| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Bellas, Diego Rial, Juliana Valdés, Leticia Vidal-Liñán, Juan I Bertucci, Soledad Muniategui, Víctor M León, Juan A Campill. Linking biochemical and individual-level effects of chlorpyrifos, triphenyl phosphate, and bisphenol A on sea urchin (Paracentrotus lividus) larvae. Environmental science and pollution research international. 2022-02-15. PMID:35165844. |
the antioxidant enzymes glutathione reductase (gr) and catalase (cat), the phase ii detoxification enzyme glutathione s-transferase (gst), and the neurotransmitter catabolism enzyme acetylcholinesterase (ache) were assessed in combination with responses at the individual level (larval growth). |
2022-02-15 |
2023-08-13 |
cat |
| Marie Closset, Katia Cailliau, Sylvain Slaby, Matthieu Mari. Effects of Aluminium Contamination on the Nervous System of Freshwater Aquatic Vertebrates: A Review. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008450. |
in addition, it activates and inhibits antioxidant enzymes and leads to changes in acetylcholinesterase activity, neurotransmitter levels, and in the expression of several neural genes and nerve cell components. |
2022-01-11 |
2023-08-13 |
human |
| Elva Fridjonsdottir, Theodosia Vallianatou, Ioannis Mantas, Reza Shariatgorji, Anna Nilsson, Luke S Schembri, Luke R Odell, Per Svenningsson, Per E André. Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems. ACS chemical biology. 2021-12-21. PMID:34932310. |
region-specific and age-dependent multitarget effects of acetylcholinesterase inhibitor tacrine on comprehensive neurotransmitter systems. |
2021-12-21 |
2023-08-13 |
mouse |
| Elva Fridjonsdottir, Theodosia Vallianatou, Ioannis Mantas, Reza Shariatgorji, Anna Nilsson, Luke S Schembri, Luke R Odell, Per Svenningsson, Per E André. Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems. ACS chemical biology. 2021-12-21. PMID:34932310. |
we used matrix-assisted laser desorption/ionization mass spectrometry imaging in combination with multivariate analysis to visualize in anatomical detail metabolic effects of aging and tacrine-mediated acetylcholinesterase inhibition on comprehensive neurotransmitter systems in multiple mouse brain regions of 12-week-old and 14-month-old mice. |
2021-12-21 |
2023-08-13 |
mouse |
| Sílvia Chaves, Katalin Várnagy, M Amélia Santo. Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity. Current medicinal chemistry. vol 28. issue 35. 2021-11-25. PMID:33602068. |
currently available drugs are used, mainly to compensate the decline of the neurotransmitter acetylcholine by acetylcholinesterase (ache) inhibition, though they only provide temporary symptomatic benefits and cannot stop ad progression. |
2021-11-25 |
2023-08-13 |
Not clear |
| Kazuhiro Murata, Naotaka Yoshikawa, Kanji Yoshimoto, Akira Namera, Haruo Takeshita, Masataka Naga. BIMP affects tubulin structure and causes abnormalities in cell division. Legal medicine (Tokyo, Japan). vol 53. 2021-11-25. PMID:34225093. |
these agents mainly irreversibly inhibit the action of acetylcholinesterase, an enzyme that breaks down acetylcholine, a neurotransmitter, and are believed to cause acute symptoms of poisoning. |
2021-11-25 |
2023-08-13 |
Not clear |
| Bhuvaneswari Sivaraman, Vijaykumar R, Bala Aakash Velmurugan, Ramalakshmi Nataraja. Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease. CNS & neurological disorders drug targets. 2021-11-23. PMID:34602041. |
acetylcholinesterase (ache), hydrolase enzyme, regulates the hydrolysis of acetylcholine neurotransmitter in the neurons. |
2021-11-23 |
2023-08-13 |
Not clear |
