| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohd Kamil Hussain, Moazzam Ahmad, Shahnaaz Khatoon, Mohsin Vahid Khan, Sarfuddin Azmi, Md Arshad, Shakir Ahamad, Mohammad Saqui. Phytomolecules as Alzheimer's therapeutics: A comprehensive review. European journal of medicinal chemistry. vol 288. 2025-02-25. PMID:39999743. |
the key mechanisms of action of these phytomolecules include modulating tau protein dynamics to reduce aggregation, inhibiting acetylcholinesterase (ache) to maintain neurotransmitter levels and enhance cognitive function, and inhibiting β-secretase (bace1) to decrease aβ production. |
2025-02-25 |
2025-02-28 |
Not clear |
| L Coppola, G Lori, S Tait, M A Sogorb, C Esteva. Evaluation of developmental toxicity of chlorpyrifos through new approach methodologies: a systematic review. Archives of toxicology. 2025-01-27. PMID:39869190. |
the comparison of the collected evidence with available adverse outcome pathways allows us to conclude that adverse outcomes observed in animals, such as memory and learning impairments as well as reduction in cognitive function, could involve several mechanisms of action including inhibition of acetylcholinesterase, overactivation of glutamate receptors and activation of mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2, followed by both disruption of neurotransmitter release and increase in oxidative stress and apoptosis. |
2025-01-27 |
2025-01-29 |
human |
| Ysaías J Alvarado, Lenin González-Paz, José L Paz, Marcos A Loroño-González, Julio Santiago Contreras, Carla Lossada, Alejandro Vivas, Yovani Marrero-Ponce, Felix Martinez-Rios, Patricia Rodriguez-Lugo, Yanpiero Balladores, Joan Vera-Villalobo. Biological Implications of the Intrinsic Deformability of Human Acetylcholinesterase Induced by Diverse Compounds: A Computational Study. Biology. vol 13. issue 12. 2025-01-08. PMID:39765732. |
the enzyme acetylcholinesterase (ache) plays a crucial role in the termination of nerve impulses by hydrolyzing the neurotransmitter acetylcholine (ach). |
2025-01-08 |
2025-01-13 |
human |
| Fatma Atef, Mostafa A Abdelkawy, Basma M Eltanany, Laura Pont, Ahmed M Fayez, Mohamed F Abdelhameed, Fernando Benavente, Inas Y Younis, Asmaa M Otif. A comprehensive investigation of Clerodendrum Infortunatum Linn. using LC-QTOF-MS/MS metabolomics as a promising anti-alzheimer candidate. Scientific reports. vol 15. issue 1. 2025-01-05. PMID:39757300. |
the extract improved cognitive function in scopolamine-induced ad rats, restored acetylcholinesterase activity, normalized neurotransmitter levels, and reduced oxidative stress and inflammation. |
2025-01-05 |
2025-01-08 |
rat |
| Ting Zeng, Chengwei Zhang, Lili Sun, Haiyan X. Water-Soluble Ginseng Oligosaccharides Prevent Scopolamine-Induced Cholinergic Dysfunction and Inflammatory Cytokine Overexpression. Cell biochemistry and biophysics. 2025-01-03. PMID:39751741. |
the effect of wgos on the cholinergic system was evaluated by measuring acetylcholine (ach) neurotransmitter concentration and acetylcholinesterase (ache) activity in the hippocampus. |
2025-01-03 |
2025-01-05 |
mouse |
| Malik Saadullah, Amna Sehar, Zunera Chauhdary, Rida Siddique, Hafsa Tariq, Muhammad Asif, Shazia Anwer Bukhari, Aisha Seth. Anti-neuroinflammatory and neuroprotective potential of Cissus tuberosa ethanol extract in Parkinson's disease model through the modulation of neuroinflammatory markers. PloS one. vol 19. issue 12. 2024-12-06. PMID:39642134. |
neurotransmitter levels were significantly improved in a dose-dependent manner (p<0.001), while acetylcholinesterase (ache) levels were significantly reduced (p<0.001). |
2024-12-06 |
2024-12-09 |
rat |
| Zhuxiao Tang, Yahui Ye, Kaichuang Yang, Xi Guo, Xin Gao, Cheng Wu, Jingyu Wang, Deqing Pen. Experimental study of cBMMSC based on nanosilver hydrogel nerve conduit for repairing spinal cord injury. Journal of cellular and molecular medicine. vol 28. issue 22. 2024-11-26. PMID:39588835. |
