| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alireza Basiri, Michelle Xiao, Alec McCarthy, Debashis Dutta, Siddappa N Byrareddy, Martin Conda-Sherida. Design and synthesis of new piperidone grafted acetylcholinesterase inhibitors. Bioorganic & medicinal chemistry letters. vol 27. issue 2. 2017-06-27. PMID:27914796. |
a common strategy to improve the well-being of ad patients consists on the inhibition of acetylcholinesterase with the concomitant increase of the neurotransmitter acetylcholine at cholinergic synapses. |
2017-06-27 |
2023-08-13 |
Not clear |
| Kei M Lau, Amy G W Gong, Miranda L Xu, Candy T W Lam, Laura M L Zhang, Cathy W C Bi, D Cui, Anthony W M Cheng, Tina T X Dong, Karl W K Tsim, Huangquan Li. Transcriptional activity of acetylcholinesterase gene is regulated by DNA methylation during C2C12 myogenesis. Brain research. vol 1642. 2017-05-22. PMID:27021952. |
the expression of acetylcholinesterase (ache), an enzyme hydrolyzes neurotransmitter acetylcholine at vertebrate neuromuscular junction, is regulated during myogenesis, indicating the significance of muscle intrinsic factors in controlling the enzyme expression. |
2017-05-22 |
2023-08-13 |
mouse |
| Hao Liu, Wei Ye, Hai-Feng Che. Positive cooperative regulation of double binding sites for human acetylcholinesterase. Chemical biology & drug design. vol 89. issue 5. 2017-05-09. PMID:27779818. |
acetylcholinesterase is a potent enzyme that regulates neurotransmission by rapidly hydrolyzing the neurotransmitter acetylcholine in synapses of the nervous system. |
2017-05-09 |
2023-08-13 |
human |
| Stanton F McHardy, Hua-Yu Leo Wang, Shelby V McCowen, Matthew C Valde. Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015). Expert opinion on therapeutic patents. vol 27. issue 4. 2017-03-22. PMID:27967267. |
acetylcholinesterase (ache) is the major enzyme that hydrolyzes acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline. |
2017-03-22 |
2023-08-13 |
Not clear |
| İlhami Gülçin, Andrea Scozzafava, Claudiu T Supuran, Hulya Akıncıoğlu, Zeynep Koksal, Fikret Turkan, Saleh Alwase. The effect of caffeic acid phenethyl ester (CAPE) on metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase, lactoperoxidase, and carbonic anhydrase isoenzymes I, II, IX, and XII. Journal of enzyme inhibition and medicinal chemistry. vol 31. issue 6. 2017-02-21. PMID:26453427. |
acetylcholinesterase (ache) is responsible for acetyl choline (ach) hydrolysis and plays a fundamental role in nerve impulse transmission by terminating the action of the ach neurotransmitter at cholinergic synapses and neuromuscular junctions. |
2017-02-21 |
2023-08-13 |
human |
| Heidi Q Xie, Tuan Xu, Yangsheng Chen, Yunping Li, Yingjie Xia, Sherry L Xu, Lingyun Wang, Karl W K Tsim, Bin Zha. New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27374124. |
acetylcholinesterase (ache; ec 3.1.1.7) is a vital functional enzyme in cholinergic neurotransmission which can rapidly hydrolyze neurotransmitter, acetylcholine, in the central and peripheral nervous systems. |
2017-01-30 |
2023-08-13 |
mouse |
| Cho Rong Kim, Soo Jung Choi, Yoon Kyung Kwon, Jae Kyeom Kim, Youn-Jung Kim, Gwi Gun Park, Dong-Hoon Shi. Cinnamomum loureirii Extract Inhibits Acetylcholinesterase Activity and Ameliorates Trimethyltin-Induced Cognitive Dysfunction in Mice. Biological & pharmaceutical bulletin. vol 39. issue 7. 2017-01-27. PMID:27374288. |
