| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laure Ginestet, Juan E Ferrario, Rita Raisman-Vozari, Etienne C Hirsch, Thomas Debei. Donepezil induces a cholinergic sprouting in basocortical degeneration. Journal of neurochemistry. vol 102. issue 2. 2007-09-07. PMID:17394553. |
one of the few currently approved therapies for alzheimer's disease (ad) consists in the administration of acetylcholinesterase inhibitors, which enhances the lifetime of the neurotransmitter acetylcholine. |
2007-09-07 |
2023-08-12 |
rat |
| Malathi Srivatsa. An analysis of acetylcholinesterase sequence for predicting mechanisms of its non-catalytic actions. Bioinformation. vol 1. issue 8. 2007-08-01. PMID:17597908. |
the enzyme acetylcholinesterase (ache) which belongs to the family of alpha/beta hydrolases is well known for hydrolyzing the neurotransmitter acetylcholine (ach). |
2007-08-01 |
2023-08-12 |
human |
| Sultan Darvesh, Ryan Walsh, Earl Marti. Homocysteine thiolactone and human cholinesterases. Cellular and molecular neurobiology. vol 27. issue 1. 2007-05-22. PMID:16955366. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) are serine hydrolase enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine, a key process in the regulation of the cholinergic system. |
2007-05-22 |
2023-08-12 |
human |
| Laura E Paraoanu, Gunnar Steinert, Janine Klaczinski, Michaela Becker-Röck, Afrim Bytyqi, Paul G Laye. On functions of cholinesterases during embryonic development. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192676. |
this means that che functioning during development fits into the classical cholinergic neurotransmitter system: acetylcholine (ach), as a signal, binds to ach receptors and then is degraded by acetylcholinesterase (ache) as the terminating enzyme. |
2007-02-23 |
2023-08-12 |
Not clear |
| Natarajan Ashokkumar, Leelavinothan Pari, Kunga Mohan Ramkuma. N-Benzoyl-D-phenylalanine attenuates brain acetylcholinesterase in neonatal streptozotocin-diabetic rats. Basic & clinical pharmacology & toxicology. vol 99. issue 3. 2007-02-13. PMID:16930298. |
the decreased activity of both salt soluble and detergent soluble acetylcholinesterase observed in diabetes may be attributed to lack of insulin which causes specific alterations in the level of neurotransmitter, thus causing brain dysfunction. |
2007-02-13 |
2023-08-12 |
rat |
| Ralph J Jense. Activation of group II metabotropic glutamate receptors reduces directional selectivity in retinal ganglion cells. Brain research. vol 1122. issue 1. 2007-01-30. PMID:17010323. |
to determine whether group ii mglurs modulate the release of the neurotransmitter acetylcholine from starburst amacrine cells, the effect of dcg-iv on on-off ds rgcs was examined in the presence of ambenonium, an acetylcholinesterase inhibitor. |
2007-01-30 |
2023-08-12 |
rabbit |
| Xiu-Ling Ji, Gui-Wen Jin, Li-Ya Qu, Jin-Ping Cheng, Wen-Hua Wan. [Effect of chronic exposure by mercury contaminated rice on neurotransmitter level changes in rat brain]. Huan jing ke xue= Huanjing kexue. vol 27. issue 1. 2007-01-19. PMID:16599137. |
the changes of neurotransmitter acetylcholine (ach) and acetylcholinesterase (ache) in rat brain were examined at different times. |
2007-01-19 |
2023-08-12 |
rat |
| Eva Alés, Francesca Gullo, Esperanza Arias, Román Olivares, Antonio G García, Enzo Wanke, Manuela G Lópe. Blockade of Ca2+ -activated K+ channels by galantamine can also contribute to the potentiation of catecholamine secretion from chromaffin cells. European journal of pharmacology. vol 548. issue 1-3. 2006-12-12. PMID:16949070. |
these results constitute the first direct evidence that galantamine can potentiate neurotransmitter release by blocking kca2 channels, in addition to its already demonstrated capacity to mildly block acetylcholinesterase or potentiate allosterically nicotinic receptors. |
2006-12-12 |
2023-08-12 |
cattle |
| Edson X Albuquerque, Edna F R Pereira, Yasco Aracava, William P Fawcett, Maristela Oliveira, William R Randall, Tracey A Hamilton, Robert K Kan, James A Romano, Michael Adle. Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 35. 2006-09-29. PMID:16914529. |
most of their acute toxicity results from the irreversible inhibition of acetylcholinesterase (ache), the enzyme that inactivates the neurotransmitter acetylcholine. |
2006-09-29 |
2023-08-12 |
Not clear |
| T-M Shih, S W Hulet, J H McDonoug. The effects of repeated low-dose sarin exposure. Toxicology and applied pharmacology. vol 215. issue 2. 2006-09-28. PMID:16556454. |
the animals were assessed for changes in body weight, red blood cell (rbc) acetylcholinesterase (ache) levels, neurobehavioral reactions to a functional observational battery (fob), cortical electroencephalographic (eeg) power spectrum, and intrinsic acetylcholine (ach) neurotransmitter (nt) regulation over the 2 weeks of sarin exposure and for up to 12 days postinjection. |
2006-09-28 |
2023-08-12 |
Not clear |
| P Rada, C Colasante, M Skirzewski, L Hernandez, B Hoebe. Behavioral depression in the swim test causes a biphasic, long-lasting change in accumbens acetylcholine release, with partial compensation by acetylcholinesterase and muscarinic-1 receptors. Neuroscience. vol 141. issue 1. 2006-09-28. PMID:16677771. |