four weeks after transplantation, the expression of neuron-specific enolase (nse) in rat anti-human nuclear monoclonal antibody (mab1281)-positive cells was detected by immunostaining in spinal cord tissue sections of the two groups to assess the differentiation of cbmmsc to neuron-like cells in the nerve conduits after transplantation; the number of brdu-positive cells was detected to assess the neuronal regeneration of the localized spinal cord injury of the two groups; and the length of axons was observed with laser confocal photography was used to observe the length of axons; he staining was used to observe the scarring and cavities in the spinal cord sections of the two groups; immunofluorescence was used to detect neuron-like markers (nestin, nse, nf200, gfap) in the two groups, and the od values were determined by the image processing and analysis system (ipaas); and western blot was used to detect the neurotransmitters of motor fibres, acetylcholinesterase (chat), sensory fibres, and sensory fibres, as well as the neurotransmission of motor fibres, acetylcholine production-limiting enzyme (chat) and sensory fibre neurotransmitter glutamate synthase (gogat); motor function was assessed by bbb score; somatosensory evoked potentials (seps) and motor evoked potentials (meps) were detected by body surface electrode assay in the two groups, and the neurophysiological recovery effect was evaluated. |
2024-11-26 |
2024-11-28 |
rat |
| Priyanka Agrawal, Pallavi Singh, K P Sing. Vilazodone exposure during pregnancy: Effects on embryo-fetal development, pregnancy outcomes and fetal neurotoxicity by BDNF/Bax-Bcl2/5-HT mediated mechanisms. Neurotoxicology. 2024-11-12. PMID:39532268. |
these effects were associated with developmental neurotoxicity, which manifested as decreased fetal brain size and weight, a substantial reduction in neocortical layer thickness, brain-derived neurotrophic factor (bdnf) expression, serotonin, dopamine, and norepinephrine neurotransmitter levels (5-ht, da, and ne), and increased apoptotic activity (bax and bcl-2 ratio) and acetylcholinesterase levels in the developing brain. |
2024-11-12 |
2024-11-17 |
rat |
| Namrita Halder, Sourabh Yadav, Girdhari La. Neuroimmune communication of the cholinergic system in gut inflammation and autoimmunity. Autoimmunity reviews. 2024-11-05. PMID:39500481. |
it includes the neurotransmitter acetylcholine (ach), the enzyme required for the synthesis of ach (choline acetyltransferase, chat), the enzyme required for its degradation (acetylcholinesterase, ache), and cholinergic receptors (nicotinic acetylcholine receptors and muscarinic acetylcholine receptors). |
2024-11-05 |
2024-11-08 |
Not clear |
| Wenhui Xiong, Binbin Liao, Yuanfa Yang, Shanglin Zhong, Jinnan Zhang, Wenxuan Sun, Yang Zou, Hui Ai, Tianrong Xin, Bin Xia, Zhiwen Zo. The deficiency of acetylcholinesterase gene in Aleuroglyphus ovatus increases its susceptibility to phoxim and natural pyrethrins and inhibits its reproduction. Journal of hazardous materials. vol 480. 2024-10-15. PMID:39405704. |
acetylcholinesterase (ache), an essential neurotransmitter hydrolase, is targeted by organophosphorus and carbamate pesticides, and its number varies among species. |
2024-10-15 |
2024-10-18 |
Not clear |
| Fatima Ezzahra Laghchioua, Carlos F M da Silva, Diana C G A Pinto, José A S Cavaleiro, Ricardo F Mendes, Filipe A Almeida Paz, Maria A F Faustino, El Mostapha Rakib, M Graça P M S Neves, Florbela Pereira, Nuno M M Mour. Design of Promising Thiazoloindazole-Based Acetylcholinesterase Inhibitors Guided by Molecular Docking and Experimental Insights. ACS chemical neuroscience. 2024-07-22. PMID:39037949. |
since acetylcholinesterase (ache) is a critical enzyme in the nervous system, responsible for breaking down the neurotransmitter acetylcholine, its inhibition holds a significant interest in the treatment of various neurological disorders. |
2024-07-22 |
2024-07-25 |
Not clear |
| Li Zhang, Xue Li, Qiang Yuan, Sujie Sun, Fasheng Liu, Xinjun Liao, Huiqiang Lu, Jianjun Chen, Zigang Ca. Isavuconazole Induces Neurodevelopment Defects and Motor Behaviour Impairment in Zebrafish Larvae. Molecular neurobiology. 2024-05-24. PMID:38787492. |
