhibition in Alzheimer's disease: is specificity the answer? Journal of Alzheimer's disease : JAD. vol 42. issue 2. 2015-07-20. PMID:24898642. |
acetylcholinesterase (ache) catalyzes the hydrolysis of the cholinergic neurotransmitter acetylcholine. |
2015-07-20 |
2023-08-13 |
Not clear |
| Ian R Macdonald, Kenneth Rockwood, Earl Martin, Sultan Darves. Cholinesterase inhibition in Alzheimer's disease: is specificity the answer? Journal of Alzheimer's disease : JAD. vol 42. issue 2. 2015-07-20. PMID:24898642. |
the lack of clinical efficacy for the highly specific and potent ache inhibitor, (-) huperzine a, is intriguing, given the known cholinergic deficit in ad. |
2015-07-20 |
2023-08-13 |
Not clear |
| Miroslav Pohanka, Vitezslav Vlce. Preparation and performance of a colorimetric biosensor using acetylcholinesterase and indoxylacetate for assay of nerve agents and drugs. Interdisciplinary toxicology. vol 7. issue 4. 2015-06-25. PMID:26109903. |
acetylcholinesterase (ache; ec 3.1.1.7) is one of the most crucial components of the cholinergic nervous system and thus many of the toxins interact with this enzyme. |
2015-06-25 |
2023-08-13 |
Not clear |
| Miroslav Pohanka, Vitezslav Vlce. Preparation and performance of a colorimetric biosensor using acetylcholinesterase and indoxylacetate for assay of nerve agents and drugs. Interdisciplinary toxicology. vol 7. issue 4. 2015-06-25. PMID:26109903. |
as to inhibitors, nerve agents used as chemical warfare, some insecticides, and drugs influencing the cholinergic system are common examples of ache inhibitors. |
2015-06-25 |
2023-08-13 |
Not clear |
| Galina F Makhaeva, Elena V Rudakova, Nichole D Hein, Olga G Serebryakova, Nadezhda V Kovaleva, Natalia P Boltneva, John K Fink, Rudy J Richardso. Further studies toward a mouse model for biochemical assessment of neuropathic potential of organophosphorus compounds. Journal of applied toxicology : JAT. vol 34. issue 12. 2015-06-22. PMID:24395470. |
inhibition and aging of neuropathy target esterase (nte) by neuropathic organophosphorus (op) compounds triggers op compound-induced delayed neuropathy (opidn), whereas inhibition of acetylcholinesterase (ache) produces cholinergic toxicity. |
2015-06-22 |
2023-08-12 |
mouse |
| Gulseher Sarah Sirin, Yingkai Zhan. How is acetylcholinesterase phosphonylated by soman? An ab initio QM/MM molecular dynamics study. The journal of physical chemistry. A. vol 118. issue 39. 2015-06-16. PMID:24786171. |
acetylcholinesterase (ache) is a crucial enzyme in the cholinergic nerve system that hydrolyzes acetylcholine (ach) and terminates synaptic signals by reducing the effective concentration of ach in the synaptic clefts. |
2015-06-16 |
2023-08-13 |
Not clear |
| Kathrine Eggers Pedersen, Niladri Basu, Robert Letcher, Alana K Greaves, Christian Sonne, Rune Dietz, Bjarne Styrishav. Brain region-specific perfluoroalkylated sulfonate (PFSA) and carboxylic acid (PFCA) accumulation and neurochemical biomarker responses in east Greenland polar bears (Ursus maritimus). Environmental research. vol 138. 2015-06-15. PMID:25682255. |
nine brain regions from nine polar bears were analyzed for enzyme activity (monoamine oxidase (mao), acetylcholinesterase (ache) and glutamine synthetase (gs)) and receptor density (dopamine-2 (d2), muscarinic cholinergic (machr) and gamma-butyric acid type a (gaba-a)) along with pfsa and pfca concentrations. |
2015-06-15 |
2023-08-13 |
Not clear |
| Nils Richter, Inka Allendorf, Oezguer A Onur, Lutz Kracht, Markus Dietlein, Marc Tittgemeyer, Bernd Neumaier, Gereon R Fink, Juraj Kukolj. The integrity of the cholinergic system determines memory performance in healthy elderly. NeuroImage. vol 100. 2015-05-12. PMID:24952230. |
cerebral acetylcholinesterase (ache) activity, a measure of the integrity of the cholinergic system, can be assessed in vivo using positron emission tomography (pet) and [(11)c]n-methyl-4-piperidyl acetate (mp4a). |
2015-05-12 |
2023-08-13 |
Not clear |
| Deok Jea Cha, Si Hyeock Le. Evolutionary origin and status of two insect acetylcholinesterases and their structural conservation and differentiation. Evolution & development. vol 17. issue 1. 2015-05-12. PMID:25627717. |
acetylcholinesterase (ache) plays a pivotal role in synaptic transmission in the cholinergic nervous system of most animals, including insects. |
2015-05-12 |
2023-08-13 |
Not clear |
| Alexandra I Zugno, Maria Paula Matos, Leila Canever, Daiane B Fraga, Renata D De Luca, Fernando V Ghedim, Pedro F Deroza, Mariana B de Oliveira, Felipe D Pacheco, Samira S Valvassori, Ana Maria Volpato, Josiane Budni, João Queved. Evaluation of acetylcholinesterase activity and behavioural alterations induced by ketamine in an animal model of schizophrenia. Acta neuropsychiatrica. vol 26. issue 1. 2015-05-11. PMID:25142099. |
cognitive deficits in schizophrenia play a crucial role in its clinical manifestation and seem to be related to changes in the cholinergic system, specifically the action of acetylcholinesterase (ache). |
2015-05-11 |
2023-08-13 |
Not clear |
