| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin G McGarry, Kevin E Schill, Tyson P Winters, Erin E Lemmon, Carol L Sabourin, Jill A Harvilchuck, Robert A Moye. Characterization of Cholinesterases From Multiple Large Animal Species for Medical Countermeasure Development Against Chemical Warfare Nerve Agents. Toxicological sciences : an official journal of the Society of Toxicology. vol 174. issue 1. 2021-06-09. PMID:31879781. |
disruption of cholinergic function through the inhibition of acetylcholinesterase (ache) leads to the accumulation of the neurotransmitter acetylcholine. |
2021-06-09 |
2023-08-13 |
Not clear |
| Leila Sadeghi, Reza Yekta, Gholamreza Dehgha. The inhibitory effects of bile acids on catalytic and non‑catalytic functions of acetylcholinesterase as a therapeutic target in Alzheimer's disease. Acta neurobiologiae experimentalis. vol 80. issue 2. 2021-06-07. PMID:32602852. |
acetylcholine is a fast-acting neurotransmitter in synapses and neuromuscular junctions that is decreased in alzheimer's disease (ad) by hyper‑activation of acetylcholinesterase (ache), which leads to progressive loss of memory and neurobehavioral abnormalities. |
2021-06-07 |
2023-08-13 |
rat |
| Congwei Yu, Ming Zhao, Zuchen Pan, Yiyang Bo, Weiwei Zhao, Xiongkui He, Jiaheng Zhan. Butyrylcholinesterase nanodepots with enhanced prophylactic and therapeutic performance for acute organophosphorus poisoning management. Journal of materials chemistry. B. vol 9. issue 7. 2021-05-31. PMID:33533366. |
as a potential alternative, delivery of mammalian-derived butyrylcholinesterase (bche) offers a cost-effective way to block organophosphorus attack on acetylcholinesterase, a key enzyme in the neurotransmitter cycle. |
2021-05-31 |
2023-08-13 |
mouse |
| Afreen Jahan Rahman, Deepti Sharma, Deepanshu Kumar, Mallika Pathak, Anju Singh, Vinod Kumar, Raman Chawla, Himanshu Ojh. Spectroscopic and molecular modelling study of binding mechanism of bovine serum albumin with phosmet. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 244. 2021-05-14. PMID:32829155. |
phosmet exerts its neurotoxicity by inhibiting acetylcholinesterase that catalyzes the degradation of acetylcholine (a neurotransmitter). |
2021-05-14 |
2023-08-13 |
cattle |
| E Wigenstam, E Forsberg, A Bucht, L Thor. Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX. Toxicology and applied pharmacology. vol 419. 2021-05-11. PMID:33785355. |
nerve agents are highly toxic organophosphorus compounds that inhibit acetylcholinesterase resulting in rapid accumulation of the neurotransmitter acetylcholine (ach) causing a cholinergic syndrome including respiratory failure. |
2021-05-11 |
2023-08-13 |
rat |
| Chansi, Pragadeeshwara Rao R, Irani Mukherjee, Tinku Basu, Lalit M Bharadwa. Metal Organic Framework steered electrosynthesis of anisotropic gold nanorods for specific sensing of organophosphate pesticides in vegetables collected from the field. Nanoscale. vol 12. issue 42. 2021-05-07. PMID:33094779. |
in the present study, we have intertwined the interfaces of a metal organic framework (mof), mof-directed rapid electrochemically grown gold nanorods (aaunr), cysteamine (cys) functionalization, and the neurotransmitter acetylcholinesterase (ache) to fabricate a novel electrochemical bioprobe ache/cys/aaunr/mof/ito for sensing op pesticides with an ultra-low detection limit of 3 ng l-1 over a linear range of 30 to 600 ng l-1. |
2021-05-07 |
2023-08-13 |
Not clear |
| Ana Matošević, Andreja Radman Kastelic, Ana Mikelić, Antonio Zandona, Maja Katalinić, Ines Primožič, Anita Bosak, Tomica Hrena. Quinuclidine-Based Carbamates as Potential CNS Active Compounds. Pharmaceutics. vol 13. issue 3. 2021-04-13. PMID:33804719. |