at the same time, exposure of zebrafish embryos to isavuconazole downregulated acetylcholinesterase (ache) and adenosine triphosphate (atpase) activities but upregulated oxidative stress, thereby disrupting neural development and gene expression of neurotransmitter pathways. |
2024-05-24 |
2024-05-27 |
zebrafish |
| Sanjeeb Lama, Hyeong-Seon Choi, Sivalingam Ramesh, Young Jun Lee, Joo Hyung Ki. Synthesis and characterization of nitrogen-doped-MWCNT@cobalt oxide for nerve agent simulant detection. Scientific reports. vol 14. issue 1. 2024-05-23. PMID:38773127. |
organophosphorus nerve agents are toxic compounds that disrupt neuromuscular transmission by inhibiting the neurotransmitter enzyme, acetylcholinesterase, leading to rapid death. |
2024-05-23 |
2024-05-27 |
Not clear |
| Ming Liu, Ping Deng, Guangyu Li, Haoling Liu, Junli Zuo, Wenwen Cui, Huixian Zhang, Xin Chen, Jingjing Yao, Xitian Peng, Lijun Peng, Jiao Liu, Wenting Zheng, Wei Yan, Ning Lua. Neurotoxicity of Combined Exposure to the Heavy Metals (Pb and As) in Zebrafish ( Toxics. vol 12. issue 4. 2024-04-26. PMID:38668505. |
to elucidate the underlying mechanisms, we examined changes in acetylcholinesterase (ache) activity, neurotransmitter (dopamine, 5-hydroxytryptamine) levels, hpi axis-related hormone (cortisol and epinephrine) contents and neurodevelopment-related gene expression in zebrafish brain. |
2024-04-26 |
2024-04-28 |
zebrafish |
| Ali Hassan, Lidong Kang, Kaixiong Zhang, Lei Wang, Xianjiao Qin, Guobin Fang, Yongyue Lu, Qiuying Huan. Effect of entomopathogenic fungi on behavior and physiology of Solenopsis invicta (Hymenoptera, Formicidae). Journal of economic entomology. 2024-04-18. PMID:38634604. |
the activity of acetylcholinesterase, which hydrolyses the important neurotransmitter acetylcholine, also decreased after fungal application compared to the control. |
2024-04-18 |
2024-04-20 |
Not clear |
| Juan David Villeda-González, José Luis Gómez-Olivares, Luis Arturo Baiza-Gutma. New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase. Journal of cellular physiology. 2024-04-12. PMID:38605655. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ach), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. |
2024-04-12 |
2024-04-14 |
Not clear |
| Gumpeny R Sridhar, Lakshmi Gumpen. Emerging significance of butyrylcholinesterase. World journal of experimental medicine. vol 14. issue 1. 2024-04-09. PMID:38590305. |
its other functions include the ability to hydrolyze acetylcholine, the cholinergic neurotransmitter in the brain, when its primary hydrolytic enzyme, acetylcholinesterase, is absent. |
2024-04-09 |
2024-04-11 |
human |
| Jae Yeon Park, Seong Doo Kang, Yun Gon Son, Ju Yeon Kim, Gihwan Lee, Kwang Dong Kim, Sang Won Lee, Jeong Yoon Ki. Eucalyptus globulus leaf-isolated isorhapontin serves as a natural insecticide via acetylcholinesterase inhibition. Pesticide biochemistry and physiology. vol 200. 2024-04-08. PMID:38582576. |
acetylcholinesterase (ache) inhibitors cause insect death by preventing the hydrolysis of the neurotransmitter acetylcholine, which overstimulates the nervous system. |
2024-04-08 |
2024-04-10 |
Not clear |
| Xiujuan Huang, Yuanyuan Cheng, Qi Zhou, Yifeng Tu, Jilin Ya. A simple fluorescence detection of acetylcholinesterase with peroxidase-like catalysis from iodide. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 313. 2024-03-15. PMID:38490124. |
acetylcholinesterase (ache) is an important enzyme in the central and peripheral nervous system that regulates the balance of the neurotransmitter acetylcholine. |
2024-03-15 |
2024-03-18 |
Not clear |
| Joana Ribeiro, Henrique Araújo-Silva, Mário Fernandes, Joilna Alves da Silva, Francisco das Chagas L Pinto, Otília Deusdenia L Pessoa, Hélcio Silva Santos, Jane Eire Silva Alencar de Menezes, Andreia C Gome. Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo. Natural products and bioprospecting. vol 14. issue 1. 2024-02-22. PMID:38383833. |
a crucial hallmark associated with this disease is associated with the deficiency of the brain neurotransmitter acetylcholine, due to an affected acetylcholinesterase (ache) activity. |
2024-02-22 |
2024-02-24 |
zebrafish |