| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomasz Tuzimski, Anna Petruczyni. Determination of Anti-Alzheimer's Disease Activity of Selected Plant Ingredients. Molecules (Basel, Switzerland). vol 27. issue 10. 2022-05-28. PMID:35630702. |
one of the most important therapeutic strategies is controlling the level of acetylcholine-a neurotransmitter in cholinergic synapses-by blocking the degradation of acetylcholine using acetylcholinesterase inhibitors such as tacrine, galantamine, donepezil and rivastigmine. |
2022-05-28 |
2023-08-13 |
Not clear |
| Kritika Kumari, Laishram R Sing. Trimethylamine N-oxide might impair cholinergic system by affecting the structural integrity of Acetylcholinesterase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555536. |
acetylcholinesterase (ache) is an important enzyme responsible for the breakdown of neurotransmitter, acetylcholine and therefore plays a crucial role in neuronal plasticity. |
2022-05-13 |
2023-08-13 |
human |
| Wanjun Zhang, Ruiqi Fan, Sunlin Luo, Ying Liu, Yongpeng Jin, Yongchen Li, Mengqin Xiong, Yiqiang Chen, Li Jia, Xiaoyan Yua. Combined effects of chlorpyrifos and cyfluthrin on neurobehavior and neurotransmitter levels in larval zebrafish. Journal of applied toxicology : JAT. 2022-04-26. PMID:35470462. |
to evaluate the risk of combined exposure, we examined the effects of both compounds, separately and together, on motor activity, acetylcholinesterase (ache) activity, and neurotransmitter levels in larval zebrafish. |
2022-04-26 |
2023-08-13 |
zebrafish |
| Shuaizhang Li, Andrew J Li, Jinghua Zhao, Michael F Santillo, Menghang Xi. Acetylcholinesterase Inhibition Assays for High-Throughput Screening. Methods in molecular biology (Clifton, N.J.). vol 2474. 2022-03-16. PMID:35294755. |
acetylcholinesterase (ache) hydrolyzes acetylcholine (ach), a vital neurotransmitter that regulates muscle movement and brain function, including memory, attention, and learning. |
2022-03-16 |
2023-08-13 |
human |
| Lukas G Schnitzler, Kathrin Baumgartner, Anna Kolb, Benedikt Braun, Christoph Westerhause. Acetylcholinesterase Activity Influenced by Lipid Membrane Area and Surface Acoustic Waves. Micromachines. vol 13. issue 2. 2022-02-25. PMID:35208411. |
according to the current model of nerve propagation, the function of acetylcholinesterase (ache) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ach) in the synaptic cleft to acetic acid (acetate) and choline. |
2022-02-25 |
2023-08-13 |
Not clear |
| Juan Bellas, Diego Rial, Juliana Valdés, Leticia Vidal-Liñán, Juan I Bertucci, Soledad Muniategui, Víctor M León, Juan A Campill. Linking biochemical and individual-level effects of chlorpyrifos, triphenyl phosphate, and bisphenol A on sea urchin (Paracentrotus lividus) larvae. Environmental science and pollution research international. 2022-02-15. PMID:35165844. |
the antioxidant enzymes glutathione reductase (gr) and catalase (cat), the phase ii detoxification enzyme glutathione s-transferase (gst), and the neurotransmitter catabolism enzyme acetylcholinesterase (ache) were assessed in combination with responses at the individual level (larval growth). |
2022-02-15 |
2023-08-13 |
cat |
| Marie Closset, Katia Cailliau, Sylvain Slaby, Matthieu Mari. Effects of Aluminium Contamination on the Nervous System of Freshwater Aquatic Vertebrates: A Review. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008450. |
in addition, it activates and inhibits antioxidant enzymes and leads to changes in acetylcholinesterase activity, neurotransmitter levels, and in the expression of several neural genes and nerve cell components. |