the pathogenesis of alzheimer's disease (ad) has been linked to the deficiency of neurotransmitter acetylcholine (ach) in the brain, and the main treatment strategy for improving ad symptoms is the inhibition of acetylcholinesterase (ache) activity. |
2017-01-27 |
2023-08-13 |
mouse |
| De Lu Zhang, Si Yi Liu, Jing Zhang, Jian Kun Zhang, Chun Xiang Hu, Yong Ding Li. Respiratory toxicity of cyanobacterial aphantoxins from Aphanizomenon flos-aquae DC-1 in the zebrafish gill. Aquatic toxicology (Amsterdam, Netherlands). vol 176. 2017-01-20. PMID:27130970. |
gill acetylcholinesterase (ache) and monoamine oxidase (mao) activities were inhibited significantly, suggesting an alteration of neurotransmitter inactivation in zebrafish gills. |
2017-01-20 |
2023-08-13 |
human |
| Michael F Santillo, Yitong Li. A fluorescence assay for measuring acetylcholinesterase activity in rat blood and a human neuroblastoma cell line (SH-SY5Y). Journal of pharmacological and toxicological methods. vol 76. 2016-09-12. PMID:26165232. |
acetylcholinesterase (ache) is an enzyme responsible for metabolism of the neurotransmitter acetylcholine, and inhibition of ache can have therapeutic applications (e.g., drugs for alzheimer's disease) or neurotoxic consequences (e.g., pesticides). |
2016-09-12 |
2023-08-13 |
human |
| Saw Simeon, Nuttapat Anuwongcharoen, Watshara Shoombuatong, Aijaz Ahmad Malik, Virapong Prachayasittikul, Jarl E S Wikberg, Chanin Nantasenama. Probing the origins of human acetylcholinesterase inhibition via QSAR modeling and molecular docking. PeerJ. vol 4. 2016-09-07. PMID:27602288. |
acetylcholinesterase (ache) is an enzyme that catalyzes the breakdown of the neurotransmitter acetylcholine that is essential for cognition and memory. |
2016-09-07 |
2023-08-13 |
human |
| Sehan Lee, Mace G Barro. Development of 3D-QSAR Model for Acetylcholinesterase Inhibitors Using a Combination of Fingerprint, Molecular Docking, and Structure-Based Pharmacophore Approaches. Toxicological sciences : an official journal of the Society of Toxicology. vol 148. issue 1. 2016-08-16. PMID:26202430. |
acetylcholinesterase (ache), a serine hydrolase vital for regulating the neurotransmitter acetylcholine in animals, has been used as a target for drugs and pesticides. |
2016-08-16 |
2023-08-13 |
Not clear |
| Christopher D Ruark, Richard R Chapleau, Deirdre A Mahle, Jeffery M Gearhar. Organophosphorus Inhibition and Characterization of Recombinant Guinea Pig Acetylcholinesterase. Protein and peptide letters. vol 22. issue 10. 2016-05-23. PMID:26216268. |
organophosphorus (op) pesticides and nerve agents have been designed to inhibit the hydrolysis of the neurotransmitter acetylcholine by covalently binding to the active site serine of acetylcholinesterase while alzheimer drugs and prophylactics, such as tacrine, are characterized by reversible binding. |
2016-05-23 |
2023-08-13 |
human |
| Zongming Ren, Xu Zhang, Xiaoguang Wang, Pingping Qi, Biao Zhang, Yang Zeng, Rongshu Fu, Mingsheng Mia. AChE inhibition: one dominant factor for swimming behavior changes of Daphnia magna under DDVP exposure. Chemosphere. vol 120. 2015-12-18. PMID:25112705. |
as a key enzyme that hydrolyzes the neurotransmitter acetylcholine in cholinergic synapses of both vertebrates and invertebrates, acetylcholinesterase (ache) is strongly inhibited by organophosphates. |
2015-12-18 |
2023-08-13 |
Not clear |
| Alžběta Kračmarová, Lucie Drtinová, Miroslav Pohank. Possibility of Acetylcholinesterase Overexpression in Alzheimer Disease Patients after Therapy with Acetylcholinesterase Inhibitors. Acta medica (Hradec Kralove). vol 58. issue 2. 2015-12-09. PMID:26455564. |
