| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tetsufumi Sato, Hideki Nakatsuk. [Anticholinesterases; peripheral and central effects]. Masui. The Japanese journal of anesthesiology. vol 62. issue 1. 2013-07-18. PMID:23431890. |
the drugs have slightly different pharmacological properties, but they all work by inhibiting the breakdown of acetylcholine, an important neurotransmitter associated with memory, by blocking the enzyme acetylcholinesterase. |
2013-07-18 |
2023-08-12 |
Not clear |
| Baldeep Kumar, Ajay Prakash, Rakesh K Sewal, Bikash Medhi, Manish Mod. Drug therapy in autism: a present and future perspective. Pharmacological reports : PR. vol 64. issue 6. 2013-07-16. PMID:23406740. |
there are classes of different pharmacological agents which are found to be effective in improving behavioral symptoms of asd such as neurotransmitter reuptake inhibitors (fluoxetine), tricyclic antidepressants (imipramine), anticonvulsants (lamotrigine), atypical antipsychotics (clozapine), acetylcholinesterase inhibitors (rivastigmine), etc. |
2013-07-16 |
2023-08-12 |
Not clear |
| Konstantin A Petrov, Artem I Malomouzh, Irina V Kovyazina, Eric Krejci, Alexandra D Nikitashina, Svetlana E Proskurina, Vladimir V Zobov, Evgeny E Nikolsk. Regulation of acetylcholinesterase activity by nitric oxide in rat neuromuscular junction via N-methyl-D-aspartate receptor activation. The European journal of neuroscience. vol 37. issue 2. 2013-06-27. PMID:23121214. |
acetylcholinesterase (ache) is an enzyme that hydrolyses the neurotransmitter acetylcholine, thereby limiting spillover and duration of action. |
2013-06-27 |
2023-08-12 |
rat |
| Vaneet Aggarwal, Xin Deng, Atac Tuli, Kean S Go. Diazinon-chemistry and environmental fate: a California perspective. Reviews of environmental contamination and toxicology. vol 223. 2013-06-24. PMID:23149814. |
diazinon is very highly to moderately toxic aquatic arganisms, diazinon inhibits the enzyme acetylcholinesterase, which hydrolyzes the neurotransmitter acetylcholine and leads to a suite of intermediate syndromes including anorexia, diarrhea, generalized weakness, muscle tremors, abnormal posturing and behavior, depression, and health. |
2013-06-24 |
2023-08-12 |
Not clear |
| Zrinka Kovarik, Nikolina Maček, Rakesh K Sit, Zoran Radić, Valery V Fokin, K Barry Sharpless, Palmer Taylo. Centrally acting oximes in reactivation of tabun-phosphoramidated AChE. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:22960624. |
organophosphates (op) inhibit acetylcholinesterase (ache, ec 3.1.1.7), both in peripheral tissues and central nervous system (cns), causing adverse and sometimes fatal effects due to the accumulation of neurotransmitter acetylcholine (ach). |
2013-05-28 |
2023-08-12 |
Not clear |
| Marcio de Araujo Furtado, Franco Rossetti, Soma Chanda, Debra Youric. Exposure to nerve agents: from status epilepticus to neuroinflammation, brain damage, neurogenesis and epilepsy. Neurotoxicology. vol 33. issue 6. 2013-05-28. PMID:23000013. |
se induced by soman is a result of cholinergic system hyperactivity caused by the irreversible inhibition of acetylcholinesterase, and the subsequent increase in the amount of the neurotransmitter acetylcholine at central and peripheral sites. |
2013-05-28 |
2023-08-12 |
Not clear |
| David A Hicks, Natalia Z Makova, Natalia N Nalivaeva, Anthony J Turne. Characterisation of acetylcholinesterase release from neuronal cells. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23047022. |
although acetylcholinesterase (ache) is primarily a hydrolytic enzyme, metabolising the neurotransmitter acetylcholine in cholinergic synapses, it also has some non-catalytic functions in the brain which are far less well characterised. |
2013-05-28 |
2023-08-12 |
mouse |
| Rachel M Kwiatkowska, Naomi Platt, Rodolphe Poupardin, Helen Irving, Roch K Dabire, Sara Mitchell, Christopher M Jones, Abdoulaye Diabaté, Hilary Ranson, Charles S Wondj. Dissecting the mechanisms responsible for the multiple insecticide resistance phenotype in Anopheles gambiae s.s., M form, from Vallée du Kou, Burkina Faso. Gene. vol 519. issue 1. 2013-05-20. PMID:23380570. |
gene ontology (go) enrichment analysis suggested that elevated neurotransmitter activity is associated with resistance, with the over-transcription of target site resistance genes such as acetylcholinesterase and the gaba receptor. |
2013-05-20 |
2023-08-12 |
Not clear |
| Gulseher Sarah Sirin, Yanzi Zhou, Lee Lior-Hoffmann, Shenglong Wang, Yingkai Zhan. Aging mechanism of soman inhibited acetylcholinesterase. The journal of physical chemistry. B. vol 116. issue 40. 2013-02-25. PMID:22984913. |
acetylcholinesterase (ache) is a crucial enzyme in the cholinergic nervous system that hydrolyzes neurotransmitter acetylcholine (ach) and terminates synaptic signals. |
2013-02-25 |
2023-08-12 |
Not clear |
| Rachel E Seltman, Brandy R Matthew. Frontotemporal lobar degeneration: epidemiology, pathology, diagnosis and management. CNS drugs. vol 26. issue 10. 2013-02-14. PMID:22950490. |
