| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Ostholm, P Ekström, A Bruun, T van Vee. Temporal disparity in pineal and retinal ontogeny. Brain research. vol 470. issue 1. 1988-10-11. PMID:3165685. |
the development of photoreceptors and two putative neurotransmitter systems in the pineal organ and retina was studied during embryogenesis in the three-spined stickleback gasterosteus aculeatus l. the investigation was performed by aid of immunocytochemistry using well characterized antisera to the retinal proteins alpha-transducin (td alpha) and s-antigen (sa) (photoreceptor-markers), antisera against l-glutamic acid decarboxylase (gad), gamma-aminobutyric acid (gaba), choline-o-acetyltransferase (chat) and with acetylcholinesterase (ache) histochemistry (neurotransmitter-markers). |
1988-10-11 |
2023-08-11 |
Not clear |
| P W Grabham, R J Grand, P J Byrd, P H Gallimor. Differentiation of normal and adenovirus-12 E1 transformed human embryo retinal cells. Experimental eye research. vol 47. issue 1. 1988-10-07. PMID:2842175. |
activity of the neurotransmitter enzyme acetylcholinesterase was also detected and found to increase after differentiation. |
1988-10-07 |
2023-08-11 |
mouse |
| P K Datta, A Banerjee, P S Basu, T K Datt. Acetylcholinesterase (EC 3.1.1.7), a neurotransmitter enzyme in scorpion hemolymph. Biochemical pharmacology. vol 37. issue 5. 1988-04-07. PMID:2964237. |
acetylcholinesterase (ec 3.1.1.7), a neurotransmitter enzyme in scorpion hemolymph. |
1988-04-07 |
2023-08-11 |
Not clear |
| T Wichmann, R B Illing, K Stark. Evidence for a neurotransmitter function of acetylcholine in rabbit superior colliculus. Neuroscience. vol 23. issue 3. 1988-04-05. PMID:2893996. |
acetylcholinesterase staining and studies on the uptake of [3h]choline into the subsequent efflux of tritium from collicular slices were carried out in order to provide evidence for a neurotransmitter function of acetylcholine in rabbit superior colliculus. |
1988-04-05 |
2023-08-11 |
rabbit |
| S P Sivam, B Hoskins, I K H. An assessment of comparative acute toxicity of diisopropyl-fluorophosphate, tabun, sarin, and soman in relation to cholinergic and GABAergic enzyme activities in rats. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 4. issue 4. 1984-11-05. PMID:6479498. |
the results indicate that (a) the acute toxicity of organophosphate acetylcholinesterase inhibitors is directly related to the inhibition of ache though there is a wide difference in their potency; (b) a substantial inhibition of ache activity (over 90% of control) is necessary for lethality to ensue after an acute exposure and the margins between lethal and nonlethal doses are extremely small; and (c) qualitative differences seem to exist among the various organophosphates in affecting noncholinergic neurotransmitter enzymes. |
1984-11-05 |
2023-08-12 |
rat |
| E Borda, N Contreras-Ortiz, R Gutnisky, M F Gimen. In vitro effect of acetylcholine and bethanechol on the contractions of the human detrusor muscle. Influence of prostaglandins. Archives internationales de pharmacodynamie et de therapie. vol 259. issue 1. 1983-02-25. PMID:6129833. |
our results suggest that endogenous pgs facilitate the action of acetylcholine through an increase in the concentration of the cholinergic neurotransmitter probably via an inhibition of the acetylcholinesterase activity. |
1983-02-25 |
2023-08-12 |
human |
| R N Wals. Effects of environmental complexity and deprivation on brain chemistry and physiology: a review. The International journal of neuroscience. vol 11. issue 2. 1981-01-26. PMID:6159333. |
greater complexity of the sensory environment results in increased total cholinesterase and acetylcholinesterase enzyme activity, while other neurotransmitter related substances, the catecholamines, show more variable responses. |
1981-01-26 |
2023-08-12 |
human |
| J A Olschowka, V K Vijaya. Postnatal development of cholinergic neurotransmitter enzymes in the mouse cerebellum. Biochemical, light microscopic and electron microscopic cytochemical investigations. The Journal of comparative neurology. vol 191. issue 1. 1980-10-27. PMID:7400393. |
the activity and distribution of the cholinergic neurotransmitter enzymes acetylcholinesterase (ache) and choline acetyltransferase (chac) in the developing cerebellum of the mouse were investigated using biochemical assays and light microscopic histochemistry for ache and chac, and electron microscopic histochemistry for ache. |
1980-10-27 |
2023-08-12 |
mouse |
| L Wecker, B Laskowski, W D Dettbar. Neuromuscular dysfunction induced by acetylcholinesterase inhibition. Federation proceedings. vol 37. issue 14. 1979-02-21. PMID:214351. |
electrophysiological studies have shown that paraoxon increases neurotransmitter release and causes spontaneous and impulse-related antidromic nerve activity, both of which can be reduced significantly by reactivation of inhibited acetylcholinesterase (ache) with pyridine-2-aldoxime methiodide. |
1979-02-21 |
2023-08-11 |
rat |
| Y Sarne, B K Schrier, H Gaine. Evidence for the local synthesis of a transmitter enzyme (glutamic acid decarboxylase) in crayfish peripheral nerve. Brain research. vol 110. issue 1. 1976-09-01. PMID:1276952. |
the activities of three enzymes of neurotransmitter metabolism (choline acetyl-transferase, cat; acetylcholinesterase, ache; and glutamic acid decarboxylase, gad) were studied in normal, transected, and organ cultured crayfish nerves. |
1976-09-01 |
2023-08-11 |
cat |
| J D Minna, J Yavelow, H G Coo. Expression of phenotypes in hybrid somatic cells derived from the nervous system. Genetics. vol 79 Suppl. 1975-11-05. PMID:1150088. |
the ability to synthesize ach and the ability to degrade this neurotransmitter (high levels of acetylcholinesterase activity, ache) appear to segregate independently in nl hybrid progeny.--when a a variety of clonal cell lines replicating in culture are fused to cells freshly derived from the embryonic nervous system, interesting phenotypes result in the hybrid progeny. |
1975-11-05 |
2023-08-11 |
mouse |
| J G Clement, E H Colhou. Presynaptic effect of the aziridinium ion of acetylcholine mustard (methyl-2-acetoxyethyl-2'-chloroethylamine) on the phrenic nerve--rat diaphragm preparation. Canadian journal of physiology and pharmacology. vol 53. issue 2. 1975-09-09. PMID:165868. |
although difficult to prove with the rat diaphragm it is possible that acetylcholinesterase of this preparation could hydrolyze acetylcholine mustard aziridinium ion at the neurotransmitter site and the resultant choline mustard aziridinium ion would interfere with the uptake of choline and eventually prevent neuromuscular transmission. |
1975-09-09 |
2023-08-11 |
mouse |