| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiyun Wu, Aster H Y Fung, Miranda L Xu, Kaman Poon, Etta Y L Liu, Xiang P Kong, Ping Yao, Qing P Xiong, Tina T X Dong, Karl W K Tsi. Microphthalmia-associated transcription factor up-regulates acetylcholinesterase expression during melanogenesis of murine melanoma cells. The Journal of biological chemistry. vol 293. issue 37. 2019-04-09. PMID:30076217. |
acetylcholinesterase (ache) hydrolyzes the neurotransmitter acetylcholine in neurons. |
2019-04-09 |
2023-08-13 |
Not clear |
| Bidisha Ukil, Suman Kundu, Larisha Mawkhlieng Lynde. Functional Imaging of Neurotransmitters in Hymenolepis diminuta Treated with Senna Plant Through Light and Confocal Microscopy. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. vol 24. issue 6. 2019-02-19. PMID:30420003. |
histochemical studies were carried out using acetylthiocholine iodide as the substrate and acetylcholinesterase as the marker enzyme for studying the expression of the neurotransmitter of the parasite and the staining intensity was observed under a light microscope. |
2019-02-19 |
2023-08-13 |
Not clear |
| Mohd Shahbaaz, Suvardhan Kanchi, Myalowenkosi Sabela, Krishna Bisett. Structural basis of pesticide detection by enzymatic biosensing: a molecular docking and MD simulation study. Journal of biomolecular structure & dynamics. vol 36. issue 6. 2019-01-31. PMID:28463066. |
accordingly, the four transducers, acetylcholinesterase (ach), cytochromes p450 (cyp), glutathione s-transferase (gst), and protein kinase c (pkc) were selected based on their applications including neurotransmitter, metabolism, detoxification enzyme, and protein phosphorylation. |
2019-01-31 |
2023-08-13 |
Not clear |
| Caio R D Assis, Amanda G Linhares, Mariana P Cabrera, Vagne M Oliveira, Kaline C C Silva, Marina Marcuschi, Elba V M Maciel Carvalho, Ranilson S Bezerra, Luiz B Carvalh. Erythrocyte acetylcholinesterase as biomarker of pesticide exposure: new and forgotten insights. Environmental science and pollution research international. vol 25. issue 19. 2018-12-20. PMID:29797194. |
acetylcholinesterase (ache) acts on the hydrolysis of acetylcholine, rapidly removing this neurotransmitter at cholinergic synapses and neuromuscular junctions as well as in neuronal growth and differentiation, modulation of cell adhesion ("electrotactins") and aryl-acylamidase activity (aaa). |
2018-12-20 |
2023-08-13 |
Not clear |
| Nazish U Tanoli, Sheraz A K Tanoli, Antonio G Ferreira, Mazhar Mehmood, Sana Gul, Julia L Monteiro, Lucas C C Vieira, Tiago Venâncio, Arlene G Correa, Zaheer Ul-Ha. Characterization of the interactions between coumarin-derivatives and acetylcholinesterase: Examination by NMR and docking simulations. Journal of molecular modeling. vol 24. issue 8. 2018-11-02. PMID:30008113. |
the rapid hydrolysis of the principal neurotransmitter into choline and acetate by acetylcholinesterase (ache) at synapses causes the loss of cognitive response that becomes the real cause of ad. |
2018-11-02 |
2023-08-13 |
Not clear |
| Yechun Xu, Shanmei Cheng, Joel L Sussman, Israel Silman, Hualiang Jian. Computational Studies on Acetylcholinesterases. Molecules (Basel, Switzerland). vol 22. issue 8. 2018-09-13. PMID:28796192. |
the catalytic triad of acetylcholinesterase is located at the bottom of a long and narrow gorge, but it catalyzes the extremely rapid hydrolysis of the neurotransmitter, acetylcholine, with a reaction rate close to the diffusion-controlled limit. |
2018-09-13 |
2023-08-13 |
Not clear |
