| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leticia Vidal-Liñán, Juan Bella. Practical procedures for selected biomarkers in mussels, Mytilus galloprovincialis--implications for marine pollution monitoring. The Science of the total environment. vol 461-462. 2014-03-05. PMID:23712116. |
antioxidant enzymes (catalase [cat] and glutathione peroxidase [gpx]), a phase ii detoxification enzyme (glutathione s-transferase [gst]) and a neurotransmitter catabolism enzyme (acetylcholinesterase [ache]), were considered. |
2014-03-05 |
2023-08-12 |
cat |
| Miroslav Pohanka, Vojtech Adam, Rene Kize. An acetylcholinesterase-based chronoamperometric biosensor for fast and reliable assay of nerve agents. Sensors (Basel, Switzerland). vol 13. issue 9. 2014-02-27. PMID:23999806. |
the enzyme acetylcholinesterase (ache) is an important part of cholinergic nervous system, where it stops neurotransmission by hydrolysis of the neurotransmitter acetylcholine. |
2014-02-27 |
2023-08-12 |
Not clear |
| María Elena Sale. Cholinergic drugs as therapeutic tools in inflammatory diseases: participation of neuronal and non-neuronal cholinergic systems. Anti-inflammatory & anti-allergy agents in medicinal chemistry. vol 12. issue 2. 2013-11-12. PMID:23360259. |
this knowledge led to expand the role of ach as a neurotransmitter and to consider it as a "cytotransmitter" and also to evaluate the existence of a non-neuronal cholinergic system comprising ach, chat, acetylcholinesterase, and the nicotinic and muscarinic ach receptors, outside the nervous system. |
2013-11-12 |
2023-08-12 |
Not clear |
| b' Mirjana B Colovi\\xc4\\x87, Danijela Z Krsti\\xc4\\x87, Tamara D Lazarevi\\xc4\\x87-Pa\\xc5\\xa1ti, Aleksandra M Bond\\xc5\\xbei\\xc4\\x87, Vesna M Vasi\\xc4\\x8. Acetylcholinesterase inhibitors: pharmacology and toxicology. Current neuropharmacology. vol 11. issue 3. 2013-11-01. PMID:24179466.' |
acetylcholinesterase is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. |
2013-11-01 |
2023-08-12 |
Not clear |
| G A Reid, N Chilukuri, S Darves. Butyrylcholinesterase and the cholinergic system. Neuroscience. vol 234. 2013-10-25. PMID:23305761. |
the cholinergic neurotransmitter acetylcholine is synthesized by choline acetyltransferase (chat) and its action terminated by acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2013-10-25 |
2023-08-12 |
mouse |
| Xiugong Gao, Hsiuling Lin, Radharaman Ray, Prabhati Ra. Toxicogenomic studies of human neural cells following exposure to organophosphorus chemical warfare nerve agent VX. Neurochemical research. vol 38. issue 5. 2013-10-22. PMID:23440544. |
op compounds are considered acting primarily via cholinergic pathways by binding irreversibly to acetylcholinesterase, an important regulator of the neurotransmitter acetylcholine. |
2013-10-22 |
2023-08-12 |
human |
| Tetsufumi Sato, Hideki Nakatsuk. [Anticholinesterases; peripheral and central effects]. Masui. The Japanese journal of anesthesiology. vol 62. issue 1. 2013-07-18. PMID:23431890. |
the drugs have slightly different pharmacological properties, but they all work by inhibiting the breakdown of acetylcholine, an important neurotransmitter associated with memory, by blocking the enzyme acetylcholinesterase. |
2013-07-18 |
2023-08-12 |
Not clear |
| Baldeep Kumar, Ajay Prakash, Rakesh K Sewal, Bikash Medhi, Manish Mod. Drug therapy in autism: a present and future perspective. Pharmacological reports : PR. vol 64. issue 6. 2013-07-16. PMID:23406740. |
there are classes of different pharmacological agents which are found to be effective in improving behavioral symptoms of asd such as neurotransmitter reuptake inhibitors (fluoxetine), tricyclic antidepressants (imipramine), anticonvulsants (lamotrigine), atypical antipsychotics (clozapine), acetylcholinesterase inhibitors (rivastigmine), etc. |
2013-07-16 |
2023-08-12 |
Not clear |
| Konstantin A Petrov, Artem I Malomouzh, Irina V Kovyazina, Eric Krejci, Alexandra D Nikitashina, Svetlana E Proskurina, Vladimir V Zobov, Evgeny E Nikolsk. Regulation of acetylcholinesterase activity by nitric oxide in rat neuromuscular junction via N-methyl-D-aspartate receptor activation. The European journal of neuroscience. vol 37. issue 2. 2013-06-27. PMID:23121214. |
acetylcholinesterase (ache) is an enzyme that hydrolyses the neurotransmitter acetylcholine, thereby limiting spillover and duration of action. |
2013-06-27 |
2023-08-12 |
rat |
| Vaneet Aggarwal, Xin Deng, Atac Tuli, Kean S Go. Diazinon-chemistry and environmental fate: a California perspective. Reviews of environmental contamination and toxicology. vol 223. 2013-06-24. PMID:23149814. |
diazinon is very highly to moderately toxic aquatic arganisms, diazinon inhibits the enzyme acetylcholinesterase, which hydrolyzes the neurotransmitter acetylcholine and leads to a suite of intermediate syndromes including anorexia, diarrhea, generalized weakness, muscle tremors, abnormal posturing and behavior, depression, and health. |
2013-06-24 |
2023-08-12 |
Not clear |
