| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Bortkiewic. [A study on the biological effects of exposure mobile-phone frequency EMF]. Medycyna pracy. vol 52. issue 2. 2002-04-23. PMID:11761657. |
the animal experimental studies indicated that exposure to emf of the microwave frequency activates the endogenous opioid system in the brain, while the studies of the brain neurotransmitter activity have not produced univocal results, some of them showed decline, others increase in acetylcholinesterase activity. |
2002-04-23 |
2023-08-12 |
human |
| Tai C Kwon. Organophosphate pesticides: biochemistry and clinical toxicology. Therapeutic drug monitoring. vol 24. issue 1. 2002-04-23. PMID:11805735. |
the mechanism of toxicity is the inhibition of acetylcholinesterase, resulting in an accumulation of the neurotransmitter acetylcholine and the continued stimulation of acetylcholine receptors. |
2002-04-23 |
2023-08-12 |
Not clear |
| J El Yazal, S N Rao, A Mehl, W Slikke. Prediction of organophosphorus acetylcholinesterase inhibition using three-dimensional quantitative structure-activity relationship (3D-QSAR) methods. Toxicological sciences : an official journal of the Society of Toxicology. vol 63. issue 2. 2001-12-12. PMID:11568366. |
neurotoxic organophosphorous compounds are known to modulate their biological effects through the inhibition of a number of esterases including acetylcholinesterase (ache), the enzyme responsible for the degradation of the neurotransmitter acetylcholine. |
2001-12-12 |
2023-08-12 |
Not clear |
| S Olivera, D Rodriguez-Ithurralde, J M Henle. Regional localization and developmental profile of acetylcholinesterase-evoked increases in [(3)H]-5-fluororwillardiine binding to AMPA receptors in rat brain. British journal of pharmacology. vol 133. issue 7. 2001-10-04. PMID:11487516. |
in addition to its role in hydrolyzing the neurotransmitter acetylcholine, the synaptically enriched enzyme acetylcholinesterase (ache) has been reported to play an important role in the development and remodelling of neural processes and synapses. |
2001-10-04 |
2023-08-12 |
rat |
| M U Delmonte Corrado, H Politi, M Ognibene, C Angelini, F Trielli, P Ballarini, C Falug. Synthesis of the signal molecule acetylcholine during the developmental cycle of Paramecium primaurelia (Protista, Ciliophora) and its possible function in conjugation. The Journal of experimental biology. vol 204. issue Pt 11. 2001-09-27. PMID:11441032. |
we recently discovered, in mating-competent paramecium primaurelia, the presence of functionally related molecules of the cholinergic system: the neurotransmitter acetylcholine (ach), both its nicotinic and muscarinic receptors and its lytic enzyme acetylcholinesterase (ache). |
2001-09-27 |
2023-08-12 |
Not clear |
| H Maruyama, T L Rakow, I N Maruyam. Synaptic exocytosis and nervous system development impaired in Caenorhabditis elegans unc-13 mutants. Neuroscience. vol 104. issue 2. 2001-08-16. PMID:11377834. |
consistent with the phenotypes, the mutants accumulated abnormally high levels of the neurotransmitter acetylcholine and were resistant to acetylcholinesterase inhibitors. |
2001-08-16 |
2023-08-12 |
caenorhabditis_elegans |
| N R Cutler, J J Srame. Review of the next generation of Alzheimer's disease therapeutics: challenges for drug development. Progress in neuro-psychopharmacology & biological psychiatry. vol 25. issue 1. 2001-06-21. PMID:11263756. |
currently, the only fda-approved ad therapies are a group of acetylcholinesterase inhibitors which slow the turnover of the neurotransmitter acetylcholine in the synapse. |
2001-06-21 |
2023-08-12 |
Not clear |
| K V Sharma, C Koenigsberger, S Brimijoin, J W Bigbe. Direct evidence for an adhesive function in the noncholinergic role of acetylcholinesterase in neurite outgrowth. Journal of neuroscience research. vol 63. issue 2. 2001-04-26. PMID:11169626. |
acetylcholinesterase (ache) can promote neurite outgrowth through a mechanism that is independent of its role in hydrolyzing the neurotransmitter acetylcholine. |
2001-04-26 |
2023-08-12 |
Not clear |
| H Soreq, S Seidma. Acetylcholinesterase--new roles for an old actor. Nature reviews. Neuroscience. vol 2. issue 4. 2001-04-19. PMID:11283752. |
the discovery of the first neurotransmitter--acetylcholine--was soon followed by the discovery of its hydrolysing enzyme, acetylcholinesterase. |
2001-04-19 |
2023-08-12 |
Not clear |
| M Pilon, X R Peng, A M Spence, R H Plasterk, H M Dosc. The diabetes autoantigen ICA69 and its Caenorhabditis elegans homologue, ric-19, are conserved regulators of neuroendocrine secretion. Molecular biology of the cell. vol 11. issue 10. 2000-12-07. PMID:11029035. |