| Ariana Beste, DeCarlos E Taylor, Tsung-Ming Shih, Thaddeus P Thoma. Mechanisms of acetylcholinesterase protection against sarin and soman by adenosine A Computational biology and chemistry. vol 75. 2018-08-29. PMID:29747078. |
mechanisms of acetylcholinesterase protection against sarin and soman by adenosine a organophosphorus nerve agents (nas) irreversibly inhibit acetylcholinesterase (ache), the enzyme responsible for breaking down the neurotransmitter acetylcholine (ach). |
2018-08-29 |
2023-08-13 |
Not clear |
| Zuoqing Yuan, Xinxin Shao, Zili Miao, Bosheng Zhao, Ziyang Zheng, Jianyong Zhan. Perfluorooctane sulfonate induced neurotoxicity responses associated with neural genes expression, neurotransmitter levels and acetylcholinesterase activity in planarians Dugesia japonica. Chemosphere. vol 206. 2018-08-28. PMID:29738904. |
perfluorooctane sulfonate induced neurotoxicity responses associated with neural genes expression, neurotransmitter levels and acetylcholinesterase activity in planarians dugesia japonica. |
2018-08-28 |
2023-08-13 |
Not clear |
| Zuoqing Yuan, Xinxin Shao, Zili Miao, Bosheng Zhao, Ziyang Zheng, Jianyong Zhan. Perfluorooctane sulfonate induced neurotoxicity responses associated with neural genes expression, neurotransmitter levels and acetylcholinesterase activity in planarians Dugesia japonica. Chemosphere. vol 206. 2018-08-28. PMID:29738904. |
in our study, the effects of pfos on neurodevelopment gene expression, neurotransmitter content, neuronal morphology, acetylcholinesterase (ache) activity were examined, and the potential neurotoxicity mechanisms of pfos were also investigated in planarians, dugesia japonica. |
2018-08-28 |
2023-08-13 |
Not clear |
| Terrone L Rosenberry, Xavier Brazzolotto, Ian R Macdonald, Marielle Wandhammer, Marie Trovaslet-Leroy, Sultan Darvesh, Florian Nacho. Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study. Molecules (Basel, Switzerland). vol 22. issue 12. 2018-07-17. PMID:29186056. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. |
2018-07-17 |
2023-08-13 |
human |
| Carlos Roca, Carlos Requena, Víctor Sebastián-Pérez, Sony Malhotra, Chris Radoux, Concepción Pérez, Ana Martinez, Juan Antonio Páez, Tom L Blundell, Nuria E Campill. Identification of new allosteric sites and modulators of AChE through computational and experimental tools. Journal of enzyme inhibition and medicinal chemistry. vol 33. issue 1. 2018-07-05. PMID:29873262. |
acetylcholinesterase (ache), which is most widely known for the hydrolysis of the neurotransmitter acetylcholine, has a peripheral allosteric subsite responsible for amyloidosis in alzheimer's disease through interaction with amyloid β-peptide. |
2018-07-05 |
2023-08-13 |
Not clear |
| Volker Strauss, Maria Cecilia Rey Moreno, Jeanette Vogt, Martina Dammann, Steffen Schneider, Sibylle Gröters, Bennard van Ravenzwaa. Acetylcholinesterase measurement in various brain regions and muscles of juvenile, adolescent, and adult rats. Toxicology mechanisms and methods. vol 27. issue 9. 2018-05-23. PMID:28671028. |
several insecticides, chemicals, and drugs are known to inhibit acetylcholinesterase (ache) activity, responsible for the cleavage of the neurotransmitter acetylcholine. |
2018-05-23 |
2023-08-13 |
rat |
| Anders Allgardsson, C David Andersson, Christine Akfur, Franz Worek, Anna Linusson, Fredrik Ekströ. An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet. Molecules (Basel, Switzerland). vol 22. issue 9. 2018-05-08. PMID:28867801. |
acetylcholinesterase (ache) is an essential enzyme that terminates cholinergic transmission by a rapid hydrolysis of the neurotransmitter acetylcholine. |
2018-05-08 |
2023-08-13 |
Not clear |
