| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maciej Noga, Agata Michalska, Kamil Jurowsk. The prediction of acute toxicity (LD Archives of toxicology. 2023-12-05. PMID:38051368. |
the prediction of acute toxicity (ld nerve agents are organophosphate chemical warfare agents that exert their toxic effects by irreversibly inhibiting acetylcholinesterase, affecting the breakdown of the neurotransmitter acetylcholine in the synaptic cleft. |
2023-12-05 |
2023-12-10 |
Not clear |
| Shehla Shoukat, Muhammad Amir Zia, Muhammad Uzair, Kotb A Attia, Asmaa M Abushady, Sajid Fiaz, Shaukat Ali, Seung Hwan Yang, Ghulam Muhammad Al. Heliyon. vol 9. issue 11. 2023-11-13. PMID:37954293. |
acetylcholinesterase breaks down the neurotransmitter acetylcholine, important for neural transmission. |
2023-11-13 |
2023-11-20 |
Not clear |
| Jordi Olloquequi, Miren Ettcheto, Amanda Cano, Ana Fortuna, Joana Bicker, Elena Sánchez-Lopez, Cristian Paz, Jesús Ureña, Ester Verdaguer, Carme Auladell, Antoni Camin. Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762479. |
lico-a also acts as an acetylcholinesterase inhibitor, leading to increased levels of the neurotransmitter acetylcholine (ach) in the brain. |
2023-09-28 |
2023-10-07 |
Not clear |
| Zainabu Majid, Qi Zhang, Zhansen Yang, Huilian Che, Nan Chen. A Multi-Enzyme Cascade Response for the Colorimetric Recognition of Organophosphorus Pesticides Utilizing Core-Shell Pd@Pt Nanoparticles with High Peroxidase-like Activity. Foods (Basel, Switzerland). vol 12. issue 17. 2023-09-09. PMID:37685251. |
their limits are closely monitored since their residual hinders the capability of acetylcholinesterase (ache) and brings out a threatening accumulation of the neurotransmitter acetylcholine (ach), which affects human well-being. |
2023-09-09 |
2023-10-07 |
human |
| Dane Sands, Andrew Davis, Scott Banfield, Ian R Pottie, Sultan Darves. Solvents and detergents compatible with enzyme kinetic studies of cholinesterases. Chemico-biological interactions. 2023-08-14. PMID:37579937. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that serve a wide range of physiological functions including the hydrolysis of the neurotransmitter acetylcholine and several other xenobiotics. |
2023-08-14 |
2023-09-07 |
Not clear |
| Anjali Suman, Archisman Mahapatra, Priya Gupta, Shubhendu Shekhar Ray, Rahul Kumar Sing. Polystyrene microplastics modulated bdnf expression triggering neurotoxicity via apoptotic pathway in zebrafish embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-07-16. PMID:37454885. |
on the last day of exposure, behaviour, accumulation, embryotoxicity, acridine orange staining, antioxidant enzyme assay, acetylcholinesterase assay, nitric oxide (no) estimation, along with neurotransmitter (serotonin, dopamine) quantification and gene expression using qrt-pcr (bdnf, p53, bcl-2, caspase-3, caspase-9) were performed. |
2023-07-16 |
2023-08-14 |
human |
| Ana Matošević, Dejan M Opsenica, Marta Spasić, Nikola Maraković, Antonio Zandona, Suzana Žunec, Marija Bartolić, Zrinka Kovarik, Anita Bosa. Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease. Chemico-biological interactions. 2023-07-05. PMID:37406982. |
the most successful therapeutic strategy in the treatment of alzheimer's disease (ad) is directed toward increasing levels of the neurotransmitter acetylcholine (ach) by inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes responsible for its hydrolysis. |
2023-07-05 |
2023-08-14 |
human |
| Vahulabaranan Rajagopalan, Swethaa Venkataraman, Devi Sri Rajendran, Vaidyanathan Vinoth Kumar, Vaithyanathan Vasanth Kumar, Gayathri Rangasam. Acetylcholinesterase biosensors for electrochemical detection of neurotoxic pesticides and acetylcholine neurotransmitter: A literature review. Environmental research. 2023-03-22. PMID:36948285. |
acetylcholinesterase biosensors for electrochemical detection of neurotoxic pesticides and acetylcholine neurotransmitter: a literature review. |
2023-03-22 |
2023-08-14 |
human |
| Abdussamat Güze. Relationship Between Phenolic Content Determined by LC-MS/MS and Antioxidant Capacity and Enzyme Inhibition of Cyclotrichium Niveum L. Chemistry & biodiversity. 2023-03-09. PMID:36891984. |
the phytochemical composition of the plant, inhibition of acetylcholinesterase (ache) (which hydrolyzes the neurotransmitter acetylcholine), inhibition of paraoxonase for antiatherosclerotic activity (hpon 1) (which detoxifies organophosphates), and antioxidant capacity of this plant. |
2023-03-09 |
2023-08-14 |
Not clear |
| Christina Rabeler, TaiXi Gong, Danielle Ireland, Olivier Cochet-Escartin, Eva-Maria S Collin. Acetylcholinesterase Activity Staining in Freshwater Planarians. Current protocols. vol 3. issue 2. 2023-02-17. PMID:36799654. |
the serine hydrolase acetylcholinesterase (ache) is an important neuronal enzyme which catalyzes the hydrolysis of the neurotransmitter acetylcholine and other choline esters. |