the treatment of central nervous system (cns) diseases related to the decrease of neurotransmitter acetylcholine in neurons is based on compounds that prevent or disrupt the action of acetylcholinesterase and butyrylcholinesterase. |
2021-04-13 |
2023-08-13 |
human |
| Alexandre A de Castro, Letícia C Assis, Flávia V Soares, Kamil Kuca, Daniel A Polisel, Elaine F F da Cunha, Teodorico C Ramalh. Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016-2019). Biomolecules. vol 10. issue 3. 2021-03-17. PMID:32178264. |
acetylcholinesterase (ache) is the key enzyme responsible for deactivating the ach neurotransmitter. |
2021-03-17 |
2023-08-13 |
Not clear |
| Mousumi Patra, Milon Banik, Pathikrit Bandopadhyay, Debanjan Dutta, Riya Mukherjee, Sreeparna Das, Naznin Ara Begum, Tarakdas Bas. Nanonization of a chemically synthesized flavone HMDF (3-hydroxy-3',4'-methylenedioxyflavone) by entrapping within calcium phosphate nanoparticles and exploring its antioxidant role on neural cells in vitro and zebrafish in vivo. Nanotechnology. vol 32. issue 23. 2021-03-16. PMID:33724928. |
hmdf-cpnps, but not hmdf alone, inhibited the in vitro activity of acetylcholinesterase enzymes to break down the major neurotransmitter compound acetylcholine. |
2021-03-16 |
2023-08-13 |
mouse |
| Bonan Liu, Jiayuan Kou, Fuyan Li, Da Huo, Jiaran Xu, Xiaoxi Zhou, Dehao Meng, Murtaza Ghulam, Bobkov Artyom, Xu Gao, Ning Ma, Dong Ha. Lemon essential oil ameliorates age-associated cognitive dysfunction via modulating hippocampal synaptic density and inhibiting acetylcholinesterase. Aging. vol 12. issue 9. 2021-02-26. PMID:32392535. |
the effects of leo on learning and memory were examined using the morris water maze (mwm) test, novel object recognition test, and correlative indicators, including a neurotransmitter (acetylcholinesterase, ache), a nerve growth factor (brain-derived neurotrophic factor, bdnf), a postsynaptic marker (psd95), and presynaptic markers (synapsin-1, and synaptophysin), in app/ps1 mice. |
2021-02-26 |
2023-08-13 |
mouse |
| Prayasee Baruah, Abhinandan Das, Debojit Paul, Suman Chakrabarty, Kripamoy Aguan, Sivaprasad Mitr. Sulfonylurea Class of Antidiabetic Drugs Inhibit Acetylcholinesterase Activity: Unexplored Auxiliary Pharmacological Benefit toward Alzheimer's Disease. ACS pharmacology & translational science. vol 4. issue 1. 2021-02-23. PMID:33615172. |
all these drugs were found to exhibit moderate to strong inhibitory efficiency on the neurotransmitter degrading enzyme acetylcholinesterase (ache) with gly (ic |
2021-02-23 |
2023-08-13 |
Not clear |
| İrem Bozbey, Zeynep Özdemir, Harun Uslu, Azime Berna Özçelik, Fatma Sezer Şenol, İlkay Erdoğan Orhan, Mehtap Uysa. A Series of New Hydrazone Derivatives: Synthesis, Molecular Docking and Anticholinesterase Activity Studies. Mini reviews in medicinal chemistry. vol 20. issue 11. 2021-02-02. PMID:31660824. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ach), which is a significant neurotransmitter for regulation of cognition in animals. |
2021-02-02 |
2023-08-13 |
Not clear |
| Tomoyo Horio, Aisa Ozawa, Junichi Kamiie, Motoharu Sakau. Immunohistochemical analysis for acetylcholinesterase and choline acetyltransferase in mouse cerebral cortex after traumatic brain injury. The Journal of veterinary medical science. vol 82. issue 6. 2021-02-02. PMID:32321871. |
acetylcholine (ach), a neurotransmitter synthesized and hydrolyzed by choline acetyltransferase (chat) and acetylcholinesterase (ache), respectively, in the central nervous system, has the potential to regulate glial cells' states, i.e., non-reactive and reactive states. |
2021-02-02 |
2023-08-13 |
mouse |
