| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nikolina Maček Hrvat, Zrinka Kovari. Counteracting poisoning with chemical warfare nerve agents. Arhiv za higijenu rada i toksikologiju. vol 71. issue 4. 2021-08-30. PMID:33410774. |
phosphylation of the pivotal enzyme acetylcholinesterase (ache) by nerve agents (nas) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of muscarinic and nicotinic membrane receptors in the central and peripheral nervous system. |
2021-08-30 |
2023-08-13 |
Not clear |
| Muskan Gori, Ashima Thakur, Abha Sharma, S J S Flor. Organic-Molecule-Based Fluorescent Chemosensor for Nerve Agents and Organophosphorus Pesticides. Topics in current chemistry (Cham). vol 379. issue 5. 2021-08-16. PMID:34346011. |
op compounds are highly toxic compounds that cause irreversible inhibition of enzyme acetylcholinesterase, which is essential for hydrolysis of neurotransmitter acetylcholine, leading to series of neurological disorders and even death. |
2021-08-16 |
2023-08-13 |
Not clear |
| Immacolata Vecchio, Luca Sorrentino, Annamaria Paoletti, Rosario Marra, Mariamena Arbitri. The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease. Journal of central nervous system disease. vol 13. 2021-07-22. PMID:34285627. |
one of the causes leading to ad is the decrease of neurotransmitter acetylcholine (ach) levels in the brain, in part due to a higher activity of acetylcholinesterase (ache), the enzyme responsible for its degradation. |
2021-07-22 |
2023-08-13 |
Not clear |
| Andrea Castaneda, Ricardo Ferraz, Mónica Vieira, Isabel Cardoso, Vitor Vasconcelos, Rosário Martin. Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer's Disease. Marine drugs. vol 19. issue 6. 2021-07-05. PMID:34208482. |
in this review, we aimed to compile the research works focused in the anti-ad potential of cyanobacteria, namely regarding the inhibition of the enzyme β-secretase (bace1) as a fundamental enzyme in the generation of β-amyloid (aβ), the inhibition of the enzyme acetylcholinesterase (ache) lead to an increase in the availability of the neurotransmitter acetylcholine in the synaptic cleft and the antioxidant and anti-inflammatory effects, as phenomena associated with neurodegeneration mechanisms. |
2021-07-05 |
2023-08-13 |
Not clear |
| M V K Reddy, K Y Rao, G Anusha, G M Kumar, A G Damu, Kakarla Raghava Reddy, Nagaraj P Shetti, Tejraj M Aminabhavi, Peddiahgari Vasu Govardhana Redd. In-vitro evaluation of antioxidant and anticholinesterase activities of novel pyridine, quinoxaline and s-triazine derivatives. Environmental research. vol 199. 2021-07-01. PMID:33991570. |
cholinesterase enzymes such as acetylcholinesterase (ache) and butyrylcholinesterase (buche) cause hydrolysis of acetylcholine (ach), a neurotransmitter responsible for the cognitive functions of the brain such as acquiring knowledge and comprehension. |
2021-07-01 |
2023-08-13 |
Not clear |
| Kevin G McGarry, Kevin E Schill, Tyson P Winters, Erin E Lemmon, Carol L Sabourin, Jill A Harvilchuck, Robert A Moye. Characterization of Cholinesterases From Multiple Large Animal Species for Medical Countermeasure Development Against Chemical Warfare Nerve Agents. Toxicological sciences : an official journal of the Society of Toxicology. vol 174. issue 1. 2021-06-09. PMID:31879781. |
disruption of cholinergic function through the inhibition of acetylcholinesterase (ache) leads to the accumulation of the neurotransmitter acetylcholine. |
2021-06-09 |
2023-08-13 |
Not clear |
| Leila Sadeghi, Reza Yekta, Gholamreza Dehgha. The inhibitory effects of bile acids on catalytic and non‑catalytic functions of acetylcholinesterase as a therapeutic target in Alzheimer's disease. Acta neurobiologiae experimentalis. vol 80. issue 2. 2021-06-07. PMID:32602852. |