| Heather B Patisaul, Mamta Behl, Linda S Birnbaum, Arlene Blum, Miriam L Diamond, Seth Rojello Fernández, Helena T Hogberg, Carol F Kwiatkowski, Jamie D Page, Anna Soehl, Heather M Stapleto. Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers. Environmental health perspectives. vol 129. issue 10. 2021-10-09. PMID:34612677. |
to date, the toxicity of organophosphate esters has primarily been studied regarding their use as pesticides and their effects on the neurotransmitter acetylcholinesterase (ache). |
2021-10-09 |
2023-08-13 |
human |
| Martina Di Rocco, Serena Galosi, Enrico Lanza, Federica Tosato, Davide Caprini, Viola Folli, Jennifer Friedman, Gianfranco Bocchinfuso, Alberto Martire, Elia Di Schiavi, Vincenzo Leuzzi, Simone Martinell. Caenorhabditis elegans provides an efficient drug screening platform for GNAO1-related disorders and highlights the potential role of caffeine in controlling dyskinesia. Human molecular genetics. 2021-10-08. PMID:34622282. |
like null mutants, homozygous knock-in animals showed increased egg laying and were hypersensitive to aldicarb, an inhibitor of acetylcholinesterase, suggesting excessive neurotransmitter release by different classes of motor neurons. |
2021-10-08 |
2023-08-13 |
caenorhabditis_elegans |
| Xu Zhao, Ling Zhang, Xu Yan, Li Zhang, Yang Lu, Jialin Pan, Meiling Zhang, Chenguang Wang, Hui Suo, Xiaoteng Jia, Xiaomin Liu, Geyu L. A near-infrared light triggered fluormetric biosensor for sensitive detection of acetylcholinesterase activity based on NaErF Talanta. vol 235. 2021-09-15. PMID:34517642. |
a near-infrared light triggered fluormetric biosensor for sensitive detection of acetylcholinesterase activity based on naerf acetylcholinesterase (ache), as an important neurotransmitter, is widely present in the peripheral and central nervous systems. |
2021-09-15 |
2023-08-13 |
Not clear |
| Nikolina Maček Hrvat, Zrinka Kovari. Counteracting poisoning with chemical warfare nerve agents. Arhiv za higijenu rada i toksikologiju. vol 71. issue 4. 2021-08-30. PMID:33410774. |
phosphylation of the pivotal enzyme acetylcholinesterase (ache) by nerve agents (nas) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of muscarinic and nicotinic membrane receptors in the central and peripheral nervous system. |
2021-08-30 |
2023-08-13 |
Not clear |
| Muskan Gori, Ashima Thakur, Abha Sharma, S J S Flor. Organic-Molecule-Based Fluorescent Chemosensor for Nerve Agents and Organophosphorus Pesticides. Topics in current chemistry (Cham). vol 379. issue 5. 2021-08-16. PMID:34346011. |
op compounds are highly toxic compounds that cause irreversible inhibition of enzyme acetylcholinesterase, which is essential for hydrolysis of neurotransmitter acetylcholine, leading to series of neurological disorders and even death. |
2021-08-16 |
2023-08-13 |
Not clear |
| Immacolata Vecchio, Luca Sorrentino, Annamaria Paoletti, Rosario Marra, Mariamena Arbitri. The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease. Journal of central nervous system disease. vol 13. 2021-07-22. PMID:34285627. |
one of the causes leading to ad is the decrease of neurotransmitter acetylcholine (ach) levels in the brain, in part due to a higher activity of acetylcholinesterase (ache), the enzyme responsible for its degradation. |
2021-07-22 |
2023-08-13 |
Not clear |
| Andrea Castaneda, Ricardo Ferraz, Mónica Vieira, Isabel Cardoso, Vitor Vasconcelos, Rosário Martin. Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer's Disease. Marine drugs. vol 19. issue 6. 2021-07-05. PMID:34208482. |