a deletion mutant was isolated and found to exhibit resistance to the drug aldicarb (an inhibitor of acetylcholinesterase), suggesting defective neurotransmitter secretion in the mutant. |
2000-12-07 |
2023-08-12 |
mouse |
| M J Drake, P Hedlund, I W Mills, R McCoy, G McMurray, B P Gardner, K E Andersson, A F Bradin. Structural and functional denervation of human detrusor after spinal cord injury. Laboratory investigation; a journal of technical methods and pathology. vol 80. issue 10. 2000-11-03. PMID:11045565. |
acetylcholinesterase histochemistry and double-label immunofluorescence were used to investigate neurotransmitter content, with confocal laser scanning microscopy to assess colocalization. |
2000-11-03 |
2023-08-12 |
human |
| M I Rodríguez-Franco, I Dorronsoro, A Martínez, C Pérez, A Badía, J E Baño. Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties. Archiv der Pharmazie. vol 333. issue 5. 2000-08-01. PMID:10863795. |
their binding properties were tested for muscarinic and other neurotransmitter receptors, together with their acetylcholinesterase inhibitory activity. |
2000-08-01 |
2023-08-12 |
Not clear |
| J W Bigbee, K V Sharma, J J Gupta, J L Dupre. Morphogenic role for acetylcholinesterase in axonal outgrowth during neural development. Environmental health perspectives. vol 107 Suppl 1. 2000-07-27. PMID:10229710. |
acetylcholinesterase (ache) is the enzyme that hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses and neuromuscular junctions. |
2000-07-27 |
2023-08-12 |
Not clear |
| M Aschne. Interactions between pesticides and glia: an unexplored experimental field. Neurotoxicology. vol 21. issue 1-2. 2000-06-30. PMID:10794397. |
it is also well established that acute exposure to the organophosphorous insecticides leads to inhibition of neuronal acetylcholinesterase activity, an enzyme responsible for the inactivation of the neurotransmitter acetylcholine. |
2000-06-30 |
2023-08-12 |
Not clear |
| P Marcho. [The fasciculin-acetylcholinesterase interaction]. Journal de la Societe de biologie. vol 193. issue 6. 2000-06-19. PMID:10783708. |
acetylcholinesterase (ache) terminates the action of the neurotransmitter acetylcholine at cholinergic synapses in the central and peripheral nervous systems. |
2000-06-19 |
2023-08-12 |
mouse |
| F J Muñoz, R Aldunate, N C Inestros. Peripheral binding site is involved in the neurotrophic activity of acetylcholinesterase. Neuroreport. vol 10. issue 17. 2000-01-19. PMID:10619655. |
acetylcholinesterase (ache) catalyses the hydrolysis of the neurotransmitter acetylcholine and it has been implicated in several non-cholinergic actions, including neurite outgrowth and amyloid formation. |
2000-01-19 |
2023-08-12 |
Not clear |
| R D Schwarz, M J Callahan, L L Coughenour, M R Dickerson, J J Kinsora, W J Lipinski, C A Raby, C J Spencer, H Tecl. Milameline (CI-979/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization. The Journal of pharmacology and experimental therapeutics. vol 291. issue 2. 1999-11-24. PMID:10525104. |
responses were not caused by the inhibition of acetylcholinesterase, and there was no significant binding to approximately 30 other neurotransmitter binding sites. |
1999-11-24 |
2023-08-12 |
human |
| E L Dovedova, L M Gershteĭn, K A Nikol'skai. [The neurochemical and behavioral indices of an acquired alcohol craving in rats under conditions of information loading]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 49. issue 2. 1999-10-19. PMID:10486902. |
the specific activities of neurotransmitter metabolizing enzymes (mao a and b, acetylcholinesterase, and acetylcholinetransferase) and the content of biogenic amines and their metabolites (serotonin, 5-hydroxyindoleacetic acid, noradrenaline, and dopamine) were measured in homogenates and subfractions of sensorimotor cortex and caudate nucleus. |
1999-10-19 |
2023-08-12 |
rat |
| M Simard, R van Reeku. Memory assessment in studies of cognition-enhancing drugs for Alzheimer's disease. Drugs & aging. vol 14. issue 3. 1999-06-15. PMID:10220105. |
tests of working, episodic, semantic and implicit memory are used as outcomes in trials with acetylcholinesterase inhibitors, drugs with other neurotransmitter strategies, metabolic enhancers and drugs which may impact upon a variety of cns processes. |
1999-06-15 |
2023-08-12 |
Not clear |
| J A Love, K Szeben. Morphology and histochemistry of the rabbit pancreatic innervation. Pancreas. vol 18. issue 1. 1999-03-15. PMID:9888661. |
here we report histochemical staining for acetylcholinesterase (ache), nadph-diaphorase (nadph-d), nitric oxide synthase (nos), and several neuropeptides to identify the neurotransmitter content of rabbit pancreatic nerves. |
1999-03-15 |
2023-08-12 |
rabbit |