pharmacological strategies have focused on neurotransmitter replacement and modulation for the treatment of behavioural, motor and cognitive symptoms of ftd, and include selective serotonin reuptake inhibitors (ssris), atypical antipsychotics, acetylcholinesterase inhibitors and glutamate nmda receptor antagonists. |
2013-02-14 |
2023-08-12 |
Not clear |
| Laura E Sperling, Janine Klaczinski, Corina Schütz, Lydia Rudolph, Paul G Laye. Mouse acetylcholinesterase enhances neurite outgrowth of rat R28 cells through interaction with laminin-1. PloS one. vol 7. issue 5. 2013-01-24. PMID:22570738. |
the enzyme acetylcholinesterase (ache) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine, but can also exert 'non-classical', morpho-regulatory effects on developing neurons such as stimulation of neurite outgrowth. |
2013-01-24 |
2023-08-12 |
mouse |
| Mathilde M Triquigneaux, Marilyn Ehrenshaft, Esther Roth, Israel Silman, Yakov Ashani, Ronald P Mason, Lev Weiner, Leesa J Deterdin. Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue. The Biochemical journal. vol 448. issue 1. 2013-01-14. PMID:22888904. |
the principal role of ache (acetylcholinesterase) is termination of impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine. |
2013-01-14 |
2023-08-12 |
Not clear |
| Xiaotong Liu, Dong Hyun Kim, Jong Min Kim, Se Jin Park, Mudan Cai, Dae Sik Jang, Jong Hoon Ry. The memory-ameliorating effects of Artemisia princeps var. orientalis against cholinergic dysfunction in mice. The American journal of Chinese medicine. vol 40. issue 5. 2012-12-31. PMID:22928830. |
these results suggest that aea could be an effective treatment against cholinergic dysfunction and its effect is mediated by the enhancement of the cholinergic neurotransmitter system via nmda receptor signaling or acetylcholinesterase inhibition. |
2012-12-31 |
2023-08-12 |
mouse |
| Ian R Macdonald, Earl Martin, Terrone L Rosenberry, Sultan Darves. Probing the peripheral site of human butyrylcholinesterase. Biochemistry. vol 51. issue 36. 2012-12-04. PMID:22901043. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) catalyze the hydrolysis of the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. |
2012-12-04 |
2023-08-12 |
human |
| Cristóbal de los Río. Cholinesterase inhibitors: a patent review (2007 - 2011). Expert opinion on therapeutic patents. vol 22. issue 8. 2012-11-27. PMID:22764681. |
cholinesterase inhibitors participate in the maintenance of the levels of the neurotransmitter acetylcholine by inhibiting the enzymes implicated in its degradation, namely, butyrylcholinesterase and acetylcholinesterase. |
2012-11-27 |
2023-08-12 |
Not clear |
| D Qujeq, T Roushan, A Norouzy, M Habibi-Rezaei, M Mehdinejad-Shan. Effects of dichlorvos and carbaryl on the activity of free and immobilized acetylcholinesterase. Toxicology and industrial health. vol 28. issue 4. 2012-10-17. PMID:21937528. |
acetylcholinesterase (ache) is responsible for the rapid hydrolytic degradation of the neurotransmitter acetylcholine into inactive products choline and acetic acid. |
2012-10-17 |
2023-08-12 |
Not clear |
| Xavier Brazzolotto, Marielle Wandhammer, Cyril Ronco, Marie Trovaslet, Ludovic Jean, Oksana Lockridge, Pierre-Yves Renard, Florian Nacho. Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure. The FEBS journal. vol 279. issue 16. 2012-10-09. PMID:22726956. |
it can accommodate larger substrates or inhibitors than acetylcholinesterase (ache), the enzyme responsible for hydrolysis of the neurotransmitter acetylcholine in the central nervous system and neuromuscular junctions. |
2012-10-09 |
2023-08-12 |
human |
| Miroslav Pohanka, Oto Pavlis, Hana Svobodova, Jiri Pikul. Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice. Interdisciplinary toxicology. vol 5. issue 1. 2012-10-02. PMID:22783145. |
the present experiment was aimed at assessing the application of neostigmine, an acetylcholinesterase (ache) pseudo-irreversible inhibitor with poor penetration through the hematoencephalitic barrier, and the neurotransmitter acetylcholine (ach). |
2012-10-02 |
2023-08-12 |
mouse |
| Adriana Bolekova, Darina Kluchova, Tatiana Spakovska, Frantisek Dorko, Kvetuse Lovasov. Postnatal development of nitrergic and cholinergic structures in rat spinal cord. Archives italiennes de biologie. vol 149. issue 3. 2012-06-21. PMID:22028090. |
other neurotransmitter is a classical neurotransmitter acetylcholine (ach), regulated by enzyme acetylcholinesterase (ache) that hydrolyses the acetylcholine after its releasing. |
2012-06-21 |
2023-08-12 |
rat |
| Amy C Halliday, Susan A Greenfiel. From protein to peptides: a spectrum of non-hydrolytic functions of acetylcholinesterase. Protein and peptide letters. vol 19. issue 2. 2012-06-08. PMID:21933122. |
acetylcholinesterase (ache), a member of the α/β-hydrolase fold superfamily of proteins, is a serine hydrolase responsible for the hydrolysis of the well studied neurotransmitter acetylcholine (ach). |
2012-06-08 |
2023-08-12 |
Not clear |