this increase in neurotransmitter may have been partially compensated by a significant increase in the degradative enzyme, acetylcholinesterase, and by a decrease in muscarinic-1 receptors and their gene expression. |
2006-09-28 |
2023-08-12 |
rat |
| Dean M Robinson, Greg L Ploske. Galantamine extended release. CNS drugs. vol 20. issue 8. 2006-09-19. PMID:16863272. |
galantamine inhibits acetylcholinesterase (ache) to slow acetylcholine hydrolysis, and may also modulate presynaptic nicotinic receptor activation, thereby increasing neurotransmitter concentrations in the synaptic cleft.black triangle once-daily galantamine extended release (er) 24 mg and twice-daily galantamine immediate release (ir) 12 mg are bioequivalent in terms of the area under the plasma concentration-time curve from time 0 to 24 hours and steady-state minimum plasma concentration.black triangle primary endpoints indicated a significantly greater effect of galantamine er on cognitive performance than placebo, with efficacy similar to galantamine ir, in a randomised, double-blind trial. |
2006-09-19 |
2023-08-12 |
Not clear |
| Manickavasagom Alkondon, Edson X Albuquerqu. Subtype-specific inhibition of nicotinic acetylcholine receptors by choline: a regulatory pathway. The Journal of pharmacology and experimental therapeutics. vol 318. issue 1. 2006-08-14. PMID:16565162. |
choline is an essential nutrient and a precursor of neurotransmitter acetylcholine (ach) and is produced at synapses during depolarization, upon hydrolysis of ach via acetylcholinesterase, and under conditions of injury and trauma. |
2006-08-14 |
2023-08-12 |
rat |
| Jacques-Philippe Colletier, Didier Fournier, Harry M Greenblatt, Jure Stojan, Joel L Sussman, Giuseppe Zaccai, Israel Silman, Martin Wei. Structural insights into substrate traffic and inhibition in acetylcholinesterase. The EMBO journal. vol 25. issue 12. 2006-08-03. PMID:16763558. |
acetylcholinesterase (ache) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine. |
2006-08-03 |
2023-08-12 |
Not clear |
| Maurizio Recanatini, Piero Valent. Acetylcholinesterase inhibitors as a starting point towards improved Alzheimer's disease therapeutics. Current pharmaceutical design. vol 10. issue 25. 2006-04-10. PMID:15544505. |
in this context, in a perspective of drug discovery, the enzyme acetylcholinesterase (ache) holds a key position, as it is a main target for cholinomimetic ad drugs being responsible for the breakdown of the neurotransmitter, and it is also involved in the aggregation of a beta and the formation of the neurotoxic fibrils. |
2006-04-10 |
2023-08-12 |
Not clear |
| J Birk. Cholinesterase inhibitors for Alzheimer's disease. The Cochrane database of systematic reviews. issue 1. 2006-04-07. PMID:16437532. |
since the introduction of the first cholinesterase inhibitor (chei) in 1997, most clinicians and probably most patients would consider the cholinergic drugs, donepezil, galantamine and rivastigmine, to be the first line pharmacotherapy for mild to moderate alzheimer's disease.the drugs have slightly different pharmacological properties, but they all work by inhibiting the breakdown of acetylcholine, an important neurotransmitter associated with memory, by blocking the enzyme acetylcholinesterase. |
2006-04-07 |
2023-08-12 |
Not clear |
| Bryan F Curtin, Lauren M Tetz, Jaimee R Compton, Bhupendra P Doctor, Richard K Gordon, Madhusoodana P Nambia. Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure. Journal of cellular biochemistry. vol 96. issue 4. 2006-02-21. PMID:16149071. |
the biological effects of organophosphorous (op) chemical warfare nerve agents (cwnas) are exerted by inhibition of acetylcholinesterase (ache), which prevents the hydrolysis of the neurotransmitter acetylcholine, leading to hypercholinergy, seizures/status epilepticus, respiratory/cardiovascular failure, and potentially death. |
2006-02-21 |
2023-08-12 |
human |
| Nigel H Greig, Tadanobu Utsuki, Donald K Ingram, Yue Wang, Giancarlo Pepeu, Carla Scali, Qian-Sheng Yu, Jacek Mamczarz, Harold W Holloway, Tony Giordano, DeMao Chen, Katsutoshi Furukawa, Kumar Sambamurti, Arnold Brossi, Debomoy K Lahir. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 47. 2006-01-12. PMID:16275899. |
like acetylcholinesterase, butyrylcholinesterase (bche) inactivates the neurotransmitter acetylcholine (ach) and is hence a viable therapeutic target in alzheimer's disease, which is characterized by a cholinergic deficit. |
2006-01-12 |
2023-08-12 |
mouse |
| Filomena A Carvalho, Luís M Graça, João Martins-Silva, Carlota Saldanh. Biochemical characterization of human umbilical vein endothelial cell membrane bound acetylcholinesterase. The FEBS journal. vol 272. issue 21. 2005-12-13. PMID:16262697. |
acetylcholinesterase is an enzyme whose best-known function is to hydrolyze the neurotransmitter acetylcholine. |
2005-12-13 |
2023-08-12 |
human |
| Fernando Cañadas, Diana Cardona, Eva Dávila, Fernando Sánchez-Sante. Long-term neurotoxicity of chlorpyrifos: spatial learning impairment on repeated acquisition in a water maze. Toxicological sciences : an official journal of the Society of Toxicology. vol 85. issue 2. 2005-08-18. PMID:15772369. |
their major mechanism of acute toxic action is the inhibition of acetylcholinesterase, which is responsible for the degradation of the neurotransmitter acetylcholine. |
2005-08-18 |
2023-08-12 |
rat |