| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N R Cutler, J J Srame. Review of the next generation of Alzheimer's disease therapeutics: challenges for drug development. Progress in neuro-psychopharmacology & biological psychiatry. vol 25. issue 1. 2001-06-21. PMID:11263756. |
currently, the only fda-approved ad therapies are a group of acetylcholinesterase inhibitors which slow the turnover of the neurotransmitter acetylcholine in the synapse. |
2001-06-21 |
2023-08-12 |
Not clear |
| K V Sharma, C Koenigsberger, S Brimijoin, J W Bigbe. Direct evidence for an adhesive function in the noncholinergic role of acetylcholinesterase in neurite outgrowth. Journal of neuroscience research. vol 63. issue 2. 2001-04-26. PMID:11169626. |
acetylcholinesterase (ache) can promote neurite outgrowth through a mechanism that is independent of its role in hydrolyzing the neurotransmitter acetylcholine. |
2001-04-26 |
2023-08-12 |
Not clear |
| H Soreq, S Seidma. Acetylcholinesterase--new roles for an old actor. Nature reviews. Neuroscience. vol 2. issue 4. 2001-04-19. PMID:11283752. |
the discovery of the first neurotransmitter--acetylcholine--was soon followed by the discovery of its hydrolysing enzyme, acetylcholinesterase. |
2001-04-19 |
2023-08-12 |
Not clear |
| M Pilon, X R Peng, A M Spence, R H Plasterk, H M Dosc. The diabetes autoantigen ICA69 and its Caenorhabditis elegans homologue, ric-19, are conserved regulators of neuroendocrine secretion. Molecular biology of the cell. vol 11. issue 10. 2000-12-07. PMID:11029035. |
a deletion mutant was isolated and found to exhibit resistance to the drug aldicarb (an inhibitor of acetylcholinesterase), suggesting defective neurotransmitter secretion in the mutant. |
2000-12-07 |
2023-08-12 |
mouse |
| M J Drake, P Hedlund, I W Mills, R McCoy, G McMurray, B P Gardner, K E Andersson, A F Bradin. Structural and functional denervation of human detrusor after spinal cord injury. Laboratory investigation; a journal of technical methods and pathology. vol 80. issue 10. 2000-11-03. PMID:11045565. |
acetylcholinesterase histochemistry and double-label immunofluorescence were used to investigate neurotransmitter content, with confocal laser scanning microscopy to assess colocalization. |
2000-11-03 |
2023-08-12 |
human |
| M I Rodríguez-Franco, I Dorronsoro, A Martínez, C Pérez, A Badía, J E Baño. Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties. Archiv der Pharmazie. vol 333. issue 5. 2000-08-01. PMID:10863795. |
their binding properties were tested for muscarinic and other neurotransmitter receptors, together with their acetylcholinesterase inhibitory activity. |
2000-08-01 |
2023-08-12 |
Not clear |
| J W Bigbee, K V Sharma, J J Gupta, J L Dupre. Morphogenic role for acetylcholinesterase in axonal outgrowth during neural development. Environmental health perspectives. vol 107 Suppl 1. 2000-07-27. PMID:10229710. |
acetylcholinesterase (ache) is the enzyme that hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses and neuromuscular junctions. |
2000-07-27 |
2023-08-12 |
Not clear |
| M Aschne. Interactions between pesticides and glia: an unexplored experimental field. Neurotoxicology. vol 21. issue 1-2. 2000-06-30. PMID:10794397. |
it is also well established that acute exposure to the organophosphorous insecticides leads to inhibition of neuronal acetylcholinesterase activity, an enzyme responsible for the inactivation of the neurotransmitter acetylcholine. |
2000-06-30 |
2023-08-12 |
Not clear |
| P Marcho. [The fasciculin-acetylcholinesterase interaction]. Journal de la Societe de biologie. vol 193. issue 6. 2000-06-19. PMID:10783708. |
acetylcholinesterase (ache) terminates the action of the neurotransmitter acetylcholine at cholinergic synapses in the central and peripheral nervous systems. |
2000-06-19 |
2023-08-12 |
mouse |
| F J Muñoz, R Aldunate, N C Inestros. Peripheral binding site is involved in the neurotrophic activity of acetylcholinesterase. Neuroreport. vol 10. issue 17. 2000-01-19. PMID:10619655. |
acetylcholinesterase (ache) catalyses the hydrolysis of the neurotransmitter acetylcholine and it has been implicated in several non-cholinergic actions, including neurite outgrowth and amyloid formation. |
2000-01-19 |
2023-08-12 |
Not clear |
| R D Schwarz, M J Callahan, L L Coughenour, M R Dickerson, J J Kinsora, W J Lipinski, C A Raby, C J Spencer, H Tecl. Milameline (CI-979/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization. The Journal of pharmacology and experimental therapeutics. vol 291. issue 2. 1999-11-24. PMID:10525104. |
