| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dou Yang, Fasheng Liu, Mengqi Wan, Jieping Liu, Ling Huang, Chao Chen, Xue Li, Li Zhang, Xiaobing Ding, Xinjun Liao, Guanghua Xiong, Huiqiang Lu, Juhua Xiao, Zigang Ca. Pamiparib Induces Neurodevelopmental Defects and Cerebral Haemorrhage in Zebrafish Embryos via Inhibiting Notch Signalling. Molecular neurobiology. 2022-08-18. PMID:35982279. |
in addition, pamiparib exposure leads to downregulation of acetylcholinesterase (ache) and adenosine triphosphate (atpase) activities, and upregulation of oxidative stress which then leads to apoptosis and disrupts the gene expression involved in the neurodevelopment, neurotransmitter pathways and parkinson's disease (pd) like symptoms. |
2022-08-18 |
2023-08-14 |
zebrafish |
| Letícia A Nascimento, Érica C M Nascimento, João B L Martin. In silico study of tacrine and acetylcholine binding profile with human acetylcholinesterase: docking and electronic structure. Journal of molecular modeling. vol 28. issue 9. 2022-08-10. PMID:35947248. |
in this way, we performed a set of theoretical tests of tacrine ligand and acetylcholine neurotransmitter against the human acetylcholinesterase enzyme. |
2022-08-10 |
2023-08-14 |
human |
| Yang Wang, Jie Song, Xuedong Wang, Qiuhui Qian, Huili Wan. Study on the toxic-mechanism of triclosan chronic exposure to zebrafish (Danio rerio) based on gut-brain axis. The Science of the total environment. 2022-06-30. PMID:35772538. |
tcs-chronic exposure affected the development of zebrafish, induced feminization, obesity physical signs and abnormal organ index and caused neurobehavioral abnormalities by inhibiting both neurotransmitter acetylcholinesterase and dopamine activity, promoting brain neuron apoptosis and accelerating diencephalic lesions. |
2022-06-30 |
2023-08-14 |
zebrafish |
| Karina Pereira Luduvico, Luiza Spohr, Mayara Sandrielly Soares de Aguiar, Fernanda Cardoso Teixeira, Natália Pontes Bona, Julia Eisenhardt de Mello, Roselia Maria Spanevello, Francieli Moro Stefanell. LPS-induced impairment of Na Metabolic brain disease. 2022-06-27. PMID:35759073. |
this neurotransmitter is hydrolyzed by acetylcholinesterase (ache), which plays other cellular roles in processes such as inflammation and oxidative stress. |
2022-06-27 |
2023-08-14 |
Not clear |
| Yan-Ling Su, Dong Liu, Yao-Jie Liu, Yang-Lin Ji, Gui-Shan Liu, Ji-Li-Te Wang, Biao Wang, Hao Wan. Phlorizin alleviates cholinergic memory impairment and regulates gut microbiota in d-galactose induced mice. Experimental gerontology. 2022-06-06. PMID:35660419. |
furthermore, a neurotransmitter of acetylcholine (ach) was enhanced, while acetylcholinesterase (ache) activity was inhibited by phlorizin administration. |
2022-06-06 |
2023-08-14 |
mouse |
| Tomasz Tuzimski, Anna Petruczyni. Determination of Anti-Alzheimer's Disease Activity of Selected Plant Ingredients. Molecules (Basel, Switzerland). vol 27. issue 10. 2022-05-28. PMID:35630702. |
one of the most important therapeutic strategies is controlling the level of acetylcholine-a neurotransmitter in cholinergic synapses-by blocking the degradation of acetylcholine using acetylcholinesterase inhibitors such as tacrine, galantamine, donepezil and rivastigmine. |
2022-05-28 |
2023-08-13 |
Not clear |
| Kritika Kumari, Laishram R Sing. Trimethylamine N-oxide might impair cholinergic system by affecting the structural integrity of Acetylcholinesterase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555536. |