acetylcholinesterase is an enzyme responsible for termination of excitatory transmission at cholinergic synapses by the hydrolyzing of a neurotransmitter acetylcholine. |
2015-12-09 |
2023-08-13 |
Not clear |
| Kosuke Yamamoto, Satoshi Shida, Yoshihiro Honda, Mariko Shono, Hiroshi Miyake, Suguru Oguri, Hikaru Sakamoto, Yoshie S Momonok. Overexpression of acetylcholinesterase gene in rice results in enhancement of shoot gravitropism. Biochemical and biophysical research communications. vol 465. issue 3. 2015-11-27. PMID:26277389. |
acetylcholine (ach), a known neurotransmitter in animals and acetylcholinesterase (ache) exists widely in plants, although its role in plant signal transduction is unclear. |
2015-11-27 |
2023-08-13 |
Not clear |
| Sangyun Lee, Ji-Hyun Kim, Sangyoub Le. Internal Diffusion-Controlled Enzyme Reaction: The Acetylcholinesterase Kinetics. Journal of chemical theory and computation. vol 8. issue 2. 2015-11-25. PMID:26596618. |
acetylcholinesterase is an enzyme with a very high turnover rate; it quenches the neurotransmitter, acetylcholine, at the synapse. |
2015-11-25 |
2023-08-13 |
Not clear |
| Da Xiao, Yan-Hui Lu, Qing-Li Shang, Dun-Lun Song, Xi-Wu Ga. Gene silencing of two acetylcholinesterases reveals their cholinergic and non-cholinergic functions in Rhopalosiphum padi and Sitobion avenae. Pest management science. vol 71. issue 4. 2015-11-16. PMID:24729410. |
the function of acetylcholinesterase (ache) is to terminate synaptic transmission by hydrolysing the neurotransmitter acetylcholine (ach) in the synaptic cleft, and thus it is an effective target for organophosphate (op) and carbamate (cb) insecticides. |
2015-11-16 |
2023-08-13 |
Not clear |
| Lucas H Hess, Alina Lyuleeva, Benno M Blaschke, Matthias Sachsenhauser, Max Seifert, Jose A Garrido, Frank Deube. Graphene transistors with multifunctional polymer brushes for biosensing applications. ACS applied materials & interfaces. vol 6. issue 12. 2015-10-16. PMID:24866105. |
to demonstrate the potential of this polymer brush functionalization scaffold, we modified solution-gated graphene field-effect transistors with the enzyme acetylcholinesterase and a transducing group, allowing the detection of the neurotransmitter acetylcholine. |
2015-10-16 |
2023-08-13 |
Not clear |
| b' Dragan Hrn\\xc4\\x8di\\xc4\\x87, Aleksandra Ra\\xc5\\xa1i\\xc4\\x87-Markovi\\xc4\\x87, Tihomir Stojkovi\\xc4\\x87, Milica Velimirovi\\xc4\\x87, Nela Pu\\xc5\\xa1ka\\xc5\\xa1, Radmila Obrenovi\\xc4\\x87, Djuro Macut, Veselinka Su\\xc5\\xa1i\\xc4\\x87, Vladimir Jakovljevi\\xc4\\x87, Dragan Djuric, Nata\\xc5\\xa1a Petronijevi\\xc4\\x87, Olivera Stanojlovi\\xc4\\x8. Hyperhomocysteinemia induced by methionine dietary nutritional overload modulates acetylcholinesterase activity in the rat brain. Molecular and cellular biochemistry. vol 396. issue 1-2. 2015-10-06. PMID:25052005.' |
acetylcholinesterase is a serine protease that rapidly hydrolyzes neurotransmitter acetylcholine. |
2015-10-06 |
2023-08-13 |
rat |
| Ying Li, Shan Hai, Yan Zhou, Bi Rong Don. Cholinesterase inhibitors for rarer dementias associated with neurological conditions. The Cochrane database of systematic reviews. issue 3. 2015-10-02. PMID:25734590. |
cholinesterase inhibitors are hypothesised to work by inhibiting the enzyme acetylcholinesterase (ache) which breaks down the neurotransmitter acetylcholine. |
2015-10-02 |
2023-08-13 |
Not clear |