responses were not caused by the inhibition of acetylcholinesterase, and there was no significant binding to approximately 30 other neurotransmitter binding sites. |
1999-11-24 |
2023-08-12 |
human |
| E L Dovedova, L M Gershteĭn, K A Nikol'skai. [The neurochemical and behavioral indices of an acquired alcohol craving in rats under conditions of information loading]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 49. issue 2. 1999-10-19. PMID:10486902. |
the specific activities of neurotransmitter metabolizing enzymes (mao a and b, acetylcholinesterase, and acetylcholinetransferase) and the content of biogenic amines and their metabolites (serotonin, 5-hydroxyindoleacetic acid, noradrenaline, and dopamine) were measured in homogenates and subfractions of sensorimotor cortex and caudate nucleus. |
1999-10-19 |
2023-08-12 |
rat |
| M Simard, R van Reeku. Memory assessment in studies of cognition-enhancing drugs for Alzheimer's disease. Drugs & aging. vol 14. issue 3. 1999-06-15. PMID:10220105. |
tests of working, episodic, semantic and implicit memory are used as outcomes in trials with acetylcholinesterase inhibitors, drugs with other neurotransmitter strategies, metabolic enhancers and drugs which may impact upon a variety of cns processes. |
1999-06-15 |
2023-08-12 |
Not clear |
| J A Love, K Szeben. Morphology and histochemistry of the rabbit pancreatic innervation. Pancreas. vol 18. issue 1. 1999-03-15. PMID:9888661. |
here we report histochemical staining for acetylcholinesterase (ache), nadph-diaphorase (nadph-d), nitric oxide synthase (nos), and several neuropeptides to identify the neurotransmitter content of rabbit pancreatic nerves. |
1999-03-15 |
2023-08-12 |
rabbit |
| K L Davi. Alzheimer's disease: seeking new ways to preserve brain function. Interview by Alice V. Luddington. Geriatrics. vol 54. issue 2. 1999-03-03. PMID:10024872. |
the cholinesterase inhibitors tacrine and donepezil block acetylcholinesterase and therefore preserve the neurotransmitter acetylcholine. |
1999-03-03 |
2023-08-12 |
Not clear |
| F H Calderón, R von Bernhardi, G De Ferrari, S Luza, R Aldunate, N C Inestros. Toxic effects of acetylcholinesterase on neuronal and glial-like cells in vitro. Molecular psychiatry. vol 3. issue 3. 1998-10-08. PMID:9672900. |
acetylcholinesterase (ache), the enzyme involved in the hydrolysis of the neurotransmitter acetylcholine, has been implicated in non-cholinergic actions which may play a role in neurodegenerative diseases such as alzheimer's disease. |
1998-10-08 |
2023-08-12 |
Not clear |
| C Opazo, N C Inestros. Crosslinking of amyloid-beta peptide to brain acetylcholinesterase. Molecular and chemical neuropathology. vol 33. issue 1. 1998-04-21. PMID:9493175. |
acetylcholinesterase (ache) is the enzyme responsible for the hydrolysis of the neurotransmitter acetylcholine in the central nervous system. |
1998-04-21 |
2023-08-12 |
Not clear |
| H R Aria. Topology of ligand binding sites on the nicotinic acetylcholine receptor. Brain research. Brain research reviews. vol 25. issue 2. 1998-01-15. PMID:9403137. |
the alpha subunits also carry the binding site for certain acetylcholinesterase inhibitors such as eserine and for the neurotransmitter 5-hydroxytryptamine which activate the receptor without interacting with the classical agonist binding sites. |
1998-01-15 |
2023-08-12 |
Not clear |
| A Alvarez, C Opazo, R Alarcón, J Garrido, N C Inestros. Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils. Journal of molecular biology. vol 272. issue 3. 1997-10-28. PMID:9325095. |
acetylcholinesterase (ache), an enzyme involved in the hydrolysis of the neurotransmitter acetylcholine, consistently colocalizes with the amyloid deposits characteristic of alzheimer's disease and may contribute to the generation of amyloid proteins and/or physically affect fibril assembly. |
1997-10-28 |
2023-08-12 |
Not clear |
| K L Yuknavage, R A Fenske, D A Kalman, M C Keifer, C E Furlon. Simulated dermal contamination with capillary samples and field cholinesterase biomonitoring. Journal of toxicology and environmental health. vol 51. issue 1. 1997-06-19. PMID:9169060. |
ops inhibit acetylcholinesterase, the enzyme responsible for breaking down the neurotransmitter acetylcholine. |
1997-06-19 |
2023-08-12 |
human |