acetylcholinesterase (ache) is an important enzyme responsible for the breakdown of neurotransmitter, acetylcholine and therefore plays a crucial role in neuronal plasticity. |
2022-05-13 |
2023-08-13 |
human |
| Wanjun Zhang, Ruiqi Fan, Sunlin Luo, Ying Liu, Yongpeng Jin, Yongchen Li, Mengqin Xiong, Yiqiang Chen, Li Jia, Xiaoyan Yua. Combined effects of chlorpyrifos and cyfluthrin on neurobehavior and neurotransmitter levels in larval zebrafish. Journal of applied toxicology : JAT. 2022-04-26. PMID:35470462. |
to evaluate the risk of combined exposure, we examined the effects of both compounds, separately and together, on motor activity, acetylcholinesterase (ache) activity, and neurotransmitter levels in larval zebrafish. |
2022-04-26 |
2023-08-13 |
zebrafish |
| Shuaizhang Li, Andrew J Li, Jinghua Zhao, Michael F Santillo, Menghang Xi. Acetylcholinesterase Inhibition Assays for High-Throughput Screening. Methods in molecular biology (Clifton, N.J.). vol 2474. 2022-03-16. PMID:35294755. |
acetylcholinesterase (ache) hydrolyzes acetylcholine (ach), a vital neurotransmitter that regulates muscle movement and brain function, including memory, attention, and learning. |
2022-03-16 |
2023-08-13 |
human |
| Lukas G Schnitzler, Kathrin Baumgartner, Anna Kolb, Benedikt Braun, Christoph Westerhause. Acetylcholinesterase Activity Influenced by Lipid Membrane Area and Surface Acoustic Waves. Micromachines. vol 13. issue 2. 2022-02-25. PMID:35208411. |
according to the current model of nerve propagation, the function of acetylcholinesterase (ache) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ach) in the synaptic cleft to acetic acid (acetate) and choline. |
2022-02-25 |
2023-08-13 |
Not clear |
| Juan Bellas, Diego Rial, Juliana Valdés, Leticia Vidal-Liñán, Juan I Bertucci, Soledad Muniategui, Víctor M León, Juan A Campill. Linking biochemical and individual-level effects of chlorpyrifos, triphenyl phosphate, and bisphenol A on sea urchin (Paracentrotus lividus) larvae. Environmental science and pollution research international. 2022-02-15. PMID:35165844. |
the antioxidant enzymes glutathione reductase (gr) and catalase (cat), the phase ii detoxification enzyme glutathione s-transferase (gst), and the neurotransmitter catabolism enzyme acetylcholinesterase (ache) were assessed in combination with responses at the individual level (larval growth). |
2022-02-15 |
2023-08-13 |
cat |
| Marie Closset, Katia Cailliau, Sylvain Slaby, Matthieu Mari. Effects of Aluminium Contamination on the Nervous System of Freshwater Aquatic Vertebrates: A Review. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008450. |
in addition, it activates and inhibits antioxidant enzymes and leads to changes in acetylcholinesterase activity, neurotransmitter levels, and in the expression of several neural genes and nerve cell components. |
2022-01-11 |
2023-08-13 |
human |
| Elva Fridjonsdottir, Theodosia Vallianatou, Ioannis Mantas, Reza Shariatgorji, Anna Nilsson, Luke S Schembri, Luke R Odell, Per Svenningsson, Per E André. Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems. ACS chemical biology. 2021-12-21. PMID:34932310. |
region-specific and age-dependent multitarget effects of acetylcholinesterase inhibitor tacrine on comprehensive neurotransmitter systems. |
2021-12-21 |
2023-08-13 |
mouse |
| Elva Fridjonsdottir, Theodosia Vallianatou, Ioannis Mantas, Reza Shariatgorji, Anna Nilsson, Luke S Schembri, Luke R Odell, Per Svenningsson, Per E André. Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems. ACS chemical biology. 2021-12-21. PMID:34932310. |