| Zrinka Kovarik, Nikolina Maček, Rakesh K Sit, Zoran Radić, Valery V Fokin, K Barry Sharpless, Palmer Taylo. Centrally acting oximes in reactivation of tabun-phosphoramidated AChE. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:22960624. |
organophosphates (op) inhibit acetylcholinesterase (ache, ec 3.1.1.7), both in peripheral tissues and central nervous system (cns), causing adverse and sometimes fatal effects due to the accumulation of neurotransmitter acetylcholine (ach). |
2013-05-28 |
2023-08-12 |
Not clear |
| Marcio de Araujo Furtado, Franco Rossetti, Soma Chanda, Debra Youric. Exposure to nerve agents: from status epilepticus to neuroinflammation, brain damage, neurogenesis and epilepsy. Neurotoxicology. vol 33. issue 6. 2013-05-28. PMID:23000013. |
se induced by soman is a result of cholinergic system hyperactivity caused by the irreversible inhibition of acetylcholinesterase, and the subsequent increase in the amount of the neurotransmitter acetylcholine at central and peripheral sites. |
2013-05-28 |
2023-08-12 |
Not clear |
| David A Hicks, Natalia Z Makova, Natalia N Nalivaeva, Anthony J Turne. Characterisation of acetylcholinesterase release from neuronal cells. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23047022. |
although acetylcholinesterase (ache) is primarily a hydrolytic enzyme, metabolising the neurotransmitter acetylcholine in cholinergic synapses, it also has some non-catalytic functions in the brain which are far less well characterised. |
2013-05-28 |
2023-08-12 |
mouse |
| Rachel M Kwiatkowska, Naomi Platt, Rodolphe Poupardin, Helen Irving, Roch K Dabire, Sara Mitchell, Christopher M Jones, Abdoulaye Diabaté, Hilary Ranson, Charles S Wondj. Dissecting the mechanisms responsible for the multiple insecticide resistance phenotype in Anopheles gambiae s.s., M form, from Vallée du Kou, Burkina Faso. Gene. vol 519. issue 1. 2013-05-20. PMID:23380570. |
gene ontology (go) enrichment analysis suggested that elevated neurotransmitter activity is associated with resistance, with the over-transcription of target site resistance genes such as acetylcholinesterase and the gaba receptor. |
2013-05-20 |
2023-08-12 |
Not clear |
| Gulseher Sarah Sirin, Yanzi Zhou, Lee Lior-Hoffmann, Shenglong Wang, Yingkai Zhan. Aging mechanism of soman inhibited acetylcholinesterase. The journal of physical chemistry. B. vol 116. issue 40. 2013-02-25. PMID:22984913. |
acetylcholinesterase (ache) is a crucial enzyme in the cholinergic nervous system that hydrolyzes neurotransmitter acetylcholine (ach) and terminates synaptic signals. |
2013-02-25 |
2023-08-12 |
Not clear |
| Rachel E Seltman, Brandy R Matthew. Frontotemporal lobar degeneration: epidemiology, pathology, diagnosis and management. CNS drugs. vol 26. issue 10. 2013-02-14. PMID:22950490. |
pharmacological strategies have focused on neurotransmitter replacement and modulation for the treatment of behavioural, motor and cognitive symptoms of ftd, and include selective serotonin reuptake inhibitors (ssris), atypical antipsychotics, acetylcholinesterase inhibitors and glutamate nmda receptor antagonists. |
2013-02-14 |
2023-08-12 |
Not clear |
| Laura E Sperling, Janine Klaczinski, Corina Schütz, Lydia Rudolph, Paul G Laye. Mouse acetylcholinesterase enhances neurite outgrowth of rat R28 cells through interaction with laminin-1. PloS one. vol 7. issue 5. 2013-01-24. PMID:22570738. |
the enzyme acetylcholinesterase (ache) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine, but can also exert 'non-classical', morpho-regulatory effects on developing neurons such as stimulation of neurite outgrowth. |
2013-01-24 |
2023-08-12 |
mouse |
| Mathilde M Triquigneaux, Marilyn Ehrenshaft, Esther Roth, Israel Silman, Yakov Ashani, Ronald P Mason, Lev Weiner, Leesa J Deterdin. Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue. The Biochemical journal. vol 448. issue 1. 2013-01-14. PMID:22888904. |
the principal role of ache (acetylcholinesterase) is termination of impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine. |
2013-01-14 |
2023-08-12 |
Not clear |
| Xiaotong Liu, Dong Hyun Kim, Jong Min Kim, Se Jin Park, Mudan Cai, Dae Sik Jang, Jong Hoon Ry. The memory-ameliorating effects of Artemisia princeps var. orientalis against cholinergic dysfunction in mice. The American journal of Chinese medicine. vol 40. issue 5. 2012-12-31. PMID:22928830. |
these results suggest that aea could be an effective treatment against cholinergic dysfunction and its effect is mediated by the enhancement of the cholinergic neurotransmitter system via nmda receptor signaling or acetylcholinesterase inhibition. |
2012-12-31 |
2023-08-12 |
mouse |
| Ian R Macdonald, Earl Martin, Terrone L Rosenberry, Sultan Darves. Probing the peripheral site of human butyrylcholinesterase. Biochemistry. vol 51. issue 36. 2012-12-04. PMID:22901043. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) catalyze the hydrolysis of the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. |
2012-12-04 |
2023-08-12 |
human |