| Chun Wang, Zhaopeng Shen, Junhong Yu, Jieru Yang, Fei Meng, Xiaolu Jiang, Changliang Zh. Protective effects of enzyme degradation extract from The British journal of nutrition. vol 123. issue 9. 2021-01-25. PMID:31787131. |
the pyede also renewed the glutathione peroxidase (gsh-px), superoxide dismutase and total antioxidant capability activities, down-regulated the inducible nitric oxide synthase activity and nitric oxide levels, normalised the hippocampal neurons and modulated multiple neurotransmitter systems by inhibiting the activities of acetylcholinesterase and monoamine oxidase in the up-regulation of acetylcholine, dopamine and noradrenaline levels. |
2021-01-25 |
2023-08-13 |
mouse |
| Jayeong Hwang, Kumju Youn, Yeongseon Ji, Seonah Lee, Gyutae Lim, Jinhyuk Lee, Chi-Tang Ho, Sun-Hee Leem, Mira Ju. Biological and Computational Studies for Dual Cholinesterases Inhibitory Effect of Zerumbone. Nutrients. vol 12. issue 5. 2021-01-20. PMID:32344943. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) mediate the degradation of acetylcholine (ach), a primary neurotransmitter in the brain. |
2021-01-20 |
2023-08-13 |
Not clear |
| Honglei Wang, Zhen Meng, Liqun Zhou, Zigang Cao, Xinjun Liao, Rongfang Ye, Huiqiang L. Effects of acetochlor on neurogenesis and behaviour in zebrafish at early developmental stages. Chemosphere. vol 220. 2021-01-05. PMID:33395817. |
acetylcholinesterase activity reduced in both embryos and larvae, and the expression of genes that are involved in neurodevelopment and the neurotransmitter system altered. |
2021-01-05 |
2023-08-13 |
cat |
| Wildson Max Barbosa da Silva, Solange de Oliveira Pinheiro, Daniela Ribeiro Alves, Jane Eire Silva Alencar de Menezes, Francisco Ernani Alves Magalhães, Francisca Crislândia Oliveira Silva, Jacilene Silva, Emmanuel Silva Marinho, Selene Maia de Morai. Synthesis of Quercetin-Metal Complexes, In Vitro and In Silico Anticholinesterase and Antioxidant Evaluation, and In Vivo Toxicological and Anxiolitic Activities. Neurotoxicity research. vol 37. issue 4. 2020-12-21. PMID:31853730. |
the level of acetylcholine, a neurotransmitter essential for processing memory and learning, is lower in the brains of patients with alzheimer's disease due to the higher concentration of the enzyme acetylcholinesterase. |
2020-12-21 |
2023-08-13 |
Not clear |
| Ewa Baranowska-Wójcik, Dominik Szwajgier, Anna Winiarska-Miecza. Regardless of the Brewing Conditions, Various Types of Tea are a Source of Acetylcholinesterase Inhibitors. Nutrients. vol 12. issue 3. 2020-12-21. PMID:32155927. |
acetylcholinesterase (ache) plays a significant role in the process through hydrolysis of the acetylcholine neurotransmitter. |
2020-12-21 |
2023-08-13 |
Not clear |
| Susete Pinteus, Marco F L Lemos, Celso Alves, Joana Silva, Rui Pedros. The marine invasive seaweeds Asparagopsis armata and Sargassum muticum as targets for greener antifouling solutions. The Science of the total environment. vol 750. 2020-11-11. PMID:32853930. |
both seaweeds revealed antifouling properties against microfoulers, namely algicidal and anti-biofilm activities; however asparagopsis armata stand out for its capacity to inhibit marine bacteria and microalgae growth, to decrease biofilm formation, and for acting as a neurotransmitter disruptor through the inhibition of acetylcholinesterase activity. |
2020-11-11 |
2023-08-13 |
Not clear |
| Stephen Brimijoin, Yang Gao, Liyi Geng, Vicky P Che. Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29535625. |
butyrylcholinesterase (bche), a plasma enzyme that hydrolyses the neurotransmitter, acetylcholine relatively well, with far lower efficiency than acetylcholinesterase (ache) but with the capability to degrade a broad range of bioactive esters. |
2020-10-01 |
2023-08-13 |
mouse |