we used matrix-assisted laser desorption/ionization mass spectrometry imaging in combination with multivariate analysis to visualize in anatomical detail metabolic effects of aging and tacrine-mediated acetylcholinesterase inhibition on comprehensive neurotransmitter systems in multiple mouse brain regions of 12-week-old and 14-month-old mice. |
2021-12-21 |
2023-08-13 |
mouse |
| Sílvia Chaves, Katalin Várnagy, M Amélia Santo. Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity. Current medicinal chemistry. vol 28. issue 35. 2021-11-25. PMID:33602068. |
currently available drugs are used, mainly to compensate the decline of the neurotransmitter acetylcholine by acetylcholinesterase (ache) inhibition, though they only provide temporary symptomatic benefits and cannot stop ad progression. |
2021-11-25 |
2023-08-13 |
Not clear |
| Kazuhiro Murata, Naotaka Yoshikawa, Kanji Yoshimoto, Akira Namera, Haruo Takeshita, Masataka Naga. BIMP affects tubulin structure and causes abnormalities in cell division. Legal medicine (Tokyo, Japan). vol 53. 2021-11-25. PMID:34225093. |
these agents mainly irreversibly inhibit the action of acetylcholinesterase, an enzyme that breaks down acetylcholine, a neurotransmitter, and are believed to cause acute symptoms of poisoning. |
2021-11-25 |
2023-08-13 |
Not clear |
| Bhuvaneswari Sivaraman, Vijaykumar R, Bala Aakash Velmurugan, Ramalakshmi Nataraja. Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease. CNS & neurological disorders drug targets. 2021-11-23. PMID:34602041. |
acetylcholinesterase (ache), hydrolase enzyme, regulates the hydrolysis of acetylcholine neurotransmitter in the neurons. |
2021-11-23 |
2023-08-13 |
Not clear |
| Heather B Patisaul, Mamta Behl, Linda S Birnbaum, Arlene Blum, Miriam L Diamond, Seth Rojello Fernández, Helena T Hogberg, Carol F Kwiatkowski, Jamie D Page, Anna Soehl, Heather M Stapleto. Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers. Environmental health perspectives. vol 129. issue 10. 2021-10-09. PMID:34612677. |
to date, the toxicity of organophosphate esters has primarily been studied regarding their use as pesticides and their effects on the neurotransmitter acetylcholinesterase (ache). |
2021-10-09 |
2023-08-13 |
human |
| Martina Di Rocco, Serena Galosi, Enrico Lanza, Federica Tosato, Davide Caprini, Viola Folli, Jennifer Friedman, Gianfranco Bocchinfuso, Alberto Martire, Elia Di Schiavi, Vincenzo Leuzzi, Simone Martinell. Caenorhabditis elegans provides an efficient drug screening platform for GNAO1-related disorders and highlights the potential role of caffeine in controlling dyskinesia. Human molecular genetics. 2021-10-08. PMID:34622282. |
like null mutants, homozygous knock-in animals showed increased egg laying and were hypersensitive to aldicarb, an inhibitor of acetylcholinesterase, suggesting excessive neurotransmitter release by different classes of motor neurons. |
2021-10-08 |
2023-08-13 |
caenorhabditis_elegans |
| Xu Zhao, Ling Zhang, Xu Yan, Li Zhang, Yang Lu, Jialin Pan, Meiling Zhang, Chenguang Wang, Hui Suo, Xiaoteng Jia, Xiaomin Liu, Geyu L. A near-infrared light triggered fluormetric biosensor for sensitive detection of acetylcholinesterase activity based on NaErF Talanta. vol 235. 2021-09-15. PMID:34517642. |
a near-infrared light triggered fluormetric biosensor for sensitive detection of acetylcholinesterase activity based on naerf acetylcholinesterase (ache), as an important neurotransmitter, is widely present in the peripheral and central nervous systems. |
2021-09-15 |
2023-08-13 |
Not clear |