2023-02-17 |
2023-08-14 |
Not clear |
| Aso Hameed Hasan, Sonam Shakya, Faiq H S Hussain, Sankaranarayanan Murugesan, Subhash Chander, Mohammad Rizki Fadhil Pratama, Shajarahtunnur Jamil, Basundhara Das, Subhrajit Biswas, Joazaizulfazli Jamali. Design, synthesis, anti-acetylcholinesterase evaluation and molecular modelling studies of novel coumarin-chalcone hybrids. Journal of biomolecular structure & dynamics. 2023-01-02. PMID:36591704. |
the major enzyme responsible for the hydrolytic breakdown of the neurotransmitter acetylcholine (ach) is acetylcholinesterase (ache). |
2023-01-02 |
2023-08-14 |
Not clear |
| Jeremy Neylon, Jarrad N Fuller, Chris van der Poel, Jarrod E Church, Sebastian Dworki. Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish. Journal of developmental biology. vol 10. issue 4. 2022-11-22. PMID:36412643. |
organophosphate (op) insecticides are used to eliminate agricultural threats posed by insects, through inhibition of the neurotransmitter acetylcholinesterase (ache). |
2022-11-22 |
2023-08-14 |
zebrafish |
| Xumin Lin, Yixi Zhang, Baojun Yang, Lingchun Zhang, Yunru Chen, Zewen Li. Multiple acetylcholinesterases in Pardosa pseudoannulata brain worked collaboratively to provide protection from organophosphorus insecticides. Ecotoxicology and environmental safety. vol 248. 2022-11-21. PMID:36410143. |
acetylcholinesterase (ache) is an essential neurotransmitter hydrolase in nervous systems of animals and its number varies among species. |
2022-11-21 |
2023-08-14 |
spider |
| Nancy D Asen, Ogadimma D Okagu, Chibuike C Udenigwe, Rotimi E Aluk. Frontiers in nutrition. vol 9. 2022-11-07. PMID:36337665. |
compounds with structural similarities to the neurotransmitter (acetylcholine) are mostly used to inhibit the activity of acetylcholinesterase (ache) in alzheimer's disease (ad) therapy. |
2022-11-07 |
2023-08-14 |
Not clear |
| Manish Kumar, Komalpreet Kaur, Thakur Gurjeet Sing. Neuroprotective Effects of Carbonic Anhydrase Inhibition and Cyclic Adenosine Monophosphate Activation in Mouse Model of Transient Global Cerebral Ischemia and Reperfusion. Neuromolecular medicine. 2022-10-28. PMID:36306034. |
dcpa and/or fsk attenuated tgci/r-induced brain edema, blood-brain barrier dysfunction, oxidative-nitrosative stress, pro-inflammatory cytokines, acetylcholinesterase activity, cell death, and neurotransmitter imbalance (e.g., glutamate, γ-aminobutyric acid). |
2022-10-28 |
2023-08-14 |
mouse |
| Jeyaraj Jeyavani, Ashokkumar Sibiya, Narayanan Gopi, Shahid Mahboob, Khalid A Al-Ghanim, Fahad Al-Misned, Zubair Ahmed, Mian Nadeem Riaz, Balasubramanian Palaniappan, Marimuthu Govindarajan, Baskaralingam Vaseehara. Ingestion and impacts of water-borne polypropylene microplastics on Daphnia similis. Environmental science and pollution research international. 2022-09-22. PMID:36136182. |
additionally, the amount of the neurotransmitter enzyme acetylcholinesterase (ache) activity was decreased. |
2022-09-22 |
2023-08-14 |
cat |
| Muslum Gok, Cigdem Cicek, Suat Sari, Ebru Bodu. Novel activity of human BChE: Lipid hydrolysis. Biochimie. 2022-09-20. PMID:36126749. |
acetylcholinesterase and butyrylcholinesterase (bche) typically hydrolyze the neurotransmitter acetylcholine. |
2022-09-20 |
2023-08-14 |
human |
| Farida Begum, Najeeb Ur Rehman, Ajmal Khan, Sajid Iqbal, Rehan Zafar Paracha, Jalal Uddin, Ahmed Al-Harrasi, Muhammad Arif Lodh. 2-Mercaptobenzimidazole clubbed hydrazone for Alzheimer's therapy: Frontiers in pharmacology. vol 13. 2022-09-05. PMID:36059999. |
it is a multifactorial disease, developed by the breakdown of the neurotransmitter acetylcholine via acetylcholinesterase (ache). |
2022-09-05 |
2023-08-14 |
Not clear |
| Dou Yang, Fasheng Liu, Mengqi Wan, Jieping Liu, Ling Huang, Chao Chen, Xue Li, Li Zhang, Xiaobing Ding, Xinjun Liao, Guanghua Xiong, Huiqiang Lu, Juhua Xiao, Zigang Ca. Pamiparib Induces Neurodevelopmental Defects and Cerebral Haemorrhage in Zebrafish Embryos via Inhibiting Notch Signalling. Molecular neurobiology. 2022-08-18. PMID:35982279. |
in addition, pamiparib exposure leads to downregulation of acetylcholinesterase (ache) and adenosine triphosphate (atpase) activities, and upregulation of oxidative stress which then leads to apoptosis and disrupts the gene expression involved in the neurodevelopment, neurotransmitter pathways and parkinson's disease (pd) like symptoms. |
2022-08-18 |
2023-08-14 |
zebrafish |
| Letícia A Nascimento, Érica C M Nascimento, João B L Martin. In silico study of tacrine and acetylcholine binding profile with human acetylcholinesterase: docking and electronic structure. Journal of molecular modeling. vol 28. issue 9. 2022-08-10. PMID:35947248. |
in this way, we performed a set of theoretical tests of tacrine ligand and acetylcholine neurotransmitter against the human acetylcholinesterase enzyme. |
2022-08-10 |
2023-08-14 |
human |