| Ji-Woon Kim, Hana Seung, Kyung Ja Kwon, Mee Jung Ko, Eun Joo Lee, Hyun Ah Oh, Chang Soon Choi, Ki Chan Kim, Edson Luck Gonzales, Jueng Soo You, Dong-Hee Choi, Jongmin Lee, Seol-Heui Han, Sung Min Yang, Jae Hoon Cheong, Chan Young Shin, Geon Ho Bah. Subchronic treatment of donepezil rescues impaired social, hyperactive, and stereotypic behavior in valproic acid-induced animal model of autism. PloS one. vol 9. issue 8. 2015-04-23. PMID:25133713. |
we found that prenatal exposure of valproic acid (vpa) induced dysregulation of cholinergic neuronal development, most notably the up-regulation of acetylcholinesterase (ache) in the prefrontal cortex of affected rat and mouse offspring. |
2015-04-23 |
2023-08-13 |
mouse |
| Cédric Lecoutey, Damien Hedou, Thomas Freret, Patrizia Giannoni, Florence Gaven, Marc Since, Valentine Bouet, Céline Ballandonne, Sophie Corvaisier, Aurélie Malzert Fréon, Serge Mignani, Thierry Cresteil, Michel Boulouard, Sylvie Claeysen, Christophe Rochais, Patrick Dallemagn. Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 36. 2015-04-20. PMID:25157130. |
we show herein that rs67333 is also a submicromolar acetylcholinesterase (ache) inhibitor and therefore, could contribute, through this effect, to the restoration of the cholinergic neurotransmission that becomes altered in ad. |
2015-04-20 |
2023-08-13 |
Not clear |
| Shun Shimoham. [Development of therapies for Alzheimer's disease based on cholinergic hypothesis-status quo and future directions]. Rinsho shinkeigaku = Clinical neurology. vol 53. issue 11. 2015-04-13. PMID:24291871. |
rivastigmine increase acetylcholine in the cholinergic synapse by inhibition of both ache and butyrylcholinesterase. |
2015-04-13 |
2023-08-12 |
Not clear |
| Linn Malmsten, Swetha Vijayaraghavan, Outi Hovatta, Amelia Marutle, Taher Darreh-Shor. Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation. Journal of cellular and molecular medicine. vol 18. issue 9. 2015-04-13. PMID:25109373. |
secretion of cytokines and the enzymes acetylcholinesterase (ache), butyrylcholinesterase (buche) and choline acetyltransferase (chat) involved in cholinergic signalling was measured in medium throughout the differentiation. |
2015-04-13 |
2023-08-13 |
human |
| Hai-Ming Xu, Heidi Qunhui Xie, Wu-Qun Tao, Zhi-Guang Zhou, Shuai-Zhang Li, Bin Zha. Dioxin and dioxin-like compounds suppress acetylcholinesterase activity via transcriptional downregulations in vitro. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24243026. |
these findings on dlcs are similar with those on 2,3,7,8-tcdd, pointing to the possibility that exposure to dioxin and dlcs, which frequently coexist in the contaminated environments, may concurrently interfere with the cholinergic functions via ache. |
2015-04-06 |
2023-08-12 |
Not clear |
| María-Letizia Campanari, María-Salud García-Ayllón, Lidia Blazquez-Llorca, Wilson K W Luk, Karl Tsim, Javier Sáez-Valer. Acetylcholinesterase protein level is preserved in the Alzheimer's brain. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24318838. |
acetylcholinesterase (ache) is a key enzyme in the cholinergic nervous system and is one of the most studied proteins in the field of alzheimer's disease (ad). |
2015-04-06 |
2023-08-12 |
Not clear |
| Karina Silvia Matos, Elaine F F da Cunha, Ruben Abagyan, Teodorico C Ramalh. Computational evidence for the reactivation process of human acetylcholinesterase inhibited by carbamates. Combinatorial chemistry & high throughput screening. vol 17. issue 6. 2015-04-06. PMID:24344993. |
acetylcholinesterase (ache) is responsible for hydrolysis of acetylcholine (ach), a function, which if disrupted, leads to cholinergic syndrome. |
2015-04-06 |
2023-08-12 |
human |
| Mihaela-Liliana Ţînţaş, Lénaïg Foucout, Sylvain Petit, Sylvain Oudeyer, Fabienne Gourand, Louisa Barré, Cyril Papamicaël, Vincent Levache. New developments in redox chemical delivery systems by means of 1,4-dihydroquinoline-based targetor: application to galantamine delivery to the brain. European journal of medicinal chemistry. vol 81. 2015-03-30. PMID:24852273. |
these strategies have been applied in the present case to the ache inhibitor galantamine with the aim of alleviating adverse effects observed with cholinergic ad treatment. |
2015-03-30 |
2023-08-13 |
Not clear |
| Ademir J Schmidel, Karla L Assmann, Chariane C Werlang, Kanandra T Bertoncello, Francini Francescon, Cassiano L Rambo, Gabriela M Beltrame, Daiane Calegari, Cibele B Batista, Rachel E Blaser, Walter A Roman Júnior, Greicy M M Conterato, Angelo L Piato, Leila Zanatta, Jacir Dal Magro, Denis B Rosember. Subchronic atrazine exposure changes defensive behaviour profile and disrupts brain acetylcholinesterase activity of zebrafish. Neurotoxicology and teratology. vol 44. 2015-03-06. PMID:24893294. |
furthermore, to investigate a putative role of cholinergic signalling on atz-mediated effects, we tested whether this herbicide alters acetylcholinesterase (ache) activity in brain and muscle preparations. |
2015-03-06 |
2023-08-13 |
zebrafish |