2022-01-11 |
2023-08-13 |
human |
| Elva Fridjonsdottir, Theodosia Vallianatou, Ioannis Mantas, Reza Shariatgorji, Anna Nilsson, Luke S Schembri, Luke R Odell, Per Svenningsson, Per E André. Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems. ACS chemical biology. 2021-12-21. PMID:34932310. |
region-specific and age-dependent multitarget effects of acetylcholinesterase inhibitor tacrine on comprehensive neurotransmitter systems. |
2021-12-21 |
2023-08-13 |
mouse |
| Elva Fridjonsdottir, Theodosia Vallianatou, Ioannis Mantas, Reza Shariatgorji, Anna Nilsson, Luke S Schembri, Luke R Odell, Per Svenningsson, Per E André. Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems. ACS chemical biology. 2021-12-21. PMID:34932310. |
we used matrix-assisted laser desorption/ionization mass spectrometry imaging in combination with multivariate analysis to visualize in anatomical detail metabolic effects of aging and tacrine-mediated acetylcholinesterase inhibition on comprehensive neurotransmitter systems in multiple mouse brain regions of 12-week-old and 14-month-old mice. |
2021-12-21 |
2023-08-13 |
mouse |
| Sílvia Chaves, Katalin Várnagy, M Amélia Santo. Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity. Current medicinal chemistry. vol 28. issue 35. 2021-11-25. PMID:33602068. |
currently available drugs are used, mainly to compensate the decline of the neurotransmitter acetylcholine by acetylcholinesterase (ache) inhibition, though they only provide temporary symptomatic benefits and cannot stop ad progression. |
2021-11-25 |
2023-08-13 |
Not clear |
| Kazuhiro Murata, Naotaka Yoshikawa, Kanji Yoshimoto, Akira Namera, Haruo Takeshita, Masataka Naga. BIMP affects tubulin structure and causes abnormalities in cell division. Legal medicine (Tokyo, Japan). vol 53. 2021-11-25. PMID:34225093. |
these agents mainly irreversibly inhibit the action of acetylcholinesterase, an enzyme that breaks down acetylcholine, a neurotransmitter, and are believed to cause acute symptoms of poisoning. |
2021-11-25 |
2023-08-13 |
Not clear |
| Bhuvaneswari Sivaraman, Vijaykumar R, Bala Aakash Velmurugan, Ramalakshmi Nataraja. Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease. CNS & neurological disorders drug targets. 2021-11-23. PMID:34602041. |
acetylcholinesterase (ache), hydrolase enzyme, regulates the hydrolysis of acetylcholine neurotransmitter in the neurons. |
2021-11-23 |
2023-08-13 |
Not clear |
| Heather B Patisaul, Mamta Behl, Linda S Birnbaum, Arlene Blum, Miriam L Diamond, Seth Rojello Fernández, Helena T Hogberg, Carol F Kwiatkowski, Jamie D Page, Anna Soehl, Heather M Stapleto. Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers. Environmental health perspectives. vol 129. issue 10. 2021-10-09. PMID:34612677. |
to date, the toxicity of organophosphate esters has primarily been studied regarding their use as pesticides and their effects on the neurotransmitter acetylcholinesterase (ache). |
2021-10-09 |
2023-08-13 |
human |
| Martina Di Rocco, Serena Galosi, Enrico Lanza, Federica Tosato, Davide Caprini, Viola Folli, Jennifer Friedman, Gianfranco Bocchinfuso, Alberto Martire, Elia Di Schiavi, Vincenzo Leuzzi, Simone Martinell. Caenorhabditis elegans provides an efficient drug screening platform for GNAO1-related disorders and highlights the potential role of caffeine in controlling dyskinesia. Human molecular genetics. 2021-10-08. PMID:34622282. |
like null mutants, homozygous knock-in animals showed increased egg laying and were hypersensitive to aldicarb, an inhibitor of acetylcholinesterase, suggesting excessive neurotransmitter release by different classes of motor neurons. |
