| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Subramanya Karanth, Todd Holbrook, Charles MacAllister, Carey N Pop. Selective inhibition of butyrylcholinesterase in vivo in horses by the feed-through larvacide Equitrol. Regulatory toxicology and pharmacology : RTP. vol 50. issue 2. 2008-04-23. PMID:18166255. |
as with other organophosphates, tcvp elicits toxicity by inhibiting acetylcholinesterase, leading to accumulation of the neurotransmitter acetylcholine and cholinergic signs. |
2008-04-23 |
2023-08-12 |
Not clear |
| Mercedes Villarroya, Antonio G García, José Marco-Contelles, Manuela G Lópe. An update on the pharmacology of galantamine. Expert opinion on investigational drugs. vol 16. issue 12. 2008-02-25. PMID:18042006. |
this review summarises the current state of the art concerning the pharmacology of galantamine, focusing on the most important details of its possibilities as an acetylcholinesterase inhibitor, an allosteric potentiator of neuronal nicotinic receptors for acetylcholine, a modulator of neurotransmitter release, and an agent causing neuroprotection through an antiapoptotic action. |
2008-02-25 |
2023-08-12 |
Not clear |
| Alemayehu A Gorfe, Chia-en A Chang, Ivaylo Ivanov, J Andrew McCammo. Dynamics of the acetylcholinesterase tetramer. Biophysical journal. vol 94. issue 4. 2008-02-11. PMID:17921202. |
acetylcholinesterase rapidly hydrolyzes the neurotransmitter acetylcholine in cholinergic synapses, including the neuromuscular junction. |
2008-02-11 |
2023-08-12 |
Not clear |
| Mariapaola Piccardi, Donatella Congiu, Alessio Squassina, Francesca Manconi, Paolo Francesco Putzu, Rosa Maria Mereu, Caterina Chillotti, Maria Del Zomp. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503475. |
the resulting reduction in cholinergic activity is associated with decreased levels of the neurotransmitter acetylcholine (ach), decreased activity of acetylcholinesterase (ache), choline acetyltransferase (chat), and increased butyrylcholinesterase (bche) activity. |
2007-12-06 |
2023-08-12 |
human |
| Benzhuo Lu, Y C Zhou, Gary A Huber, Stephen D Bond, Michael J Holst, J Andrew McCammo. Electrodiffusion: a continuum modeling framework for biomolecular systems with realistic spatiotemporal resolution. The Journal of chemical physics. vol 127. issue 13. 2007-11-26. PMID:17919055. |
the second is a time-dependent diffusion process: the consumption of the neurotransmitter acetylcholine by acetylcholinesterase, determined by the se and a single uncoupled solution of the poisson-boltzmann equation. |
2007-11-26 |
2023-08-12 |
Not clear |
| Isabel Martinez-Pena y Valenzuela, Mohammed Akaaboun. Acetylcholinesterase mobility and stability at the neuromuscular junction of living mice. Molecular biology of the cell. vol 18. issue 8. 2007-10-17. PMID:17538015. |
acetylcholinesterase (ache) is an enzyme that terminates acetylcholine neurotransmitter function at the synaptic cleft of cholinergic synapses. |
2007-10-17 |
2023-08-12 |
mouse |
| Laure Ginestet, Juan E Ferrario, Rita Raisman-Vozari, Etienne C Hirsch, Thomas Debei. Donepezil induces a cholinergic sprouting in basocortical degeneration. Journal of neurochemistry. vol 102. issue 2. 2007-09-07. PMID:17394553. |
one of the few currently approved therapies for alzheimer's disease (ad) consists in the administration of acetylcholinesterase inhibitors, which enhances the lifetime of the neurotransmitter acetylcholine. |
2007-09-07 |
2023-08-12 |
rat |
| Malathi Srivatsa. An analysis of acetylcholinesterase sequence for predicting mechanisms of its non-catalytic actions. Bioinformation. vol 1. issue 8. 2007-08-01. PMID:17597908. |
the enzyme acetylcholinesterase (ache) which belongs to the family of alpha/beta hydrolases is well known for hydrolyzing the neurotransmitter acetylcholine (ach). |
2007-08-01 |
2023-08-12 |
human |
| Sultan Darvesh, Ryan Walsh, Earl Marti. Homocysteine thiolactone and human cholinesterases. Cellular and molecular neurobiology. vol 27. issue 1. 2007-05-22. PMID:16955366. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) are serine hydrolase enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine, a key process in the regulation of the cholinergic system. |
2007-05-22 |
2023-08-12 |
human |
| Laura E Paraoanu, Gunnar Steinert, Janine Klaczinski, Michaela Becker-Röck, Afrim Bytyqi, Paul G Laye. On functions of cholinesterases during embryonic development. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192676. |
this means that che functioning during development fits into the classical cholinergic neurotransmitter system: acetylcholine (ach), as a signal, binds to ach receptors and then is degraded by acetylcholinesterase (ache) as the terminating enzyme. |
2007-02-23 |
2023-08-12 |
Not clear |
| Natarajan Ashokkumar, Leelavinothan Pari, Kunga Mohan Ramkuma. N-Benzoyl-D-phenylalanine attenuates brain acetylcholinesterase in neonatal streptozotocin-diabetic rats. Basic & clinical pharmacology & toxicology. vol 99. issue 3. 2007-02-13. PMID:16930298. |