| Paula Rayane de Souza, Kelma Sirleide de Souza, Caio Rodrigo Dias de Assis, Marlyete Chagas de Araújo, Kaline Catiely Campos Silva, Juliett de Fátima Xavier da Silva, Andreia Cybelle Marques Ferreira, Valdir Luna da Silva, Mônica Lúcia Adam, Luiz Bezerra de Carvalho, Ranilson de Souza Bezerr. Acetylcholinesterase of mangrove oyster Crassostrea rhizophorae: A highly thermostable enzyme with promising features for estuarine biomonitoring. Aquatic toxicology (Amsterdam, Netherlands). vol 197. 2018-05-07. PMID:29462762. |
acetylcholinesterase (ache; ec 3.1.1.7) is an enzyme of the group of serine esterases that acts on the hydrolysis of the neurotransmitter acetylcholine allowing the intermittence of the nerve impulses responsible for the neuronal communication. |
2018-05-07 |
2023-08-13 |
Not clear |
| Shih-Ya Hung, Wen-Mei F. Drug candidates in clinical trials for Alzheimer's disease. Journal of biomedical science. vol 24. issue 1. 2018-05-01. PMID:28720101. |
these investigations include acetylcholinesterase inhibitors, agonists and antagonists of neurotransmitter receptors, β-secretase (bace) or γ-secretase inhibitors, vaccines or antibodies targeting aβ clearance or tau protein, as well as anti-inflammation compounds. |
2018-05-01 |
2023-08-13 |
Not clear |
| Irini Doytchinova, Mariyana Atanasova, Iva Valkova, Georgi Stavrakov, Irena Philipova, Zvetanka Zhivkova, Dimitrina Zheleva-Dimitrova, Spiro Konstantinov, Ivan Dimitro. Novel hits for acetylcholinesterase inhibition derived by docking-based screening on ZINC database. Journal of enzyme inhibition and medicinal chemistry. vol 33. issue 1. 2018-05-01. PMID:29651876. |
the inhibition of the enzyme acetylcholinesterase (ache) increases the levels of the neurotransmitter acetylcholine and symptomatically improves the affected cognitive function. |
2018-05-01 |
2023-08-13 |
Not clear |
| Stacey A Rimkus, David A Wassarma. A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant. PloS one. vol 13. issue 1. 2018-02-05. PMID:29338042. |
ronnel and other suppressor compounds are known to cause mitochondrial dysfunction or to inhibit the enzyme acetylcholinesterase, which controls the levels of the neurotransmitter acetylcholine, suggesting that detrimental consequences of reduced atm kinase activity can be rescued by inhibiting the function of mitochondria or increasing acetylcholine levels. |
2018-02-05 |
2023-08-13 |
drosophila_melanogaster |
| Sunita Thapa, Min Lv, Hui X. Acetylcholinesterase: A Primary Target for Drugs and Insecticides. Mini reviews in medicinal chemistry. vol 17. issue 17. 2017-12-05. PMID:28117022. |
acetylcholinesterase is a serine hydrolase that terminates the action of the neurotransmitter acetylcholine by hydrolyzing it into acetic acid and choline. |
2017-12-05 |
2023-08-13 |
Not clear |
| Tamara Lazarevic-Pasti, Andreja Leskovac, Tatjana Momic, Sandra Petrovic, Vesna Vasi. Modulators of Acetylcholinesterase Activity: From Alzheimer's Disease to Anti-Cancer Drugs. Current medicinal chemistry. vol 24. issue 30. 2017-11-29. PMID:28685687. |
acetylcholinesterase (ache) is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. |
2017-11-29 |
2023-08-13 |
Not clear |
| Mohammad Nazim, Akio Masuda, Mohammad Alinoor Rahman, Farhana Nasrin, Jun-Ichi Takeda, Kenji Ohe, Bisei Ohkawara, Mikako Ito, Kinji Ohn. Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms. Nucleic acids research. vol 45. issue 3. 2017-10-30. PMID:28180311. |
acetylcholinesterase (ache), encoded by the ache gene, hydrolyzes the neurotransmitter acetylcholine to terminate synaptic transmission. |
2017-10-30 |
2023-08-13 |
human |