2021-10-08 |
2023-08-13 |
caenorhabditis_elegans |
| Xu Zhao, Ling Zhang, Xu Yan, Li Zhang, Yang Lu, Jialin Pan, Meiling Zhang, Chenguang Wang, Hui Suo, Xiaoteng Jia, Xiaomin Liu, Geyu L. A near-infrared light triggered fluormetric biosensor for sensitive detection of acetylcholinesterase activity based on NaErF Talanta. vol 235. 2021-09-15. PMID:34517642. |
a near-infrared light triggered fluormetric biosensor for sensitive detection of acetylcholinesterase activity based on naerf acetylcholinesterase (ache), as an important neurotransmitter, is widely present in the peripheral and central nervous systems. |
2021-09-15 |
2023-08-13 |
Not clear |
| Nikolina Maček Hrvat, Zrinka Kovari. Counteracting poisoning with chemical warfare nerve agents. Arhiv za higijenu rada i toksikologiju. vol 71. issue 4. 2021-08-30. PMID:33410774. |
phosphylation of the pivotal enzyme acetylcholinesterase (ache) by nerve agents (nas) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of muscarinic and nicotinic membrane receptors in the central and peripheral nervous system. |
2021-08-30 |
2023-08-13 |
Not clear |
| Muskan Gori, Ashima Thakur, Abha Sharma, S J S Flor. Organic-Molecule-Based Fluorescent Chemosensor for Nerve Agents and Organophosphorus Pesticides. Topics in current chemistry (Cham). vol 379. issue 5. 2021-08-16. PMID:34346011. |
op compounds are highly toxic compounds that cause irreversible inhibition of enzyme acetylcholinesterase, which is essential for hydrolysis of neurotransmitter acetylcholine, leading to series of neurological disorders and even death. |
2021-08-16 |
2023-08-13 |
Not clear |
| Immacolata Vecchio, Luca Sorrentino, Annamaria Paoletti, Rosario Marra, Mariamena Arbitri. The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease. Journal of central nervous system disease. vol 13. 2021-07-22. PMID:34285627. |
one of the causes leading to ad is the decrease of neurotransmitter acetylcholine (ach) levels in the brain, in part due to a higher activity of acetylcholinesterase (ache), the enzyme responsible for its degradation. |
2021-07-22 |
2023-08-13 |
Not clear |
| Andrea Castaneda, Ricardo Ferraz, Mónica Vieira, Isabel Cardoso, Vitor Vasconcelos, Rosário Martin. Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer's Disease. Marine drugs. vol 19. issue 6. 2021-07-05. PMID:34208482. |
in this review, we aimed to compile the research works focused in the anti-ad potential of cyanobacteria, namely regarding the inhibition of the enzyme β-secretase (bace1) as a fundamental enzyme in the generation of β-amyloid (aβ), the inhibition of the enzyme acetylcholinesterase (ache) lead to an increase in the availability of the neurotransmitter acetylcholine in the synaptic cleft and the antioxidant and anti-inflammatory effects, as phenomena associated with neurodegeneration mechanisms. |
2021-07-05 |
2023-08-13 |
Not clear |
| M V K Reddy, K Y Rao, G Anusha, G M Kumar, A G Damu, Kakarla Raghava Reddy, Nagaraj P Shetti, Tejraj M Aminabhavi, Peddiahgari Vasu Govardhana Redd. In-vitro evaluation of antioxidant and anticholinesterase activities of novel pyridine, quinoxaline and s-triazine derivatives. Environmental research. vol 199. 2021-07-01. PMID:33991570. |
cholinesterase enzymes such as acetylcholinesterase (ache) and butyrylcholinesterase (buche) cause hydrolysis of acetylcholine (ach), a neurotransmitter responsible for the cognitive functions of the brain such as acquiring knowledge and comprehension. |
2021-07-01 |
2023-08-13 |
Not clear |