| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephen Brimijoin, Yang Gao, Liyi Geng, Vicky P Che. Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29535625. |
butyrylcholinesterase (bche), a plasma enzyme that hydrolyses the neurotransmitter, acetylcholine relatively well, with far lower efficiency than acetylcholinesterase (ache) but with the capability to degrade a broad range of bioactive esters. |
2020-10-01 |
2023-08-13 |
mouse |
| Adriana M Dos Santos, Ariele C Moreira, Bianca Rebelo Lopes, Mariana F Fracola, Fernando G de Almeida, Odair C Bueno, Quezia B Cass, Dulce Helena F Souz. Acetylcholinesterases from Leaf-Cutting ant Enzyme research. vol 2019. 2020-09-30. PMID:31354985. |
acetylcholinesterases from leaf-cutting ant acetylcholinesterase (ache) is responsible for catalyzing the hydrolysis of the neurotransmitter acetylcholine (ach) leading to acetate and choline (ch) release. |
2020-09-30 |
2023-08-13 |
Not clear |
| Suvi Ruuskanen, Miia J Rainio, Carlos Gómez-Gallego, Otto Selenius, Seppo Salminen, Maria Carmen Collado, Kari Saikkonen, Irma Saloniemi, Marjo Helande. Glyphosate-based herbicides influence antioxidants, reproductive hormones and gut microbiome but not reproduction: A long-term experiment in an avian model. Environmental pollution (Barking, Essex : 1987). vol 266. issue Pt 1. 2020-09-15. PMID:32768925. |
gbh exposure decreased hepatic activity of an intracellular antioxidant enzyme (catalase), independent of sex, but did not influence other intracellular oxidative stress biomarkers or neurotransmitter enzyme (acetylcholinesterase). |
2020-09-15 |
2023-08-13 |
human |
| Yameng Han, Zhongju Ye, Fuyan Wang, Tianyu Chen, Lin Wei, Langxing Chen, Lehui Xia. Single-particle enumeration-based ultrasensitive enzyme activity quantification with fluorescent polymer nanoparticles. Nanoscale. vol 11. issue 31. 2020-09-11. PMID:31353389. |
acetylcholinesterase (ache) plays a vital role in nerve conduction through rapidly hydrolyzing the neurotransmitter acetylcholine (ach) and is correlated with alzheimer's disease. |
2020-09-11 |
2023-08-13 |
human |
| Mengyuan Liu, Shiwen Song, Chenyan Hu, Lizhu Tang, James C W Lam, Paul K S Lam, Lianguo Che. Dietary administration of probiotic Lactobacillus rhamnosus modulates the neurological toxicities of perfluorobutanesulfonate in zebrafish. Environmental pollution (Barking, Essex : 1987). vol 265. issue Pt B. 2020-08-18. PMID:32454362. |
the results showed that, compared to the single effects, pfbs and probiotic coexposure significantly altered the acetylcholinesterase activity and neurotransmitter profiles in gut and brain of zebrafish, with mild effects on neuronal integrity. |
2020-08-18 |
2023-08-13 |
zebrafish |
| Axel Eduardo Rico-Sánchez, Alexis Joseph Rodríguez-Romero, Jacinto Elías Sedeño-Díaz, Eugenia López-Lópe. Assessment of seasonal and spatial variations of biochemical markers in Corydalus sp. (Megaloptera: Corydalidae), a non-conventional biomonitor, in a mountain cloud forest in Mexico. Environmental science and pollution research international. vol 27. issue 24. 2020-07-28. PMID:32474780. |
we assessed the health condition of this river system using a non-conventional biomonitor, corydalus sp., with a set of early-warning biomarkers including lipid peroxidation levels (lpo) and antioxidant activity, superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), and the neurotransmitter acetylcholinesterase (ache) considering their spatial and temporal variations. |
2020-07-28 |
2023-08-13 |
human |