the decreased activity of both salt soluble and detergent soluble acetylcholinesterase observed in diabetes may be attributed to lack of insulin which causes specific alterations in the level of neurotransmitter, thus causing brain dysfunction. |
2007-02-13 |
2023-08-12 |
rat |
| Ralph J Jense. Activation of group II metabotropic glutamate receptors reduces directional selectivity in retinal ganglion cells. Brain research. vol 1122. issue 1. 2007-01-30. PMID:17010323. |
to determine whether group ii mglurs modulate the release of the neurotransmitter acetylcholine from starburst amacrine cells, the effect of dcg-iv on on-off ds rgcs was examined in the presence of ambenonium, an acetylcholinesterase inhibitor. |
2007-01-30 |
2023-08-12 |
rabbit |
| Xiu-Ling Ji, Gui-Wen Jin, Li-Ya Qu, Jin-Ping Cheng, Wen-Hua Wan. [Effect of chronic exposure by mercury contaminated rice on neurotransmitter level changes in rat brain]. Huan jing ke xue= Huanjing kexue. vol 27. issue 1. 2007-01-19. PMID:16599137. |
the changes of neurotransmitter acetylcholine (ach) and acetylcholinesterase (ache) in rat brain were examined at different times. |
2007-01-19 |
2023-08-12 |
rat |
| Eva Alés, Francesca Gullo, Esperanza Arias, Román Olivares, Antonio G García, Enzo Wanke, Manuela G Lópe. Blockade of Ca2+ -activated K+ channels by galantamine can also contribute to the potentiation of catecholamine secretion from chromaffin cells. European journal of pharmacology. vol 548. issue 1-3. 2006-12-12. PMID:16949070. |
these results constitute the first direct evidence that galantamine can potentiate neurotransmitter release by blocking kca2 channels, in addition to its already demonstrated capacity to mildly block acetylcholinesterase or potentiate allosterically nicotinic receptors. |
2006-12-12 |
2023-08-12 |
cattle |
| Edson X Albuquerque, Edna F R Pereira, Yasco Aracava, William P Fawcett, Maristela Oliveira, William R Randall, Tracey A Hamilton, Robert K Kan, James A Romano, Michael Adle. Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 35. 2006-09-29. PMID:16914529. |
most of their acute toxicity results from the irreversible inhibition of acetylcholinesterase (ache), the enzyme that inactivates the neurotransmitter acetylcholine. |
2006-09-29 |
2023-08-12 |
Not clear |
| T-M Shih, S W Hulet, J H McDonoug. The effects of repeated low-dose sarin exposure. Toxicology and applied pharmacology. vol 215. issue 2. 2006-09-28. PMID:16556454. |
the animals were assessed for changes in body weight, red blood cell (rbc) acetylcholinesterase (ache) levels, neurobehavioral reactions to a functional observational battery (fob), cortical electroencephalographic (eeg) power spectrum, and intrinsic acetylcholine (ach) neurotransmitter (nt) regulation over the 2 weeks of sarin exposure and for up to 12 days postinjection. |
2006-09-28 |
2023-08-12 |
Not clear |
| P Rada, C Colasante, M Skirzewski, L Hernandez, B Hoebe. Behavioral depression in the swim test causes a biphasic, long-lasting change in accumbens acetylcholine release, with partial compensation by acetylcholinesterase and muscarinic-1 receptors. Neuroscience. vol 141. issue 1. 2006-09-28. PMID:16677771. |
this increase in neurotransmitter may have been partially compensated by a significant increase in the degradative enzyme, acetylcholinesterase, and by a decrease in muscarinic-1 receptors and their gene expression. |
2006-09-28 |
2023-08-12 |
rat |
| Dean M Robinson, Greg L Ploske. Galantamine extended release. CNS drugs. vol 20. issue 8. 2006-09-19. PMID:16863272. |
galantamine inhibits acetylcholinesterase (ache) to slow acetylcholine hydrolysis, and may also modulate presynaptic nicotinic receptor activation, thereby increasing neurotransmitter concentrations in the synaptic cleft.black triangle once-daily galantamine extended release (er) 24 mg and twice-daily galantamine immediate release (ir) 12 mg are bioequivalent in terms of the area under the plasma concentration-time curve from time 0 to 24 hours and steady-state minimum plasma concentration.black triangle primary endpoints indicated a significantly greater effect of galantamine er on cognitive performance than placebo, with efficacy similar to galantamine ir, in a randomised, double-blind trial. |
2006-09-19 |
2023-08-12 |
Not clear |
| Manickavasagom Alkondon, Edson X Albuquerqu. Subtype-specific inhibition of nicotinic acetylcholine receptors by choline: a regulatory pathway. The Journal of pharmacology and experimental therapeutics. vol 318. issue 1. 2006-08-14. PMID:16565162. |
choline is an essential nutrient and a precursor of neurotransmitter acetylcholine (ach) and is produced at synapses during depolarization, upon hydrolysis of ach via acetylcholinesterase, and under conditions of injury and trauma. |
2006-08-14 |
2023-08-12 |
rat |
| Jacques-Philippe Colletier, Didier Fournier, Harry M Greenblatt, Jure Stojan, Joel L Sussman, Giuseppe Zaccai, Israel Silman, Martin Wei. Structural insights into substrate traffic and inhibition in acetylcholinesterase. The EMBO journal. vol 25. issue 12. 2006-08-03. PMID:16763558. |
acetylcholinesterase (ache) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine. |
2006-08-03 |
2023-08-12 |
Not clear |