acetylcholine is a fast-acting neurotransmitter in synapses and neuromuscular junctions that is decreased in alzheimer's disease (ad) by hyper‑activation of acetylcholinesterase (ache), which leads to progressive loss of memory and neurobehavioral abnormalities. |
2021-06-07 |
2023-08-13 |
rat |
| Congwei Yu, Ming Zhao, Zuchen Pan, Yiyang Bo, Weiwei Zhao, Xiongkui He, Jiaheng Zhan. Butyrylcholinesterase nanodepots with enhanced prophylactic and therapeutic performance for acute organophosphorus poisoning management. Journal of materials chemistry. B. vol 9. issue 7. 2021-05-31. PMID:33533366. |
as a potential alternative, delivery of mammalian-derived butyrylcholinesterase (bche) offers a cost-effective way to block organophosphorus attack on acetylcholinesterase, a key enzyme in the neurotransmitter cycle. |
2021-05-31 |
2023-08-13 |
mouse |
| Afreen Jahan Rahman, Deepti Sharma, Deepanshu Kumar, Mallika Pathak, Anju Singh, Vinod Kumar, Raman Chawla, Himanshu Ojh. Spectroscopic and molecular modelling study of binding mechanism of bovine serum albumin with phosmet. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 244. 2021-05-14. PMID:32829155. |
phosmet exerts its neurotoxicity by inhibiting acetylcholinesterase that catalyzes the degradation of acetylcholine (a neurotransmitter). |
2021-05-14 |
2023-08-13 |
cattle |
| E Wigenstam, E Forsberg, A Bucht, L Thor. Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX. Toxicology and applied pharmacology. vol 419. 2021-05-11. PMID:33785355. |
nerve agents are highly toxic organophosphorus compounds that inhibit acetylcholinesterase resulting in rapid accumulation of the neurotransmitter acetylcholine (ach) causing a cholinergic syndrome including respiratory failure. |
2021-05-11 |
2023-08-13 |
rat |
| Chansi, Pragadeeshwara Rao R, Irani Mukherjee, Tinku Basu, Lalit M Bharadwa. Metal Organic Framework steered electrosynthesis of anisotropic gold nanorods for specific sensing of organophosphate pesticides in vegetables collected from the field. Nanoscale. vol 12. issue 42. 2021-05-07. PMID:33094779. |
in the present study, we have intertwined the interfaces of a metal organic framework (mof), mof-directed rapid electrochemically grown gold nanorods (aaunr), cysteamine (cys) functionalization, and the neurotransmitter acetylcholinesterase (ache) to fabricate a novel electrochemical bioprobe ache/cys/aaunr/mof/ito for sensing op pesticides with an ultra-low detection limit of 3 ng l-1 over a linear range of 30 to 600 ng l-1. |
2021-05-07 |
2023-08-13 |
Not clear |
| Ana Matošević, Andreja Radman Kastelic, Ana Mikelić, Antonio Zandona, Maja Katalinić, Ines Primožič, Anita Bosak, Tomica Hrena. Quinuclidine-Based Carbamates as Potential CNS Active Compounds. Pharmaceutics. vol 13. issue 3. 2021-04-13. PMID:33804719. |
the treatment of central nervous system (cns) diseases related to the decrease of neurotransmitter acetylcholine in neurons is based on compounds that prevent or disrupt the action of acetylcholinesterase and butyrylcholinesterase. |
2021-04-13 |
2023-08-13 |
human |
| Alexandre A de Castro, Letícia C Assis, Flávia V Soares, Kamil Kuca, Daniel A Polisel, Elaine F F da Cunha, Teodorico C Ramalh. Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016-2019). Biomolecules. vol 10. issue 3. 2021-03-17. PMID:32178264. |
acetylcholinesterase (ache) is the key enzyme responsible for deactivating the ach neurotransmitter. |
2021-03-17 |
2023-08-13 |
Not clear |
| Mousumi Patra, Milon Banik, Pathikrit Bandopadhyay, Debanjan Dutta, Riya Mukherjee, Sreeparna Das, Naznin Ara Begum, Tarakdas Bas. Nanonization of a chemically synthesized flavone HMDF (3-hydroxy-3',4'-methylenedioxyflavone) by entrapping within calcium phosphate nanoparticles and exploring its antioxidant role on neural cells in vitro and zebrafish in vivo. Nanotechnology. vol 32. issue 23. 2021-03-16. PMID:33724928. |