| Fereshteh Shiri, Somayeh Pirhadi, Jahan B Ghasem. Dynamic structure based pharmacophore modeling of the Acetylcholinesterase reveals several potential inhibitors. Journal of biomolecular structure & dynamics. vol 37. issue 7. 2020-06-02. PMID:29695192. |
acetylcholinesterase is a critical enzyme that regulates neurotransmission by catalyzing the breakdown of neurotransmitter acetylcholine in synapses of the nervous system. |
2020-06-02 |
2023-08-13 |
Not clear |
| Xiao Hu, Cerasela Zoica Din. Nanoporous gold electrode for ultrasensitive detection of neurotoxin fasciculin. Analytica chimica acta. vol 1085. 2020-03-16. PMID:31522735. |
acetylcholinesterase (ache), an efficient biocatalyst known to hydrolyze the neurotransmitter acetylcholine, could be inactivated in the presence of insecticides, nerve agents or other drug inhibitors to thus result in disrupted neurotransmission. |
2020-03-16 |
2023-08-13 |
Not clear |
| Lilai Yuan, Le Qian, Yu Qian, Jia Liu, Ke Yang, Ying Huang, Chengju Wang, Yingren Li, Xiyan M. Bisphenol F-Induced Neurotoxicity toward Zebrafish Embryos. Environmental science & technology. vol 53. issue 24. 2020-03-16. PMID:31702913. |
additionally, no significant change was found in neurotransmitter levels (5-hydroxytryptamine, dopamine, and acetylcholine) or acetylcholinesterase (ache) enzyme activity after bpf exposure, indicating that bpf may not affect neurotransmission. |
2020-03-16 |
2023-08-13 |
zebrafish |
| Yasmina M Abd-Elhakim, Nabela I El-Sharkawy, Hesham H Mohammed, Lamiaa L M Ebraheim, Mostafa A Shalab. Camel milk rescues neurotoxic impairments induced by fenpropathrin via regulating oxidative stress, apoptotic, and inflammatory events in the brain of rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 135. 2020-02-17. PMID:31838190. |
the levels of dopamine (dopa) neurotransmitter, acetylcholinesterase (ache) enzyme, oxidative stress, and inflammatory markers were determined. |
2020-02-17 |
2023-08-13 |
rat |
| Pablo Zambrano, Mario Suwalsky, Malgorzata Jemiola-Rzeminska, Kazimierz Strzalka, Benjamin Sepúlveda, María J Gallardo, Luis F Aguila. The acetylcholinesterase (AChE) inhibitor and anti-Alzheimer drug donepezil interacts with human erythrocytes. Biochimica et biophysica acta. Biomembranes. vol 1861. issue 6. 2020-02-14. PMID:30904408. |
this drug is a specific inhibitor of the enzyme acetylcholinesterase (ache), whose main physiological function is to hydrolyze the neurotransmitter acetylcholine. |
2020-02-14 |
2023-08-13 |
human |
| b' Kre\\xc5\\xa1imir Baumann, Lorena Kordi\\xc4\\x87, Marko Mo\\xc4\\x8dibob, Goran \\xc5\\xa0inko, Sr\\xc4\\x91anka Tomi\\xc4\\x8. Synthesis and In Vitro Screening of Novel Heterocyclic \\xce\\xb2-d-Gluco- and \\xce\\xb2-d-Galactoconjugates as Butyrylcholinesterase Inhibitors. Molecules (Basel, Switzerland). vol 24. issue 15. 2020-01-14. PMID:31382668.' |
the development of selective butyrylcholinesterase (bche) inhibitors may improve the treatment of alzheimer's disease by increasing lower synaptic levels of the neurotransmitter acetylcholine, which is hydrolysed by acetylcholinesterase, as well as by overexpressed bche. |
2020-01-14 |
2023-08-13 |
Not clear |
| Yaghoub Pourshojaei, Khalil Eskandari, Ali Asadipou. Highly Significant Scaffolds to Design and Synthesis Cholinesterase Inhibitors as Anti-Alzheimer Agents. Mini reviews in medicinal chemistry. vol 19. issue 19. 2019-12-26. PMID:31538893. |
based on the cholinergic hypothesis, and xray crystallographic determination of the structure of acetylcholinesterase (ache) enzyme, the level of acetylcholine (ach, an important neurotransmitter associated with memory) in the hippocampus and cortex area of the brain has a direct effect on alzheimer. |
2019-12-26 |