in this review, we aimed to compile the research works focused in the anti-ad potential of cyanobacteria, namely regarding the inhibition of the enzyme β-secretase (bace1) as a fundamental enzyme in the generation of β-amyloid (aβ), the inhibition of the enzyme acetylcholinesterase (ache) lead to an increase in the availability of the neurotransmitter acetylcholine in the synaptic cleft and the antioxidant and anti-inflammatory effects, as phenomena associated with neurodegeneration mechanisms. |
2021-07-05 |
2023-08-13 |
Not clear |
| M V K Reddy, K Y Rao, G Anusha, G M Kumar, A G Damu, Kakarla Raghava Reddy, Nagaraj P Shetti, Tejraj M Aminabhavi, Peddiahgari Vasu Govardhana Redd. In-vitro evaluation of antioxidant and anticholinesterase activities of novel pyridine, quinoxaline and s-triazine derivatives. Environmental research. vol 199. 2021-07-01. PMID:33991570. |
cholinesterase enzymes such as acetylcholinesterase (ache) and butyrylcholinesterase (buche) cause hydrolysis of acetylcholine (ach), a neurotransmitter responsible for the cognitive functions of the brain such as acquiring knowledge and comprehension. |
2021-07-01 |
2023-08-13 |
Not clear |
| Kevin G McGarry, Kevin E Schill, Tyson P Winters, Erin E Lemmon, Carol L Sabourin, Jill A Harvilchuck, Robert A Moye. Characterization of Cholinesterases From Multiple Large Animal Species for Medical Countermeasure Development Against Chemical Warfare Nerve Agents. Toxicological sciences : an official journal of the Society of Toxicology. vol 174. issue 1. 2021-06-09. PMID:31879781. |
disruption of cholinergic function through the inhibition of acetylcholinesterase (ache) leads to the accumulation of the neurotransmitter acetylcholine. |
2021-06-09 |
2023-08-13 |
Not clear |
| Leila Sadeghi, Reza Yekta, Gholamreza Dehgha. The inhibitory effects of bile acids on catalytic and non‑catalytic functions of acetylcholinesterase as a therapeutic target in Alzheimer's disease. Acta neurobiologiae experimentalis. vol 80. issue 2. 2021-06-07. PMID:32602852. |
acetylcholine is a fast-acting neurotransmitter in synapses and neuromuscular junctions that is decreased in alzheimer's disease (ad) by hyper‑activation of acetylcholinesterase (ache), which leads to progressive loss of memory and neurobehavioral abnormalities. |
2021-06-07 |
2023-08-13 |
rat |
| Congwei Yu, Ming Zhao, Zuchen Pan, Yiyang Bo, Weiwei Zhao, Xiongkui He, Jiaheng Zhan. Butyrylcholinesterase nanodepots with enhanced prophylactic and therapeutic performance for acute organophosphorus poisoning management. Journal of materials chemistry. B. vol 9. issue 7. 2021-05-31. PMID:33533366. |
as a potential alternative, delivery of mammalian-derived butyrylcholinesterase (bche) offers a cost-effective way to block organophosphorus attack on acetylcholinesterase, a key enzyme in the neurotransmitter cycle. |
2021-05-31 |
2023-08-13 |
mouse |
| Afreen Jahan Rahman, Deepti Sharma, Deepanshu Kumar, Mallika Pathak, Anju Singh, Vinod Kumar, Raman Chawla, Himanshu Ojh. Spectroscopic and molecular modelling study of binding mechanism of bovine serum albumin with phosmet. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 244. 2021-05-14. PMID:32829155. |
phosmet exerts its neurotoxicity by inhibiting acetylcholinesterase that catalyzes the degradation of acetylcholine (a neurotransmitter). |
2021-05-14 |
2023-08-13 |
cattle |
| E Wigenstam, E Forsberg, A Bucht, L Thor. Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX. Toxicology and applied pharmacology. vol 419. 2021-05-11. PMID:33785355. |
nerve agents are highly toxic organophosphorus compounds that inhibit acetylcholinesterase resulting in rapid accumulation of the neurotransmitter acetylcholine (ach) causing a cholinergic syndrome including respiratory failure. |
2021-05-11 |
2023-08-13 |
rat |