hmdf-cpnps, but not hmdf alone, inhibited the in vitro activity of acetylcholinesterase enzymes to break down the major neurotransmitter compound acetylcholine. |
2021-03-16 |
2023-08-13 |
mouse |
| Bonan Liu, Jiayuan Kou, Fuyan Li, Da Huo, Jiaran Xu, Xiaoxi Zhou, Dehao Meng, Murtaza Ghulam, Bobkov Artyom, Xu Gao, Ning Ma, Dong Ha. Lemon essential oil ameliorates age-associated cognitive dysfunction via modulating hippocampal synaptic density and inhibiting acetylcholinesterase. Aging. vol 12. issue 9. 2021-02-26. PMID:32392535. |
the effects of leo on learning and memory were examined using the morris water maze (mwm) test, novel object recognition test, and correlative indicators, including a neurotransmitter (acetylcholinesterase, ache), a nerve growth factor (brain-derived neurotrophic factor, bdnf), a postsynaptic marker (psd95), and presynaptic markers (synapsin-1, and synaptophysin), in app/ps1 mice. |
2021-02-26 |
2023-08-13 |
mouse |
| Prayasee Baruah, Abhinandan Das, Debojit Paul, Suman Chakrabarty, Kripamoy Aguan, Sivaprasad Mitr. Sulfonylurea Class of Antidiabetic Drugs Inhibit Acetylcholinesterase Activity: Unexplored Auxiliary Pharmacological Benefit toward Alzheimer's Disease. ACS pharmacology & translational science. vol 4. issue 1. 2021-02-23. PMID:33615172. |
all these drugs were found to exhibit moderate to strong inhibitory efficiency on the neurotransmitter degrading enzyme acetylcholinesterase (ache) with gly (ic |
2021-02-23 |
2023-08-13 |
Not clear |
| İrem Bozbey, Zeynep Özdemir, Harun Uslu, Azime Berna Özçelik, Fatma Sezer Şenol, İlkay Erdoğan Orhan, Mehtap Uysa. A Series of New Hydrazone Derivatives: Synthesis, Molecular Docking and Anticholinesterase Activity Studies. Mini reviews in medicinal chemistry. vol 20. issue 11. 2021-02-02. PMID:31660824. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ach), which is a significant neurotransmitter for regulation of cognition in animals. |
2021-02-02 |
2023-08-13 |
Not clear |
| Tomoyo Horio, Aisa Ozawa, Junichi Kamiie, Motoharu Sakau. Immunohistochemical analysis for acetylcholinesterase and choline acetyltransferase in mouse cerebral cortex after traumatic brain injury. The Journal of veterinary medical science. vol 82. issue 6. 2021-02-02. PMID:32321871. |
acetylcholine (ach), a neurotransmitter synthesized and hydrolyzed by choline acetyltransferase (chat) and acetylcholinesterase (ache), respectively, in the central nervous system, has the potential to regulate glial cells' states, i.e., non-reactive and reactive states. |
2021-02-02 |
2023-08-13 |
mouse |
| Chun Wang, Zhaopeng Shen, Junhong Yu, Jieru Yang, Fei Meng, Xiaolu Jiang, Changliang Zh. Protective effects of enzyme degradation extract from The British journal of nutrition. vol 123. issue 9. 2021-01-25. PMID:31787131. |
the pyede also renewed the glutathione peroxidase (gsh-px), superoxide dismutase and total antioxidant capability activities, down-regulated the inducible nitric oxide synthase activity and nitric oxide levels, normalised the hippocampal neurons and modulated multiple neurotransmitter systems by inhibiting the activities of acetylcholinesterase and monoamine oxidase in the up-regulation of acetylcholine, dopamine and noradrenaline levels. |
2021-01-25 |
2023-08-13 |
mouse |
| Jayeong Hwang, Kumju Youn, Yeongseon Ji, Seonah Lee, Gyutae Lim, Jinhyuk Lee, Chi-Tang Ho, Sun-Hee Leem, Mira Ju. Biological and Computational Studies for Dual Cholinesterases Inhibitory Effect of Zerumbone. Nutrients. vol 12. issue 5. 2021-01-20. PMID:32344943. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) mediate the degradation of acetylcholine (ach), a primary neurotransmitter in the brain. |
2021-01-20 |
2023-08-13 |
Not clear |