2023-08-13 |
Not clear |
| Zrinka Kovarik, Jarosław Kalisiak, Nikolina Maček Hrvat, Maja Katalinić, Tamara Zorbaz, Suzana Žunec, Carol Green, Zoran Radić, Valery V Fokin, K Barry Sharpless, Palmer Taylo. Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase. Chemistry (Weinheim an der Bergstrasse, Germany). vol 25. issue 16. 2019-11-26. PMID:30458057. |
acetylcholinesterase (ache), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (ops), such as nerve agents and pesticides, can be reactivated by oximes. |
2019-11-26 |
2023-08-13 |
mouse |
| Muhammed Khairujjaman Mazumder, Shuvasish Choudhur. Tea polyphenols as multi-target therapeutics for Alzheimer's disease: An in silico study. Medical hypotheses. vol 125. 2019-08-27. PMID:30902161. |
with neurodegeneration, the level of the neurotransmitter acetylcholine (ach), as well as acetylcholinesterase (ache), decreases in the synaptic cleft, called cholinergic deficiency. |
2019-08-27 |
2023-08-13 |
Not clear |
| Nashwa H Ashmawy, Abdulrahman A Almehizia, Teraze A Youssef, Abd El-Galil E Amr, Mohamed A Al-Omar, Ayman H Kame. Novel Carbon/PEDOT/PSS-Based Screen-Printed Biosensors for Acetylcholine Neurotransmitter and Acetylcholinesterase Detection in Human Serum. Molecules (Basel, Switzerland). vol 24. issue 8. 2019-08-12. PMID:31003551. |
novel carbon/pedot/pss-based screen-printed biosensors for acetylcholine neurotransmitter and acetylcholinesterase detection in human serum. |
2019-08-12 |
2023-08-13 |
human |
| Tahira Javed, Rabia Habib, Sania Ghafoor, Baseerat Rumman, Sliha Awan, Leonel J M Ntepe, Sajida Batool, Syed M Nurulai. Association of status of acetylcholinesterase and ACHE gene 3' UTR variants (rs17228602, rs17228616) with drug addiction vulnerability in pakistani population. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31129131. |
acetylecholine (ach), a cholinergic neurotransmitter hydrolyzed by acetylcholinesterase (ache), is an essential neurotransmitter and neuromodulator in central and peripheral nervous system and has regulatory influence on numerous neuronal functions including addiction. |
2019-07-22 |
2023-08-13 |
human |
| Minky Son, Chanin Park, Shailima Rampogu, Amir Zeb, Keun Woo Le. Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer's Disease. International journal of molecular sciences. vol 20. issue 4. 2019-07-17. PMID:30823604. |
acetylcholinesterase (ache) catalyzes the hydrolysis of neurotransmitter acetylcholine to acetate and choline in a synaptic cleft. |
2019-07-17 |
2023-08-13 |
human |
| Agung Nugroho, Jong-Hyuk Park, Jae Sue Choi, Kyoung-Sik Park, Joon-Pyo Hong, Hee-Juhn Par. Structure determination and quantification of a new flavone glycoside with anti-acetylcholinesterase activity from the herbs of Elsholtzia ciliata. Natural product research. vol 33. issue 6. 2019-06-20. PMID:29224362. |
acetylcholinesterase (ache) inhibition activity was assayed to find anti-alzheimer's activity, since this enzyme increases the concentration of acetylcholine (ach), a neurotransmitter, responsible for brain's memory. |
2019-06-20 |
2023-08-13 |
Not clear |
| Mridula Saxena, Ragini Dube. Target Enzyme in Alzheimer's Disease: Acetylcholinesterase Inhibitors. Current topics in medicinal chemistry. vol 19. issue 4. 2019-04-24. PMID:30706815. |
the enzyme acetylcholinesterase enzyme (ache) is the key enzyme in the hydrolysis of the neurotransmitter acetylcholine and is also the target of most of the clinically used drugs for the treatment of ad but these drugs provide only symptomatic treatment and have the limitation of loss of therapeutic efficacy with time. |
2019-04-24 |
2023-08-13 |
Not clear |